Charles Berde's research focuses on relieving neuropathic pain in children. The Pain Treatment Service at Children's Hospital in Boston has become a referral center for children with many types of neuropathic pain, but especially limb pain associated with signs of abnormal circulation, which has been variously named reflex sympathetic (or neurovascular) dystrophy (RSD/RND), sympathetically maintained pain (SMP), and complex regional pain syndrome type 1 (CRPS1).
Research Background
Charles Berde received an MD and PhD from Stanford University School of Medicine. He completed an internship and residency in pediatrics at Children's Hospital Boston, a residency in anesthesia at Massachusetts General Hospital, and a fellowship in pediatric anesthesia at Children's Hospital. He has received several awards and honors for his pioneering work in pediatric pain relief, including the 2003 Scientific Achievement Award of the Reflex Sympathetic Dystrophy Syndrome Association. He was profiled as one of Time Magazine's "Heroes in Medicine" in 1997.
Education
Medical School
Stanford University School of Medicine
1980
Stanford
CA
Internship
Boston Children's Hospital
1981
Boston
MA
Residency
Boston Children's Hospital
1983
Boston
MA
Residency
Anesthesia
Massachusetts General Hospital
1985
Boston
MA
Fellowship
Pediatric Anesthesia
Boston Children's Hospital
1985
Boston
MA
Media
Caregiver Profile
Meet Dr. Charles Berde
Publications
Pediatric erythromelalgia from multidisciplinary perspectives: a scoping review. Pediatr Res. 2025 Jan 16. View Abstract
Development and validation of a home quantitative sensory testing tool-kit to assess changes in sensory and pain processing: a study in healthy young adults. Pain. 2025 Jan 01; 166(1):52-66. View Abstract
Neurodevelopment of children exposed to prolonged anesthesia in infancy: GABA study interim analysis of resting-state brain networks at 2, 4, and 10-months old. Neuroimage Clin. 2024; 42:103614. View Abstract
Rescue designs in analgesic trials from 0 to 2 years of age: scoping review. Pediatr Res. 2024 Apr; 95(5):1237-1245. View Abstract
Clinical Characterization of Pediatric Erythromelalgia: A Single-Center Case Series. Children (Basel). 2023 Jul 26; 10(8). View Abstract
Late-presenting dural leak following spine fusion in the pediatric population. Spine Deform. 2023 Nov; 11(6):1371-1380. View Abstract
A framework for individualized splice-switching oligonucleotide therapy. Nature. 2023 Jul; 619(7971):828-836. View Abstract
Electroencephalographic delta and alpha oscillations reveal phase-amplitude coupling in paediatric patients undergoing sevoflurane-based general anaesthesia. Br J Anaesth. 2023 05; 130(5):595-602. View Abstract
Anesthesia and epidural analgesia for "heroic" cancer surgery. Paediatr Anaesth. 2023 03; 33(3):182-184. View Abstract
Tactile sensitivity and motor coordination in infancy: Effect of age, prior surgery, anaesthesia & critical illness. PLoS One. 2022; 17(12):e0279705. View Abstract
Ultrasound-guided spinal anesthesia in infants: a narrative review. Reg Anesth Pain Med. 2023 12; 48(12):608-614. View Abstract
Mendelian Disorders in an Interstitial Cystitis/Bladder Pain Syndrome Cohort. Adv Genet (Hoboken). 2023 Mar; 4(1):2200013. View Abstract
Emerging functional connectivity patterns during sevoflurane anaesthesia in the developing human brain. Br J Anaesth. 2023 02; 130(2):e381-e390. View Abstract
Nusinersen for Patients With Spinal Muscular Atrophy: 1415 Doses via an Interdisciplinary Institutional Approach. Pediatr Neurol. 2022 07; 132:33-40. View Abstract
Ultrasound-guided "saline myelogram": Confirmation of intrathecal drug delivery despite "dry tap" in infants for spinal anesthesia and spinal therapeutics. Paediatr Anaesth. 2022 07; 32(7):883-884. View Abstract
Transforaminal lumbar puncture for spinal anesthesia or novel drug administration: a technique combining C-arm fluoroscopy and ultrasound. Reg Anesth Pain Med. 2022 06; 47(6):380-383. View Abstract
Modified Sensory Testing in Non-verbal Patients Receiving Novel Intrathecal Therapies for Neurological Disorders. Front Neurol. 2022; 13:664710. View Abstract
Standardizing Opioid Prescribing in a Pediatric Hospital: A Quality Improvement Effort. Hosp Pediatr. 2022 02 01; 12(2):164-173. View Abstract
Mendelian etiologies identified with whole exome sequencing in cerebral palsy. Ann Clin Transl Neurol. 2022 02; 9(2):193-205. View Abstract
Initial Adjustment to the COVID-19 Pandemic and the Associated Shutdown in Children and Adolescents With Chronic Pain and Their Families. Front Pain Res (Lausanne). 2021; 2:713430. View Abstract
Racial and Ethnic Disparities in Pain Management of Children With Limb Fractures or Suspected Appendicitis: A Retrospective Cross-Sectional Study. Front Pediatr. 2021; 9:652854. View Abstract
The Effectiveness of Cancer Pain Management in a Tertiary Hospital Outpatient Pain Clinic in Thailand: A Prospective Observational Study. Pain Res Manag. 2021; 2021:5599023. View Abstract
Trends in Gabapentin and Pregabalin Prescribing in a Tertiary Pediatric Medical Center. Hosp Pediatr. 2021 08; 11(8):909-914. View Abstract
Intrathecal catheter and port placement for nusinersen infusion in children with spinal muscular atrophy and spinal fusion. Pediatr Radiol. 2021 12; 51(13):2588-2595. View Abstract
Explicit and implicit bias based on race, ethnicity, and weight among pediatric emergency physicians. Acad Emerg Med. 2021 09; 28(9):1073-1076. View Abstract
Nonpharmacological Interventions for Pediatric Migraine: A Network Meta-analysis. Pediatrics. 2021 04; 147(4). View Abstract
Association of Genetic Variants With Migraine Subclassified by Clinical Symptoms in Adult Females. Front Neurol. 2020; 11:617472. View Abstract
Epidural catheter placement in children with baclofen pumps. Paediatr Anaesth. 2021 02; 31(2):178-185. View Abstract
Case Studies Using the Electroencephalogram to Monitor Anesthesia-Induced Brain States in Children. Anesth Analg. 2020 10; 131(4):1043-1056. View Abstract
Neurophysiological Assessment of Prolonged Recovery From Neuromuscular Blockade in the Neonatal Intensive Care Unit. Front Pediatr. 2020; 8:580. View Abstract
Genome-wide association analysis of opioid use disorder: A novel approach using clinical data. Drug Alcohol Depend. 2020 12 01; 217:108276. View Abstract
Case Studies Using the Electroencephalogram to Monitor Anesthesia-Induced Brain States in Children. Anesth Analg. 2020 Aug 17. View Abstract
Effect of lumbar medial branch blocks on extension-related axial chronic low back pain in a pediatric population: a retrospective chart review and prospective follow-up. Reg Anesth Pain Med. 2020 12; 45(12):1019-1020. View Abstract
Efficacy, Safety, and Acceptability of Pharmacologic Treatments for Pediatric Migraine Prophylaxis: A Systematic Review and Network Meta-analysis. JAMA Pediatr. 2020 04 01; 174(4):341-349. View Abstract
Off-label use of prescription analgesics among hospitalized children in the United States. Pharmacoepidemiol Drug Saf. 2020 04; 29(4):474-481. View Abstract
d-Oscillation Correlates of Anesthesia-induced Unconsciousness in Large-scale Brain Networks of Human Infants. Anesthesiology. 2019 12; 131(6):1239-1253. View Abstract
Developing a pediatric pain data repository. JAMIA Open. 2020 Apr; 3(1):31-36. View Abstract
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease. N Engl J Med. 2019 10 24; 381(17):1644-1652. View Abstract
Electroencephalographic features of discontinuous activity in anesthetized infants and children. PLoS One. 2019; 14(10):e0223324. View Abstract
Morphine compared to placebo for procedural pain in preterm infants: safety, efficacy and equipoise. J Perinatol. 2019 10; 39(10):1428-1431. View Abstract
The effect of suprainguinal fascia iliaca block on the recovery of patients after arthroscopic hip surgery. Paediatr Anaesth. 2019 08; 29(8):829-834. View Abstract
The Society for Pediatric Anesthesia recommendations for the use of opioids in children during the perioperative period. Paediatr Anaesth. 2019 06; 29(6):547-571. View Abstract
Neural Correlates of Anesthesia in Newborn Mice and Humans. Front Neural Circuits. 2019; 13:38. View Abstract
Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial. Lancet. 2019 02 16; 393(10172):664-677. View Abstract
Patient- and Nurse-Controlled Analgesia: 22-Year Experience in a Pediatric Hospital. Hosp Pediatr. 2019 02; 9(2):129-133. View Abstract
An open label pilot study of a dexmedetomidine-remifentanil-caudal anesthetic for infant lower abdominal/lower extremity surgery: The T REX pilot study. Paediatr Anaesth. 2019 01; 29(1):59-67. View Abstract
Maximum Recommended Dosage of Ropivacaine and Bupivacaine for Pediatric Regional Anesthesia. Reg Anesth Pain Med. 2018 11; 43(8):895-896. View Abstract
Effects of Childhood Life Events on Adjustment Problems in Adolescence: A Longitudinal Study. J Dev Behav Pediatr. 2018 Oct/Nov; 39(8):629-641. View Abstract
Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients. Pain Rep. 2018 May; 3(3):e651. View Abstract
Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old. Br J Anaesth. 2018 Jun; 120(6):1274-1286. View Abstract
Clinical trial designs and models for analgesic medications for acute pain in neonates, infants, toddlers, children, and adolescents: ACTTION recommendations. Pain. 2018 02; 159(2):193-205. View Abstract
Clinical signs and electroencephalographic patterns of emergence from sevoflurane anaesthesia in children: An observational study. Eur J Anaesthesiol. 2018 01; 35(1):49-59. View Abstract
Children With Chronic Pain: Response Trajectories After Intensive Pain Rehabilitation Treatment. J Pain. 2018 02; 19(2):207-218. View Abstract
Electroencephalographic discontinuity during sevoflurane anesthesia in infants and children. Paediatr Anaesth. 2017 Mar; 27(3):251-262. View Abstract
Image-guided intrathecal baclofen pump catheter implantation: a technical note and case series. J Neurosurg Spine. 2017 May; 26(5):621-627. View Abstract
Measurement of neosaxitoxin in human plasma using liquid-chromatography tandem mass spectrometry: Proof of concept for a pharmacokinetic application. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 15; 1036-1037:42-49. View Abstract
Lidocaine Infusions and Other Options for Opioid-Resistant Pain Due to Pediatric Advanced Cancer. Pediatr Blood Cancer. 2016 07; 63(7):1141-3. View Abstract
Fear and Reward Circuit Alterations in Pediatric CRPS. Front Hum Neurosci. 2015; 9:703. View Abstract
Epidural Steroid Injections for Radiculopathy and/or Back Pain in Children and Adolescents: A Retrospective Cohort Study With a Prospective Follow-Up. Reg Anesth Pain Med. 2016 Jan-Feb; 41(1):86-92. View Abstract
Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial. Lancet. 2016 Jan 16; 387(10015):239-50. View Abstract
Electroencephalography during general anaesthesia differs between term-born and premature-born children. Clin Neurophysiol. 2016 Feb; 127(2):1216-1222. View Abstract
A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia. Anesthesiology. 2015 Oct; 123(4):873-85. View Abstract
Neosaxitoxin in Rat Sciatic Block: Improved Therapeutic Index Using Combinations with Bupivacaine, with and without Epinephrine. Anesthesiology. 2015 Oct; 123(4):886-98. View Abstract
Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants. Elife. 2015 Jun 23; 4:e06513. View Abstract
Transient Alterations of Cutaneous Sensory Nerve Function by Noninvasive Cryolipolysis. J Invest Dermatol. 2015 Nov; 135(11):2623-2631. View Abstract
Endogenous cholinergic neurotransmission contributes to behavioral sensitization to morphine. PLoS One. 2015; 10(2):e0117601. View Abstract
Immediate rescue designs in pediatric analgesic trials: a systematic review and meta-analysis. Anesthesiology. 2015 Jan; 122(1):150-171. View Abstract
Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study. Pediatr Rheumatol Online J. 2014; 12:39. View Abstract
Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome. Neuroimage Clin. 2014; 6:347-69. View Abstract
The responsive amygdala: treatment-induced alterations in functional connectivity in pediatric complex regional pain syndrome. Pain. 2014 Sep; 155(9):1727-1742. View Abstract
Paravertebral block for analgesia after pediatric thoracic surgery. Reg Anesth Pain Med. 2014 May-Jun; 39(3):179-80. View Abstract
Documented electronic medical record-based pain intensity scores at a tertiary pediatric medical center: a cohort analysis. J Pain Symptom Manage. 2014 Nov; 48(5):924-33. View Abstract
A single institution's effort to translate codeine knowledge into specific clinical practice. J Pain Symptom Manage. 2014 Jul; 48(1):119-26. View Abstract
Regional anesthesia approaches to pain management in pediatric palliative care: a review of current knowledge. J Pain Symptom Manage. 2013 Dec; 46(6):859-73. View Abstract
A case of cerebrospinal fluid leak in an infant after spinal anesthesia. J Clin Anesth. 2013 May; 25(3):217-9. View Abstract
Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome. PLoS One. 2013; 8(3):e57205. View Abstract
Children and adolescents with complex regional pain syndrome: more psychologically distressed than other children in pain? Pain Res Manag. 2013 Mar-Apr; 18(2):87-93. View Abstract
Pediatric regional anesthesia: drawing inferences on safety from prospective registries and case reports. Anesth Analg. 2012 Dec; 115(6):1259-62. View Abstract
A day-hospital approach to treatment of pediatric complex regional pain syndrome: initial functional outcomes. Clin J Pain. 2012 Nov-Dec; 28(9):766-74. View Abstract
Periaqueductal gray neuroplasticity following chronic morphine varies with age: role of oxidative stress. Neuroscience. 2012 Dec 13; 226:165-77. View Abstract
Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas. Brain Res. 2012 May 31; 1457:1-12. View Abstract
Respiratory, neuromuscular, and cardiovascular effects of neosaxitoxin in isoflurane-anesthetized sheep. Reg Anesth Pain Med. 2012 Mar-Apr; 37(2):152-8. View Abstract
Response to "A new definition of neuropathic pain". Pain. 2012 Apr; 153(4):934-935. View Abstract
Pediatric analgesic clinical trial designs, measures, and extrapolation: report of an FDA scientific workshop. Pediatrics. 2012 Feb; 129(2):354-64. View Abstract
Tetrodotoxin-bupivacaine-epinephrine combinations for prolonged local anesthesia. Mar Drugs. 2011 Dec; 9(12):2717-2728. View Abstract
Spinal anesthesia in infant rats: development of a model and assessment of neurologic outcomes. Anesthesiology. 2011 Jun; 114(6):1325-35. View Abstract
Comparison of neosaxitoxin versus bupivacaine via port infiltration for postoperative analgesia following laparoscopic cholecystectomy: a randomized, double-blind trial. Reg Anesth Pain Med. 2011 Mar-Apr; 36(2):103-9. View Abstract
The Fear of Pain Questionnaire (FOPQ): assessment of pain-related fear among children and adolescents with chronic pain. J Pain. 2011 Jun; 12(6):677-86. View Abstract
Fatigue in children with cancer at the end of life. J Pain Symptom Manage. 2010 Oct; 40(4):483-94. View Abstract
Blood sampling and other needle procedures - the Achilles heel of newborn intensive care. Pain. 2009 Dec 15; 147(1-3):15-6. View Abstract
Pain measurement and Beecher's challenge: 50 years later. Anesthesiology. 2009 Sep; 111(3):473-4. View Abstract
Lumbar sympathetic blockade in children with complex regional pain syndromes: a double blind placebo-controlled crossover trial. Anesthesiology. 2009 Aug; 111(2):372-80. View Abstract
Challenges of functional imaging research of pain in children. Mol Pain. 2009 Jun 16; 5:30. View Abstract
In vivo lipid diffusion coefficient measurements in rat bone marrow. Magn Reson Imaging. 2009 Jul; 27(6):859-64. View Abstract
fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children. Brain. 2008 Jul; 131(Pt 7):1854-79. View Abstract
Opioid side effects--mechanism-based therapy. N Engl J Med. 2008 May 29; 358(22):2400-2. View Abstract
Easing of suffering in children with cancer at the end of life: is care changing? J Clin Oncol. 2008 Apr 01; 26(10):1717-23. View Abstract
Postoperative pain and other sequelae of dental rehabilitations performed on children under general anesthesia. Pediatr Dent. 2008 Mar-Apr; 30(2):111-21. View Abstract
Stable plasma concentrations of unbound ropivacaine during postoperative epidural infusion for 24-72 hours in children. Eur J Anaesthesiol. 2008 May; 25(5):410-7. View Abstract
Pharmacologic management of painful bladder syndrome/interstitial cystitis: a systematic review. Arch Intern Med. 2007 Oct 08; 167(18):1922-9. View Abstract
Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model. Anesthesiology. 2007 Aug; 107(2):312-21. View Abstract
Cutaneous sensory abnormalities in children and adolescents with complex regional pain syndromes. Pain. 2007 Sep; 131(1-2):153-61. View Abstract
Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 1): hyperalgesia, edema, and systemic cytokines. Anesthesiology. 2006 Jul; 105(1):128-38. View Abstract
Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 2): cytokines and p38 mitogen-activated protein kinases in dorsal root ganglia and spinal cord. Anesthesiology. 2006 Jul; 105(1):139-45. View Abstract
Factors associated with fatigue in children with cancer at the end of life. J Clin Oncol. 2006 Jun 20; 24(18_suppl):8574. View Abstract
Complex regional pain syndromes in children and adolescents: regional and systemic signs and symptoms and hemodynamic response to tilt table testing. Clin J Pain. 2006 May; 22(4):399-406. View Abstract
Summary proceedings from the neonatal pain-control group. Pediatrics. 2006 Mar; 117(3 Pt 2):S9-S22. View Abstract
Use of complementary and alternative medicine in pediatric pain management service: a survey. Pain Med. 2005 Nov-Dec; 6(6):452-8. View Abstract
Biexponential parameterization of diffusion and T2 relaxation decay curves in a rat muscle edema model: decay curve components and water compartments. Magn Reson Med. 2005 Sep; 54(3):524-31. View Abstract
Pain management for the hospitalized pediatric patient. Pediatr Clin North Am. 2005 Aug; 52(4):995-1027, vii-viii. View Abstract
Analgesia and anesthesia for neonates: study design and ethical issues. Clin Ther. 2005 Jun; 27(6):814-43. View Abstract
Anesthesia and analgesia during and after surgery in neonates. Clin Ther. 2005 Jun; 27(6):900-21. View Abstract
Caudal analgesia and anesthesia techniques in children. Curr Opin Anaesthesiol. 2005 Jun; 18(3):283-8. View Abstract
Complex regional pain syndromes in children and adolescents. Anesthesiology. 2005 Feb; 102(2):252-5. View Abstract
A randomized controlled trial to evaluate S-Caine patch for reducing pain associated with vascular access in children. Anesthesiology. 2005 Feb; 102(2):403-8. View Abstract
Epinephrine prevents muscle blood flow increases after perineural injection of tetrodotoxin. Anesthesiology. 2004 Dec; 101(6):1428-34. View Abstract
Self-mutilation in young children following brachial plexus birth injury. Pain. 2004 Jul; 110(1-2):123-9. View Abstract
Local anesthetics in infants and children: an update. Paediatr Anaesth. 2004 May; 14(5):387-93. View Abstract
The use of herbs and complementary and alternative medicine in pediatric preoperative patients. J Clin Anesth. 2004 Feb; 16(1):4-6. View Abstract
Effects of repeated injection of local anesthetic on sciatic nerve blocks response. J Huazhong Univ Sci Technolog Med Sci. 2004; 24(5):497-9. View Abstract
Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block. Anesthesiology. 2003 Dec; 99(6):1402-8. View Abstract
Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Pain. 2003 Jul; 104(1-2):415-21. View Abstract
Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle. J Neurophysiol. 2003 Oct; 90(4):2098-105. View Abstract
Opioids: more to learn, improvements to be made. Anesthesiology. 2003 Jun; 98(6):1309-12. View Abstract
Pain, anxiety, distress, and suffering: interrelated, but not interchangeable. J Pediatr. 2003 Apr; 142(4):361-3. View Abstract
Activation of peripheral excitatory amino acid receptors decreases the duration of local anesthesia. Anesthesiology. 2003 Feb; 98(2):521-9. View Abstract
Analgesics for the treatment of pain in children. N Engl J Med. 2002 Oct 03; 347(14):1094-103. View Abstract
The effects of lidocaine and adrenergic agonists on rat sciatic nerve and skeletal muscle blood flow in vivo. Anesth Analg. 2002 Oct; 95(4):1080-6, table of contents. View Abstract
Diagnosis and management of MNGIE syndrome in children: case report and review of the literature. J Pediatr Gastroenterol Nutr. 2002 Sep; 35(3):377-83. View Abstract
Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes. J Pediatr. 2002 Jul; 141(1):135-40. View Abstract
Prolonged sensory and motor deficit following short-term lumbar epidural analgesia in a patient with mixed connective tissue disease. J Pain Symptom Manage. 2002 Feb; 23(2):89-92. View Abstract
Glutamate-induced sensitization of rat masseter muscle fibers. Neuroscience. 2002; 109(2):389-99. View Abstract
Quantitative assessment of cutaneous thermal and vibration sensation and thermal pain detection thresholds in healthy children and adolescents. Muscle Nerve. 2001 Oct; 24(10):1339-45. View Abstract
The pharmacokinetics of epidural ropivacaine in infants and young children. Anesth Analg. 2001 Oct; 93(4):893-7. View Abstract
Evidence that spinal segmental nitric oxide mediates tachyphylaxis to peripheral local anesthetic nerve block. Acta Anaesthesiol Scand. 2001 Sep; 45(8):945-53. View Abstract
Osmotic effects on the T2 relaxation decay of in vivo muscle. Magn Reson Med. 2001 Sep; 46(3):592-9. View Abstract
High concentrations of adrenergic antagonists prolong sciatic nerve blockade by tetrodotoxin. Acta Anaesthesiol Scand. 2001 Aug; 45(7):899-905. View Abstract
Effects of adrenergic agonists and antagonists on tetrodotoxin-induced nerve block. Reg Anesth Pain Med. 2001 May-Jun; 26(3):239-45. View Abstract
Developmental pharmacology across species: promise and problems. Anesth Analg. 2000 Jul; 91(1):1-5. View Abstract
Reports of pain by children undergoing rapid palatal expansion. Pediatr Dent. 2000 May-Jun; 22(3):221-6. View Abstract
On pins and needles? Pediatric pain patients' experience with acupuncture. Pediatrics. 2000 Apr; 105(4 Pt 2):941-7. View Abstract
The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo. Reg Anesth Pain Med. 2000 Jan-Feb; 25(1):52-9. View Abstract
Survey of acupuncturists: practice characteristics and pediatric care. West J Med. 1999 Sep; 171(3):153-7. View Abstract
Acupressure-acupuncture antiemetic prophylaxis in children undergoing tonsillectomy. Anesthesiology. 1999 May; 90(5):1311-6. View Abstract
Prolonged local myometrial blockade prevents preterm labor after fetal surgery in a leporine model. J Pediatr Surg. 1999 Apr; 34(4):540-2. View Abstract
Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 sodium channel blockers. Anesthesiology. 1999 Feb; 90(2):524-34. View Abstract
Sciatic nerve blockade in infant, adolescent, and adult rats: a comparison of ropivacaine with bupivacaine. Anesthesiology. 1998 Nov; 89(5):1199-208; discussion 10A. View Abstract
Prolonged intercostal nerve blockade in sheep using controlled-release of bupivacaine and dexamethasone from polymer microspheres. Anesthesiology. 1998 Oct; 89(4):969-79. View Abstract
A re-examination of tetrodotoxin for prolonged duration local anesthesia. Anesthesiology. 1998 Jul; 89(1):119-31. View Abstract
End-of-life care in cystic fibrosis. Pediatrics. 1997 Aug; 100(2 Pt 1):205-9. View Abstract
Neurologic evaluation of infant and adult rats before and after sciatic nerve blockade. Anesthesiology. 1997 Apr; 86(4):957-65. View Abstract
"Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid". 1997. View Abstract
"Biodegradable polymer matrices for sustained delivery of local anesthetic agents". 1997. View Abstract
NG-nitro-L-arginine methyl ester (L-NAME) prevents tachyphylaxis to local anesthetics in a dose-dependent manner. Anesth Analg. 1996 Dec; 83(6):1251-5. View Abstract
Regional anesthesia in children: what have we learned? Anesth Analg. 1996 Nov; 83(5):897-900. View Abstract
Halothane and cardiac autonomic control in infants: assessment with quantitative respiratory sinus arrhythmia. Pediatr Res. 1996 Nov; 40(5):710-7. View Abstract
Glucocorticoids prolong rat sciatic nerve blockade in vivo from bupivacaine microspheres. Anesthesiology. 1996 Nov; 85(5):1157-66. View Abstract
Patient-controlled analgesia for mucositis pain in children: a three-period crossover study comparing morphine and hydromorphone. J Pediatr. 1996 Nov; 129(5):722-8. View Abstract
Pediatric oncology procedures: to sleep or perchance to dream? Pain. 1995 Jul; 62(1):1-2. View Abstract
Control of severe pain in children with terminal malignancy. J Pediatr. 1995 Apr; 126(4):653-7. View Abstract
A double-blind evaluation of ketorolac tromethamine versus acetaminophen in pediatric tonsillectomy: analgesia and bleeding. Anesth Analg. 1995 Feb; 80(2):226-9. View Abstract
The risk of infection from epidural analgesia in children: a review of 1620 cases. Anesth Analg. 1995 Feb; 80(2):234-8. View Abstract
Infants tolerate spinal anesthesia with minimal overall autonomic changes: analysis of heart rate variability in former premature infants undergoing hernia repair. Anesth Analg. 1995 Jan; 80(1):20-7. View Abstract
L-nitroso-arginine methyl ester prevents tachyphylaxis to sciatic nerve blockade in a dose-dependent manner. Anesthesiology. 1995; 83:A808. View Abstract
Epidural analgesia accelerates recovery following major pediatric urologic reconstructive surgery. Society for Pediatric Anesthesia/American Academy of Pediatrics. 1995. View Abstract
Anesthesia and perioperative care in cystic fibrosis. Anesth. Analg. 1995. View Abstract
Thermal hyperalgesia accelerates and MK-801 prevents the development of tachyphylaxis to rat sciatic nerve blockade. Anesthesiology. 1994 Nov; 81(5):1284-93. View Abstract
Epidural analgesia in children. Can J Anaesth. 1994 Jul; 41(7):555-60. View Abstract
A double blind evaluation of ketorolac tromethamine versus acetaminophen in the pediatric tonsillectomy patient, effects on analgesia and bleeding. American Academy of Pediatrics, Section on Anesthesiology. 1994. View Abstract
Dextroamphetamine or methylphenidate as adjuvants to opioid analgesia for adolescents with cancer. J Pain Symptom Manage. 1994 Feb; 9(2):122-5. View Abstract
Management of tracheobronchial and esophageal foreign bodies in children: a survey study. J Clin Anesth. 1994 Jan-Feb; 6(1):28-32. View Abstract
Tachyphylaxis to sciatic blockade persists in spinalized rats. Anesthesiology. 1994; 81:A964. View Abstract
Neuropathic pain in children. Abstracts of the 3rd International Pediatric Pain Symposium. 1994. View Abstract
Evaluation of epinephrine epidural test dose in children receiving isoflurane anesthesia. Anesthesiology. 1994; 81:A1344. View Abstract
Absolute volume predicts duration of sciatic blockade better than volume/kilogram in infant and adult rats. Anesthesiology. 1994; 81:A1375. View Abstract
The dose-response of epidural hydromorphone in children. Anesthesiology. 1994; 81:A1346. View Abstract
Epinephrine prolongs sciatic nerve block in infant but not adult rats. Anesthesiology. 1994; 81:A1356. View Abstract
The safety in pediatric regional analgesia study group: a multicenter study of safety and risk factors in pediatric regional analgesia. Anesthesiology. 1994; 81:A1386. View Abstract
Optimal pain relief in infants and children. BMJ. 1993 Oct 02; 307(6908):815-6. View Abstract
Sustained local anesthetic release from bioerodible polymer matrices: a potential method for prolonged regional anesthesia. Pharm Res. 1993 Oct; 10(10):1527-32. View Abstract
Chronic exposure to lidocaine does not alter flux through sodium channels in cultured neuronal cells. Reg Anesth. 1993 Sep-Oct; 18(5):283-9. View Abstract
Prolonged regional nerve blockade by controlled release of local anesthetic from a biodegradable polymer matrix. Anesthesiology. 1993 Aug; 79(2):340-6. View Abstract
Performance of pediatric resuscitation bags assessed with an infant lung simulator. Anesth Analg. 1993 Aug; 77(2):261-4. View Abstract
Venous air embolism during identification of the epidural space in children. Anesth Analg. 1993 May; 76(5):925-7. View Abstract
Toxicity of local anesthetics in infants and children. J Pediatr. 1993 May; 122(5 Pt 2):S14-20. View Abstract
Continuous caudal anesthesia for inguinal hernia repair in former preterm infants. J Clin Anesth. 1993 Mar-Apr; 5(2):129-33. View Abstract
Pain, euthanasia, and anesthesiologists. Anesthesiology. 1993 Feb; 78(2):353-60. View Abstract
Pain management in pediatrics. West J Med. 1993 Feb; 158(2):178-9. View Abstract
Intravenous isoproterenol as a marker for epidural test-dosing in children. Anesth Analg. 1993 Jan; 76(1):178-81. View Abstract
Comparison of injection and sustained release bupivicaine sciatic nerve blockade between adult and weaning rats. Anesthesiology. 1993; 79(3A):A908. View Abstract
Comparison of sciatic nerve blockade between infant and adult rats. Anesthesiology. 1993; 79(3A):A1137. View Abstract
Barbiturates in the care of the terminally ill. N Engl J Med. 1992 Dec 03; 327(23):1678-82. View Abstract
Reflex sympathetic dystrophy in children. Clinical characteristics and follow-up of seventy patients. J Bone Joint Surg Am. 1992 Jul; 74(6):910-9. View Abstract
High sensitivity quantification of RNA from gels and autoradiograms with affordable optical scanning. Biotechniques. 1992 Jun; 12(6):902-6, 908-11. View Abstract
Laser Doppler measurements of skin blood flow before, during, and after lumbar sympathetic blockade in children and young adults with reflex sympathetic dystrophy syndrome. J Clin Monit. 1992 Jan; 8(1):16-9. View Abstract
The risk of infection from pediatric epidural analgesia is low. Anesthesiology. 1992; 77:A1158. View Abstract
Patient-controlled analgesia in children and adolescents: safety and outcome amoung 1,589 patients. Anesthesiology. 1992; 77:A1187. View Abstract
Performance of pediatric resuscitation bags assessed with an infant lung simulator. Anesthesiology. 1992; 77:A509. View Abstract
Midazolam for conscious sedation during pediatric oncology procedures: safety and recovery parameters. Pediatrics. 1991 Dec; 88(6):1172-9. View Abstract
Continuous subarachnoid analgesia in two adolescents with severe scoliosis and impaired pulmonary function. Reg Anesth. 1991 Nov-Dec; 16(6):333-6. View Abstract
Comparison of morphine and methadone for prevention of postoperative pain in 3- to 7-year-old children. J Pediatr. 1991 Jul; 119(1 Pt 1):136-41. View Abstract
Patient-controlled analgesia in children and adolescents: a randomized, prospective comparison with intramuscular administration of morphine for postoperative analgesia. J Pediatr. 1991 Mar; 118(3):460-6. View Abstract
Efficacy of adrenaline, lignocaine-adrenaline and isoprenaline as a test dose in halothane-anaesthetized lambs. Eur J Anaesthesiol. 1991 Mar; 8(2):123-8. View Abstract
Memories of pain in three- to seven-year-old children. Journal of Pain and Symptom Management. 1991; 6:174. View Abstract
Methylphenidate or dextraamphetamine as adjuvants in opioid analgesia. Journal of Pain and Symptom Management. 1991; 6:162. View Abstract
Implementation of a PCA program. Journal of Pain and Symptom Management. 1991; 6:187. View Abstract
Recognition and treatment of pain in pediatric patients with AIDS. Journal of Pain and Symptom Management. 1991; 6:162. View Abstract
Porlonged sciatic nerve blockade using sustained release of bupivicaine from a biodegradable polymer matrix. Anesthesiology. 1991; 75:A765. View Abstract
Experience with 852 epidural infusions in a children's hospital. Journal of Pain and Symptom Management. 1991; 6:164. View Abstract
Continuous caudal anesthesia with 2-chloroprocaine for premature infants undergoing inguinal hernia repair. Anesthesiology. 1991; 75:A693. View Abstract
Reflex sympathetic dystrophy in children and adolescents: follow-up of 70 patients adn development of a treatment algorithm. Anesthesiology. 1991; 75:A916. View Abstract
Children's pain and family functioning: a comparative analysis. J. Pain and Symptom Management. 1991; 6:146. View Abstract
Discordance between self-report and behavioral pain measures in children aged 3-7 years after surgery. J Pain Symptom Manage. 1990 Dec; 5(6):350-6. View Abstract
Celiac plexus blockade for a 3-year-old boy with hepatoblastoma and refractory pain. Pediatrics. 1990 Nov; 86(5):779-81. View Abstract
American Academy of Pediatrics Report of the Subcommittee on Disease-Related Pain in Childhood Cancer. Pediatrics. 1990 Nov; 86(5 Pt 2):818-25. View Abstract
Subarachnoid bupivacaine analgesia for seven months for a patient with a spinal cord tumor. Anesthesiology. 1990 Jun; 72(6):1094-6. View Abstract
Continuous epidural bupivacaine-fentanyl infusions in children following ureteral reimplantation. Anesthesiology. 1990; 73:A775. View Abstract
Hypotension, flushing and bronchospasm in myelodysplasia patients undergoing surgery. Section on Anesthesiology, American Academy of Pediatrics. 1990; Spring. View Abstract
Patient-controlled analgesia in children and adolescents: a randomized comparison with intramuscular morphine. Anesthesiology. 1990; 73:A1102. View Abstract
Isoproterenol for test dosing in pediatric regional blockade. Anesthesiology. 1990; 73:A1127. View Abstract
Sustained release of dibucaine from a biodegradable polymer matrix: a potential method for prolonged neural blockade. Anesthesiology. 1990; 73:A776. View Abstract
Regional analgesia in the management of chronic pain in childhood. J Pain Symptom Manage. 1989 Dec; 4(4):232-7. View Abstract
Meningococcal purpura fulminans: treatment of vascular insufficiency in a 2-yr-old child with lumbar epidural sympathetic blockade. Anesthesiology. 1989 Sep; 71(3):463-4. View Abstract
Pharmacologic management of pain in children and adolescents. Pediatr Clin North Am. 1989 Aug; 36(4):855-71. View Abstract
Sufentanil, morphine, met-enkephalin, and kappa-agonist (U-50,488H) inhibit substance P release from primary sensory neurons: a model for presynaptic spinal opioid actions. Anesthesiology. 1989 Apr; 70(4):672-7. View Abstract
Caudal epidural morphine analgesia for an infant with advanced neuroblastoma: report of a case. Pain. 1989 Feb; 36(2):219-223. View Abstract
Pediatric pain clinics: recommendations for their development. Pediatrician. 1989; 16(1-2):94-102. View Abstract
Regional analgesia on pediatric medical and surgical wards. Intensive Care Med. 1989; 15 Suppl 1:S40-3. View Abstract
Postoperative lordoscoliosis causing extrinsic compression of the right main stem bronchus and respiratory insufficiency. A case report. Spine (Phila Pa 1976). 1989 Jan; 14(1):110-4. View Abstract
Epidural test dosing in halothane-anesthesized lambs. Anesthesiology. 1989; 72:A1022. View Abstract
Spinal vs. general anesthesia in infants undergoing hernia repair. Section on Anesthesiology, American Academy of Pediatrics. 1989. View Abstract
Stellate ganglion blockade in children and adolescents. Anesthesiology. 1989; 71:A1023. View Abstract
Reflex sympathetic dystrophy in children and adolescents. Society for Behavioral Medicine. 1989. View Abstract
Radiological case of the month. Bronchial compression and ventilatory dysfunction in scoliosis. Am J Dis Child. 1988 May; 142(5):545-6. View Abstract
A technique for continuous lumbar sympathetic blockade for severe reflex sympathetic dystrophy in children and adolescents. Anesth Analg. 1988; 67:S4. View Abstract
A comparison of methadone and morphine for postoperative analgesia in children and adolescents. Anesthesiology. 1988; 69:A768. View Abstract
Initial experience with a multidiscplinary pediatric pain treatment service. Pain. 1987; Supplement 4:S99. View Abstract
Pharmacokinetics of methadone in children and adolescents in the perioperative period. Anesthesiology. 1987; 67:A519. View Abstract
Regional anesthetic approaches to post-operative pain in children and adolescents. Intensive Care Med. 1987; 13:460. View Abstract
Opioids inhibit substance P release from cultured dorsal root ganglia: a model for spinal narcotic action. Anesthesiology. 1987; 67:A388. View Abstract
Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin. J Biol Chem. 1984 Jun 25; 259(12):7870-7. View Abstract
Zoonotic filariasis with lymphedema in an immunodeficient infant. N Engl J Med. 1984 May 10; 310(19):1243-5. View Abstract
Bilirubin binding in the plasma of newborns: critical evaluation of a fluorescence quenching method and comparison to the peroxidase method. Pediatr Res. 1984 Apr; 18(4):349-54. View Abstract
Some functional effects of physical changes in the membranes of white cells. Kroc Found Ser. 1984; 16:111-27. View Abstract
The excitable membrane of phagocytic leukocytes. Prog Clin Biol Res. 1984; 164:347-54. View Abstract
Pregnancy in women with pseudoxanthoma elasticum. Obstet Gynecol Surv. 1983 Jun; 38(6):339-44. View Abstract
Gel to liquid-crystalline phase transitions of aqueous dispersions of polyunsaturated mixed-acid phosphatidylcholines. Biochemistry. 1983 Mar 15; 22(6):1466-73. View Abstract
Cytochalasin E diminishes the lag phase in the release of superoxide by human neutrophils. Biochem Biophys Res Commun. 1982 May 14; 106(1):170-4. View Abstract
Phase transitions of dispersions of polyunsaturated mixed acid phosphatidyl cholines: calorimetric measurements and a statistical-mechanical description. Mackinac Conference on Artificial Surfactant Proceedings. 1982. View Abstract
Monitoring intravenous fat emulsions in neonates with the fatty acid/serum albumin molar ratio. JPEN J Parenter Enteral Nutr. 1981 Nov-Dec; 5(6):517-8. View Abstract
A theory of the effects of head-group structure and chain unsaturation on the chain melting transition of phospholipid dispersions. Biochemistry. 1980 Sep 02; 19(18):4279-93. View Abstract
Use of the conjugated polyene fatty acid, parinaric acid, in assaying fatty acids in serum or plasma. Clin Chem. 1980 Jul; 26(8):1173-7. View Abstract
Human alpha-fetoprotein. Fluorescence studies on binding and proximity relationships for fatty acids and bilirubin. J Biol Chem. 1979 Dec 25; 254(24):12609-14. View Abstract
Human serum albumin. Spectroscopic studies of binding and proximity relationships for fatty acids and bilirubin. J Biol Chem. 1979 Jan 25; 254(2):391-400. View Abstract
Binding of bilirubin and fatty acids in the sera of neonates. Clin Res. 1979; 27:134A. View Abstract
Two coupled oscillators: simulations of the circadian pacemaker in mammalian activity rhythms. J Theor Biol. 1978 Feb 06; 70(3):297-313. View Abstract
A free fatty acid binding index for serum. Pediatr Res. 1978; 12:502. View Abstract
Activation of purified 3-hydroxy-3-methylglutaryl-CoA reductase by phospholipids. Biochim Biophys Acta. 1977 Jul 20; 488(1):112-20. View Abstract
A population-family planning resource center: a community educational service. Fam Plann Resume. 1977; 1(1):142-3. View Abstract
Nonmonotonic transients and some mathematical models of circadian rhythms. J Theor Biol. 1976 Feb; 56(2):435-41. View Abstract