Blood vessels are the lifeline of every tissue, and building them reliably is central to the promise of regenerative medicine. Our research follows the full arc of vascular biology and engineering. We study the progenitor cells that give rise to new vessels, generate vascular cells from human pluripotent stem cells, bioengineer perfused vascular networks in vivo, and genetically engineer the vasculature to deliver therapeutic proteins. Together, these efforts aim to turn reliable vascularization into a foundation for the next generation of cell-based and tissue-engineered therapies.