A three-item illustration highlights the research behind a clinical trial for mitochondrial transplantation for children undergoing cardiogenic shock. On the left, an illustration depicts a patient on an ECMO machine. The patient has ischemia-reperfusion injury and is receiving ECMO support (n =24). An illustration in the middle shows a color-coded heart to depict the direct injection of mitochondria. At right, a box offers the following research outcomes: no difference in WBC and lactates; successful separation from ECMO; lower cardiovascular events; enhanced ventricular strain.
Guariento A, Piekarski BL, Doulamis IP, Blitzer D, Ferraro AM, Harrild DM, Zurakowski D, Del Nido PJ, McCully JD, Emani SM. Autologous mitochondrial transplantation for cardiogenic shock in pediatric patients following ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2020 Dec 01. PMID: 33349443.