Generous funding support by the Massachusetts Life Science Center enabled the Stem Cell and Regenerative Biology Program at Boston Children’s Hospital to set up and equip the Stem Cell Imaging and Therapeutics Center with transformative imaging and automated tissue culture technologies for high throughput stem cell culture, drug screening, organoid imaging, and superresolution live cell analysis. The instruments are available to the broad academic community and to biopharma, facilitating the translation of the work to Massachusetts companies and allowing us to continue to train the next generation of the Massachusetts biotech workforce.
Zeiss LSM900 with Airyscan 2 Superresolution Imager
Yokogawa CellVoyager 8000 Live Confocal Imager
Formulatrix CellMatic Automated Tissue Culture System
Zeiss LSM900 with Airyscan : Super-Resolution Imaging
CV8000: Time-Lapse Confocal Imaging of Embryoid Bodies
Formulatrix Cellmatic Automated TC System: hiPSC Culture
Selected Publications
Design of soluble Notch agonists that drive T cell development and boost immunity. Cell. 2025 Oct 16;188(21):5980-5994.e28.
Airway Epithelium Derived from Induced Pluripotent Stem Cells to Model Asthma Susceptibility Loci. Am J Respir Crit Care Med. 2025 Sep;211(9):1717-1720.
DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells. bioRxiv 2025. Oct 6:2025.10.05.680464. doi: 10.1101/2025.10.05.680464.
Association of microtubule destabilization with platelet yields in terminally differentiating hiPSCderived megakaryocyte lines. PLoS One. 2025 Jun 25;20(6):e0326165.
Contact
Thorsten Schlaeger, PhD
Director, Stem Cell Core Facility
Stem Cell Imaging and Therapeutics Center
Stem Cell and Regenerative Biology Program
Boston Children's Hospital
Karp RB05213
1 Blackfan Circle
Boston, MA 02115
Email: thorsten.schlaeger@childrens.harvard.edu