Tobias Loddenkemper's research is focused on identifying the factors that determine epileptic encephalopathies and status epilepticus as well as functional outcome later in life. Repetitive seizures and epileptic encephalopathy can impair development, plasticity and cognitive function of eloquent areas including language and memory. Seizure frequency reduction and seizure freedom, in particular after epilepsy surgery, has been shown to improve neurocognitive and developmental outcome. By identifying biomarkers that indicate predictors of cerebral damage and developmental outcome in epileptic encephalopathies and status epilepticus, we intend to reduce the occurrence of brain damage and later developmental disabilities and aim to identify novel therapeutic approaches.
Research Interests:
What are we doing?
Comparative effectiveness and interventional clinical trials in pediatric status epilepticus and epileptic encephalopathies
How do we do it?
Inventing, evaluating and implementing clinically relevant biomarkers and treatment paradigms to assess and benchmark these based on clinical data, neurophysiology, imaging, pharmacogenomics and genetics, in collaboration with basic researcher locally, nationally, and internationally.
Developing and evaluating monitoring tools for clinical biomarkers to further clinical epilepsy outcome measures including seizure characterization, neuropsychological outcome assessment, and quality of life assessment by means of seizure sensors and electronic tools including ICISS, the RENCI seizure tracking and outcome prediction modeling software, and novel in- and outpatient monitoring devices and algorithms, and neurophysiological, biochemical and genetic periodicity markers and implement these techniques into clinical workflow.
Research networks and collaborations are essential for our work, like the pediatric status epilepticus research group (www.pserg.org), the Pediatric Epilepsy Research Consortium , the pediatric critical care epilepsy research group, the Critical Care EEG consortium, the pediatric neurocritical care research group and other consortia.
Utilizing natural language processing to identify pediatric patients experiencing status epilepticus. Seizure. 2025 Jan 08; 125:54-61. View Abstract
Improving the health literacy of persons with epilepsy. Epilepsy Behav. 2024 Dec 31; 163:110237. View Abstract
Diagnosis and management of status epilepticus: improving the status quo. Lancet Neurol. 2025 Jan; 24(1):65-76. View Abstract
Lack of association of first and second-line medication dosing and progression to refractory status epilepticus in children. Seizure. 2024 Dec; 123:133-141. View Abstract
Effects of epileptic seizures on the quality of biosignals recorded from wearables. Epilepsia. 2024 Dec; 65(12):3513-3525. View Abstract
Autonomic biosignals, seizure detection, and forecasting. Epilepsia. 2024 Jun 05. View Abstract
Veni, Vidi, Vici-When Is Home Video Seizure Monitoring Helpful? Epilepsy Curr. 2024 May 16; 15357597241253426. View Abstract
Minimum clinical utility standards for wearable seizure detectors: A simulation study. Epilepsia. 2024 Apr; 65(4):1017-1028. View Abstract
Ultradian rhythms in accelerometric and autonomic data vary based on seizure occurrence in paediatric epilepsy patients. Brain Commun. 2024; 6(2):fcae034. View Abstract
Biologic Correlates and Consequences of the Social Determinants of Health and Disease. Perspect Biol Med. 2024; 67(3):305-324. View Abstract
Review on the current long-term, limited lead electroencephalograms. Epilepsy Behav. 2024 Jan; 150:109557. View Abstract
Design, implementation, and inferential issues associated with clinical trials that rely on data in electronic medical records: a narrative review. BMC Med Res Methodol. 2023 11 16; 23(1):271. View Abstract
Biases in Electronic Health Records Data for Generating Real-World Evidence: An Overview. J Healthc Inform Res. 2024 Mar; 8(1):121-139. View Abstract
Natural language processing for identification of refractory status epilepticus in children. Epilepsia. 2023 Dec; 64(12):3227-3237. View Abstract
Development of a Multivariable Seizure Likelihood Assessment Based on Clinical Information and Short Autonomic Activity Recordings for Children With Epilepsy. Pediatr Neurol. 2023 Nov; 148:118-127. View Abstract
Pediatric status epilepticus management by Emergency Medical Services (the pSERG cohort). Seizure. 2023 Oct; 111:51-55. View Abstract
Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children. Neurology. 2023 08 01; 101(5):e546-e557. View Abstract
Explainable AI for wearable seizure logging: Impact of data quality, patient age, and antiseizure medication on performance. Seizure. 2023 Aug; 110:99-108. View Abstract
Self-management education for children with epilepsy and their caregivers. A scoping review. Epilepsy Behav. 2023 Jul; 144:109232. View Abstract
Creation of a Novel Child Simulator and Curriculum to Optimize Administration of Seizure Rescue Medication. Simul Healthc. 2024 Oct 01; 19(5):326-332. View Abstract
Survey of Pediatric ICU EEG Monitoring-Reassessment After a Decade. J Clin Neurophysiol. 2024 Jul 01; 41(5):458-472. View Abstract
Detect, predict, and prevent acute seizures and status epilepticus. Epilepsy Behav. 2023 04; 141:109141. View Abstract
Systemic inflammation as a biomarker of seizure propensity and a target for treatment to reduce seizure propensity. Epilepsia Open. 2023 03; 8(1):221-234. View Abstract
Data quality evaluation in wearable monitoring. Sci Rep. 2022 Dec 10; 12(1):21412. View Abstract
Challenges for Emergency Medical Services in Status Epilepticus Management. Pediatr Neurol. 2023 01; 138:5-6. View Abstract
Genotype-phenotype correlations in SCN8A-related disorders reveal prognostic and therapeutic implications. Brain. 2022 09 14; 145(9):2991-3009. View Abstract
Prevalence and Predictors of Seizure Clusters in Pediatric Patients With Epilepsy: The Harvard-Yale Pediatric Seizure Cluster Study. Pediatr Neurol. 2022 12; 137:22-29. View Abstract
Measuring Real-Time Medication Effects From Electroencephalography. J Clin Neurophysiol. 2024 Jan 01; 41(1):72-82. View Abstract
Inequities in Therapy for Infantile Spasms: A Call to Action. Ann Neurol. 2022 07; 92(1):32-44. View Abstract
Identifying Barriers to Care in the Pediatric Acute Seizure Care Pathway. Int J Integr Care. 2022 Jan-Mar; 22(1):28. View Abstract
Wearable device assessments of antiseizure medication effects on diurnal patterns of electrodermal activity, heart rate, and heart rate variability. Epilepsy Behav. 2022 04; 129:108635. View Abstract
Coarse-graining and the Haar wavelet transform for multiscale analysis. Bioelectron Med. 2022 Feb 02; 8(1):3. View Abstract
Super-Refractory Status Epilepticus in Children: A Retrospective Cohort Study. Pediatr Crit Care Med. 2021 12 01; 22(12):e613-e625. View Abstract
Generalized tonic-clonic seizures are accompanied by changes of interrelations within the autonomic nervous system. Epilepsy Behav. 2021 Oct 05; 124:108321. View Abstract
Genomic analysis of "microphenotypes" in epilepsy. Am J Med Genet A. 2022 01; 188(1):138-146. View Abstract
Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort. Neurology. 2021 Sep 20; 97(12):e1217-e1228. View Abstract
Wearable devices for seizure detection: Practical experiences and recommendations from the Wearables for Epilepsy And Research (WEAR) International Study Group. Epilepsia. 2021 10; 62(10):2307-2321. View Abstract
Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus. Epilepsia. 2021 11; 62(11):2766-2777. View Abstract
Prospective Study of a Multimodal Convulsive Seizure Detection Wearable System on Pediatric and Adult Patients in the Epilepsy Monitoring Unit. Front Neurol. 2021; 12:724904. View Abstract
Association between semiologic, autonomic, and electrographic seizure characteristics in children with generalized tonic-clonic seizures. Epilepsy Behav. 2021 09; 122:108228. View Abstract
EEG Biomarkers of Repository Corticotropin Injection Treatment. J Clin Neurophysiol. 2023 Mar 01; 40(3):236-243. View Abstract
Video-Based Detection of Generalized Tonic-Clonic Seizures Using Deep Learning. IEEE J Biomed Health Inform. 2021 08; 25(8):2997-3008. View Abstract
Seizure detection using wearable sensors and machine learning: Setting a benchmark. Epilepsia. 2021 08; 62(8):1807-1819. View Abstract
Factors associated with long-term outcomes in pediatric refractory status epilepticus. Epilepsia. 2021 09; 62(9):2190-2204. View Abstract
Measuring the effects of sleep on epileptogenicity with multifrequency entropy. Clin Neurophysiol. 2021 09; 132(9):2012-2018. View Abstract
Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort). Epilepsia. 2021 07; 62(7):1629-1642. View Abstract
Prediction of Seizure Recurrence. A Note of Caution. Front Neurol. 2021; 12:675728. View Abstract
Time to Treatment in Pediatric Convulsive Refractory Status Epilepticus: The Weekend Effect. Pediatr Neurol. 2021 07; 120:71-79. View Abstract
Author Response: Association of Guideline Publication and Delays to Treatment in Pediatric Status Epilepticus. Neurology. 2021 03 09; 96(10):503. View Abstract
Evaluation and recommendations for effective data visualization for seizure forecasting algorithms. JAMIA Open. 2021 Jan; 4(1):ooab009. View Abstract
Twenty-four-hour patterns in electrodermal activity recordings of patients with and without epileptic seizures. Epilepsia. 2021 04; 62(4):960-972. View Abstract
Efficacy and Tolerability of Rufinamide in Epileptic Children Younger Than 4 Years. J Child Neurol. 2021 03; 36(4):281-287. View Abstract
Status Epilepticus-Work-Up and Management in Children. Semin Neurol. 2020 12; 40(6):661-674. View Abstract
Machine learning from wristband sensor data for wearable, noninvasive seizure forecasting. Epilepsia. 2020 12; 61(12):2653-2666. View Abstract
The burden of decisional uncertainty in the treatment of status epilepticus. Epilepsia. 2020 10; 61(10):2150-2162. View Abstract
First-line medication dosing in pediatric refractory status epilepticus. Neurology. 2020 11 10; 95(19):e2683-e2696. View Abstract
Treatment of Refractory Convulsive Status Epilepticus: A Comprehensive Review by the American Epilepsy Society Treatments Committee. Epilepsy Curr. 2020 Sep; 20(5):245-264. View Abstract
Photoplethysmography: A measure for the function of the autonomic nervous system in focal impaired awareness seizures. Epilepsia. 2020 08; 61(8):1617-1626. View Abstract
Retrospective observational study on hospital readmission for status epilepticus in the United States over 2016. Epilepsia. 2020 07; 61(7):1386-1396. View Abstract
Autonomic nervous system changes detected with peripheral sensors in the setting of epileptic seizures. Sci Rep. 2020 07 14; 10(1):11560. View Abstract
EEG features of brain injury during extracorporeal membrane oxygenation in children. Neurology. 2020 09 08; 95(10):e1372-e1380. View Abstract
Slow wave activity during NREM sleep in patients with electrical status epilepticus in sleep. Seizure. 2020 08; 80:257-258. View Abstract
Association of guideline publication and delays to treatment in pediatric status epilepticus. Neurology. 2020 09 01; 95(9):e1222-e1235. View Abstract
Nonlinear Analysis of Visually Normal EEGs to Differentiate Benign Childhood Epilepsy with Centrotemporal Spikes (BECTS). Sci Rep. 2020 05 21; 10(1):8419. View Abstract
Mortality in infantile spasms: A hospital-based study. Epilepsia. 2020 04; 61(4):702-713. View Abstract
Electrocardiographic changes associated with epilepsy beyond heart rate and their utilization in future seizure detection and forecasting methods. Clin Neurophysiol. 2020 04; 131(4):866-879. View Abstract
Pharmacotherapy for Pediatric Convulsive Status Epilepticus. CNS Drugs. 2020 01; 34(1):47-63. View Abstract
Novel treatment approaches and pediatric research networks in status epilepticus. Epilepsy Behav. 2019 12; 101(Pt B):106564. View Abstract
Estimating the cost of status epilepticus admissions in the United States of America using ICD-10 codes. Seizure. 2019 Oct; 71:295-303. View Abstract
Electroencephalographic Reporting for Refractory Status Epilepticus. J Clin Neurophysiol. 2019 Sep; 36(5):365-370. View Abstract
Bone Health Screening Practices Among Neurologists in Patients on Antiepileptic Drugs: A Quality Improvement Project. Pediatr Neurol. 2020 01; 102:49-55. View Abstract
The onset of pediatric refractory status epilepticus is not distributed uniformly during the day. Seizure. 2019 Aug; 70:90-96. View Abstract
Immediate outcomes in early life epilepsy: A contemporary account. Epilepsy Behav. 2019 08; 97:44-50. View Abstract
Encephalopathy with continuous spike-waves during slow-wave sleep: evolution and prognosis. Epileptic Disord. 2019 Jun 01; 21(S1):15-21. View Abstract
Encephalopathy related to Status Epilepticus during slow Sleep: from concepts to terminology. Epileptic Disord. 2019 Jun 01; 21(S1):5-12. View Abstract
Automated detection of sudden unexpected death in epilepsy risk factors in electronic medical records using natural language processing. Epilepsia. 2019 06; 60(6):1209-1220. View Abstract
Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus. Neurology. 2019 05 14; 92(20):e2339-e2348. View Abstract
Peripheral multimodal monitoring of ANS changes related to epilepsy. Epilepsy Behav. 2019 07; 96:69-79. View Abstract
Seizure Prediction Models in the Neonatal Intensive Care Unit. J Clin Neurophysiol. 2019 May; 36(3):186-194. View Abstract
Characteristics of Future Models of Integrated Outpatient Care. Healthcare (Basel). 2019 Apr 27; 7(2). View Abstract
New onset refractory status epilepticus research: What is on the horizon? Neurology. 2019 04 23; 92(17):802-810. View Abstract
Outcome of ambulatory video-EEG monitoring in a ˜10,000 patient nationwide cohort. Seizure. 2019 Mar; 66:104-111. View Abstract
Timely Interventions for Children with ADHD through Web-Based Monitoring Algorithms. Diseases. 2019 Feb 07; 7(1). View Abstract
Using EHRs to advance epilepsy care. Neurol Clin Pract. 2019 Feb; 9(1):83-88. View Abstract
Diagnostic yield of genetic tests in epilepsy: A meta-analysis and cost-effectiveness study. Neurology. 2019 Jan 28; 92(5):e418-e428. View Abstract
KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect. Ann Neurol. 2018 11; 84(5):766-780. View Abstract
Status epilepticus prevention, ambulatory monitoring, early seizure detection and prediction in at-risk patients. Seizure. 2019 May; 68:31-37. View Abstract
Caring electronically for young outpatients who have epilepsy. Epilepsy Behav. 2018 10; 87:226-232. View Abstract
Long-term outcomes of status epilepticus: A critical assessment. Epilepsia. 2018 10; 59 Suppl 2:155-169. View Abstract
Estimating the cost of admissions related to convulsive status epilepticus in the United States of America. Seizure. 2018 Oct; 61:186-198. View Abstract
Neuroimaging of Early Life Epilepsy. Pediatrics. 2018 09; 142(3). View Abstract
Hospital Emergency Treatment of Convulsive Status Epilepticus: Comparison of Pathways From Ten Pediatric Research Centers. Pediatr Neurol. 2018 09; 86:33-41. View Abstract
Automating Interictal Spike Detection: Revisiting A Simple Threshold Rule. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:299-302. View Abstract
Timing in the treatment of status epilepticus: From basics to the clinic. Seizure. 2019 May; 68:22-30. View Abstract
Machine Learning for Outcome Prediction in Electroencephalograph (EEG)-Monitored Children in the Intensive Care Unit. J Child Neurol. 2018 07; 33(8):546-553. View Abstract
Efficacy and safety of ketogenic diet for treatment of pediatric convulsive refractory status epilepticus. Epilepsy Res. 2018 08; 144:1-6. View Abstract
Different as night and day: Patterns of isolated seizures, clusters, and status epilepticus. Epilepsia. 2018 05; 59(5):e73-e77. View Abstract
Towards acute pediatric status epilepticus intervention teams: Do we need "Seizure Codes"? Seizure. 2018 May; 58:133-140. View Abstract
Factors associated with treatment delays in pediatric refractory convulsive status epilepticus. Neurology. 2018 05 08; 90(19):e1692-e1701. View Abstract
Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus. JAMA Neurol. 2018 04 01; 75(4):410-418. View Abstract
Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy. JAMA Pediatr. 2018 04 01; 172(4):352-360. View Abstract
Common data elements for epilepsy mobile health systems. Epilepsia. 2018 05; 59(5):1020-1026. View Abstract
Can a collaborative healthcare network improve the care of people with epilepsy? Epilepsy Behav. 2018 05; 82:189-193. View Abstract
Conscious control of breathing: A key to prevention of sudden unexpected death in epilepsy? Ann Neurol. 2018 03; 83(3):449-450. View Abstract
Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms. PLoS One. 2018; 13(3):e0193599. View Abstract
New-onset refractory status epilepticus (NORSE) and febrile infection-related epilepsy syndrome (FIRES): State of the art and perspectives. Epilepsia. 2018 04; 59(4):745-752. View Abstract
Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions. Epilepsia. 2018 04; 59(4):739-744. View Abstract
Should patients with complex febrile seizure be admitted for further management? Am J Emerg Med. 2018 08; 36(8):1386-1390. View Abstract
Devices for Ambulatory Monitoring of Sleep-Associated Disorders in Children with Neurological Diseases. Children (Basel). 2017 Dec 25; 5(1). View Abstract
The Need for Antiepileptic Drug Chronotherapy to Treat Selected Childhood Epilepsy Syndromes and Avert the Harmful Consequences of Drug Resistance. J Cent Nerv Syst Dis. 2017; 9:1179573516685883. View Abstract
New-Onset Status Epilepticus in Pediatric Patients: Causes, Characteristics, and Outcomes. Pediatr Neurol. 2018 03; 80:61-69. View Abstract
Sleep patterns predictive of daytime challenging behavior in individuals with low-functioning autism. Autism Res. 2018 02; 11(2):391-403. View Abstract
Response to clobazam in continuous spike-wave during sleep. Dev Med Child Neurol. 2018 03; 60(3):283-289. View Abstract
Time to continuous electroencephalogram in repeated admissions to the pediatric intensive care unit. Seizure. 2018 Jan; 54:19-26. View Abstract
The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium. Epilepsia. 2017 12; 58(12):2098-2103. View Abstract
Behaviorally-determined sleep phenotypes are robustly associated with adaptive functioning in individuals with low functioning autism. Sci Rep. 2017 10 27; 7(1):14228. View Abstract
Rescue Medications in Epilepsy Patients: A Family Perspective. Seizure. 2017 Nov; 52:188-194. View Abstract
Early-Life Epilepsies and the Emerging Role of Genetic Testing. JAMA Pediatr. 2017 09 01; 171(9):863-871. View Abstract
Continuous EEG in Pediatric Critical Care: Yield and Efficiency of Seizure Detection. J Clin Neurophysiol. 2017 Sep; 34(5):421-426. View Abstract
Novel clinical manifestations in patients with KCNA2 mutations. Seizure. 2017 Oct; 51:74-76. View Abstract
Disparities in epilepsy surgery in the United States of America. J Neurol. 2017 Aug; 264(8):1735-1745. View Abstract
Effect of vigabatrin on seizure control and safety profile in different subgroups of children with epilepsy. Epilepsia. 2017 09; 58(9):1575-1585. View Abstract
Electrographic Seizures in Preterm Neonates in the Neonatal Intensive Care Unit. J Child Neurol. 2017 Sep; 32(10):880-885. View Abstract
Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus. Pediatr Neurol. 2017 Oct; 75:73-79. View Abstract
Nonintravenous rescue medications for pediatric status epilepticus: A cost-effectiveness analysis. Epilepsia. 2017 08; 58(8):1349-1359. View Abstract
Diagnostic and Therapeutic Management of a First Unprovoked Seizure in Children and Adolescents With a Focus on the Revised Diagnostic Criteria for Epilepsy. J Child Neurol. 2017 07; 32(8):774-788. View Abstract
Use of EEG in critically ill children and neonates in the United States of America. J Neurol. 2017 Jun; 264(6):1165-1173. View Abstract
Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders. Brain. 2017 May 01; 140(5):1316-1336. View Abstract
Increasing Ketamine Use for Refractory Status Epilepticus in US Pediatric Hospitals. J Child Neurol. 2017 06; 32(7):638-646. View Abstract
Genetics and genotype-phenotype correlations in early onset epileptic encephalopathy with burst suppression. Ann Neurol. 2017 Mar; 81(3):419-429. View Abstract
Understanding Death in Children With Epilepsy. Pediatr Neurol. 2017 05; 70:7-15. View Abstract
Time to electroencephalography is independently associated with outcome in critically ill neonates and children. Epilepsia. 2017 03; 58(3):420-428. View Abstract
Reduced thalamic volume in patients with Electrical Status Epilepticus in Sleep. Epilepsy Res. 2017 02; 130:74-80. View Abstract
Refractory status epilepticus in children with and without prior epilepsy or status epilepticus. Neurology. 2017 Jan 24; 88(4):386-394. View Abstract
Seizures caused by brain tumors in children. Seizure. 2017 Jan; 44:98-107. View Abstract
Refractory Status Epilepticus in Children: Intention to Treat With Continuous Infusions of Midazolam and Pentobarbital. Pediatr Crit Care Med. 2016 10; 17(10):968-975. View Abstract
Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort. Epilepsia. 2016 11; 57(11):1834-1842. View Abstract
Interictal epileptiform discharges and cognition. Dev Med Child Neurol. 2017 01; 59(1):13-14. View Abstract
HHV-6 and seizure: A systematic review and meta-analysis. J Med Virol. 2017 01; 89(1):161-169. View Abstract
The future of medicine will be dark without international collaboration [corrected]. Seizure. 2016 10; 41:42. View Abstract
Automated seizure detection systems and their effectiveness for each type of seizure. Seizure. 2016 Aug; 40:88-101. View Abstract
Real-time multi-channel monitoring of burst-suppression using neural network technology during pediatric status epilepticus treatment. Clin Neurophysiol. 2016 08; 127(8):2820-2831. View Abstract
Clobazam higher-evening differential dosing as an add-on therapy in refractory epilepsy. Seizure. 2016 Aug; 40:1-6. View Abstract
2014 Epilepsy Benchmarks Area III: Improve Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects. Epilepsy Curr. 2016 May-Jun; 16(3):192-7. View Abstract
Effectiveness of once-daily high-dose ACTH for infantile spasms. Epilepsy Behav. 2016 06; 59:4-8. View Abstract
Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research. J Clin Neurophysiol. 2016 Apr; 33(2):133-40. View Abstract
Response to treatment in a prospective national infantile spasms cohort. Ann Neurol. 2016 Mar; 79(3):475-84. View Abstract
Effectiveness of antiepileptic therapy in patients with PCDH19 mutations. Seizure. 2016 Feb; 35:106-10. View Abstract
Yield of emergent neuroimaging in children with new-onset seizure and status epilepticus. Seizure. 2016 Feb; 35:4-10. View Abstract
aEEG and cEEG: Two complementary techniques to assess seizures and encephalopathy in neonates: Editorial on "Amplitude-integrated EEG for detection of neonatal seizures: A systematic review" by Rakshasbhuvankar et al. Seizure. 2015 Dec; 33:88-9. View Abstract
Utility of initial EEG in first complex febrile seizure. Epilepsy Behav. 2015 Nov; 52(Pt A):200-4. View Abstract
Treatment of electrical status epilepticus in sleep: A pooled analysis of 575 cases. Epilepsia. 2015 Nov; 56(11):1738-46. View Abstract
Incidence, risk factors, and longitudinal outcome of seizures in long-term survivors of pediatric brain tumors. Epilepsia. 2015 Oct; 56(10):1599-604. View Abstract
Should epileptiform discharges be treated? Epilepsia. 2015 Oct; 56(10):1492-504. View Abstract
Outcomes in pediatric patients with nonconvulsive status epilepticus. Epilepsy Behav. 2015 Aug; 49:98-103. View Abstract
Acute seizure suppression by transcranial direct current stimulation in rats. Ann Clin Transl Neurol. 2015 Aug; 2(8):843-56. View Abstract
Autonomic changes following generalized tonic clonic seizures: An analysis of adult and pediatric patients with epilepsy. Epilepsy Res. 2015 Sep; 115:113-8. View Abstract
Seizures and brain regulatory systems: consciousness, sleep, and autonomic systems. J Clin Neurophysiol. 2015 Jun; 32(3):188-93. View Abstract
Time from convulsive status epilepticus onset to anticonvulsant administration in children. Neurology. 2015 Jun 09; 84(23):2304-11. View Abstract
Therapeutic choices in convulsive status epilepticus. Expert Opin Pharmacother. 2015 Mar; 16(4):487-500. View Abstract
Pediatric refractory epilepsy: A decision analysis comparing medical versus surgical treatment. Epilepsia. 2015 Feb; 56(2):263-72. View Abstract
Autonomic changes in psychogenic nonepileptic seizures: toward a potential diagnostic biomarker? Clin EEG Neurosci. 2015 Jan; 46(1):16-25. View Abstract
Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum. J Neuroimaging. 2015 Sep-Oct; 25(5):824-31. View Abstract
Febrile status epilepticus: time is of the essence. Epilepsy Curr. 2014 Nov-Dec; 14(6):345-7. View Abstract
Development and validation of a seizure prediction model in critically ill children. Seizure. 2015 Feb; 25:104-11. View Abstract
Passive fMRI mapping of language function for pediatric epilepsy surgical planning: validation using Wada, ECS, and FMAER. Epilepsy Res. 2014 Dec; 108(10):1874-88. View Abstract
Subunit composition of neurotransmitter receptors in the immature and in the epileptic brain. Biomed Res Int. 2014; 2014:301950. View Abstract
Seizure detection, seizure prediction, and closed-loop warning systems in epilepsy. Epilepsy Behav. 2014 Aug; 37:291-307. View Abstract
Localization of sleep spindles, k-complexes, and vertex waves with subdural electrodes in children. J Clin Neurophysiol. 2014 Aug; 31(4):367-74. View Abstract
Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Epilepsia. 2014 Aug; 55(8):1235-44. View Abstract
Management of pediatric status epilepticus. Curr Treat Options Neurol. 2014 Jul; 16(7):301. View Abstract
Comparison of pediatric patients with status epilepticus lasting 5-29 min versus =30 min. Epilepsy Behav. 2014 Aug; 37:1-6. View Abstract
Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58. View Abstract
Treatment for continuous spikes and waves during sleep (CSWS): survey on treatment choices in North America. Epilepsia. 2014 Jul; 55(7):1099-108. View Abstract
Comparison of risk factors for pediatric convulsive status epilepticus when defined as seizures = 5 min versus seizures = 30 min. Seizure. 2014 Oct; 23(9):692-8. View Abstract
Pediatric status epilepticus: how common is cerebrospinal fluid pleocytosis in the absence of infection? Seizure. 2014 Aug; 23(7):573-5. View Abstract
Predicting diurnal and sleep/wake seizure patterns in paediatric patients of different ages. Epileptic Disord. 2014 Mar; 16(1):56-66. View Abstract
Subunit composition of glutamate and gamma-aminobutyric acid receptors in status epilepticus. Epilepsy Res. 2014 May; 108(4):605-15. View Abstract
Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Pediatr Neurol. 2014 Jul; 51(1):60-6. View Abstract
Development and implementation of a quality improvement curriculum for child neurology residents: lessons learned. Pediatr Neurol. 2014 May; 50(5):452-7. View Abstract
Diagnostic delays in children with early onset epilepsy: impact, reasons, and opportunities to improve care. Epilepsia. 2014 Jan; 55(1):123-32. View Abstract
Electrocorticography for seizure foci mapping in epilepsy surgery. J Clin Neurophysiol. 2013 Dec; 30(6):554-70. View Abstract
Electrographic seizures after convulsive status epilepticus in children and young adults: a retrospective multicenter study. J Pediatr. 2014 Feb; 164(2):339-46.e1-2. View Abstract
Outcomes of vagal nerve stimulation in a pediatric population: a single center experience. Seizure. 2014 Feb; 23(2):105-11. View Abstract
Gaps and opportunities in refractory status epilepticus research in children: a multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG). Seizure. 2014 Feb; 23(2):87-97. View Abstract
Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep. Pediatr Neurol. 2013 Sep; 49(3):163-170.e4. View Abstract
Clinical application and evaluation of the Bien diagnostic criteria for Rasmussen encephalitis. Epilepsia. 2013 Oct; 54(10):1753-60. View Abstract
The diagnostic yield of pediatric polysomnography based on the professional background of referring physicians. Clin Pediatr (Phila). 2013 Dec; 52(12):1154-60. View Abstract
Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management. Epilepsy Res Treat. 2013; 2013:583531. View Abstract
Electroencephalography monitoring in critically ill children: current practice and implications for future study design. Epilepsia. 2013 Aug; 54(8):1419-27. View Abstract
Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. Int J Comput Assist Radiol Surg. 2014 Jan; 9(1):91-105. View Abstract
Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality. Neurology. 2013 Jul 23; 81(4):383-91. View Abstract
Intravenous ketamine for the treatment of refractory status epilepticus: a retrospective multicenter study. Epilepsia. 2013 Aug; 54(8):1498-503. View Abstract
Visual aids to medical data and computational diagnostics: new frontiers in pediatric neurology. Epilepsy Behav. 2013 Aug; 28(2):258-60. View Abstract
Pediatric ICU EEG monitoring: current resources and practice in the United States and Canada. J Clin Neurophysiol. 2013 Apr; 30(2):156-60. View Abstract
Should readmission within 30 days after discharge of children hospitalized for a neurologic disorder be considered a quality assurance failure? J Child Neurol. 2013 Jun; 28(6):758-61. View Abstract
Electroencephalographic monitoring in the pediatric intensive care unit. Curr Neurol Neurosci Rep. 2013 Mar; 13(3):330. View Abstract
Sturge-Weber syndrome: clinical and radiological correlates in 86 patients. Ideggyogy Sz. 2013 Jan 30; 66(1-2):53-7. View Abstract
Electrical status epilepticus in sleep: clinical presentation and pathophysiology. Pediatr Neurol. 2012 Dec; 47(6):390-410. View Abstract
The tower of Babel: survey on concepts and terminology in electrical status epilepticus in sleep and continuous spikes and waves during sleep in North America. Epilepsia. 2013 Apr; 54(4):741-50. View Abstract
Risk factors associated with death in in-hospital pediatric convulsive status epilepticus. PLoS One. 2012; 7(10):e47474. View Abstract
Clinical evolution of seizures: distribution across time of day and sleep/wakefulness cycle. J Neurol. 2013 Feb; 260(2):549-57. View Abstract
Dacrystic seizures: demographic, semiologic, and etiologic insights from a multicenter study in long-term video-EEG monitoring units. Epilepsia. 2012 Oct; 53(10):1810-9. View Abstract
Chrono-epileptology: time to reconsider seizure timing. Seizure. 2012 Jul; 21(6):411. View Abstract
Circadian patterns of generalized tonic-clonic evolutions in pediatric epilepsy patients. Seizure. 2012 Sep; 21(7):535-9. View Abstract
Effect of treatment of obstructive sleep apnea on seizure outcomes in children with epilepsy. Pediatr Neurol. 2012 Jun; 46(6):359-62. View Abstract
Diurnal and sleep/wake patterns of epileptic spasms in different age groups. Epilepsia. 2012 Jul; 53(7):1170-7. View Abstract
Clinical staging and electroencephalographic evolution of continuous spikes and waves during sleep. Epilepsia. 2012 Jul; 53(7):1185-95. View Abstract
Outcomes of epileptic spasms in patients aged less than 3 years: single-center United States experience. Pediatr Neurol. 2012 May; 46(5):276-80. View Abstract
Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep. Pediatr Neurol. 2012 May; 46(5):312-8. View Abstract
Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 May 29; 78(22):1721-7. View Abstract
Autonomic changes with seizures correlate with postictal EEG suppression. Neurology. 2012 Jun 05; 78(23):1868-76. View Abstract
Patients with electrical status epilepticus in sleep share similar clinical features regardless of their focal or generalized sleep potentiation of epileptiform activity. J Child Neurol. 2013 Jan; 28(1):83-9. View Abstract
Convulsive seizure detection using a wrist-worn electrodermal activity and accelerometry biosensor. Epilepsia. 2012 May; 53(5):e93-7. View Abstract
Analysis of EEG patterns and genotypes in patients with Angelman syndrome. Epilepsy Behav. 2012 Mar; 23(3):261-5. View Abstract
Behavioral measures and EEG monitoring using the Brain Symmetry Index during the Wada test in children. Epilepsy Behav. 2012 Mar; 23(3):247-53. View Abstract
Epileptic syndromes with focal seizures of childhood and adolescence. Handb Clin Neurol. 2012; 107:195-208. View Abstract
An electroencephalographic recording platform for real-time seizure detection. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:875-8. View Abstract
Signal subspace integration for improved seizure localization. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:1016-9. View Abstract
Treatment of pediatric status epilepticus. Curr Treat Options Neurol. 2011 Dec; 13(6):560-73. View Abstract
Teaching NeuroImages: mesial temporal sclerosis after a prolonged unprovoked seizure in an infant. Neurology. 2011 Nov 08; 77(19):e112-3. View Abstract
What is quality improvement and why should child neurologists care? J Child Neurol. 2012 Feb; 27(2):251-7. View Abstract
Outcome of no resection after long-term subdural electroencephalography evaluation in children with epilepsy. J Neurosurg Pediatr. 2011 Sep; 8(3):269-78. View Abstract
Selective serotonin reuptake inhibitors and periodic limb movements of sleep. Pediatr Neurol. 2011 Sep; 45(3):175-7. View Abstract
Necrotizing granulomatous meningoencephalitis due to Balamuthia in an immunocompetent child. Neurology. 2011 Aug 23; 77(8):801-2. View Abstract
Effect of continuous positive airway pressure treatment on seizure control in patients with obstructive sleep apnea and epilepsy. Epilepsia. 2011 Nov; 52(11):e168-71. View Abstract
Sleep-wake patterns of seizures in children with lesional epilepsy. Pediatr Neurol. 2011 Aug; 45(2):109-13. View Abstract
Experience with lacosamide in a series of children with drug-resistant focal epilepsy. Pediatr Neurol. 2011 Jun; 44(6):414-9. View Abstract
Electroencephalogram monitoring during intracranial surgery for moyamoya disease. Pediatr Neurol. 2011 Jun; 44(6):427-32. View Abstract
An empirical investigation of motion effects in eMRI of interictal epileptiform spikes. Magn Reson Imaging. 2011 Dec; 29(10):1401-9. View Abstract
Continuous spike and waves during sleep and electrical status epilepticus in sleep. J Clin Neurophysiol. 2011 Apr; 28(2):154-64. View Abstract
Chronobiology of epilepsy: diagnostic and therapeutic implications of chrono-epileptology. J Clin Neurophysiol. 2011 Apr; 28(2):146-53. View Abstract
Circadian distribution and sleep/wake patterns of generalized seizures in children. Epilepsia. 2011 Jun; 52(6):1076-83. View Abstract
Can semiology predict psychogenic nonepileptic seizures? A prospective study. Ann Neurol. 2011 Jun; 69(6):997-1004. View Abstract
Treatment of malignant migrating partial epilepsy of infancy with rufinamide: report of five cases. Epileptic Disord. 2011 Mar; 13(1):18-21. View Abstract
Rufinamide for the treatment of epileptic spasms. Epilepsy Behav. 2011 Feb; 20(2):344-8. View Abstract
Circadian patterns of pediatric seizures. Neurology. 2011 Jan 11; 76(2):145-53. View Abstract
Septo-optic dysplasia complicated by infantile spasms and bilateral choroidal fissure arachnoid cysts. J Neuroimaging. 2011 Jan; 21(1):89-91. View Abstract
Higher evening antiepileptic drug dose for nocturnal and early-morning seizures. Epilepsy Behav. 2011 Feb; 20(2):334-7. View Abstract
Incidence and clinical decision making for the Wada test over one decade: 1997-2007. Epileptic Disord. 2010 Dec; 12(4):249-54. View Abstract
Experience with rufinamide in a pediatric population: a single center's experience. Pediatr Neurol. 2010 Sep; 43(3):155-8. View Abstract
Surgical treatment of refractory status epilepticus in children: candidate selection and outcome. Semin Pediatr Neurol. 2010 Sep; 17(3):182-9. View Abstract
Fears and promises of comparative effectiveness research. Acta Paediatr. 2010 Sep; 99(9):1311-3. View Abstract
Clinical correlations of midline spikes in children. Epilepsy Behav. 2010 Aug; 18(4):460-5. View Abstract
Crying with left temporal lobe seizures and Wada testing. Epilepsy Behav. 2010 Jul; 18(3):303-5. View Abstract
Neuroimaging findings in children with benign focal epileptiform discharges. Epilepsy Res. 2010 Jun; 90(1-2):91-8. View Abstract
Visual naming performance after ATL resection: impact of atypical language dominance. Neuropsychologia. 2010 Jun; 48(7):2221-5. View Abstract
A self-administered screening instrument for psychogenic nonepileptic seizures. Neurology. 2010 Jan 19; 74(3):270; author reply 271. View Abstract
Continuous monitoring of electrodermal activity during epileptic seizures using a wearable sensor. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:4415-8. View Abstract
Childhood absence epilepsy in patients with benign focal epileptiform discharges. Pediatr Neurol. 2009 Dec; 41(6):428-34. View Abstract
Language assessment in Wada test: comparison of methohexital and amobarbital. Seizure. 2009 Nov; 18(9):656-9. View Abstract
Longer duration of epilepsy and earlier age at epilepsy onset correlate with impaired cognitive development in infancy. Epilepsy Behav. 2009 Nov; 16(3):431-5. View Abstract
Memory performance is related to language dominance as determined by the intracarotid amobarbital procedure. Epilepsy Behav. 2009 Sep; 16(1):145-9. View Abstract
A self-administered screening instrument for psychogenic nonepileptic seizures. Neurology. 2009 May 12; 72(19):1646-52. View Abstract
Atypical language lateralization in epilepsy patients. Epilepsia. 2009 Jun; 50(6):1505-16. View Abstract
Epilepsy surgery in children with electrical status epilepticus in sleep. Neurosurgery. 2009 Feb; 64(2):328-37; discussion 337. View Abstract
Epilepsy surgery in epidermal nevus syndrome variant with hemimegalencephaly and intractable seizures. J Neurol. 2008 Nov; 255(11):1829-31. View Abstract
Lateralizing value of epileptic nystagmus. Epilepsy Behav. 2008 Nov; 13(4):700-2. View Abstract
Complications during the Wada test. Epilepsy Behav. 2008 Oct; 13(3):551-3. View Abstract
Quo vadis Wada? Epilepsy Behav. 2008 Jul; 13(1):1-2. View Abstract
Discontinuation of medications after successful epilepsy surgery in children. Pediatr Neurol. 2008 May; 38(5):340-4. View Abstract
Pituitary stalk duplication in association with moya moya disease and bilateral morning glory disc anomaly - broadening the clinical spectrum of midline defects. J Neurol. 2008 Jun; 255(6):885-90. View Abstract
Mononeuropathy of the laryngeal recurrent nerve as possible manifestation of human immunodeficiency virus infection. Otolaryngol Head Neck Surg. 2004 Oct; 131(4):556-7. View Abstract
Validity of language lateralisation by unilateral intracarotid Wada test. J Neurol Neurosurg Psychiatry. 2004 Sep; 75(9):1367; author reply 1367-8. View Abstract
Lateralizing signs during seizures in infants. J Neurol. 2004 Sep; 251(9):1075-9. View Abstract
Localising and lateralising value of ictal piloerection. J Neurol Neurosurg Psychiatry. 2004 Jun; 75(6):879-83. View Abstract
Non-epileptic seizures of the elderly. J Neurol. 2004 Jun; 251(6):704-9. View Abstract
Seizure semiology in the elderly: a video analysis. Epilepsia. 2004 Mar; 45(3):263-7. View Abstract
Specific epileptic syndromes are rare even in tertiary epilepsy centers: a patient-oriented approach to epilepsy classification. Epilepsia. 2004 Mar; 45(3):268-75. View Abstract
Aphasia after hemispherectomy in an adult with early onset epilepsy and hemiplegia. J Neurol Neurosurg Psychiatry. 2004 Jan; 75(1):149-51. View Abstract
Late language transfer in patients with Rasmussen encephalitis. Epilepsia. 2003 Jun; 44(6):870-1. View Abstract
Effects of subthalamic nucleus (STN) stimulation on motor cortex excitability. Neurology. 2003 Mar 11; 60(5):885-6; author reply 885-6. View Abstract
Ictal urinary urge: further evidence for lateralization to the nondominant hemisphere. Epilepsia. 2003 Jan; 44(1):124-6. View Abstract
Carotid artery dissection after the intracarotid amobarbital test. Neurology. 2002 Dec 10; 59(11):1797-8. View Abstract
Neurological manifestations of the oculodentodigital dysplasia syndrome. J Neurol. 2002 May; 249(5):584-95. View Abstract
Deep brain stimulation in epilepsy. J Clin Neurophysiol. 2001 Nov; 18(6):514-32. View Abstract
[Experience with tiagabine in the clinical practice; new insights as to the efficacy and safety profile]. Nervenarzt. 2001 Oct; 72(10):764-9. View Abstract