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Related Research Units

Research Overview

Dr. Daly's research is largely focused on novel, noninvasive techniques for the diagnosis and monitoring of cardiac allograft vasculopathy (CAV), including the development of serum biomarkers and novel imaging technologies.

Currently, he is studying the underpinnings of chronic allograft rejection—the major cause of mortality following pediatric heart transplant. Through his research, Dr. Daly aims to determine if endothelial injury and repair responses can be monitored in recipients of cardiac transplantation, and to establish if patterns of these biomarkers predict, or are associated with, the development of chronic allograft rejection. In addition, Dr. Daly's research aims to establish whether molecular imaging studies of myocardial blood flow and endothelial cell activation are associated with early CAV/chronic rejection.

Research Background

Dr. Daly received his MD from Columbia University College of Physicians & Surgeons. He completed his internship and residency at the Children’s Hospital at Montefiore (Albert Einstein College of Medicine) and his fellowship at Boston Children's Hospital.

Education

Undergraduate School

Biochemical Sciences Harvard University
2000 Boston MA

Medical School

Columbia University College of Physicians & Surgeons
2004 New York NY

Internship

Children’s Hospital at Montefiore
2005 Bronx NY

Residency

Pediatrics Children’s Hospital at Montefiore
2007 Bronx NY

Fellowship

Pediatric Cardiology Boston Children's Hospital
2009 Boston MA

Fellowship

Chief Fellow, Pediatric Cardiology Boston Children's Hospital
2010 Boston MA

Fellowship

Pediatric Cardiology; Heart Failure; Transplantation Senior Fellow Boston Children's Hospital
2011 Boston MA

Publications

  1. Socioeconomic Status and Major Adverse Transplant Events in Pediatric Heart Transplant Recipients. JAMA Netw Open. 2024 Oct 01; 7(10):e2437255. View Abstract
  2. Sacubitril/Valsartan in Pediatric Heart Failure (PANORAMA-HF): A Randomized, Multicenter, Double-Blind Trial. Circulation. 2024 Nov 26; 150(22):1756-1766. View Abstract
  3. International Society for Heart and Lung Transplantation Guidelines for the Evaluation and Care of Cardiac Transplant Candidates-2024. J Heart Lung Transplant. 2024 Oct; 43(10):1529-1628.e54. View Abstract
  4. Improving Mechanical Circulatory Support Outcomes in Failing Bidirectional Glenn Physiology. Pediatr Cardiol. 2024 Jul 19. View Abstract
  5. Pathology of explanted pediatric hearts: An 11-year study. Population characteristics and implications for outcomes. Pediatr Transplant. 2024 Jun; 28(4):e14742. View Abstract
  6. Impact of a positive crossmatch on pediatric heart transplant outcomes. J Heart Lung Transplant. 2024 Jun; 43(6):963-972. View Abstract
  7. Detecting and managing cardiac allograft vasculopathy within the transition from pediatric to adult heart transplantation care: Lighting the pathway ahead. J Heart Lung Transplant. 2024 02; 43(2):238-240. View Abstract
  8. Medium-term Outcomes in Pediatric Heart Transplant Recipients Managed Using a Steroid Avoidance Immune Suppression Protocol. Transplantation. 2024 Jan 01; 108(1):e8-e14. View Abstract
  9. Survivors of Pediatric Hematopoietic Stem Cell Transplantation Exhibit Progressive Diastolic Dysfunction Over Years of Follow-Up. Transplant Cell Ther. 2023 Dec; 29(12):774.e1-774.e8. View Abstract
  10. ABO-Incompatible Heart Transplantation: Where Science, Society, and Policy Collide. J Card Fail. 2024 Mar; 30(3):486-487. View Abstract
  11. External assessment and refinement of a population pharmacokinetic model to guide tacrolimus dosing in pediatric heart transplant. Pharmacotherapy. 2023 07; 43(7):650-658. View Abstract
  12. Fecal Microbiota Transplant in Pediatric Solid Organ Transplant Recipients. Transplantation. 2023 09 01; 107(9):2073-2077. View Abstract
  13. The teammate trial: Study design and rationale tacrolimus and everolimus against tacrolimus and MMF in pediatric heart transplantation using the major adverse transplant event (MATE) score. Am Heart J. 2023 06; 260:100-112. View Abstract
  14. Apixaban Anticoagulation in Children and Young Adults Supported With the HeartMate 3 Ventricular Assist Device. ASAIO J. 2023 06 01; 69(6):e267-e269. View Abstract
  15. Equity factors in pediatric transplant listing: Initial findings from a single center review. Pediatr Transplant. 2023 03; 27(2):e14467. View Abstract
  16. The International Society for Heart and Lung Transplantation (ISHLT) guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2023 05; 42(5):e1-e141. View Abstract
  17. Prognostic Value of Exercise Stress Echocardiography in Pediatric Cardiac Transplant Recipients. J Am Soc Echocardiogr. 2022 11; 35(11):1133-1138.e2. View Abstract
  18. The Burden of Pediatric Heart Failure That Lies Just Under the Surface. J Am Coll Cardiol. 2022 05 17; 79(19):1929-1931. View Abstract
  19. Experience with live attenuated varicella vaccination in pediatric heart transplant recipients: Considering a new path forward. J Heart Lung Transplant. 2022 08; 41(8):1027-1028. View Abstract
  20. Waitlist Outcomes for Children With Congenital Heart Disease: Lessons Learned From Over 5000 Heart Transplant Listings in the United States. J Card Fail. 2022 06; 28(6):982-990. View Abstract
  21. Pediatric heart transplant waiting times in the United States since the 2016 allocation policy change. Am J Transplant. 2022 03; 22(3):833-842. View Abstract
  22. Giant Cell Myocarditis and Left Ventricular Apical Aneurysm in a Child With Severe Combined Immunodeficiency. Circ Cardiovasc Imaging. 2021 12; 14(12):1157-1158. View Abstract
  23. Giant Cell Myocarditis in Children: Elusive Giant Cells Might Not Be the Only Clue. Pediatr Dev Pathol. 2022 Mar-Apr; 25(2):197-202. View Abstract
  24. Clinical and hemodynamic characteristics of the pediatric failing Fontan. J Heart Lung Transplant. 2021 12; 40(12):1529-1539. View Abstract
  25. ISHLT consensus statement for the selection and management of pediatric and congenital heart disease patients on ventricular assist devices Endorsed by the American Heart Association. J Heart Lung Transplant. 2021 08; 40(8):709-732. View Abstract
  26. Assessment and Treatment of a Young Adult with Congenital Heart Disease and ADHD. J Dev Behav Pediatr. 2021 05 01; 42(4):340-342. View Abstract
  27. Hepatorenal dysfunction assessment with the Model for End-Stage Liver Disease Excluding INR score predicts worse survival after heart transplant in pediatric Fontan patients. J Thorac Cardiovasc Surg. 2022 04; 163(4):1462-1473.e12. View Abstract
  28. Retrospective Analysis of Clinical Genetic Testing in Pediatric Primary Dilated Cardiomyopathy: Testing Outcomes and the Effects of Variant Reclassification. J Am Heart Assoc. 2020 06 02; 9(11):e016195. View Abstract
  29. The ABO-incompatible paradigm shifts only as far as allocation policy allows. J Heart Lung Transplant. 2020 07; 39(7):636-638. View Abstract
  30. Brighter Future for Children with Congenital Heart Disease Requiring Heart Transplantation? A UNOS Registry Analysis over the Last Three Decades. J Heart Lung Transplant. 2020 Apr; 39(4S):S206-S207. View Abstract
  31. The TEAMMATE Trial: Study Design and Rationale of the First Pediatric Heart Transplant Randomized Clinical Trial. J Heart Lung Transplant. 2020 Apr; 39(4S):S207-S208. View Abstract
  32. Coagulation Monitoring Correlation with Bivalirudin Dosing in Pediatric Ventricular Assist Device Support. J Heart Lung Transplant. 2020 Apr; 39(4S):S467-S468. View Abstract
  33. Marijuana in pediatric and adult congenital heart disease heart transplant listing: A survey of provider practices and attitudes. Pediatr Transplant. 2020 03; 24(2):e13640. View Abstract
  34. Association of Clinical Rejection Versus Rejection on Protocol Biopsy With Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients. Transplantation. 2020 01; 104(1):e31-e37. View Abstract
  35. Use of the terminal complement inhibitor eculizumab in paediatric heart transplant recipients. Cardiol Young. 2020 Jan; 30(1):107-113. View Abstract
  36. Current evaluation and management of plastic bronchitis in the pediatric population. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130:109799. View Abstract
  37. T Cells Are Dominant Population in Human Abdominal Aortic Aneurysms and Their Infiltration in the Perivascular Tissue Correlates With Disease Severity. Front Immunol. 2019; 10:1979. View Abstract
  38. Myocardial Infarct After Marijuana Inhalation in a 16-year-old Adolescent Boy. Pediatr Dev Pathol. 2019 Jan-Feb; 22(1):80-86. View Abstract
  39. Heart failure after the Norwood procedure: An analysis of the Single Ventricle Reconstruction Trial. J Heart Lung Transplant. 2018 07; 37(7):879-885. View Abstract
  40. Managing risk of surgical procedures in pediatric transplant recipients taking mTOR inhibitors: What is the optimal strategy? Pediatr Transplant. 2018 02; 22(1). View Abstract
  41. Clinical practice patterns are relatively uniform between pediatric heart transplant centers: A survey-based assessment. Pediatr Transplant. 2017 Aug; 21(5). View Abstract
  42. The Evolution of a Pediatric Ventricular Assist Device Program: The Boston Children's Hospital Experience. Pediatr Cardiol. 2017 Jun; 38(5):1032-1041. View Abstract
  43. Development and validation of a major adverse transplant event (MATE) score to predict late graft loss in pediatric heart transplantation. J Heart Lung Transplant. 2018 04; 37(4):441-450. View Abstract
  44. Into the hearts of babes: Stem cell therapy for pediatric heart failure. J Heart Lung Transplant. 2017 08; 36(8):830-832. View Abstract
  45. Dilated Cardiomyopathy in a 2-Year-Old Infant. Clin Chem. 2017 01; 63(1):433-435. View Abstract
  46. Vascular endothelial growth factor A is associated with the subsequent development of moderate or severe cardiac allograft vasculopathy in pediatric heart transplant recipients. J Heart Lung Transplant. 2017 Apr; 36(4):434-442. View Abstract
  47. Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients. J Heart Lung Transplant. 2016 11; 35(11):1295-1302. View Abstract
  48. Is Endomyocardial Biopsy a Safe and Useful Procedure in Children with Suspected Cardiomyopathy? Pediatr Cardiol. 2016 Oct; 37(7):1200-10. View Abstract
  49. Finding the correct role for heart transplant in the treatment of hypoplastic left heart syndrome. J Heart Lung Transplant. 2016 Mar; 35(3):299-300. View Abstract
  50. What Is the Role of Developmental Disability in Patient Selection for Pediatric Solid Organ Transplantation? Am J Transplant. 2016 Mar; 16(3):767-72. View Abstract
  51. Use of [18F]FDG Positron Emission Tomography to Monitor the Development of Cardiac Allograft Rejection. Transplantation. 2015 Sep; 99(9):e132-9. View Abstract
  52. Multicenter Analysis of Immune Biomarkers and Heart Transplant Outcomes: Results of the Clinical Trials in Organ Transplantation-05 Study. Am J Transplant. 2016 Jan; 16(1):121-36. View Abstract
  53. Summary of the 2015 International Paediatric Heart Failure Summit of Johns Hopkins All Children's Heart Institute. Cardiol Young. 2015 Aug; 25 Suppl 2:8-30. View Abstract
  54. Emerging science in paediatric heart transplantation: donor allocation, biomarkers, and the quest for evidence-based medicine. Cardiol Young. 2015 Aug; 25 Suppl 2:117-23. View Abstract
  55. Translational implications of endothelial cell dysfunction in association with chronic allograft rejection. Pediatr Nephrol. 2016 Jan; 31(1):41-51. View Abstract
  56. Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection? Ann Transl Med. 2015 Mar; 3(4):47. View Abstract
  57. Safety and efficacy of radiofrequency wire recanalization of chronic central venous occlusions. J Vasc Access. 2015 Jul-Aug; 16(4):309-14. View Abstract
  58. Antibody depletion for the treatment of crossmatch-positive pediatric heart transplant recipients. Pediatr Transplant. 2013 Nov; 17(7):661-9. View Abstract
  59. Effect of inhaled iloprost on the exercise function of Fontan patients: a demonstration of concept. Int J Cardiol. 2013 Oct 03; 168(3):2435-40. View Abstract
  60. VEGF-C, VEGF-A and related angiogenesis factors as biomarkers of allograft vasculopathy in cardiac transplant recipients. J Heart Lung Transplant. 2013 Jan; 32(1):120-8. View Abstract
  61. Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation. Front Immunol. 2012; 3:54. View Abstract
  62. Endomyocardial biopsy and selective coronary angiography are low-risk procedures in pediatric heart transplant recipients: results of a multicenter experience. J Heart Lung Transplant. 2012 Apr; 31(4):398-409. View Abstract
  63. Sudden death after pediatric heart transplantation: analysis of data from the Pediatric Heart Transplant Study Group. J Heart Lung Transplant. 2011 Dec; 30(12):1395-402. View Abstract
  64. Changes in echocardiographic measures of systolic and diastolic function in children 1 year after hematopoietic SCT. Bone Marrow Transplant. 2011 Dec; 46(12):1532-9. View Abstract
  65. Variant translocation with a deletion of derivative (9q) in a case of Philadelphia chromosome positive (Ph +) essential thrombocythemia (ET), a variant of chronic myelogenous leukemia (CML) with a poor prognosis. Leuk Lymphoma. 2005 Dec; 46(12):1801-6. View Abstract

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