Dr. Goobie has an interest in management of pediatric patients undergoing major surgery such as neurosurgery, craniofacial surgery and orthopedic surgery with particular emphasis on blood conservation methods, coagulation disorders, thromboelastography and pharmacological research. She is currently investigating the PK/PD profile of the antifibrinolytic, tranexamic acid (TXA) and its role in reducing blood loss in non-cardiac surgery. She and her colleagues showed that TXA significantly reduced blood loss and blood transfusion peri-operatively in children undergoing craniofacial surgery.
She published a manuscript entitled, 'Population Pharmacokinetics of TXA in Pediatric Patients Undergoing Craniosynostosis Surgery' in which she predicts the safest dose of TXA for this population. She has a double-blind placebo-controlled study in progress investigating TXA and the reduction in blood transfusion in children undergoing idiopathic scoliosis surgery. She also is recruiting for a multicenter international study entitled 'The Efficacy and Population Pharmacokinetics and Pharmacogenetics of a Reduced Dose of TXA for Craniosynostosis Surgery'. This trial will hopefully answer many questions regarding the appropriate dose of TXA, safety, the PK characteristics and unique patient factors which influence peri-operative bleeding.
Education
Undergraduate School
Memorial University of Newfoundland
1988
Newfoundland
Canada
Graduate School
Memorial University of Newfoundland
1992
Newfoundland
Canada
Medical School
Memorial University of Newfoundland
1992
Newfoundland
Canada
Internship
Memorial University of Newfoundland
1993
Newfoundland
Canada
Residency
Anesthesia
Memorial University of Newfoundland
1997
Newfoundland
Canada
Fellowship
Pediatric Anesthesia
Boston Children's Hospital
1998
Boston
MA
Fellowship
Pediatric Anesthesia Research
Boston Children's Hospital
Perioperative considerations in the paediatric patient with congenital and acquired coagulopathy. BJA Open. 2024 Dec; 12:100310. View Abstract
Trends in Gender of Authors of Patient Blood Management Publications. Anesth Analg. 2024 Jun 01; 138(6):1267-1274. View Abstract
Dexmedetomidine and neurophysiologic monitoring-A call for evidence to guide contemporary best practice for pediatric anesthesiologists. Paediatr Anaesth. 2024 02; 34(2):101-103. View Abstract
Implementation of an Enhanced Recovery after Surgery Pathway for Transgender and Gender-Diverse Individuals Undergoing Chest Reconstruction Surgery: An Observational Cohort Study. J Clin Med. 2023 Nov 14; 12(22). View Abstract
Regional Tissue Oximetry in Pediatric Patient Blood Management: A New Physiologic Tool in the Transfusion Toolbox? Anesth Analg. 2023 11 01; 137(5):983-986. View Abstract
Can identifying disparities in neonatal transfusion practices in low and middle resource countries improve postoperative outcomes through patient blood management? Paediatr Anaesth. 2023 09; 33(9):689-690. View Abstract
Tranexamic Acid Use in Pediatric Craniotomies at a Large Tertiary Care Pediatric Hospital: A Five Year Retrospective Study. J Clin Med. 2023 Jun 30; 12(13). View Abstract
Error traps in Pediatric Patient Blood Management in the Perioperative Period. Paediatr Anaesth. 2023 08; 33(8):609-619. View Abstract
Evaluation of a Pre-Filled Table and a Flowchart-Based Algorithm as Cognitive Aids to Reduce Deviations in Dose Calculation for Intraoperative Red Blood Cell Transfusions in Children-An International Web-Based Simulation. Children (Basel). 2023 Apr 29; 10(5). View Abstract
Perioperative management of pediatric patients undergoing juvenile angiofibroma resection. A case series and educational review highlighting patient blood management. Paediatr Anaesth. 2023 07; 33(7):510-519. View Abstract
Perioperative Pediatric Erythrocyte Transfusions: Incorporating Hemoglobin Thresholds and Physiologic Parameters in Decision-making. Anesthesiology. 2022 11 01; 137(5):604-619. View Abstract
Tranexamic acid for cesarean delivery: evidence of fibrinolysis? Am J Obstet Gynecol. 2023 01; 228(1):111-112. View Abstract
Patient Blood Management Is a New Standard of Care to Optimize Blood Health. Anesth Analg. 2022 09 01; 135(3):443-446. View Abstract
Update on Applications and Limitations of Perioperative Tranexamic Acid. Anesth Analg. 2022 09 01; 135(3):460-473. View Abstract
Patient Blood Management: The Forgotten Element of Enhanced Recovery After Surgery Programs. Anesth Analg. 2022 09 01; 135(3):474-475. View Abstract
Transfusion Strategies for Hemostatic Blood Products in Critically Ill Children: A Narrative Review and Update on Expert Consensus Guidelines. Anesth Analg. 2022 09 01; 135(3):545-557. View Abstract
Safety of antifibrinolytics in 6583 pediatric patients having craniosynostosis surgery: A decade of data reported from the multicenter Pediatric Craniofacial Collaborative Group. Paediatr Anaesth. 2022 12; 32(12):1339-1346. View Abstract
Large Vertex Encephaloceles: Management and Outcomes. J Craniofac Surg. 2023 Jan-Feb 01; 34(1):262-266. View Abstract
Tranexamic acid administered during cesarean delivery in high-risk patients: maternal pharmacokinetics, pharmacodynamics, and coagulation status. Am J Obstet Gynecol. 2022 Nov; 227(5):763.e1-763.e10. View Abstract
Plasma and Platelet Transfusion Strategies in Critically Ill Children Following Severe Trauma, Traumatic Brain Injury, and/or Intracranial Hemorrhage: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 01 01; 23(13 Suppl 1 1S):e14-e24. View Abstract
Plasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 01 01; 23(13 Suppl 1 1S):e37-e49. View Abstract
Plasma and Platelet Transfusion Strategies in Critically Ill Children Following Noncardiac Surgery and Critically Ill Children Undergoing Invasive Procedures Outside the Operating Room: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 01 01; 23(13 Supple 1 1S):e50-e62. View Abstract
Research Priorities for Plasma and Platelet Transfusion Strategies in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 01 01; 23(13 Supple 1 1S):e63-e73. View Abstract
Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB). Pediatr Crit Care Med. 2022 01 01; 23(1):34-51. View Abstract
Life-Threatening Bleeding in Children: A Prospective Observational Study. Crit Care Med. 2021 11 01; 49(11):1943-1954. View Abstract
Preoperative Anemia Screening and Treatment: Is It Worth the Return on Investment? Anesth Analg. 2021 02 01; 132(2):341-343. View Abstract
The Pediatric Craniofacial Collaborative Group (PCCG) Consensus Conference Methodology. Paediatr Anaesth. 2021 02; 31(2):145-149. View Abstract
Enhanced recovery: The evolution of pediatric spinal fusion care. Paediatr Anaesth. 2020 10; 30(10):1066-1067. View Abstract
One Size Does Not Fit All in Treating Massive Hemorrhage. Anesth Analg. 2020 08; 131(2):480-482. View Abstract
Consensus Guidelines for Perioperative Care in Neonatal Intestinal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations. World J Surg. 2020 08; 44(8):2482-2492. View Abstract
A systematic review of outcomes reported inpediatric perioperative research: A report from the Pediatric Perioperative Outcomes Group. Paediatr Anaesth. 2020 Jul 30. View Abstract
Balancing Supply and Demand for Blood during the COVID-19 Pandemic. Anesthesiology. 2020 07; 133(1):16-18. View Abstract
Essential Role of Patient Blood Management in a Pandemic: A Call for Action. Anesth Analg. 2020 07; 131(1):74-85. View Abstract
High-dose versus low-dose tranexamic acid for paediatric craniosynostosis surgery: a double-blind randomised controlled non-inferiority trial. Br J Anaesth. 2020 09; 125(3):336-345. View Abstract
Patient blood management during the COVID-19 pandemic: a narrative review. Anaesthesia. 2020 08; 75(8):1105-1113. View Abstract
Pediatric non-red cell blood product transfusion practices: what's the evidence to guide transfusion of the 'yellow' blood products? Curr Opin Anaesthesiol. 2020 Apr; 33(2):259-267. View Abstract
Implementing a Multidisciplinary Clinical Pathway Can Reduce the Deep Surgical Site Infection Rate After Posterior Spinal Fusion in High-Risk Patients. Spine Deform. 2019 Jan; 7(1):33-39. View Abstract
Bleeding Assessment Scale in Critically Ill Children (BASIC): Physician-Driven Diagnostic Criteria for Bleeding Severity. Crit Care Med. 2019 12; 47(12):1766-1772. View Abstract
Minimally Invasive Endoscopic Surgery for Infantile Craniosynostosis: A Longitudinal Cohort Study. J Pediatr. 2020 01; 216:142-149.e2. View Abstract
Dosing clonidine for sedation in intensive care. Paediatr Anaesth. 2019 10; 29(10):983-984. View Abstract
Perioperative Outcomes and Surgical Case Volume in Pediatric Complex Cranial Vault Reconstruction: A Multicenter Observational Study From the Pediatric Craniofacial Collaborative Group. Anesth Analg. 2019 10; 129(4):1069-1078. View Abstract
Tranexamic acid and perioperative bleeding in children: what do we still need to know? Curr Opin Anaesthesiol. 2019 Jun; 32(3):343-352. View Abstract
Are opioids pediatric anesthesiologists' sword of Damocles? With great power comes great responsibility and risk. Paediatr Anaesth. 2019 06; 29(6):544-546. View Abstract
Society for the advancement of blood management administrative and clinical standards for patient blood management programs. 4th edition (pediatric version). Paediatr Anaesth. 2019 Mar; 29(3):231-236. View Abstract
Corrigendum to 'Predictors of perioperative complications in paediatric cranial vault reconstruction surgery: a multicentre observational study from the Pediatric Craniofacial Collaborative Group' [Br J Anaesth 2019; 122: 215-223]. Br J Anaesth. 2019 05; 122(5):703. View Abstract
Predictors of transfusion outcomes in pediatric complex cranial vault reconstruction: a multicentre observational study from the Pediatric Craniofacial Collaborative Group. Can J Anaesth. 2019 05; 66(5):512-526. View Abstract
Sedative and Analgesic Drug Sequestration After a Single Bolus Injection in an Ex Vivo Extracorporeal Membrane Oxygenation Infant Circuit. ASAIO J. 2019 02; 65(2):187-191. View Abstract
Implementing a Multidisciplinary Clinical Pathway Can Reduce the Deep Surgical Site Infection Rate After Posterior Spinal Fusion in High-Risk Patients. Spine Deform. 2019 01; 7(1):33-39. View Abstract
Predictors of perioperative complications in paediatric cranial vault reconstruction surgery: a multicentre observational study from the Pediatric Craniofacial Collaborative Group. Br J Anaesth. 2019 Feb; 122(2):215-223. View Abstract
Tranexamic Acid Is Efficacious at Decreasing the Rate of Blood Loss in Adolescent Scoliosis Surgery: A Randomized Placebo-Controlled Trial. J Bone Joint Surg Am. 2018 Dec 05; 100(23):2024-2032. View Abstract
Patient Blood Management in Pediatric Cardiac Surgery: A Review. Anesth Analg. 2018 10; 127(4):1002-1016. View Abstract
Improving venous thromboembolism management in children undergoing surgery. Paediatr Anaesth. 2018 05; 28(5):378-379. View Abstract
Multi-modal 3D Simulation Makes the Impossible Possible. Plast Reconstr Surg Glob Open. 2018 Apr; 6(4):e1751. View Abstract
Endoscopic Versus Open Repair for Craniosynostosis in Infants Using Propensity Score Matching to Compare Outcomes: A Multicenter Study from the Pediatric Craniofacial Collaborative Group. Anesth Analg. 2018 03; 126(3):968-975. View Abstract
High-dose Versus Low-dose Tranexamic Acid to Reduce Transfusion Requirements in Pediatric Scoliosis Surgery. J Pediatr Orthop. 2017 Dec; 37(8):e552-e557. View Abstract
Ceftaroline pharmacokinetics and pharmacodynamics in patients with cystic fibrosis. J Cyst Fibros. 2018 05; 17(3):e25-e31. View Abstract
Tranexamic Acid: What Is Known and Unknown, and Where Do We Go From Here? Anesthesiology. 2017 09; 127(3):405-407. View Abstract
Incidence and predictors of massive bleeding in children undergoing liver transplantation: A single-center retrospective analysis. Paediatr Anaesth. 2017 Jul; 27(7):718-725. View Abstract
Tranexamic acid: still far to go. Br J Anaesth. 2017 03 01; 118(3):293-295. View Abstract
Safety of antifibrinolytics in cranial vault reconstructive surgery: a report from the pediatric craniofacial collaborative group. Paediatr Anaesth. 2017 03; 27(3):271-281. View Abstract
Perioperative Outcomes and Management in Pediatric Complex Cranial Vault Reconstruction: A Multicenter Study from the Pediatric Craniofacial Collaborative Group. Anesthesiology. 2017 02; 126(2):276-287. View Abstract
Association of Preoperative Anemia With Postoperative Mortality in Neonates-Reply. JAMA Pediatr. 2017 02 01; 171(2):196-197. View Abstract
Relationship Between Preoperative Anemia and In-Hospital Mortality in Children Undergoing Noncardiac Surgery. Anesth Analg. 2016 12; 123(6):1582-1587. View Abstract
The translational value of chart reviews and the need for trials. Paediatr Anaesth. 2016 Sep; 26(9):864-5. View Abstract
Association of Preoperative Anemia With Postoperative Mortality in Neonates. JAMA Pediatr. 2016 09 01; 170(9):855-62. View Abstract
Multivariable predictors of substantial blood loss in children undergoing craniosynostosis repair: implications for risk stratification. Paediatr Anaesth. 2016 Oct; 26(10):960-9. View Abstract
Relationship between transfusion volume and outcomes in children undergoing noncardiac surgery. Transfusion. 2016 Oct; 56(10):2487-2494. View Abstract
Tranexamic Acid Use in United States Children's Hospitals. J Emerg Med. 2016 Jun; 50(6):868-874.e1. View Abstract
Post-Operative Outcomes in Children With and Without Congenital Heart Disease Undergoing Noncardiac Surgery. J Am Coll Cardiol. 2016 Feb 23; 67(7):793-801. View Abstract
A blood transfusion can save a child's life or threaten it. Paediatr Anaesth. 2015 Dec; 25(12):1182-3. View Abstract
Quantification of Fibrinolysis Using Velocity Curves Measured with Thromboelastometry in Children with Congenital Heart Disease. Anesth Analg. 2015 Aug; 121(2):486-91. View Abstract
Predictors of clinically significant postoperative events after open craniosynostosis surgery. Anesthesiology. 2015 May; 122(5):1021-32. View Abstract
Use of tranexamic acid in infants undergoing choroid plexus papilloma surgery: a report of two cases. Paediatr Anaesth. 2014 Jul; 24(7):791-3. View Abstract
Bleeding management for pediatric craniotomies and craniofacial surgery. Paediatr Anaesth. 2014 Jul; 24(7):678-89. View Abstract
The efficacy of antifibrinolytic drugs in children undergoing noncardiac surgery: a systematic review of the literature. Anesth Analg. 2014 Mar; 118(3):628-36. View Abstract
Should aprotinin be reconsidered for use in pediatric surgery? Paediatr Anaesth. 2014 Feb; 24(2):137-40. View Abstract
Improvements in patient blood management for pediatric craniosynostosis surgery using a ROTEM(®) -assisted strategy - feasibility and costs. Paediatr Anaesth. 2014 Jul; 24(7):774-80. View Abstract
New insights about the use of tranexamic acid in children undergoing cardiac surgery: from pharmacokinetics to pharmacodynamics. Anesth Analg. 2013 Oct; 117(4):760-762. View Abstract
Autosomal recessive hereditary spastic paraplegia-clinical and genetic characteristics of a well-defined cohort. Neurogenetics. 2013 Nov; 14(3-4):181-8. View Abstract
Population pharmacokinetics of tranexamic acid in paediatric patients undergoing craniosynostosis surgery. Clin Pharmacokinet. 2013 Apr; 52(4):267-76. View Abstract
Intraoperative management of blood loss during craniosynostosis surgery. Paediatr Anaesth. 2013 Mar; 23(3):278-80. View Abstract
The case for the use of tranexamic acid. Paediatr Anaesth. 2013 Mar; 23(3):281-4. View Abstract
Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology. 2011 Apr; 114(4):862-71. View Abstract
Endoscopic strip craniectomy in early infancy: the initial five years of anesthesia experience. Anesth Analg. 2011 Feb; 112(2):407-14. View Abstract
Molecular and clinical characterization of de novo and familial cases with microduplication 3q29: guidelines for copy number variation case reporting. Cytogenet Genome Res. 2008; 123(1-4):65-78. View Abstract
The use of a laryngeal mask airway for emergent airway management in a prone child. Anesth Analg. 2005 Mar; 100(3):670-671. View Abstract
Confirmation of direct epidural catheter placement using nerve stimulation in pediatric anesthesia. Anesth Analg. 2003 Oct; 97(4):984-988. View Abstract
An admixture of 3 mg x kg(-1) of propofol and 3 mg x kg(-1) of thiopentone reduces pain on injection in pediatric anesthesia. Can J Anaesth. 2002 Dec; 49(10):1064-9. View Abstract
Hemostatic changes in pediatric neurosurgical patients as evaluated by thrombelastograph. Anesth Analg. 2001 Oct; 93(4):887-92. View Abstract
Shwachman-Diamond syndrome with exocrine pancreatic dysfunction and bone marrow failure maps to the centromeric region of chromosome 7. Am J Hum Genet. 2001 Apr; 68(4):1048-54. View Abstract
Segregation analysis in Shwachman-Diamond syndrome: evidence for recessive inheritance. Am J Hum Genet. 2000 Apr; 66(4):1413-6. View Abstract
Exclusion of linkage of Shwachman-Diamond syndrome to chromosome regions 6q and 12q implicated by a de novo translocation. Am J Med Genet. 1999 Jul 16; 85(2):171-4. View Abstract