At our core, the Renthal Research Group delves into the intricate world of skeletal biology, with a particular emphasis on the growth plate and the process of endochondral ossification—the formation of a healthy skeleton. Through rigorous scientific investigations, the group seeks to decipher the genetic mechanisms that underlie bone growth and development, shedding light on the fundamental aspects of skeletal health. Additionally, the group explores how chondrocytes, the vital cells responsible for cartilage production, contribute to the intricate process of fracture repair.
Innovatively, our group combines cutting-edge genome-wide CRISPR screening techniques within cell culture growth plate models, bridging these findings with extensive genetic studies focused on human height and bone density. By working with both mouse and human chondrocytes, the Renthal Research Group strives to gain a comprehensive understanding of the genetic dynamics governing the chondrocyte life cycle.