Discovery of a small molecule TLR3 agonist adjuvant; Dec 3, 2025; pubmed:41339634. View Discovery of a small molecule TLR3 agonist adjuvant on PubMed Deep phenomics of PRR agonist activated human blood; Nov 9, 2025; pubmed:41206680. View Deep phenomics of PRR agonist activated human blood on PubMed Incorporating meningeal immunity into vaccine development; Oct 9, 2025; pubmed:41068115. View Incorporating meningeal immunity into vaccine development on PubMed Nanomedicine and Spleen-Targeting Strategies for Precision Immunomodulation: Advances, Challenges, and Future Perspectives; Jun 27, 2025; pubmed:40576399. View Nanomedicine and Spleen-Targeting Strategies for Precision Immunomodulation: Advances, Challenges, and Future Perspectives on PubMed mRNA vaccines: miRNA-based controlled biodistribution and directed adjuvantation; Apr 23, 2025; pubmed:40268657. View mRNA vaccines: miRNA-based controlled biodistribution and directed adjuvantation on PubMed OMIP-111: Immune-Profiling of T Helper 1 (Th1), Th2, and Th17 Signatures in Murine Splenocytes by Targeting Intracellular Cytokines; Mar 17, 2025; pubmed:40095325. View OMIP-111: Immune-Profiling of T Helper 1 (Th1), Th2, and Th17 Signatures in Murine Splenocytes by Targeting Intracellular Cytokines on PubMed Product and trial design considerations on the path towards a vaccine to combat opioid overdose; Feb 19, 2025; pubmed:39971929. View Product and trial design considerations on the path towards a vaccine to combat opioid overdose on PubMed BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice; Feb 13, 2025; pubmed:39946867. View BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice on PubMed Protocol for measuring anti-fentanyl antibodies in mouse serum by enzyme-linked immunosorbent assay; Dec 8, 2024; pubmed:39645655. View Protocol for measuring anti-fentanyl antibodies in mouse serum by enzyme-linked immunosorbent assay on PubMed The BNT162b2 mRNA vaccine demonstrates reduced age-associated TH1 support in vitro and in vivo; Nov 21, 2024; pubmed:39569372. View The BNT162b2 mRNA vaccine demonstrates reduced age-associated T<sub>H</sub>1 support <em>in vitro</em> and <em>in vivo</em> on PubMed Improving the Effectiveness of Collaboration Between Neuropsychology and Primary Care; Nov 5, 2024; pubmed:39499958. View Improving the Effectiveness of Collaboration Between Neuropsychology and Primary Care on PubMed An ionic liquid-based adjuvant for modulating cellular and humoral immune responses; Oct 22, 2024; pubmed:39437967. View An ionic liquid-based adjuvant for modulating cellular and humoral immune responses on PubMed Author Correction: AI is a viable alternative to high throughput screening: a 318-target study; Sep 16, 2024; pubmed:39284864. View Author Correction: AI is a viable alternative to high throughput screening: a 318-target study on PubMed Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70; Jul 24, 2024; pubmed:39047117. View Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70 on PubMed Need for strategic communications and stakeholder engagement to advance acceptability of an overdose preventing vaccine targeting fentanyl; Jul 11, 2024; pubmed:38991914. View Need for strategic communications and stakeholder engagement to advance acceptability of an overdose preventing vaccine targeting fentanyl on PubMed From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation; Jul 3, 2024; pubmed:38959314. View From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation on PubMed BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice; Jul 1, 2024; pubmed:38946947. View BECC-engineered live-attenuated <em>Shigella</em> vaccine candidates display reduced endotoxicity with robust immunogenicity in mice on PubMed Immune profiling of age and adjuvant-specific activation of human blood mononuclear cells in vitro; Jun 8, 2024; pubmed:38851856. View Immune profiling of age and adjuvant-specific activation of human blood mononuclear cells in vitro on PubMed AI is a viable alternative to high throughput screening: a 318-target study; Apr 2, 2024; pubmed:38565852. View AI is a viable alternative to high throughput screening: a 318-target study on PubMed Human in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen; Oct 26, 2023; pubmed:37884538. View Human in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen on PubMed Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance; Aug 18, 2023; pubmed:37595760. View Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance on PubMed A protocol for high-throughput screening for immunomodulatory compounds using human primary cells; Jul 15, 2023; pubmed:37453068. View A protocol for high-throughput screening for immunomodulatory compounds using human primary cells on PubMed Precision Vaccinology Approaches for the Development of Adjuvanted Vaccines Targeted to Distinct Vulnerable Populations; Jun 28, 2023; pubmed:37376214. View Precision Vaccinology Approaches for the Development of Adjuvanted Vaccines Targeted to Distinct Vulnerable Populations on PubMed Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice; Mar 3, 2023; pubmed:36869134. View Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice on PubMed Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice; Feb 14, 2023; pubmed:36788219. View Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice on PubMed The mRNA vaccine BNT162b2 demonstrates impaired TH1 immunogenicity in human elders in vitro and aged mice in vivo; Jan 4, 2023; pubmed:36597547. View The mRNA vaccine BNT162b2 demonstrates impaired T<sub>H</sub>1 immunogenicity in human elders <em>in vitro</em> and aged mice <em>in vivo</em> on PubMed Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance; Dec 16, 2022; pubmed:36523401. View Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance on PubMed Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination; Oct 18, 2022; pubmed:36258023. View Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination on PubMed Shaping Neonatal Immunization by Tuning the Delivery of Synergistic Adjuvants via Nanocarriers; Aug 26, 2022; pubmed:36028220. View Shaping Neonatal Immunization by Tuning the Delivery of Synergistic Adjuvants via Nanocarriers on PubMed mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant; Aug 6, 2022; pubmed:35933439. View mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant on PubMed Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells; Jul 21, 2022; pubmed:35860217. View Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells on PubMed Acceptability of a Fentanyl Vaccine to Prevent Opioid Overdose and Need for Personalized Decision-Making; May 17, 2022; pubmed:35579508. View Acceptability of a Fentanyl Vaccine to Prevent Opioid Overdose and Need for Personalized Decision-Making on PubMed A Precision Adjuvant Approach to Enhance Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines Optimized for Immunologically Distinct Vulnerable Populations; May 5, 2022; pubmed:35512145. View A Precision Adjuvant Approach to Enhance Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines Optimized for Immunologically Distinct Vulnerable Populations on PubMed Precision Vaccine Adjuvants for Older Adults: A Scoping Review; Apr 19, 2022; pubmed:35439286. View Precision Vaccine Adjuvants for Older Adults: A Scoping Review on PubMed Precision Vaccine Development: Cues From Natural Immunity; Feb 28, 2022; pubmed:35222350. View Precision Vaccine Development: Cues From Natural Immunity on PubMed An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity; Feb 12, 2022; pubmed:35148840. View An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity on PubMed An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice; Nov 16, 2021; pubmed:34783582. View An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice on PubMed Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity; May 25, 2021; pubmed:34031655. View Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity on PubMed Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference; Nov 12, 2020; pubmed:33178222. View Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference on PubMed Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model; Oct 21, 2020; pubmed:33082466. View Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model on PubMed The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems; Sep 14, 2020; pubmed:32927471. View The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems on PubMed BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny; Mar 29, 2020; pubmed:32218774. View BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny on PubMed The TLR5 Agonist Flagellin Shapes Phenotypical and Functional Activation of Lung Mucosal Antigen Presenting Cells in Neonatal Mice; Mar 6, 2020; pubmed:32132997. View The TLR5 Agonist Flagellin Shapes Phenotypical and Functional Activation of Lung Mucosal Antigen Presenting Cells in Neonatal Mice on PubMed Toward precision adjuvants: optimizing science and safety; Jan 7, 2020; pubmed:31904601. View Toward precision adjuvants: optimizing science and safety on PubMed Recent Advances in the Discovery and Delivery of TLR7/8 Agonists as Vaccine Adjuvants; Apr 26, 2019; pubmed:31022686. View Recent Advances in the Discovery and Delivery of TLR7/8 Agonists as Vaccine Adjuvants on PubMed Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro; Nov 28, 2018; pubmed:30478007. View Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro on PubMed Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro; Oct 3, 2018; pubmed:30275087. View Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes <em>In Vitro</em> on PubMed Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro; May 2, 2018; pubmed:29715306. View Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro on PubMed Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn; Feb 9, 2018; pubmed:29416539. View Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn on PubMed Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization; Jan 10, 2018; pubmed:29312305. View Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization on PubMed TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth; Mar 30, 2017; pubmed:28352660. View TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth on PubMed Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses; Mar 28, 2017; pubmed:28343701. View Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses on PubMed Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns; Jan 11, 2017; pubmed:28072760. View Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns on PubMed A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity; Dec 24, 2016; pubmed:28008331. View A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity on PubMed Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization; Nov 4, 2016; pubmed:27793997. View Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization on PubMed Early life immune ontogeny - understanding how we build and sustain immunity to infection; Jun 30, 2016; pubmed:27354502. View Early life immune ontogeny - understanding how we build and sustain immunity to infection on PubMed Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells; Jun 3, 2016; pubmed:27252169. View Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells on PubMed Osteopathic Manipulative Treatment Technique Scores on the COMLEX-USA Level 2-PE: An Analysis of the Skills Assessed; May 24, 2016; pubmed:27214776. View Osteopathic Manipulative Treatment Technique Scores on the COMLEX-USA Level 2-PE: An Analysis of the Skills Assessed on PubMed In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant; Apr 16, 2016; pubmed:27081760. View In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant on PubMed Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures; Mar 3, 2016; pubmed:26933193. View Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures on PubMed Pediatric Vaccine Adjuvants: Components of the Modern Vaccinologist's Toolbox; Sep 10, 2015; pubmed:26353029. View Pediatric Vaccine Adjuvants: Components of the Modern Vaccinologist's Toolbox on PubMed Effect of Table Trainer-to-Student Ratios on Outcome in Student Assessments of Cervical Muscle Energy Techniques; Sep 1, 2015; pubmed:26322934. View Effect of Table Trainer-to-Student Ratios on Outcome in Student Assessments of Cervical Muscle Energy Techniques on PubMed The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes; Aug 15, 2015; pubmed:26274907. View The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes on PubMed The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells; Jul 16, 2014; pubmed:25023392. View The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells on PubMed Ontogeny of early life immunity; Jun 2, 2014; pubmed:24880460. View Ontogeny of early life immunity on PubMed Consistency of interrater scoring of student performances of osteopathic manipulative treatment on COMLEX-USA Level 2-PE; Mar 29, 2014; pubmed:24677464. View Consistency of interrater scoring of student performances of osteopathic manipulative treatment on COMLEX-USA Level 2-PE on PubMed The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes; Mar 14, 2013; pubmed:23483986. View The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes on PubMed Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum; Jan 9, 2013; pubmed:23294670. View Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum on PubMed Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40; Oct 2, 2012; pubmed:23021260. View Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40 on PubMed Frequency of specific osteopathic manipulative treatment modalities used by candidates while taking COMLEX-USA Level 2-PE; Aug 21, 2012; pubmed:22904248. View Frequency of specific osteopathic manipulative treatment modalities used by candidates while taking COMLEX-USA Level 2-PE on PubMed The Sigma class glutathione transferase from the liver fluke Fasciola hepatica; Jun 6, 2012; pubmed:22666515. View The Sigma class glutathione transferase from the liver fluke Fasciola hepatica on PubMed Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways; Apr 24, 2012; pubmed:22521247. View Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways on PubMed Ascaris lumbricoides pseudocoelomic body fluid induces a partially activated dendritic cell phenotype with Th2 promoting ability in vivo; Oct 27, 2010; pubmed:20974144. View Ascaris lumbricoides pseudocoelomic body fluid induces a partially activated dendritic cell phenotype with Th2 promoting ability in vivo on PubMed Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses; Nov 18, 2009; pubmed:19917714. View Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses on PubMed The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function; Apr 1, 2009; pubmed:19332532. View The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function on PubMed Assessing the ability of medical students to perform osteopathic manipulative treatment techniques; Jun 5, 2004; pubmed:15176519. View Assessing the ability of medical students to perform osteopathic manipulative treatment techniques on PubMed Yield from colonoscopic screening in people with a strong family history of common colorectal cancer; Oct 7, 2000; pubmed:11022837. View Yield from colonoscopic screening in people with a strong family history of common colorectal cancer on PubMed Progressive inhibition of neuromuscular structures (PINS) technique; Jun 13, 2000; pubmed:10850014. View Progressive inhibition of neuromuscular structures (PINS) technique on PubMed Artificial liver support in acute liver failure; Sep 30, 1999; pubmed:10503835. View Artificial liver support in acute liver failure on PubMed Show More Publications Show Fewer Publications Dr. Dowling's Google Scholar