Education

Undergraduate School

University of Washington
1998 Seattle WA

Graduate School

PhD, Biophysics Harvard University
2004 Cambridge MA

Medical School

Harvard Medical School
2006 Boston MA

Internship

Boston Children's Hospital
2009 Boston MA

Fellowship

Pediatric Cardiology Boston Children's Hospital
2011 Boston MA

Fellowship

Cardiac Electrophysiology Boston Children's Hospital
2013 Boston MA

Publications

  1. CHD4 Interacts With TBX5 to Maintain the Gene Regulatory Network of Postnatal Atrial Cardiomyocytes. bioRxiv. 2024 Dec 05. View Abstract
  2. Cardiac Applications of CRISPR/AAV-Mediated Precise Genome Editing. bioRxiv. 2024 Dec 04. View Abstract
  3. Antisense Oligonucleotide Therapy for Calmodulinopathy. Circulation. 2024 Oct 08; 150(15):1199-1210. View Abstract
  4. Management of ultrarare inherited arrhythmia syndromes. Heart Rhythm. 2024 Aug 16. View Abstract
  5. CITED4 gene therapy protects against maladaptive cardiac remodeling after ischemia/reperfusion injury in mice. Mol Ther. 2024 Oct 02; 32(10):3683-3694. View Abstract
  6. Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy. Res Sq. 2024 Jul 19. View Abstract
  7. Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems. Nat Commun. 2024 Jul 15; 15(1):5929. View Abstract
  8. Premature ventricular contractions in children and young adults: natural history and clinical implications. Europace. 2024 Mar 01; 26(3). View Abstract
  9. Efficient and reproducible generation of human iPSC-derived cardiomyocytes using a stirred bioreactor. bioRxiv. 2024 Feb 28. View Abstract
  10. Author Correction: Tbx5 maintains atrial identity in postnatal cardiomyocytes by regulating an atrial-specific enhancer network. Nat Cardiovasc Res. 2023 Nov; 2(11):1095. View Abstract
  11. Hypertrophic Cardiomyopathy and Ventricular Preexcitation in the Young: Cause and Accessory Pathway Characteristics. Circ Arrhythm Electrophysiol. 2023 11; 16(11):e012191. View Abstract
  12. Medical cardioversion of atrial fibrillation and flutter with class IC antiarrhythmic drugs in young patients with and without congenital heart disease. J Cardiovasc Electrophysiol. 2023 12; 34(12):2545-2551. View Abstract
  13. Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network. Nat Cardiovasc Res. 2023 Oct; 2(10):881-898. View Abstract
  14. An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor. Sci Transl Med. 2023 06 21; 15(701):eabq7839. View Abstract
  15. Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia. Heart Lung Circ. 2023 Jul; 32(7):790-797. View Abstract
  16. Radiofrequency Catheter Ablation for Pediatric Atrioventricular Nodal Reentrant Tachycardia: Impact of Age on Procedural Methods and Durable Success. J Am Heart Assoc. 2022 06 21; 11(12):e022799. View Abstract
  17. Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association With Arrhythmogenic Right Ventricular Cardiomyopathy: A UK Biobank Analysis. Circ Genom Precis Med. 2022 06; 15(3):e003507. View Abstract
  18. Pacemaker use for the treatment of reflex-mediated syncope: 40-year experience at a single paediatric institution. Cardiol Young. 2021 Oct 28; 1-6. View Abstract
  19. Increased Reactive Oxygen Species-Mediated Ca2+/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome. Circulation. 2021 05 11; 143(19):1894-1911. View Abstract
  20. Two sides of the same coin: new insights into mechanisms of ventricular fibrillation. Cardiovasc Res. 2021 03 21; 117(4):983-984. View Abstract
  21. Risk Factors for Early Recurrence Following Ablation for Accessory Pathways: The Role of Consolidation Lesions. Circ Arrhythm Electrophysiol. 2020 11; 13(11):e008848. View Abstract
  22. Drug screening platform using human induced pluripotent stem cell-derived atrial cardiomyocytes and optical mapping. Stem Cells Transl Med. 2021 01; 10(1):68-82. View Abstract
  23. Paediatric/congenital cardiology physician scientists-An endangered species. Eur J Clin Invest. 2020 Oct; 50(10):e13367. View Abstract
  24. MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. J Clin Invest. 2020 09 01; 130(9):4663-4678. View Abstract
  25. Value of provocative electrophysiology testing in the management of pediatric patients after congenital heart surgery. Pacing Clin Electrophysiol. 2020 09; 43(9):901-907. View Abstract
  26. Gene therapy for inherited arrhythmias. Cardiovasc Res. 2020 07 15; 116(9):1635-1650. View Abstract
  27. CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress. Circ Res. 2020 08 14; 127(5):631-646. View Abstract
  28. Clinical and Genetic Findings in Children Presenting With Ventricular Fibrillation as the First Manifestation of Cardiovascular Disease. J Am Heart Assoc. 2020 05 18; 9(10):e016322. View Abstract
  29. AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome. Circ Res. 2020 04 10; 126(8):1024-1039. View Abstract
  30. Low mortality in fetal supraventricular tachycardia: Outcomes in a 30-year single-institution experience. J Cardiovasc Electrophysiol. 2020 05; 31(5):1105-1113. View Abstract
  31. Adverse event rate during inpatient sotalol initiation for the management of supraventricular and ventricular tachycardia in the pediatric and young adult population. Heart Rhythm. 2020 06; 17(6):984-990. View Abstract
  32. Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence. Circulation. 2020 01 28; 141(4):285-300. View Abstract
  33. Phenotypic Manifestations of Arrhythmogenic Cardiomyopathy in Children and Adolescents. J Am Coll Cardiol. 2019 07 23; 74(3):346-358. View Abstract
  34. Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. Circulation. 2019 07 30; 140(5):390-404. View Abstract
  35. Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II. Circulation. 2019 07 30; 140(5):405-419. View Abstract
  36. Activin type II receptor signaling in cardiac aging and heart failure. Sci Transl Med. 2019 03 06; 11(482). View Abstract
  37. Phenotypic Characterization of Individuals With Variants in Cardiovascular Genes in the Absence of a Primary Cardiovascular Indication for Testing. Circ Genom Precis Med. 2019 03; 12(3):e002463. View Abstract
  38. Differentiation of fasciculoventricular fibers from anteroseptal accessory pathways using the surface electrocardiogram. Heart Rhythm. 2019 07; 16(7):1072-1079. View Abstract
  39. The Real-World Utility of the LINQ Implantable Loop Recorder in Pediatric and Adult Congenital Heart Patients. JACC Clin Electrophysiol. 2019 02; 5(2):245-251. View Abstract
  40. Dual-Site Ventricular Pacing in Patients With Fontan Physiology and Heart Block: Does it Mitigate the Detrimental Effects of Single-Site Ventricular Pacing? JACC Clin Electrophysiol. 2018 10; 4(10):1289-1297. View Abstract
  41. Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes. Stem Cell Reports. 2018 09 11; 11(3):626-634. View Abstract
  42. Utility of incomplete right bundle branch block as an isolated ECG finding in children undergoing initial cardiac evaluation. Congenit Heart Dis. 2018 May; 13(3):419-427. View Abstract
  43. Low molecular weight heparin as an anticoagulation strategy for left-sided ablation procedures. Congenit Heart Dis. 2018 Mar; 13(2):222-225. View Abstract
  44. Genotype-phenotype-guided medical and surgical intervention in long QT syndrome. HeartRhythm Case Rep. 2018 Jan; 4(1):14-17. View Abstract
  45. Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation. Circ Res. 2018 01 05; 122(1):74-87. View Abstract
  46. Cardiac Events During Competitive, Recreational, and Daily Activities in Children and Adolescents With Long QT Syndrome. J Am Heart Assoc. 2017 Sep 21; 6(9). View Abstract
  47. Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders. Sci Rep. 2017 03 23; 7(1):346. View Abstract
  48. Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ J. 2016 Dec 22; 81(1):12-21. View Abstract
  49. Pausing With the Gauze: Inhibition of Temporary Pacemakers by Radiofrequency Scan During Cardiac Surgery. Anesth Analg. 2016 11; 123(5):1143-1148. View Abstract
  50. Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Dev Cell. 2016 11 21; 39(4):466-479. View Abstract
  51. S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1854-67. View Abstract
  52. CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury. JCI Insight. 2016 Jun 16; 1(9). View Abstract
  53. miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell Metab. 2015 Apr 07; 21(4):584-95. View Abstract
  54. Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation. J Mol Cell Cardiol. 2014 Jul; 72:74-84. View Abstract
  55. Saying yes to exercise and NO to cardiac injury. Circ Res. 2011 Jun 10; 108(12):1414-6. View Abstract
  56. Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol. 2004 Aug; 6(8):709-20. View Abstract
  57. SPIE- The International Society for Optical Engineering. Near-membrane protein dynamics revealed by evanescent field microscopy. 2004; (5467):326-337. View Abstract
  58. Mechanism of persistent protein kinase D1 translocation and activation. Dev Cell. 2003 Apr; 4(4):561-74. View Abstract
  59. The effects of buoyancy on sonoluminescing bubbles. Acoustics research letters online : ARLO. 2000; (1):12-18. View Abstract
  60. The search for electrical discharges from single- and multi-bubble sonoluminescence. The Journal of the Acoustical Society of America. 1999; 1020(105). View Abstract

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