Dr. Sun’s research interests focus on the roles of neurovascular interaction and neuroinflammation in the development of vascular eye disorders including neovascular AMD, retinopathy of prematurity and diabetic retinopathy and tumorigenesis using mouse models, and develop effective ways to treat or prevent vision loss and cancer. Her current research projects include: 1) the mechanisms of neurovascular interaction in controlling retinal neovascularization; 2) SOCS3 mediates retinal neovascularization and neuroinflammation; 3) c-Fos controls neovascularization and inflammation.
Research Background
Dr. Ye Sun obtained her PhD from Jilin University at China and completed her postdoctoral fellowship training at Department of Urology/Surgery at Boston Children’s Hospital before joining Department of Ophthalmology at Boston Children’s Hospital.
Publications
Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3. Angiogenesis. 2024 Nov; 27(4):753-764. View Abstract
SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages. Mol Ther. 2024 May 01; 32(5):1425-1444. View Abstract
Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos. Angiogenesis. 2024 Aug; 27(3):379-395. View Abstract
FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report. Arterioscler Thromb Vasc Biol. 2024 01; 44(1):143-155. View Abstract
Ocular Vascular Diseases: From Retinal Immune Privilege to Inflammation. Int J Mol Sci. 2023 Jul 28; 24(15). View Abstract
Genetic deficiency and pharmacological modulation of RORa regulate laser-induced choroidal neovascularization. Aging (Albany NY). 2023 01 10; 15(1):37-52. View Abstract
Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation. JCI Insight. 2022 03 22; 7(6). View Abstract
Myeloid lineage contributes to pathological choroidal neovascularization formation via SOCS3. EBioMedicine. 2021 Nov; 73:103632. View Abstract
Quantification of retinal blood leakage in fundus fluorescein angiography in a retinal angiogenesis model. Sci Rep. 2021 10 06; 11(1):19903. View Abstract
Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier. Sci Adv. 2020 08; 6(35):eaba7457. View Abstract
Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche. Sci Transl Med. 2020 08 05; 12(555). View Abstract
Targeting Neuroinflammation in Neovascular Retinal Diseases. Front Pharmacol. 2020; 11:234. View Abstract
Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice. Angiogenesis. 2020 08; 23(3):385-394. View Abstract
Targeting Neurovascular Interaction in Retinal Disorders. Int J Mol Sci. 2020 Feb 22; 21(4). View Abstract
Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models. Int J Mol Sci. 2020 Feb 11; 21(4). View Abstract
Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 06 07; 22(6):692. View Abstract
Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. View Abstract
Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis. Circ Res. 2016 Mar 18; 118(6):957-969. View Abstract
SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94. View Abstract
Nuclear receptor RORa regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10401-6. View Abstract
Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. View Abstract
Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. View Abstract
A mouse model of urofacial syndrome with dysfunctional urination. Hum Mol Genet. 2015 Apr 01; 24(7):1991-9. View Abstract
Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20; 55(12):8267-77. View Abstract
The PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway. Oncogene. 2015 May 07; 34(19):2527-37. View Abstract
The canonical wnt signal restricts the glycogen synthase kinase 3/fbw7-dependent ubiquitination and degradation of eya1 phosphatase. Mol Cell Biol. 2014 Jul; 34(13):2409-17. View Abstract
Dkk1 in the peri-cloaca mesenchyme regulates formation of anorectal and genitourinary tracts. Dev Biol. 2014 Jan 01; 385(1):41-51. View Abstract
EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1. Cancer Res. 2013 Jul 15; 73(14):4488-99. View Abstract
Asymmetric requirement of surface epithelial ß-catenin during the upper and lower jaw development. Dev Dyn. 2012 Apr; 241(4):663-74. View Abstract
Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development. Dev Biol. 2011 Dec 01; 360(1):186-94. View Abstract
A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011 Apr; 121(4):1585-95. View Abstract
A novel selenium-containing glutathione transferase zeta1-1, the activity of which surpasses the level of some native glutathione peroxidases. Int J Biochem Cell Biol. 2008; 40(10):2090-7. View Abstract
Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis. Mol Cell Biol. 2007 Aug; 27(15):5393-402. View Abstract
The molecular mechanism of protecting cells against oxidative stress by 2-selenium-bridged beta-cyclodextrin with glutathione peroxidase activity. Biochim Biophys Acta. 2005 Apr 15; 1743(3):199-204. View Abstract
Selenium-containing 15-mer peptides with high glutathione peroxidase-like activity. J Biol Chem. 2004 Sep 03; 279(36):37235-40. View Abstract
Protection of epidermal cells against UVB injury by the antioxidant selenium-containing single-chain Fv catalytic antibody. Arch Biochem Biophys. 2003 Apr 01; 412(1):90-4. View Abstract