The Musculoskeletal Digital Innovation and Informatics (MDI2) Program in the Department of Orthopedics and Sports Medicine at Boston Children’s Hospital and Harvard Medical School has an immediate opening for an outstanding, highly motivated Postdoctoral Research fellow to work on several image processing and modeling projects to assist with clinical decision making in patients with spinal deformities. The Postdoctoral Research Fellow will work with a multidisciplinary team of biomedical engineers, orthopedic surgeons, and computer and data scientists to develop algorithms to analyze medical images (e.g., MRI and CT).
This fellowship opportunity is primarily focused on translational research with immediate impact on clinical care of patients with a range of spinal conditions, through publication of novel findings and development of computational tools used by clinicians. The postdoctoral fellow will have joint appointments at Boston Children’s Hospital and Harvard Medical School and will benefit from access to the largest medical R&D community in the world (Longwood / Boston), along with numerous career development resources offered by Harvard University and its affiliated hospitals and research centers. The successful candidate will have:
Required skill and experiences:
Desired skills and experiences:
This is a full-time 3-year position, renewed annually based on the applicant’s performance. Interested applicants, please send your CV along with a copy of a technical paper, a "paragraph" including statement of goals and contact information for three references to MDI2.Program@childrens.harvard.edu.
The Pediatric Pain Pathway lab at Boston Children’s Hospital is looking for a Post-Doctoral Research Fellow (PDF) for a new program focused on exercise, pain, and women’s health. This initiative integrates neuroimaging with clinical and behavioral data and has programs focused on brain health (integrated EEG and MRI), and pelvic floor health (EMG, fMRI). There is currently a program being developed on pregnancy and the relationship between maternal fitness and the health of both the mother and offspring after birth. These initiatives are geared around neuroscience underlying pain perception and their relationship to physical activity / movement.
We are looking for a PDF for a one-year period, with possibility of extension to a two-year contract based on availability of funds. The time of the PDF will be focused on data collection, manuscript preparation and grant preparation / submission. They will work closely with a team of clinical research assistants and interns in a highly collaborative environment. There are opportunities to contribute to existing programs focused on headache and brain imaging. There are significant opportunities for leadership in mentoring, manuscript preparation and grant preparation.
The ideal candidate has a PhD in Neuroscience or related field. Experience in neuroimaging, EEG, and computer science are all considered assets. A strong publication record and record of funding that is appropriate for their level of training will be evaluated. This position will include direct interface with patients, their families, and researchers / clinicians. The proposed timing of the position start is January 1st, 2026 and is open to negotiation. Our office is located at 1 Autumn Street in Boston, and our main data collection facility is located at 2 Brookline Place.
The D’Gama Lab at Boston Children’s Hospital conducts translational research at the intersection of developmental neuroscience, genetics/genomics, and neonatology. Our goal is to advance equitable precision medicine for infants and children with neurological and genetic conditions, especially infants with epilepsy and related neurogenetic disorders. We aim to accomplish this goal by conducting research across the translational spectrum: discovering fundamental underlying molecular genetic mechanisms (precision diagnoses) and evaluating their impact, enabling development of innovative precision therapies and readiness for clinical trials, and implementing precision medicine equitably for these populations. Ultimately, we hope to improve outcomes for pediatric patients with these conditions and their families.
The D’Gama Lab is recruiting a talented and highly motivated postdoctoral fellow with experience in
translational research to join our group. As a new lab, we are building a welcoming, collaborative, and
rigorous environment to conduct impactful research. This individual will have the opportunity to develop
and lead studies, help set the research directions of the lab, and be involved in grant writing, manuscript
preparation and presentations, and training and mentoring of junior lab members.
Qualifications
Required:
Preferred:
How to Apply
Interested individuals should send the following to alissa.dgama@childrens.harvard.edu:
A postdoctoral fellow position in Dr. Gregory Priebe’s Laboratory at Boston Children’s Hospital (BCH) is immediately available for studies of vaccines for Pseudomonas aeruginosa in animal models, with focus on lung TRM Th17 cells.
The Priebe Lab utilizes a variety of experimental approaches, including mouse models of infection, microbiology, microbial genomics, immunology, carbohydrate and protein chemistry, and molecular biology. This project is part of an NIH-funded Center of Excellence for Translational Research (CETR) run by Dr. Priebe along with Dr. Richard Malley at BCH and Dr. Jay Kolls at Tulane.
The successful candidate will hold a PhD, MD/PhD, or DVM/PhD with strong immunology background. Applicants with multicolor flow cytometry expertise are preferred. Must be willing to handle mice and infectious materials.
Please respond by email to gregory.priebe@childrens.harvard.edu with:
1. Cover letter briefly describing your scientific accomplishments and career goals
2. CV including contact information for at least 2 references
A postdoctoral position is immediately available for research focusing on vaccine development and cellular immunity against bacterial pathogens in the Malley laboratory at Boston Children's Hospital, Harvard Medical School in Boston, MA USA.
One of the main areas of focus of the laboratory is the study of tissue-resident, antigen-specific protective T cells against bacterial pathogens, both naturally acquired and following vaccination. The Malley lab works on several important human bacterial pathogens, including Staphylococcus aureus, Streptococcus pneumoniae, Group B Streptococcus and Mycobacterium tuberculosis.
Qualifications
Required:
Boston Children’s Hospital offers competitive compensation and unmatched benefits, including a rotating days/evenings and week-end schedule, affordable health, vision and dental insurance, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition Reimbursement, cell phone plan discounts and discounted rates on T-passes (50% off).
For more information or to apply, please send CV and the names of 3 references to:
Dr. Richard Malley, Boston Children's Hospital and Harvard Medical School
Research Focus: Visual Neuroscience and Cortical Circuit Plasticity
The Gaier Lab at Boston Children’s Hospital and Harvard Medical School is recruiting a highly motivated postdoctoral fellow to investigate the neural circuit mechanisms that support binocular vision, visual cortical plasticity, and recovery from amblyopia. This is a 2-3 year position with an opportunity to extend, provided the fellow demonstrates effort towards seeking self-funding prior to the end of year 2.
Our group uses in vivo electrophysiology, optogenetics, and visual behavior assays in mice to investigate how early visual experience shapes cortical function and how those circuits can be re-engaged for recovery later in life.
Current research areas include:
Our lab offers a collaborative, rigorous, and highly interdisciplinary environment with strong ties to both basic neuroscience and clinical neuro-ophthalmology.
Key Responsibilities
Eligibility
Preferred Qualifications
What We Offer
How to Apply
Please include the following:
The mission of the Biddinger lab is to improve the lives of people with metabolic disease. We are particularly fascinated by the liver, which simultaneously coordinates hundreds of metabolic pathways to maintain homeostasis. The Biddinger lab has used single cell technologies to understand the heterogeneous populations of cells in this organ and the complex collaboration required to meet metabolic demands.
We are looking for like-minded individuals who like solving hard problems and being creative.
Requirements
Please send a CV and thoughts about how you could fit into our team to biddingerlab@gmail.com. More information can be found on the Biddinger Lab website.
Two-year postdoctoral fellowships funded by the National Institute of Mental Health (NIMH) are available for researchers who seek to improve or expand their ability to conduct interdisciplinary, translational neuroscience research in neurodevelopment and neurodevelopmental or mental disorders.
Research Areas
Postdoctoral projects can encompass basic and/or clinical research and might include investigation into one or more of the following areas:
Program Areas/Faculty Department Affiliations
Fellows with MD or PhD degrees conduct research during the program with mentors/advisors from the following areas:
Trainee Program
This two-year training program provides trainees with the essential guidance, training, and mentoring critical to launching an independent career in academic research. The training program starts by recruiting the most talented trainees from MD/PhD, MD, and PhD programs who are interested in pursuing a career in translational neuroscience research and academia. Close interaction between T32 mentors and trainees are supplemented by a structured training program that provides a common knowledge base with respect to translational neuroscience research. Supplemental work will focus on Translational Neuroscience Seminar Series and Proseminars complemented by trainee specific coursework. Administratively, the program consists of co-directors (Drs. Nelson & Glahn) and a group of 19 highly skilled and successful training faculty from diverse array of disciplines.
How to Apply
Applicants should first consult the list of potential mentors and confirm that he/she is willing to serve as primary mentor. Eligible candidates should submit one PDF via email to T32translationaldevelopment@childrens.harvard.edu with the following documents: (1) trainee’s CV, (2) trainee’s research statement (max 2 pages) about research interest and specifically why they have selected this training program, and (3) names and contact information of 2 potential letter writers. Project proposals should clearly state the interdisciplinary nature of the project. If selected for an interview, we will also require: (4) 2 letters of support (one from trainee’s mentor) and (5) mentor’s NIH other support document.
Applications should be submitted by March 14, 2025, with the expectation that trainees will be selected by April 30 and will start as early as July 2025. Applicants must be U.S. citizens or permanent residents with an MD and/or PhD (must be completed at the time training begins). Commitment to the goals of the program and strong academic and research credentials are important criteria used in the selection process.
Further inquiries can be made by reaching out to us directly at T32Translationaldevelopment@childrens.harvard.edu. Download the position ad for more information.
The Koehler Lab at Boston Children’s Hospital and Harvard Medical School is at the forefront of developing and refining organoid-based systems to study sensory organ development, disease modeling, and therapeutic applications. Our lab has pioneered two first-of-their-kind organoid models—hair-bearing skin organoids and multi-lineage inner ear organoids—and developed custom microfluidic systems to support their long-term growth, maturation, and continuous imaging.
We are seeking a talented and motivated postdoctoral scientist with a Ph.D. in bioengineering, stem cell biology, or related fields and 0–4 years of postdoctoral experience. This position offers a unique opportunity to work at the intersection of basic biology, engineering, and translational science. The successful candidate will contribute to designing and improving in vitro systems for testing gene and cell therapies.
Key Responsibilities
Qualifications
About the Lab
The Koehler Lab is uniquely positioned to design next-generation in vitro systems for therapeutic testing. Our custom microfluidic platforms allow for the long-term culture of complex tissues while enabling real-time monitoring and imaging. We are dedicated to advancing regenerative therapies for congenital disorders and acquired sensory organ dysfunctions. This position will provide access to world-class facilities, including the HMS Microfabrication Core, Cellular Imaging Core, and advanced microscopy resources.
Opportunities
This role offers an unparalleled opportunity to engage in groundbreaking research at the interface of fundamental biology, engineering innovation, and translational medicine. The postdoctoral scientist will be part of an interdisciplinary team driving impactful research and collaborating with clinicians and leading investigators.
Application Instructions
To apply, please send the following to Dr. Karl Koehler at karl.koehler@childrens.harvard.edu:
The Julia Li Lab at Boston Children’s Hospital and Harvard Medical School is seeking a postdoctoral candidate who shares our passion in solving the key questions surrounding this previously missing link between repeat DNA, genome stability, and viruses. While we welcome any area of expertise in the biological sciences, the ideal candidate will have a strong background in cell and molecular biology, biochemistry, microscopy, virology, and cancer genomics.
Our lab focuses on how virus-like repeat sequences pose a threat to genome stability, yet contribute to normal genome structure and function. Half of our genome consists of repeat sequences that resemble viral DNA, yet the functional significant of these virus-like repeats remains a mystery. Abnormal repeat sequences have been found at unstable genomic regions implicated in cancer and genome diseases. However, how repeat sequences threaten the stability of our genome is not well understood. Finally, DNA viruses detected in cancer cells are also prime suspects in promoting genomic instability. For decades, these unsolved, seemingly connected observations pointed towards a missing mechanism. By observing two fluorescent nuclear signals of the Epstein Barr Virus Nuclear Antigen 1 (EBNA1), we found this missing piece to the puzzle: a cluster of Epstein Bar Virus (EBV)-like repeat sequences in our genome that can break and trigger chromosomal abnormalities in cells infected with EBV. This cluster of virus-like repeats, with no known mechanisms or function, provides an unprecedented opportunity to investigate site-specific breakage at endogenous repeats, induced by a viral protein expressed in more than 95% of the human population.
The overall goal of our lab is to uncover the missing mechanistic link between DNA repeats, genome stability, and viruses that involves binding of a viral protein to virus-like repeat sequences and its role in both health and disease. Specifically, we employ advanced techniques in molecular biology, cell biology, single cell analysis, microscopy, genome-wide sequencing, unbiased proteomics, and functional genomics to answer the following questions:
In the long run, we are excited about potentially uncovering a class of viral proteins that play a role in human health and disease by binding to virus-like repeat sequences in our genome. Ultimately, understanding basic mechanisms surrounding virus-like repeat sequences will create new opportunities for the prevention and treatment of viral infection-associated cancer and genetic diseases.
We invite you to learn more about our work at thejulialilab.com. To apply, please contact Julia Li at Julia.li@childrens.harvard.edu.
The Naqvi Lab at Boston Children’s Hospital and Harvard Medical School is looking for a highly motivated and driven Postdoctoral Research Fellow to work on projects studying cell type-specific effects of transcription factor dosage during development.
We combine functional genomics and computational modeling using stem cell-derived in vitro models of development to understand the quantitative control of gene expression in development. A major focus of the lab is addressing these questions in the context of the human neural crest, an embryonic cell population that gives rise to a fascinating array of cell types including the craniofacial skeleton and the enteric nervous system.
The successful candidate will utilize genome editing, chemical genetics, functional genomics, and stem cell-derived models to understand why and how quantitative changes in transcription factor dosage have cell type-specific effects. Projects include studying neural crest in both craniofacial and enteric nervous system development, as well as additional lineages with transcription factor dosage sensitivity. This candidate will also incorporate cutting-edge deep learning models or collaborate with others to do so. In addition to research, this position entails training and mentoring of other lab members as well as general laboratory maintenance.
As a new lab, we are looking to welcome new members to help build a welcoming, inclusive, and intellectually engaging environment for training and mentoring. The candidate will have opportunities to set the direction of research in the lab and be involved in grant writing, all excellent training for a variety of subsequent careers. The candidate will also present their work and obtain feedback from seminars in the Division of Gastroenterology, with the ability to interact more broadly in the intellectually stimulating scientific ecosystems of Boston Children’s Hospital and Harvard Medical School. Additional professional development opportunities, including conference and seminar attendance, will also be provided.
To apply, email Dr. Sahin Naqvi at sahin.naqvi@childrens.harvard.edu with:
Applications will be considered on a rolling basis. For more information, visit naqvilab.org or contact Dr. Naqvi with questions about the position.
The Nigrovic lab at Boston Children’s Hospital and Harvard Medical School is seeking a postdoctoral fellow to spearhead studies exploring the immune role of megakaryocytes, including via emperipolesis, a new form of cell-in-cell interaction between megakaryocytes and neutrophils.
This work will build on our observation that megakaryocytes contribute to systemic inflammatory disease, even independent of their platelets (J Clin Invest. 2017:1714-1724; J Leuk Biol 2019;105:1111-1121). Using tools including 2-photon microscopy, we seek to understand how megakaryocytes function as immune cells through their surface receptors, soluble mediators, and microparticles. We seek to deepen our understanding of emperipolesis, whereby neutrophils penetrate into the megakaryocyte cytoplasm to pass surface membrane to platelets before leaving intact (eLife 2019;8:e440312019; Blood Adv. 2022;6:2081-2091). We will explore the cell biology of emperipolesis as well as its implications for the function of megakaryocytes, neutrophils, and platelets.
Applicants should have a PhD (or MD with substantial laboratory experience) related to cellular and immune biology. Specific megakaryocyte, platelet, and/or neutrophil experience, and/or 2-photon microscopy experience, is helpful but not required.
The Nigrovic lab is a basic and translational research group based in the Division of Immunology at Boston Children’s Hospital. Funding is provided by NIH R01 grants and other sources. Human samples are available. Successful applicants will have a track record of productivity that confirms their ability to work independently at a high level in a friendly, collegial, and supportive but demanding environment. Potential for partial self-funding is welcome but not essential.
Inquiries and applications (including CV, name/email address of 2-3 referees, and reprints of 2 most significant publications) should be directed to:
Peter A. Nigrovic, MD
Chief, Division of Immunology, Boston Children’s Hospital
Prince Turki bin Abdul Aziz al-Saud Professor of Pediatrics and Medicine
Harvard Medical School
Peter.nigrovic@childrens.harvard.edu
The focus of the Sampson Lab at Boston Children’s Hospital/Harvard Medical School is to discover the molecular basis of nephrotic syndrome through human genomics to inform mechanisms, treatments, and cures for this disease.
We integrate genomics data with other molecular and clinical datasets to discover the biological and clinical impact of the disease-associated genomic variants we discover. We also focus on using large Biobanks to empower genomic discovery for NS. Finally, we are also using new technologies and developing analytic strategies to make definitive genomic diagnoses for patients. We now seek an intellectually curious and independent thinking post-doctoral fellow to drive forward projects in one or more of these broad research areas.
Specific projects available include:
We are most interested in applicants with excellent skills in biostatistics, as well as a strong understanding of human genetics, bioinformatics, and/or genome biology. They will use both well-established and newer methods for analysis of diverse types of genomic data, including genome and exome sequencing, and bulk and single cell transcriptomics. They will drive their own projects and also support the efforts of other members of the group.
The Sampson Lab is located at Boston Children’s Hospital and is affiliated with Harvard Medical School, the Broad Institute of MIT and Harvard, and Brigham & Women’s Hospital. It is well-funded through multiple Federal grants and other resources. It is a vibrant, highly collaborative, and multidisciplinary environment made up of nephrologists, computational geneticists, biostatisticians, and epidemiologists, and bench researchers.
Preferred qualifications:
Interested candidates should send a cover letter & CV to matthew.sampson@childrens.harvard.edu.
Matt Sampson, MD MSCE ASCI
Warren E. Grupe Chair in Pediatric Nephrology, Boston Children’s Hospital
Associate Professor of Pediatrics and Medicine, Harvard Medical School
Associate Member, Broad Institute
Research Faculty, Brigham and Women’s Hospital
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.
The Osterweil lab is recruiting a motivated individual to fill a postdoctoral position in molecular neuroscience. You will be joining the exciting, fast-paced environment at Boston Children’s Hospital/ Harvard Medical School investigating cell type-specific mRNA translation in neural function and dysfunction.
Our group has a number of hypothesis-driven projects that are aimed at identifying critical mechanisms in neural plasticity, and determining how these processes go awry in neurodevelopmental disorders such as fragile X syndrome. We are using molecular approaches including TRAP-seq, scRNA-seq, and spatial transcriptomics, and combining these with electrophysiological and behavioral assays to answer research questions and test potential therapeutic approaches that arise from this work. We are also employing new models to determine the conservation of synaptic mechanisms between mouse and human.
Candidates must have a PhD in neuroscience, cell biology, or a related field, and show evidence of good productivity in the form of publications. Experience with either molecular neuroscience and mouse brain surgical techniques, or RNA-seq and bioinformatics, is greatly preferred.
Please send a CV, cover letter with statement of interest, and 2-3 letters of references to Emily.osterweil@childrens.harvard.edu. Applications will be accepted until a suitable candidate is found.
Boston Children’s Hospital is an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability.
Boston Children’s Hospital requires all employees to be vaccinated against COVID-19 and Flu, (unless you are eligible for a medical or religious exemption).
A postdoctoral fellow position is open for a highly creative and motivated applicant who has an interest in cardiovascular biomechanics and computational modeling within the cardio-engineering group at the Department of Cardiac Surgery. We are dedicated toward developing advanced computational modeling methods integrated with experimental approaches in cardiovascular biomechanics to improve diagnostic, surgical predictability, and personalization. The candidate will work with a multidisciplinary team of engineers, cardiac surgeons, and cardiologists to achieve this goal.
Working primarily with Dr. Vijay Govindarajan, the post-doctoral fellow will conduct research in the field of heart valves and thrombosis using various computational methods, including non-linear finite element modeling and computational fluid dynamics. The post-doctoral fellow will also collaborate with other researchers in the group to develop experimental approaches for validating these computational models. Ultimately, these modeling frameworks will be used in both research and integrated into clinical workflows, aiming to enhance surgical predictability and personalization.
Qualifications necessary for the position are as follows:
The application review process will start right away. Applications will be reviewed continuously.
Full-time position with competitive salary/benefits commensurate with experience. Candidate will work in fully funded projects for a minimum period of 3 years.
To apply, please submit a CV, a cover letter detailing research and career interests, motivation, and experience, to Vijay.govindarajan@childrens.harvard.edu. Please also include contact information of three references.
Research Focus: Cell Biology of Hereditary Spastic Paraplegia - Functional Genomics & Drug Discovery
In the Ebrahimi-Fakhari lab, our mission is to use cutting-edge research techniques to understand and treat rare neurological disorders in children. Our goal is to build a translational research platform that can take discoveries from the bedside to the bench and back. Through our commitment to collaboration, mentorship, and scientific excellence, we strive to make a lasting impact on the patients we serve. We are recruiting Post-Doctoral Research Fellows to expand our work on high-throughput platforms for functional genomics screens and drug discovery in cellular and in vivo models of hereditary spastic paraplegia.
We are looking for talented trainees who are passionate about disease-oriented translational research. We are particularly interested in colleagues with a background in molecular biology, cell biology, neuroscience, gene editing and/or work with transgenic mouse lines.
Our lab embraces all kinds of diversity, including race, ethnicity, gender, sexual orientation, socioeconomic background, disability, and religion. We're committed to ensuring everyone can succeed in their pursuit of the advancement of biomedical knowledge.
Boston Children's Hospital is a global leader in pediatric healthcare. Affiliated with Harvard Medical School, we provide an unparalleled environment for scientific advancement, fostering collaboration and innovation in pursuit of improving children's health worldwide.
Please submit the following documents to def.lab@childrens.harvard.edu.
Exempt Role:
The posted pay range is Boston Children’s reasonable and good-faith expectation for this pay at the time of posting.
Pay offer provided depends on skills, experience, education, certifications, and a variety of other job-related factors.
BCH offers a comprehensive benefits package that includes flexible schedules, medical/vision/dental coverage, child-care and student-loan subsidies, generous paid time off, a 403(b) retirement plan, commuter and other employee discounts.
Boston Children’s Hospital requires influenza vaccination for all employees, unless eligible for a medical or religious exemption.
Boston Children’s Hospital is an Equal Opportunity/Affirmative Action Employer; all qualified applicants will receive consideration without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status, disability, or other protected status.