Research projects
Key projects include NIH-funded programs and grants for novel adjuvants targeting pertussis, opioids, SARS and influenza, integrating human in vitro modeling, early-and later-life animal studies, and multi-omics analyses. Major discoveries encompass patented adjuvant formulations, like lipid nanoparticle-encapsulated mRNA encoding IL-12p70 for controlled, tissue-specific immune enhancement, age-specific profiling revealing impaired Th1 support in at the extremes of age, which can be overcome via endosomal targeting PRR agonist adjuvanted vaccines, and innovative applications to opioid overdose prevention and immunization against diseases of poverty, yielding over 70 publications and advancing precision vaccinology for global health impact.