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Research Overview

Dr Fu’s research interest is in the understanding of basic mechanism of retinal neurovascular biology, particularly the metabolic effects on diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration.

 

Research Background

Dr. Fu graduated from the Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong with a Ph.D. in Ophthalmology and joined Prof. Lois Smith’s group at Ophthalmology, Boston Children’s Hospital for postdoctoral training. Dr. Fu’s current focus is to investigate the effects of diets, hormones, glucose/lipid metabolism on the progression of retinopathies.

Publications

  1. Correction: Mitochondrial control of hypoxia-induced pathological retinal angiogenesis. Angiogenesis. 2024 Nov; 27(4):701-702. View Abstract
  2. Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity. Angiogenesis. 2024 Nov; 27(4):903-917. View Abstract
  3. Mitochondrial control of hypoxia-induced pathological retinal angiogenesis. Angiogenesis. 2024 Nov; 27(4):691-699. View Abstract
  4. Bietti's crystalline dystrophy: genotyping and deep qualitative and quantitative phenotyping in preparation for clinical trials. Br J Ophthalmol. 2024 Jul 23; 108(8):1145-1153. View Abstract
  5. Targeted lipidomics uncovers oxylipin perturbations and potential circulation biomarkers in Bietti's crystalline dystrophy. Graefes Arch Clin Exp Ophthalmol. 2024 Dec; 262(12):3773-3786. View Abstract
  6. Therapeutic Effects of Anti-Inflammatory and Anti-Oxidant Nutritional Supplementation in Retinal Ischemic Diseases. Int J Mol Sci. 2024 May 18; 25(10). View Abstract
  7. A versatile pumpless multi-channel fluidics system for maintenance and real-time functional assessment of tissue and cells. Cell Rep Methods. 2023 11 20; 3(11):100642. View Abstract
  8. Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP). iScience. 2023 Oct 20; 26(10):108021. View Abstract
  9. Metabolomic Profiling of Long-Chain Polyunsaturated Fatty Acid Oxidation in Adults with Retinal Vein Occlusion: A Case-Control Study. Am J Clin Nutr. 2023 09; 118(3):579-590. View Abstract
  10. In vivo noninvasive mitochondrial redox assessment of the optic nerve head to predict disease. PNAS Nexus. 2023 May; 2(5):pgad148. View Abstract
  11. Neural and Müller glial adaptation of the retina to photoreceptor degeneration. Neural Regen Res. 2023 Apr; 18(4):701-707. View Abstract
  12. Ectopic Rod Photoreceptor Development in Mice with Genetic Deficiency of WNT2B. Cells. 2023 03 28; 12(7). View Abstract
  13. FGF21 via mitochondrial lipid oxidation promotes physiological vascularization in a mouse model of Phase I ROP. Angiogenesis. 2023 08; 26(3):409-421. View Abstract
  14. Therapeutic activation of endothelial sphingosine-1-phosphate receptor 1 by chaperone-bound S1P suppresses proliferative retinal neovascularization. EMBO Mol Med. 2023 05 08; 15(5):e16645. View Abstract
  15. Editorial: Regulation of inflammation and metabolism in retinal neurodegenerative disorders. Front Neurosci. 2022; 16:1102385. View Abstract
  16. Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis. Elife. 2022 12 01; 11. View Abstract
  17. Retinopathy of prematurity: Metabolic risk factors. Elife. 2022 11 24; 11. View Abstract
  18. Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis. Elife. 2022 Oct 05; 11. View Abstract
  19. Dysfunctional peroxisomal lipid metabolisms and their ocular manifestations. Front Cell Dev Biol. 2022; 10:982564. View Abstract
  20. Retinal microglia protect against vascular damage in a mouse model of retinopathy of prematurity. Front Pharmacol. 2022; 13:945130. View Abstract
  21. Cytochrome P450 oxidase 2J inhibition suppresses choroidal neovascularization in mice. Metabolism. 2022 09; 134:155266. View Abstract
  22. Omega-3/Omega-6 Long-Chain Fatty Acid Imbalance in Phase I Retinopathy of Prematurity. Nutrients. 2022 Mar 23; 14(7). View Abstract
  23. REV-ERBa regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2. Redox Biol. 2022 05; 51:102261. View Abstract
  24. Retinal Disease and Metabolism. Life (Basel). 2022 Jan 27; 12(2). View Abstract
  25. Müller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa. Exp Mol Med. 2021 11; 53(11):1748-1758. View Abstract
  26. Metabolism in Retinopathy of Prematurity. Life (Basel). 2021 Oct 21; 11(11). View Abstract
  27. Editorial: Novel Therapeutic Target and Drug Development in Neurovascular Retinal Diseases. Front Pharmacol. 2021; 12:657684. View Abstract
  28. Cellular senescence in pathologic retinal angiogenesis. Trends Endocrinol Metab. 2021 07; 32(7):415-416. View Abstract
  29. Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration. iScience. 2021 Apr 23; 24(4):102376. View Abstract
  30. Fatty acid oxidation and photoreceptor metabolic needs. J Lipid Res. 2021; 62:100035. View Abstract
  31. Vitreous metabolomics profiling of proliferative diabetic retinopathy. Diabetologia. 2021 01; 64(1):70-82. View Abstract
  32. IGF1, serum glucose, and retinopathy of prematurity in extremely preterm infants. JCI Insight. 2020 10 02; 5(19). View Abstract
  33. Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier. Sci Adv. 2020 08; 6(35):eaba7457. View Abstract
  34. An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis. J Vis Exp. 2020 08 06; (162). View Abstract
  35. Lutein Supplementation for Eye Diseases. Nutrients. 2020 Jun 09; 12(6). View Abstract
  36. Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice. Angiogenesis. 2020 08; 23(3):385-394. View Abstract
  37. Targeting Neurovascular Interaction in Retinal Disorders. Int J Mol Sci. 2020 Feb 22; 21(4). View Abstract
  38. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020 03 23; 52(6):779-793.e7. View Abstract
  39. Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models. Int J Mol Sci. 2020 Feb 11; 21(4). View Abstract
  40. Dyslipidemia in retinal metabolic disorders. EMBO Mol Med. 2019 10; 11(10):e10473. View Abstract
  41. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018 05; 67(5):974-985. View Abstract
  42. Photoreceptor glucose metabolism determines normal retinal vascular growth. EMBO Mol Med. 2018 01; 10(1):76-90. View Abstract
  43. PPARa is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017 Nov 28; 15(1):113. View Abstract
  44. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun. 2017 09 19; 8(1):584. View Abstract
  45. Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3862-3870. View Abstract
  46. ?-3 and ?-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases. Am J Clin Nutr. 2017 Jul; 106(1):16-26. View Abstract
  47. FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice. Cell Rep. 2017 02 14; 18(7):1606-1613. View Abstract
  48. Lutein facilitates physiological revascularization in a mouse model of retinopathy of prematurity. Clin Exp Ophthalmol. 2017 Jul; 45(5):529-538. View Abstract
  49. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Nov; 13:201-211. View Abstract
  50. Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1919-27. View Abstract
  51. Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 06 07; 22(6):692. View Abstract
  52. Review: adiponectin in retinopathy. Biochim Biophys Acta. 2016 08; 1862(8):1392-400. View Abstract
  53. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. View Abstract
  54. Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. View Abstract
  55. Deficiency of aldose reductase attenuates inner retinal neuronal changes in a mouse model of retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2015 Sep; 253(9):1503-13. View Abstract
  56. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. View Abstract
  57. Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20; 55(12):8267-77. View Abstract
  58. Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):581-6. View Abstract
  59. Stem cell therapy for retinopathy of prematurity. Anatomy & Physiology. 2013; 126(3):2161-0940. View Abstract
  60. Hypoxia-induced oxidative stress in ischemic retinopathy. Oxid Med Cell Longev. 2012; 2012:426769. View Abstract
  61. Anti-inflammatory effects of lutein in retinal ischemic/hypoxic injury: in vivo and in vitro studies. Invest Ophthalmol Vis Sci. 2012 Sep 06; 53(10):5976-84. View Abstract
  62. Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 Aug 20; 53(9):5698-712. View Abstract
  63. Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke. Neurobiol Dis. 2012 Jan; 45(1):624-32. View Abstract
  64. Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):836-43. View Abstract

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