Dr. Daly's research is largely focused on novel, noninvasive techniques for the diagnosis and monitoring of cardiac allograft vasculopathy (CAV), including the development of serum biomarkers and novel imaging technologies.
Currently, he is studying the underpinnings of chronic allograft rejection—the major cause of mortality following pediatric heart transplant. Through his research, Dr. Daly aims to determine if endothelial injury and repair responses can be monitored in recipients of cardiac transplantation, and to establish if patterns of these biomarkers predict, or are associated with, the development of chronic allograft rejection. In addition, Dr. Daly's research aims to establish whether molecular imaging studies of myocardial blood flow and endothelial cell activation are associated with early CAV/chronic rejection.
Research Background
Dr. Daly received his MD from Columbia University College of Physicians & Surgeons. He completed his internship and residency at the Children’s Hospital at Montefiore (Albert Einstein College of Medicine) and his fellowship at Boston Children's Hospital.
Education
Undergraduate School
Biochemical Sciences
Harvard University
2000
Boston
MA
Medical School
Columbia University College of Physicians & Surgeons
2004
New York
NY
Internship
Children’s Hospital at Montefiore
2005
Bronx
NY
Residency
Pediatrics
Children’s Hospital at Montefiore
2007
Bronx
NY
Fellowship
Pediatric Cardiology
Boston Children's Hospital
2009
Boston
MA
Fellowship
Chief Fellow, Pediatric Cardiology
Boston Children's Hospital
2010
Boston
MA
Fellowship
Pediatric Cardiology; Heart Failure; Transplantation Senior Fellow
Boston Children's Hospital
2011
Boston
MA
Publications
Socioeconomic Status and Major Adverse Transplant Events in Pediatric Heart Transplant Recipients. JAMA Netw Open. 2024 Oct 01; 7(10):e2437255. View Abstract
Sacubitril/Valsartan in Pediatric Heart Failure (PANORAMA-HF): A Randomized, Multicenter, Double-Blind Trial. Circulation. 2024 Nov 26; 150(22):1756-1766. View Abstract
International Society for Heart and Lung Transplantation Guidelines for the Evaluation and Care of Cardiac Transplant Candidates-2024. J Heart Lung Transplant. 2024 Oct; 43(10):1529-1628.e54. View Abstract
Improving Mechanical Circulatory Support Outcomes in Failing Bidirectional Glenn Physiology. Pediatr Cardiol. 2024 Jul 19. View Abstract
Pathology of explanted pediatric hearts: An 11-year study. Population characteristics and implications for outcomes. Pediatr Transplant. 2024 Jun; 28(4):e14742. View Abstract
Impact of a positive crossmatch on pediatric heart transplant outcomes. J Heart Lung Transplant. 2024 Jun; 43(6):963-972. View Abstract
Detecting and managing cardiac allograft vasculopathy within the transition from pediatric to adult heart transplantation care: Lighting the pathway ahead. J Heart Lung Transplant. 2024 02; 43(2):238-240. View Abstract
Medium-term Outcomes in Pediatric Heart Transplant Recipients Managed Using a Steroid Avoidance Immune Suppression Protocol. Transplantation. 2024 Jan 01; 108(1):e8-e14. View Abstract
Survivors of Pediatric Hematopoietic Stem Cell Transplantation Exhibit Progressive Diastolic Dysfunction Over Years of Follow-Up. Transplant Cell Ther. 2023 Dec; 29(12):774.e1-774.e8. View Abstract
ABO-Incompatible Heart Transplantation: Where Science, Society, and Policy Collide. J Card Fail. 2024 Mar; 30(3):486-487. View Abstract
External assessment and refinement of a population pharmacokinetic model to guide tacrolimus dosing in pediatric heart transplant. Pharmacotherapy. 2023 07; 43(7):650-658. View Abstract
Fecal Microbiota Transplant in Pediatric Solid Organ Transplant Recipients. Transplantation. 2023 09 01; 107(9):2073-2077. View Abstract
The teammate trial: Study design and rationale tacrolimus and everolimus against tacrolimus and MMF in pediatric heart transplantation using the major adverse transplant event (MATE) score. Am Heart J. 2023 06; 260:100-112. View Abstract
Apixaban Anticoagulation in Children and Young Adults Supported With the HeartMate 3 Ventricular Assist Device. ASAIO J. 2023 06 01; 69(6):e267-e269. View Abstract
Equity factors in pediatric transplant listing: Initial findings from a single center review. Pediatr Transplant. 2023 03; 27(2):e14467. View Abstract
The International Society for Heart and Lung Transplantation (ISHLT) guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2023 05; 42(5):e1-e141. View Abstract
Prognostic Value of Exercise Stress Echocardiography in Pediatric Cardiac Transplant Recipients. J Am Soc Echocardiogr. 2022 11; 35(11):1133-1138.e2. View Abstract
The Burden of Pediatric Heart Failure That Lies Just Under the Surface. J Am Coll Cardiol. 2022 05 17; 79(19):1929-1931. View Abstract
Experience with live attenuated varicella vaccination in pediatric heart transplant recipients: Considering a new path forward. J Heart Lung Transplant. 2022 08; 41(8):1027-1028. View Abstract
Waitlist Outcomes for Children With Congenital Heart Disease: Lessons Learned From Over 5000 Heart Transplant Listings in the United States. J Card Fail. 2022 06; 28(6):982-990. View Abstract
Pediatric heart transplant waiting times in the United States since the 2016 allocation policy change. Am J Transplant. 2022 03; 22(3):833-842. View Abstract
Giant Cell Myocarditis and Left Ventricular Apical Aneurysm in a Child With Severe Combined Immunodeficiency. Circ Cardiovasc Imaging. 2021 12; 14(12):1157-1158. View Abstract
Giant Cell Myocarditis in Children: Elusive Giant Cells Might Not Be the Only Clue. Pediatr Dev Pathol. 2022 Mar-Apr; 25(2):197-202. View Abstract
Clinical and hemodynamic characteristics of the pediatric failing Fontan. J Heart Lung Transplant. 2021 12; 40(12):1529-1539. View Abstract
ISHLT consensus statement for the selection and management of pediatric and congenital heart disease patients on ventricular assist devices Endorsed by the American Heart Association. J Heart Lung Transplant. 2021 08; 40(8):709-732. View Abstract
Assessment and Treatment of a Young Adult with Congenital Heart Disease and ADHD. J Dev Behav Pediatr. 2021 05 01; 42(4):340-342. View Abstract
Hepatorenal dysfunction assessment with the Model for End-Stage Liver Disease Excluding INR score predicts worse survival after heart transplant in pediatric Fontan patients. J Thorac Cardiovasc Surg. 2022 04; 163(4):1462-1473.e12. View Abstract
Retrospective Analysis of Clinical Genetic Testing in Pediatric Primary Dilated Cardiomyopathy: Testing Outcomes and the Effects of Variant Reclassification. J Am Heart Assoc. 2020 06 02; 9(11):e016195. View Abstract
The ABO-incompatible paradigm shifts only as far as allocation policy allows. J Heart Lung Transplant. 2020 07; 39(7):636-638. View Abstract
Brighter Future for Children with Congenital Heart Disease Requiring Heart Transplantation? A UNOS Registry Analysis over the Last Three Decades. J Heart Lung Transplant. 2020 Apr; 39(4S):S206-S207. View Abstract
The TEAMMATE Trial: Study Design and Rationale of the First Pediatric Heart Transplant Randomized Clinical Trial. J Heart Lung Transplant. 2020 Apr; 39(4S):S207-S208. View Abstract
Marijuana in pediatric and adult congenital heart disease heart transplant listing: A survey of provider practices and attitudes. Pediatr Transplant. 2020 03; 24(2):e13640. View Abstract
Association of Clinical Rejection Versus Rejection on Protocol Biopsy With Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients. Transplantation. 2020 01; 104(1):e31-e37. View Abstract
Use of the terminal complement inhibitor eculizumab in paediatric heart transplant recipients. Cardiol Young. 2020 Jan; 30(1):107-113. View Abstract
Current evaluation and management of plastic bronchitis in the pediatric population. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130:109799. View Abstract
T Cells Are Dominant Population in Human Abdominal Aortic Aneurysms and Their Infiltration in the Perivascular Tissue Correlates With Disease Severity. Front Immunol. 2019; 10:1979. View Abstract
Myocardial Infarct After Marijuana Inhalation in a 16-year-old Adolescent Boy. Pediatr Dev Pathol. 2019 Jan-Feb; 22(1):80-86. View Abstract
Heart failure after the Norwood procedure: An analysis of the Single Ventricle Reconstruction Trial. J Heart Lung Transplant. 2018 07; 37(7):879-885. View Abstract
Managing risk of surgical procedures in pediatric transplant recipients taking mTOR inhibitors: What is the optimal strategy? Pediatr Transplant. 2018 02; 22(1). View Abstract
Clinical practice patterns are relatively uniform between pediatric heart transplant centers: A survey-based assessment. Pediatr Transplant. 2017 Aug; 21(5). View Abstract
The Evolution of a Pediatric Ventricular Assist Device Program: The Boston Children's Hospital Experience. Pediatr Cardiol. 2017 Jun; 38(5):1032-1041. View Abstract
Development and validation of a major adverse transplant event (MATE) score to predict late graft loss in pediatric heart transplantation. J Heart Lung Transplant. 2018 04; 37(4):441-450. View Abstract
Into the hearts of babes: Stem cell therapy for pediatric heart failure. J Heart Lung Transplant. 2017 08; 36(8):830-832. View Abstract
Dilated Cardiomyopathy in a 2-Year-Old Infant. Clin Chem. 2017 01; 63(1):433-435. View Abstract
Vascular endothelial growth factor A is associated with the subsequent development of moderate or severe cardiac allograft vasculopathy in pediatric heart transplant recipients. J Heart Lung Transplant. 2017 Apr; 36(4):434-442. View Abstract
Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients. J Heart Lung Transplant. 2016 11; 35(11):1295-1302. View Abstract
Is Endomyocardial Biopsy a Safe and Useful Procedure in Children with Suspected Cardiomyopathy? Pediatr Cardiol. 2016 Oct; 37(7):1200-10. View Abstract
Finding the correct role for heart transplant in the treatment of hypoplastic left heart syndrome. J Heart Lung Transplant. 2016 Mar; 35(3):299-300. View Abstract
What Is the Role of Developmental Disability in Patient Selection for Pediatric Solid Organ Transplantation? Am J Transplant. 2016 Mar; 16(3):767-72. View Abstract
Use of [18F]FDG Positron Emission Tomography to Monitor the Development of Cardiac Allograft Rejection. Transplantation. 2015 Sep; 99(9):e132-9. View Abstract
Multicenter Analysis of Immune Biomarkers and Heart Transplant Outcomes: Results of the Clinical Trials in Organ Transplantation-05 Study. Am J Transplant. 2016 Jan; 16(1):121-36. View Abstract
Summary of the 2015 International Paediatric Heart Failure Summit of Johns Hopkins All Children's Heart Institute. Cardiol Young. 2015 Aug; 25 Suppl 2:8-30. View Abstract
Emerging science in paediatric heart transplantation: donor allocation, biomarkers, and the quest for evidence-based medicine. Cardiol Young. 2015 Aug; 25 Suppl 2:117-23. View Abstract
Translational implications of endothelial cell dysfunction in association with chronic allograft rejection. Pediatr Nephrol. 2016 Jan; 31(1):41-51. View Abstract
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection? Ann Transl Med. 2015 Mar; 3(4):47. View Abstract
Safety and efficacy of radiofrequency wire recanalization of chronic central venous occlusions. J Vasc Access. 2015 Jul-Aug; 16(4):309-14. View Abstract
Antibody depletion for the treatment of crossmatch-positive pediatric heart transplant recipients. Pediatr Transplant. 2013 Nov; 17(7):661-9. View Abstract
Effect of inhaled iloprost on the exercise function of Fontan patients: a demonstration of concept. Int J Cardiol. 2013 Oct 03; 168(3):2435-40. View Abstract
VEGF-C, VEGF-A and related angiogenesis factors as biomarkers of allograft vasculopathy in cardiac transplant recipients. J Heart Lung Transplant. 2013 Jan; 32(1):120-8. View Abstract
Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation. Front Immunol. 2012; 3:54. View Abstract
Endomyocardial biopsy and selective coronary angiography are low-risk procedures in pediatric heart transplant recipients: results of a multicenter experience. J Heart Lung Transplant. 2012 Apr; 31(4):398-409. View Abstract
Sudden death after pediatric heart transplantation: analysis of data from the Pediatric Heart Transplant Study Group. J Heart Lung Transplant. 2011 Dec; 30(12):1395-402. View Abstract
Changes in echocardiographic measures of systolic and diastolic function in children 1 year after hematopoietic SCT. Bone Marrow Transplant. 2011 Dec; 46(12):1532-9. View Abstract
Variant translocation with a deletion of derivative (9q) in a case of Philadelphia chromosome positive (Ph +) essential thrombocythemia (ET), a variant of chronic myelogenous leukemia (CML) with a poor prognosis. Leuk Lymphoma. 2005 Dec; 46(12):1801-6. View Abstract