Publications

Gonzalez-Heydrich J, Bosquet Enlow M,  D'Angelo EJ, Seidman L, Gumlak S, Kim A, Woodberry KA, Rober A, Tembulkar S, O’Donnell K, Hamoda H, Kimball K, Rotenberg A, Oberman L, Pascual-Leone A, Keshavan MS, Duffy FH Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample. Schizophrenia Research. 2015; 169: 340-345.

Duffy F, D’Angelo EJ, Rotenberg A, Gonzalez-Heydrich J. Neurophysiological differences between pa-tients clinically at high risk for schizophrenia (CHR) and neurotypical controls (CON) – First steps in development of a biomarker. BMC Medicine. 2015; 13: 276, 1-17.

Gonzalez-Heydrich J,  Bosquet Enlow M,  D'Angelo EJ, Seidman L, Gumlak S, Kim A, Woodberry KA,   Robert A, Tembulkar S, O’Donnell K, Hamoda  H, Kimball K, Rotenberg A, Oberman L, Pascual-Leone A,  Keshavan MS, Duffy FH. N100 Repetition Suppression Indexes Neuroplastic Defects in  Clinical High Risk and Psychotic Youth. Neural Plasticity. 2016; 1-11.

Brownstein C, Kleiman RJ, Engle EC, Towne MC, D’Angelo EJ, Yu TW, Beggs AH, Pickar J,  Fogler, J, Carroll, D, Schmitt, R, Wolff, R, Kim. A, Tembulkar, S, O’Donnell, K, Gonzalez-Heydrich, J. Overlapping 16p13.11 deletion and gain of copies variations associated with childhood onset psychosis include genes with mechanistic implications for autism associated pathways: Two case reports. American Journal of Medical Genetics Part A. 2016; 17, 2-36.

Frost K, Lincoln SH, Norkett E. Jin MX, Gonzalez-Heydrich J, D’Angelo EJ. The ethical inclusion of chil-dren with psychotic disorders in research: Recommendations for an educative, multimodal assent process. Ethics & Behavior. 2016; 26, 163-175.

Lincoln SH, Norkett E, Frost K, Gonzalez-Heydrich J. D’Angelo EJ. A developmental perspective on social cognition difficulties in youth at clinical high risk for psychosis. Harvard Review of Psychiatry. 2017; 25, 4-14.

Lincoln SH, Norkett E, Graber E, Tembulkar S, Morelli N, Gonzalez-Heydrich J, D’Angelo EJ. Suicide in Children and Adolescents with Psychotic Disorders. Schizophrenia Research. 2017; 179, 13-16.

Norkett E, Lincoln SH, Gonzalez-Heydrich J, D’Angelo EJ. Social cognitive impairment in 22q11 deletion syndrome: a review. Psychiatry Research. 2017; 253, 99-106.

D’Angelo, E., Lincoln, S. H., Norkett, E., Graber, K., Tembulkar S., Morelli, N., & Gonzalez-Heydrich, J. (in press).  Suicidal Behaviors and Their Relationship with Psychotic-Like Symptoms in Children and Adolescents at Clinical High Risk for Psychosis. Comprehensive Psychiatry.

Presentations

Gene Discovery at Boston Children’s Hospital. Brownstein CA. Front Line Genomics. Boston, MA. 2015.

Big Data for genomic discovery at Boston Children’s Hospital. Big Data for Personalized Medicine and Biomarker Discovery. Philadelphia, PA, 2015.

Diagnostic challenges and interpretive genomics at Boston Children’s Hospital. Brownstein CA. Hu-man Genome Organization (HUGO), Houston, TX, 2016.

Big Data, Big Problems. Brownstein CA. Keynote: Bio-IT World 2016.

The Social and Ethical Challenges in Precision Medicine, Brownstein CA. Biodata World Congress USA. Boston MA 2016.

Rare Mendelian disorders, diagnostic sequencing, and precision medicine at Boston Children’s Hos-pital. Brownstein CA. Genome Variation in Precision Medicine, Shenzhen China, 2016.

An armoury of methods for diagnosis. Brownstein CA. Festival of Genomics, Boston MA, 2016.

Big Data at Boston Children’s Hospital. Brownstein CA. Big Data in Precision Medicine, Washington D.C., 2016.

Gene discovery and biomarker development at the Manton Center for Orphan Disease Research. Brownstein CA. Biomarker Summit, San Diego CA,2017

Gene Discovery at Boston Children’s Hospital.  Brownstein CA.  ACMG, Phoenix AZ 2017.

Mental Health Disorder Gene Discovery at Boston Children’s Hospital. Bio-IT West, San Francisco CA, 2017.

Posters

Efficiency of chromosomal microarray for determining genetic origins of juvenile psychosis without abberations in 22q.  Brownstein CA, Gonzalez-Heydrich J.  American Society of Human Genetics, Baltimore, MD, 2015. 2014.

Don’t lose the forest for the trees- Developmental Psychiatry research at BCH. Brownstein CA.  AACAP’s 62nd Annual Meeting in San Antonio, TX, 2015. 

Brownstein CA, Gonzalez-Heydrich J.  Efficiency of chromosomal microarray for determining genetic origins of juvenile psychosis without aberrations in 22q. Brownstein CA, Gonzalez-Heydrich J. Cold Spring Harbor Laboratory Biology of Genomes, Cold Spring Harbor, 2016.

Genes and pathways in childhood-onset schizophrenia. Brownstein CA, Gonzalez-Heydrich J.  American Society of Human Genetics, Vancouver Canada, 2016.

Providing new information on associated risks to genetic testing expands opportunities for prevention through precision medicine. Brownstein, C, Graber, K, Tembulkar, S, Torres, A, and Gonzalez-Heydrich, J. Neurodevelopmental Disorders Symposium, Boston MA, 2016.

Rare copy number variants in NRXN3 and binding partner NXPH1 are associated with childhood-onset psychosis: Two case reports. Brownstein, C, Tembulkar, S, Graber, K, Beggs, A, Agrawal, P, Genetti, C and Gonzalez-Heydrich, J. Neurodevelopmental Disorders Symposium, Boston MA, 2016.

Genes and pathways in childhood-onset schizophrenia. Brownstein CA, Gonzalez-Heydrich J.  American College of Medical Genetics, Phoenix AZ, 2017.

Genes and pathways in childhood-onset schizophrenia. Brownstein CA, Gonzalez-Heydrich J.  Keystone Meeting. Rare and Undiagnosed Diseases: Discovery and Models of Precision Therapy, Boston MA, 2017. 

16p13.11 Deletion and Psychosis: 3 Additional Families. Graber K, Brownstein C, Tembulkar S, Torres A, Shen Y, D’Angelo E, Genetti C, Brewster S, Beggs A, Agrawal P and Gonzalez-Heydrich J. Poster presented at the Meeting of the Society of Biological Psychiatry meeting, San Diego 2017.