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Research Overview
Wade's research focuses on the generation of hematopoietic stem cells from endothelium during development, with an emphasis on how mechanical cues from blood flow are interpreted to guide the endothelial-to-hematopoietic transition.
Research Background
Wade holds a Bachelor's of Science degree in Biology from the University of Oregon (2011). He did his doctoral studies at the Max Planck Institute for Molecular Biomedicine (Münster, Germany), investigating how genetic circuits and biomechanical signals intersect to control the correct diameter of blood vessels during development using the zebrafish model (2017). Pursuing his interest in mechanical control of cardiovascular development, Wade joined the lab of Dr. Trista E. North in December 2017 to study the development of the blood and the influence of biophysical forces on this process.
Publications
- Bnip3lb-driven mitophagy sustains expansion of the embryonic hematopoietic stem cell pool. bioRxiv. 2024 Sep 23. View Abstract
- CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development. Nat Cell Biol. 2022 04; 24(4):579-589. View Abstract
- Making Blood from the Vessel: Extrinsic and Environmental Cues Guiding the Endothelial-to-Hematopoietic Transition. Life (Basel). 2021 Sep 29; 11(10). View Abstract
- YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow. Dev Cell. 2020 02 24; 52(4):446-460.e5. View Abstract
- Endothelial cell biology of Endoglin in hereditary hemorrhagic telangiectasia. Curr Opin Hematol. 2018 05; 25(3):237-244. View Abstract
- Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs). PLoS One. 2017; 12(8):e0183433. View Abstract
- Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nat Cell Biol. 2017 Jun; 19(6):653-665. View Abstract