Located in the heart of the Harvard Medical community, at the Division of Newborn Medicine, Boston Children’s Hospital, our research focuses on newborn biology and the sequelae of perinatal inflammation associated with several perinatal conditions linked to immune dysregulation, and multiorgan injury affecting the developing newborn. The Kourembanas laboratory focuses on basic, fundamental research on lung biology and applied translational studies for perinatal lung diseases, aiming to facilitate the advancement of neonatal care. As part of a highly skilled multi-disciplinary team composed of biologists, immunologists, biochemists and physicians, our mission is to execute novel, evidence-based scientific approaches, to ultimately improve our understanding of disease pathophysiology, identify new biomarkers and therapeutic targets, but also drive the development of new emerging therapeutics.
Key Research Areas
- Immune dysregulation and neonatal lung disease
- The function of mesenchymal stromal cell extracellular vesicles (MSC-EVs) on innate and adaptive immunity
- MSC-EV therapy for neonatal lung disease using experimental models
- Bronchopulmonary Dysplasia—from pathophysiology to novel therapeutic strategies aiming to advance into clinical trials
- Hypoxic signaling, inflammation, and pulmonary arterial hypertension
- The role of myeloid cells in disease development and resolution of injury