William Pu

Publications

1. Somatic Genomic and Transcriptomic Changes in Single Ischemic Human Heart Cardiomyocytes. Res Sq. 2025 Jan 31. View Abstract
2. Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer. J Clin Invest. 2024 Dec 17; 135(4). View Abstract
3. CHD4 Interacts With TBX5 to Maintain the Gene Regulatory Network of Postnatal Atrial Cardiomyocytes. bioRxiv. 2024 Dec 05. View Abstract
4. Genetic and Molecular Underpinnings of Atrial Fibrillation. NPJ Cardiovasc Health. 2024; 1. View Abstract
5. Cardiac Applications of CRISPR/AAV-Mediated Precise Genome Editing. bioRxiv. 2024 Dec 04. View Abstract
6. Virally delivered CMYA5 enhances the assembly of cardiac dyads. Nat Biomed Eng. 2024 Sep 05. View Abstract
7. Non-Cell-Autonomous Cardiomyocyte Regulation Complicates Gene Supplementation Therapy for Lmna-Associated Cardiac Defects in Mice. JACC Basic Transl Sci. 2024 Nov; 9(11):1308-1325. View Abstract
8. Antisense Oligonucleotide Therapy for Calmodulinopathy. Circulation. 2024 Oct 08; 150(15):1199-1210. View Abstract
9. Activation of VGLL4 Suppresses Cardiomyocyte Maturational Hypertrophic Growth. Cells. 2024 08 13; 13(16). View Abstract
10. Vestigial like 4 regulates the adipogenesis of classical brown adipose tissue. bioRxiv. 2024 Jul 27. View Abstract
11. In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury. Acta Pharmacol Sin. 2024 Dec; 45(12):2540-2552. View Abstract
12. Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy. Res Sq. 2024 Jul 19. View Abstract
13. Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems. Nat Commun. 2024 Jul 15; 15(1):5929. View Abstract
14. Therapeutic Inhibition of LincRNA-p21 Protects Against Cardiac Hypertrophy. Circ Res. 2024 Jul 19; 135(3):434-449. View Abstract
15. Remote assessment and management of patients with dizziness: development, validation, and feasibility of a gamified vestibular rehabilitation therapy platform. Front Neurol. 2024; 15:1367582. View Abstract
16. Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment. bioRxiv. 2024 May 30. View Abstract
17. MicroRNA-122-Mediated Liver Detargeting Enhances the Tissue Specificity of Cardiac Genome Editing. Circulation. 2024 May 28; 149(22):1778-1781. View Abstract
18. Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy. Circulation. 2024 Jul 23; 150(4):283-298. View Abstract
19. The long noncoding RNA CARDINAL attenuates cardiac hypertrophy by modulating protein translation. J Clin Invest. 2024 May 14; 134(13). View Abstract
20. Efficient and reproducible generation of human iPSC-derived cardiomyocytes using a stirred bioreactor. bioRxiv. 2024 Feb 28. View Abstract
21. From vitality to vulnerability: the impact of oxygen on cardiac function and regeneration. J Cardiovasc Aging. 2024 Apr; 4(2). View Abstract
22. Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease. Nat Genet. 2024 Mar; 56(3):420-430. View Abstract
23. Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution. Circ Res. 2024 03; 134(5):529-546. View Abstract
24. Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice. Cell Res. 2024 Apr; 34(4):327-330. View Abstract
25. A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024 Apr 09; 149(15):1205-1230. View Abstract
26. In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-line-associated mitigator of isoproterenol-induced cardiac injury. bioRxiv. 2023 Dec 07. View Abstract
27. Author Correction: Tbx5 maintains atrial identity in postnatal cardiomyocytes by regulating an atrial-specific enhancer network. Nat Cardiovasc Res. 2023 Nov; 2(11):1095. View Abstract
28. Reduced Mitochondrial Protein Translation Promotes Cardiomyocyte Proliferation and Heart Regeneration. Circulation. 2023 12 05; 148(23):1887-1906. View Abstract
29. Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network. Nat Cardiovasc Res. 2023 Oct; 2(10):881-898. View Abstract
30. Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy. Stem Cell Reports. 2023 09 12; 18(9):1811-1826. View Abstract
31. A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation. Sci China Life Sci. 2023 Dec; 66(12):2939-2942. View Abstract
32. Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles. Nat Mater. 2023 08; 22(8):1039-1046. View Abstract
33. Editing the trajectory of hypertrophic cardiomyopathy. J Cardiovasc Aging. 2023 Jul; 3(3). View Abstract
34. Genetic modifiers modulate phenotypic expression of tafazzin deficiency in a mouse model of Barth syndrome. Hum Mol Genet. 2023 06 05; 32(12):2055-2067. View Abstract
35. Molecule in mothers' milk nurses pups' heart cells to maturity. Nature. 2023 Jun; 618(7964):242-243. View Abstract
36. Tbx5 maintains atrial identity by regulating an atrial enhancer network. bioRxiv. 2023 Apr 22. View Abstract
37. Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation. Dev Cell. 2023 05 22; 58(10):898-914.e7. View Abstract
38. Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation. Cardiovasc Res. 2023 03 17; 119(1):221-235. View Abstract
39. Future Directions and Resource Needs for National Heart, Lung, and Blood Institute (NHLBI) Gene Therapy Research: A Report of an NHLBI Workshop. Hum Gene Ther. 2023 02; 34(3-4):83-89. View Abstract
40. In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity. Circulation. 2023 03 14; 147(11):881-896. View Abstract
41. RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. Circ Res. 2022 12 02; 131(12):980-1000. View Abstract
42. Addendum: A tissue-engineered scale model of the heart ventricle. Nat Biomed Eng. 2022 Nov; 6(11):1318. View Abstract
43. GATA4 Regulates Developing Endocardium Through Interaction With ETS1. Circ Res. 2022 11 11; 131(11):e152-e168. View Abstract
44. Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome. Nat Commun. 2022 10 05; 13(1):5877. View Abstract
45. Yap1 modulates cardiomyocyte hypertrophy via impaired mitochondrial biogenesis in response to chronic mechanical stress overload. Theranostics. 2022; 12(16):7009-7031. View Abstract
46. Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development. Cells. 2022 09 10; 11(18). View Abstract
47. ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes. Cells. 2022 09 02; 11(17). View Abstract
48. Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association With Arrhythmogenic Right Ventricular Cardiomyopathy: A UK Biobank Analysis. Circ Genom Precis Med. 2022 06; 15(3):e003507. View Abstract
49. A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosis. Blood Adv. 2022 04 26; 6(8):2557-2577. View Abstract
50. CMYA5 establishes cardiac dyad architecture and positioning. Nat Commun. 2022 04 21; 13(1):2185. View Abstract
51. CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart. Genes Dev. 2022 04 01; 36(7-8):468-482. View Abstract
52. Cardiac ISL1-Interacting Protein, a Cardioprotective Factor, Inhibits the Transition From Cardiac Hypertrophy to Heart Failure. Front Cardiovasc Med. 2022; 9:857049. View Abstract
53. Efficient In Vivo Homology-Directed Repair Within Cardiomyocytes. Circulation. 2022 03 08; 145(10):787-789. View Abstract
54. Current and future treatment approaches for Barth syndrome. J Inherit Metab Dis. 2022 01; 45(1):17-28. View Abstract
55. Author Correction: Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation. Nat Commun. 2021 Aug 19; 12(1):5105. View Abstract
56. Experimental models of Barth syndrome. J Inherit Metab Dis. 2022 01; 45(1):72-81. View Abstract
57. Cardiac CIP protein regulates dystrophic cardiomyopathy. Mol Ther. 2022 02 02; 30(2):898-914. View Abstract
58. Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation. Nat Commun. 2021 07 21; 12(1):4442. View Abstract
59. Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts. Elife. 2021 07 14; 10. View Abstract
60. YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes. Int J Mol Sci. 2021 Jun 22; 22(13). View Abstract
61. Calcific aortic valve disease: turning therapeutic discovery up a notch. Nat Rev Cardiol. 2021 05; 18(5):309-310. View Abstract
62. Increased Reactive Oxygen Species-Mediated Ca2+/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome. Circulation. 2021 05 11; 143(19):1894-1911. View Abstract
63. Two sides of the same coin: new insights into mechanisms of ventricular fibrillation. Cardiovasc Res. 2021 03 21; 117(4):983-984. View Abstract
64. LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. Circulation. 2021 05 18; 143(20):2007-2022. View Abstract
65. TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes. Cell Death Differ. 2021 07; 28(7):2045-2059. View Abstract
66. Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling. Proc Natl Acad Sci U S A. 2021 01 12; 118(2). View Abstract
67. AAV Gene Transfer to the Heart. Methods Mol Biol. 2021; 2158:269-280. View Abstract
68. Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease. Dev Cell. 2021 02 08; 56(3):292-309.e9. View Abstract
69. Intercalated disc protein Xinß is required for Hippo-YAP signaling in the heart. Nat Commun. 2020 09 16; 11(1):4666. View Abstract
70. MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. J Clin Invest. 2020 09 01; 130(9):4663-4678. View Abstract
71. Enhancer dependence of cell-type-specific gene expression increases with developmental age. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21450-21458. View Abstract
72. LARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 Aug 18; 32(7):108058. View Abstract
73. L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 07 28; 32(4):107974. View Abstract
74. Regulation of myonuclear positioning and muscle function by the skeletal muscle-specific CIP protein. Proc Natl Acad Sci U S A. 2020 08 11; 117(32):19254-19265. View Abstract
75. Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA. Sci Adv. 2020 07; 6(30):eaba7606. View Abstract
76. Gene therapy for inherited arrhythmias. Cardiovasc Res. 2020 07 15; 116(9):1635-1650. View Abstract
77. The architecture and function of cardiac dyads. Biophys Rev. 2020 Aug; 12(4):1007-1017. View Abstract
78. Genetic and Epigenetic Control of Heart Development. Cold Spring Harb Perspect Biol. 2020 07 01; 12(7). View Abstract
79. Cardiomyocyte Maturation: New Phase in Development. Circ Res. 2020 04 10; 126(8):1086-1106. View Abstract
80. AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome. Circ Res. 2020 04 10; 126(8):1024-1039. View Abstract
81. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. Elife. 2020 02 24; 9. View Abstract
82. Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis. Cell Death Dis. 2020 01 30; 11(1):75. View Abstract
83. aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model. Life Sci Alliance. 2020 01; 3(1). View Abstract
84. Investigation of Streptococcus agalactiae using pcsB-based LAMP in milk, tilapia and vaginal swabs in Haikou, China. J Appl Microbiol. 2020 Mar; 128(3):784-793. View Abstract
85. A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. Nat Commun. 2019 10 28; 10(1):4907. View Abstract
86. Immunoglobulin G galactosylation levels are decreased in systemic sclerosis patients and differ according to disease subclassification. Scand J Rheumatol. 2020 Mar; 49(2):146-153. View Abstract
87. Molecular mechanisms of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2019 09; 16(9):519-537. View Abstract
88. Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. Circulation. 2019 07 30; 140(5):390-404. View Abstract
89. Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II. Circulation. 2019 07 30; 140(5):405-419. View Abstract
90. Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. Nat Commun. 2019 04 17; 10(1):1802. View Abstract
91. Three species of Aeromonas (A. dhakensis, A. hydrophila and A. jandaei) isolated from freshwater crocodiles (Crocodylus siamensis) with pneumonia and septicemia. Lett Appl Microbiol. 2019 Mar; 68(3):212-218. View Abstract
92. A dynamic and integrated epigenetic program at distal regions orchestrates transcriptional responses to VEGFA. Genome Res. 2019 02; 29(2):193-207. View Abstract
93. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 01 04; 124(1):161-169. View Abstract
94. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 11 20; 138(21):e653-e711. View Abstract
95. Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor. Nat Commun. 2018 09 21; 9(1):3837. View Abstract
96. Effectiveness of mHealth Interventions in Improving Medication Adherence Among People with Hypertension: a Systematic Review. Curr Hypertens Rep. 2018 08 07; 20(10):86. View Abstract
97. A tissue-engineered scale model of the heart ventricle. Nat Biomed Eng. 2018 12; 2(12):930-941. View Abstract
98. Exercising engineered heart muscle to maturity. Nat Rev Cardiol. 2018 07; 15(7):383-384. View Abstract
99. Genetic Mosaics for Greater Precision in Cardiovascular Research. Circ Res. 2018 06 22; 123(1):27-29. View Abstract
100. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med. 2017 Dec; 23(12):1488-1498. View Abstract
101. Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation. Circ Res. 2018 01 05; 122(1):74-87. View Abstract
102. CASAAV: A CRISPR-Based Platform for Rapid Dissection of Gene Function In Vivo. Curr Protoc Mol Biol. 2017 10 02; 120:31.11.1-31.11.14. View Abstract
103. VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 08 29; 8(1):383. View Abstract
104. Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun. 2017 07 20; 8(1):87. View Abstract
105. Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks. Nat Biomed Eng. 2017; 1. View Abstract
106. The complex genetics of hypoplastic left heart syndrome. Nat Genet. 2017 Jul; 49(7):1152-1159. View Abstract
107. Divergent Requirements for EZH1 in Heart Development Versus Regeneration. Circ Res. 2017 Jul 07; 121(2):106-112. View Abstract
108. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 06 05; 214(6):1753-1767. View Abstract
109. Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis. Cell Death Dis. 2017 04 13; 8(4):e2744. View Abstract
110. [Long-term outcomes after cataract surgery in infants with congenital cataract]. Zhonghua Yan Ke Za Zhi. 2017 Apr 11; 53(4):266-273. View Abstract
111. EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife. 2017 04 10; 6. View Abstract
112. Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo. Circ Res. 2017 Jun 09; 120(12):1874-1888. View Abstract
113. Cardiac Regeneration: Lessons From Development. Circ Res. 2017 Mar 17; 120(6):941-959. View Abstract
114. Mapping cell type-specific transcriptional enhancers using high affinity, lineage-specific Ep300 bioChIP-seq. Elife. 2017 01 25; 6. View Abstract
115. Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts. J Vis Exp. 2016 12 17; (118). View Abstract
116. Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies. Nat Protoc. 2017 Jan; 12(1):88-103. View Abstract
117. Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ J. 2016 Dec 22; 81(1):12-21. View Abstract
118. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev Cell. 2016 11 21; 39(4):480-490. View Abstract
119. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation. 2017 Jan 03; 135(1):59-72. View Abstract
120. Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. Cardiovasc Res. 2016 Nov 01; 112(2):543-554. View Abstract
121. Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Dev Cell. 2016 11 21; 39(4):466-479. View Abstract
122. Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types. Genome Biol. 2016 06 03; 17(1):120. View Abstract
123. Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart. Dev Biol. 2016 05 15; 413(2):153-159. View Abstract
124. GATA4 regulates Fgf16 to promote heart repair after injury. Development. 2016 Mar 15; 143(6):936-49. View Abstract
125. Recounting Cardiac Cellular Composition. Circ Res. 2016 Feb 05; 118(3):368-70. View Abstract
126. Contribution of Fetal, but Not Adult, Pulmonary Mesothelium to Mesenchymal Lineages in Lung Homeostasis and Fibrosis. Am J Respir Cell Mol Biol. 2016 Feb; 54(2):222-30. View Abstract
127. Failed cooperative, but not competitive, interaction between large-scale brain networks impairs working memory in schizophrenia. Psychol Med. 2016 Apr; 46(6):1211-24. View Abstract
128. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest. 2015 Nov 02; 125(11):4122-34. View Abstract
129. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94. View Abstract
130. Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction. PLoS One. 2015; 10(9):e0136025. View Abstract
131. Nuclear receptor RORa regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10401-6. View Abstract
132. Trbp regulates heart function through microRNA-mediated Sox6 repression. Nat Genet. 2015 Jul; 47(7):776-83. View Abstract
133. Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase. PLoS One. 2015; 10(5):e0128105. View Abstract
134. Cellular origin and developmental program of coronary angiogenesis. Circ Res. 2015 Jan 30; 116(3):515-30. View Abstract
135. Releasing YAP from an a-catenin trap increases cardiomyocyte proliferation. Circ Res. 2015 Jan 02; 116(1):9-11. View Abstract
136. Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. Nat Commun. 2014 Nov 26; 5:5507. View Abstract
137. Introduction to the special issue on heart regeneration and rejuvenation. Stem Cell Res. 2014 Nov; 13(3 Pt B):521-2. View Abstract
138. Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders. Cold Spring Harb Perspect Med. 2014 Oct 01; 4(10). View Abstract
139. Epicardium-to-fat transition in injured heart. Cell Res. 2014 Nov; 24(11):1367-9. View Abstract
140. Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease. Nat Commun. 2014 Sep 24; 5:4907. View Abstract
141. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res. 2015 Jan 02; 116(1):35-45. View Abstract
142. Optimization of genome engineering approaches with the CRISPR/Cas9 system. PLoS One. 2014; 9(8):e105779. View Abstract
143. Ultrasound-guided transthoracic intramyocardial injection in mice. J Vis Exp. 2014 Aug 05; (90):e51566. View Abstract
144. Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014 Jul 04; 345(6192):90-4. View Abstract
145. Strategies for cardiac regeneration and repair. Sci Transl Med. 2014 Jun 04; 6(239):239rv1. View Abstract
146. GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27. Biochim Biophys Acta. 2014 Nov; 1839(11):1273-82. View Abstract
147. Notching up vascular regeneration. Cell Res. 2014 Jul; 24(7):777-8. View Abstract
148. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res. 2014 Jul 18; 115(3):354-63. View Abstract
149. Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion. J Biol Chem. 2014 Jul 04; 289(27):18681-92. View Abstract
150. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 Jun; 20(6):616-23. View Abstract
151. Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation. Stem Cell Res. 2014 Nov; 13(3 Pt B):571-81. View Abstract
152. Hippo activation in arrhythmogenic cardiomyopathy. Circ Res. 2014 Jan 31; 114(3):402-5. View Abstract
153. Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heart. PLoS One. 2013; 8(11):e80857. View Abstract
154. WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14; 27(1):5-18. View Abstract
155. Developing insights into cardiac regeneration. Development. 2013 Oct; 140(19):3933-7. View Abstract
156. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol. 2013 Oct; 31(10):898-907. View Abstract
157. Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):15395-400. View Abstract
158. HCN4 charges up the first heart field. Circ Res. 2013 Aug 02; 113(4):350-1. View Abstract
159. The mysterious origins of coronary vessels. Cell Res. 2013 Sep; 23(9):1063-4. View Abstract
160. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation. 2013 Jul 09; 128(2):101-14. View Abstract
161. A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. Genome Res. 2013 Jun; 23(6):917-27. View Abstract
162. A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds. Sci Rep. 2013; 3:2243. View Abstract
163. GATA factors promote ER integrity and ß-cell survival and contribute to type 1 diabetes risk. Mol Endocrinol. 2014 Jan; 28(1):28-39. View Abstract
164. Genetic Cre-loxP assessment of epicardial cell fate using Wt1-driven Cre alleles. Circ Res. 2012 Nov 09; 111(11):e276-80. View Abstract
165. Myocardial regeneration: expanding the repertoire of thymosin ß4 in the ischemic heart. Ann N Y Acad Sci. 2012 Oct; 1269:92-101. View Abstract
166. Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14035-40. View Abstract
167. Mature cardiomyocytes recall their progenitor experience via polycomb repressive complex 2. Circ Res. 2012 Jul 06; 111(2):162-4. View Abstract
168. Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11306-11. View Abstract
169. Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease. Circ Res. 2012 Jun 08; 110(12):1628-45. View Abstract
170. Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet. 2012; 8(5):e1002690. View Abstract
171. Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells. Angiogenesis. 2012 Sep; 15(3):443-55. View Abstract
172. Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4. Mol Cell Biol. 2012 May; 32(10):1830-43. View Abstract
173. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ Res. 2012 Mar 16; 110(6):818-30. View Abstract
174. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2394-9. View Abstract
175. Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy. J Biol Chem. 2012 Mar 23; 287(13):9827-9834. View Abstract
176. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev. 2012 Jan 01; 26(1):37-42. View Abstract
177. Isolation and characterization of embryonic and adult epicardium and epicardium-derived cells. Methods Mol Biol. 2012; 843:155-68. View Abstract
178. Regulation of GATA4 transcriptional activity in cardiovascular development and disease. Curr Top Dev Biol. 2012; 100:143-69. View Abstract
179. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res. 2012 Feb 03; 110(3):406-15. View Abstract
180. Adult cardiac-resident MSC-like stem cells with a proepicardial origin. Cell Stem Cell. 2011 Dec 02; 9(6):527-40. View Abstract
181. Epicardial epithelial-to-mesenchymal transition in injured heart. J Cell Mol Med. 2011 Dec; 15(12):2781-3. View Abstract
182. Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J Mol Cell Cardiol. 2012 Jan; 52(1):43-7. View Abstract
183. miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation. J Biol Chem. 2011 Oct 14; 286(41):35339-35346. View Abstract
184. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12331-6. View Abstract
185. De novo cardiomyocytes from within the activated adult heart after injury. Nature. 2011 Jun 08; 474(7353):640-4. View Abstract
186. WT1 regulates epicardial epithelial to mesenchymal transition through ß-catenin and retinoic acid signaling pathways. Dev Biol. 2011 Aug 15; 356(2):421-31. View Abstract
187. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest. 2011 May; 121(5):1894-904. View Abstract
188. A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011 Apr; 121(4):1585-95. View Abstract
189. Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. Proc Natl Acad Sci U S A. 2011 Apr 05; 108(14):5632-7. View Abstract
190. Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation. Dev Biol. 2011 May 15; 353(2):229-41. View Abstract
191. Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4006-11. View Abstract
192. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar; 53(3):983-95. View Abstract
193. Reprogramming fibroblasts into cardiomyocytes. N Engl J Med. 2011 Jan 13; 364(2):177-8. View Abstract
194. CompleteMOTIFs: DNA motif discovery platform for transcription factor binding experiments. Bioinformatics. 2011 Mar 01; 27(5):715-7. View Abstract
195. Genome-wide location analysis by pull down of in vivo biotinylated transcription factors. Curr Protoc Mol Biol. 2010 Oct; Chapter 21:Unit 21.20. View Abstract
196. Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. J Mol Cell Cardiol. 2010 Nov; 49(5):841-50. View Abstract
197. Expression and function of microRNAs in heart disease. Curr Drug Targets. 2010 Aug; 11(8):913-25. View Abstract
198. Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine. Gut. 2010 Jul; 59(7):888-95. View Abstract
199. Dissecting spatio-temporal protein networks driving human heart development and related disorders. Mol Syst Biol. 2010 Jun 22; 6:381. View Abstract
200. Heart failure-associated changes in RNA splicing of sarcomere genes. Circ Cardiovasc Genet. 2010 Apr; 3(2):138-46. View Abstract
201. Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse. Genesis. 2010 Jan; 48(1):63-72. View Abstract
202. Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev Biol. 2010 Feb 15; 338(2):251-61. View Abstract
203. Identification of a cardiac disease modifier gene using forward genetics in the mouse. PLoS Genet. 2009 Sep; 5(9):e1000643. View Abstract
204. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest. 2009 Jun; 119(6):1462-76. View Abstract
205. MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol Cell Biol. 2009 Apr; 29(8):2193-204. View Abstract
206. Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res. 2008 Dec 05; 103(12):1393-401. View Abstract
207. More than a cover: epicardium as a novel source of cardiac progenitor cells. Regen Med. 2008 Sep; 3(5):633-5. View Abstract
208. Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Dev Biol. 2008 Nov 01; 323(1):98-104. View Abstract
209. Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium. Biochem Biophys Res Commun. 2008 Oct 24; 375(3):450-3. View Abstract
210. GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium. Mol Cell Biol. 2008 Sep; 28(17):5420-31. View Abstract
211. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 03; 454(7200):109-13. View Abstract
212. Altered microRNA expression in human heart disease. Physiol Genomics. 2007 Nov 14; 31(3):367-73. View Abstract
213. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med. 2007 Aug; 13(8):952-61. View Abstract
214. Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol. 2007 Dec; 43(6):677-85. View Abstract
215. Therapeutic neovascularization for peripheral arterial diseases: advances and perspectives. Histol Histopathol. 2007 06; 22(6):677-86. View Abstract
216. Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H829-35. View Abstract
217. Mesenchymal stem/stromal cells (MSC) transfected with stromal derived factor 1 (SDF-1) for therapeutic neovascularization: enhancement of cell recruitment and entrapment. Med Hypotheses. 2007; 68(6):1268-71. View Abstract
218. Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol. 2007 Jan 15; 301(2):602-14. View Abstract
219. Chaperoning of estrogen receptor and induction of mammary gland proliferation by neuronal protein synuclein gamma. Oncogene. 2007 Mar 29; 26(14):2115-25. View Abstract
220. Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14471-6. View Abstract
221. Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol Cell Biol. 2006 Dec; 26(23):9060-70. View Abstract
222. Development of heart valves requires Gata4 expression in endothelial-derived cells. Development. 2006 Sep; 133(18):3607-18. View Abstract
223. Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure . Proc. Natl. Acad. Sci USA. 2006; 103:14471-14476. View Abstract
224. A multivariate approach for integrating genome-wide expression data and biological knowledge. Bioinformatics. 2006 Oct 01; 22(19):2373-80. View Abstract
225. Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. Circ Res. 2006 Aug 18; 99(4):415-23. View Abstract
226. Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail. 2006 Jun; 12(5):392-8. View Abstract
227. Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo. FASEB J. 2006 Apr; 20(6):800-2. View Abstract
228. Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest. 2005 Jun; 115(6):1522-31. View Abstract
229. GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev Biol. 2004 Nov 01; 275(1):235-44. View Abstract
230. Molecular Basis of Heart Failure. Heart Failure: A Companion to Braunwald's Heart Disease (D. L. Mann, ed.). 2004; 10-40. View Abstract
231. Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos. Circ Res. 2003 Oct 31; 93(9):857-65. View Abstract
232. NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro. Circ Res. 2003 Apr 18; 92(7):725-31. View Abstract
233. Structural characterization of the mouse Girk genes. Gene. 2002 Feb 06; 284(1-2):241-50. View Abstract
234. Transcription factors and heart failure: does the stressed heart need a hand? J Mol Cell Cardiol. 2001 Oct; 33(10):1765-7. View Abstract
235. Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. J Am Coll Cardiol. 2001 Jun 15; 37(8):2136-43. View Abstract
236. [Diagnostic and differential diagnostic potential of mitochondrial DNA assessment in patients with Leber's hereditary optic neuropathy]. Zhonghua Yan Ke Za Zhi. 2001 May; 37(3):174-7. View Abstract
237. Diagnostic potential of mitochondrial DNA assessment in patients with optic neuropathy. Chin Med J (Engl). 2000 Aug; 113(8):743-6. View Abstract
238. ICln is essential for cellular and early embryonic viability. J Biol Chem. 2000 Apr 28; 275(17):12363-6. View Abstract
239. pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. Mol Cell Biol. 1999 Jun; 19(6):4113-20. View Abstract
240. pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. J Biol Chem. 1998 May 01; 273(18):10811-4. View Abstract
241. [An experimental study on effects of biomembrane on prevention of filtering bleb adhesion in trabeculectomy]. Zhonghua Yan Ke Za Zhi. 1998 Jan; 34(1):68-70. View Abstract
242. Diagnosis and management of agenesis of the right lung and left pulmonary artery sling. Am J Cardiol. 1996 Sep 15; 78(6):723-7. View Abstract
243. Dimerization of leucine zippers analyzed by random selection. Nucleic Acids Res. 1993 Sep 11; 21(18):4348-55. View Abstract
244. Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2007-11. View Abstract
245. Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex. Nucleic Acids Res. 1992 Feb 25; 20(4):771-5. View Abstract
246. Highly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding. Mol Cell Biol. 1991 Oct; 11(10):4918-26. View Abstract
247. The leucine zipper symmetrically positions the adjacent basic regions for specific DNA binding. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):6901-5. View Abstract
248. Biosynthesis of glucose oxidase by producing strain Z-I-C in batch and chemostat culture. Chin J Biotechnol. 1991; 7(4):309-18. View Abstract
249. UvrABC incision of N-methylmitomycin A-DNA monoadducts and cross-links. J Biol Chem. 1989 Dec 05; 264(34):20697-704. View Abstract
250. Effects of pH and sulfhydryl specific reagents on 4-fumarylacetoacetate fumarylhydrolase. Biochim Biophys Acta. 1981 Jan 15; 657(1):203-11. View Abstract
Show All Publications Show Fewer Publications