Dr Fu’s research interest is in the understanding of basic mechanism of retinal neurovascular biology, particularly the metabolic effects on diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration.
Research Background
Dr. Fu graduated from the Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong with a Ph.D. in Ophthalmology and joined Prof. Lois Smith’s group at Ophthalmology, Boston Children’s Hospital for postdoctoral training. Dr. Fu’s current focus is to investigate the effects of diets, hormones, glucose/lipid metabolism on the progression of retinopathies.
Publications
Correction: Mitochondrial control of hypoxia-induced pathological retinal angiogenesis. Angiogenesis. 2024 Nov; 27(4):701-702. View Abstract
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity. Angiogenesis. 2024 Nov; 27(4):903-917. View Abstract
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis. Angiogenesis. 2024 Nov; 27(4):691-699. View Abstract
Bietti's crystalline dystrophy: genotyping and deep qualitative and quantitative phenotyping in preparation for clinical trials. Br J Ophthalmol. 2024 Jul 23; 108(8):1145-1153. View Abstract
Therapeutic Effects of Anti-Inflammatory and Anti-Oxidant Nutritional Supplementation in Retinal Ischemic Diseases. Int J Mol Sci. 2024 May 18; 25(10). View Abstract
A versatile pumpless multi-channel fluidics system for maintenance and real-time functional assessment of tissue and cells. Cell Rep Methods. 2023 11 20; 3(11):100642. View Abstract
Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP). iScience. 2023 Oct 20; 26(10):108021. View Abstract
Metabolomic Profiling of Long-Chain Polyunsaturated Fatty Acid Oxidation in Adults with Retinal Vein Occlusion: A Case-Control Study. Am J Clin Nutr. 2023 09; 118(3):579-590. View Abstract
In vivo noninvasive mitochondrial redox assessment of the optic nerve head to predict disease. PNAS Nexus. 2023 May; 2(5):pgad148. View Abstract
Neural and Müller glial adaptation of the retina to photoreceptor degeneration. Neural Regen Res. 2023 Apr; 18(4):701-707. View Abstract
Ectopic Rod Photoreceptor Development in Mice with Genetic Deficiency of WNT2B. Cells. 2023 03 28; 12(7). View Abstract
FGF21 via mitochondrial lipid oxidation promotes physiological vascularization in a mouse model of Phase I ROP. Angiogenesis. 2023 08; 26(3):409-421. View Abstract
Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis. Elife. 2022 Oct 05; 11. View Abstract
Dysfunctional peroxisomal lipid metabolisms and their ocular manifestations. Front Cell Dev Biol. 2022; 10:982564. View Abstract
Retinal microglia protect against vascular damage in a mouse model of retinopathy of prematurity. Front Pharmacol. 2022; 13:945130. View Abstract
PPARa is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017 Nov 28; 15(1):113. View Abstract
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun. 2017 09 19; 8(1):584. View Abstract
Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3862-3870. View Abstract
?-3 and ?-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases. Am J Clin Nutr. 2017 Jul; 106(1):16-26. View Abstract
FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice. Cell Rep. 2017 02 14; 18(7):1606-1613. View Abstract
Lutein facilitates physiological revascularization in a mouse model of retinopathy of prematurity. Clin Exp Ophthalmol. 2017 Jul; 45(5):529-538. View Abstract
Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. View Abstract
Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. View Abstract
Deficiency of aldose reductase attenuates inner retinal neuronal changes in a mouse model of retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2015 Sep; 253(9):1503-13. View Abstract
Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. View Abstract
Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20; 55(12):8267-77. View Abstract
Stem cell therapy for retinopathy of prematurity. Anatomy & Physiology. 2013; 126(3):2161-0940. View Abstract
Hypoxia-induced oxidative stress in ischemic retinopathy. Oxid Med Cell Longev. 2012; 2012:426769. View Abstract
Anti-inflammatory effects of lutein in retinal ischemic/hypoxic injury: in vivo and in vitro studies. Invest Ophthalmol Vis Sci. 2012 Sep 06; 53(10):5976-84. View Abstract
Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 Aug 20; 53(9):5698-712. View Abstract
Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke. Neurobiol Dis. 2012 Jan; 45(1):624-32. View Abstract
Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):836-43. View Abstract