Technical Support Staff
Lab Manager
Lee Barrett, PhD, ARCS
Background
Lee graduated from the Imperial College of Science, Technology and Medicine, London. It was at this time that he developed an interest in CNS repair and regeneration, studying ALS models in the laboratory of Dr. Robert A Hallewell. A PhD in neuroscience at the CRC Institute for Cancer Studies focusing on CNS regeneration in rodents led to a BBSRC post-doctoral fellowship at the University of Birmingham where he continued his work using gene therapy and small drug-like compounds in CNS regeneration. In 2004, Lee moved to the Neural Plasticity Research Group at Massachusetts General Hospital. The research he conducts in the Woolf laboratory is focused on the transcriptional control of PNS regeneration and the study of the potential application of these transcription factors for the successful repair of the injured CNS.
Research interests
Nerve injury causes a dramatic change in the transcriptional programming of injured neurons. My research is focused on sciatic nerve pre-conditioning lesion in adult rats to effect such a molecular change. Using transcription factor over-expressors, chromatin immunoprecipitation (ChIP), ChIP on chip microarrays and knockout mice we hope to learn what are the master regulators in the repair and regeneration of insulted CNS neurons.
Lee is the lab manager for the Woolf lab and core manager of the Assay development and drug screening facility (ADSF) at Boston Children's Hospital.
Selected publications
1. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.
Wainger BJ et al. Nat Neurosci. 2015
2. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.
Chiu IM et al. Elife. 2014
Research Assistants
Alyssa Grantham
- Alyssa graduated Summa Cum Laude from the University of New Hampshire with a BS degree in Biochemistry, Molecular, and Cellular Biology. Her research interests involve CRISPR work, High Throughput Screening, and genome editing. She's also interested in the brain's role in addiction. Alyssa's currently working on a Masters in Pharmaceutical Sciences at Northeastern University, and someday hopes to have a job as a Scientist or Screening facility director at a Pharmaceutical company.
Ashley Ferreira
Rachel Moon
Benjamin Doyle
Dan Dou
Rie Maeda