Anesthetic-induced neuromodulation of the developing brain. He has published several studies demonstrating the essential role of adhesion in cerebral ischemia. Ongoing studies with Dr. Koichi Yuki now look at the effects of anesthetics on adhesion molecule function; with the intention of using them as anti-inflammatory agents in the setting of anesthesia and critical care. The effect of anesthetic neurotoxicity is an area of investigation that has significant impact on the practice of pediatric anesthesia. With the perspective of a pediatric anesthesiologist, Dr. Soriano is utilizing clinically relevant paradigms in preclinical models to interrogate potential pathways of anesthetic neuromodulation.
Education
Medical School
University of Pennsylvania School of Medicine
1985
Philadelphia
PA
Internship
St. Mary's Hospital and Medical Center
1986
San Francisco
CA
Residency
University of California Davis Medical Center
1989
Sacramento
CA
Fellowship
Boston Children's Hospital
1990
Boston
MA
Publications
Dexmedetomidine and Clonidine Attenuate Sevoflurane-Induced Tau Phosphorylation and Cognitive Impairment in Young Mice via a-2 Adrenergic Receptor. Anesth Analg. 2021 03 01; 132(3):878-889. View Abstract
Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes. Clin Immunol. 2021 01; 222:108635. View Abstract
The Unspoken Question! Anesth Analg. 2020 09; 131(3):720-722. View Abstract
Is Anesthesia Bad for the Brain? Current Knowledge on the Impact of Anesthetics on the Developing Brain. Anesthesiol Clin. 2020 Sep; 38(3):477-492. View Abstract
Does general anesthesia affect neurodevelopment in infants and children? BMJ. 2019 Dec 09; 367:l6459. View Abstract
The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction. FASEB J. 2019 11; 33(11):12668-12679. View Abstract
Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial. Lancet. 2019 02 16; 393(10172):664-677. View Abstract
A Summary of Preclinical Poster Presentations at the Sixth Biennial Pediatric Anesthesia Neurodevelopment Assessment (PANDA) Symposium. J Neurosurg Anesthesiol. 2019 Jan; 31(1):163-165. View Abstract
Anesthesia and the developing brain: A way forward for laboratory and clinical research. Paediatr Anaesth. 2018 09; 28(9):758-763. View Abstract
Sevoflurane Acts on Ubiquitination-Proteasome Pathway to Reduce Postsynaptic Density 95 Protein Levels in Young Mice. Anesthesiology. 2017 12; 127(6):961-975. View Abstract
Differences in Blood Pressure in Infants After General Anesthesia Compared to Awake Regional Anesthesia (GAS Study-A Prospective Randomized Trial). Anesth Analg. 2017 09; 125(3):837-845. View Abstract
Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neuroplasticity. Br J Anaesth. 2017 09 01; 119(3):443-447. View Abstract
Coenzyme Q10 reduces sevoflurane-induced cognitive deficiency in young mice. Br J Anaesth. 2017 Sep 01; 119(3):481-491. View Abstract
From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis. Toxicol Sci. 2017 04 01; 156(2):402-411. View Abstract
Anesthesia, brain changes, and behavior: Insights from neural systems biology. Prog Neurobiol. 2017 06; 153:121-160. View Abstract
Dexmedetomidine-Induced Neuroapoptosis Is Dependent on Its Cumulative Dose. Anesth Analg. 2016 10; 123(4):1008-17. View Abstract
Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis. World J Clin Cases. 2015 Sep 16; 3(9):793-806. View Abstract
Imaging the progression of anesthetic-induced neurotoxicity: a leap toward translational relevance. Anesthesiology. 2015 Sep; 123(3):497-8. View Abstract
The role of macrophage 1 antigen in polymicrobial sepsis. Shock. 2014 Dec; 42(6):532-9. View Abstract
Anesthesia for intracranial surgery in infants and children. Curr Opin Anaesthesiol. 2014 Oct; 27(5):465-9. View Abstract
Progress in anesthesia and management of the newborn surgical patient. Semin Pediatr Surg. 2014 Oct; 23(5):244-8. View Abstract
Not just neuroanesthesia, but Pediatric neuroanesthesia! Paediatr Anaesth. 2014 Jul; 24(7):645-6. View Abstract
Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar. Br J Anaesth. 2013 Aug; 111(2):143-51. View Abstract
Population pharmacokinetics of tranexamic acid in paediatric patients undergoing craniosynostosis surgery. Clin Pharmacokinet. 2013 Apr; 52(4):267-76. View Abstract
Role of glycogen synthase kinase-3ß in ketamine-induced developmental neuroapoptosis in rats. Br J Anaesth. 2013 Jun; 110 Suppl 1:i3-9. View Abstract
Morphine-enhanced apoptosis in selective brain regions of neonatal rats. Int J Dev Neurosci. 2013 Jun; 31(4):258-66. View Abstract
Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment. Anesthesiology. 2013 Mar; 118(3):502-15. View Abstract
Neuroanesthesiology fellowship training: curricular guidelines from the Society for Neuroscience in Anesthesiology and Critical Care. J Neurosurg Anesthesiol. 2013 Jan; 25(1):1-7. View Abstract
Perioperative central nervous system injury in neonates. Br J Anaesth. 2012 Dec; 109 Suppl 1:i60-i67. View Abstract
Neurotoxicity of ketamine: known unknowns. Crit Care Med. 2012 Aug; 40(8):2518-9. View Abstract
Noxious stimulation attenuates ketamine-induced neuroapoptosis in the developing rat brain. Anesthesiology. 2012 Jul; 117(1):64-71. View Abstract
General anesthetics in pediatric anesthesia: influences on the developing brain. Curr Drug Targets. 2012 Jun; 13(7):944-51. View Abstract
Anesthetic concerns for pediatric patients in an intraoperative MRI suite. Curr Opin Anaesthesiol. 2011 Oct; 24(5):480-6. View Abstract
Spinal anesthesia in infant rats: development of a model and assessment of neurologic outcomes. Anesthesiology. 2011 Jun; 114(6):1325-35. View Abstract
Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology. 2011 Apr; 114(4):862-71. View Abstract
Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg. 2011 Apr; 112(4):830-8. View Abstract
Endoscopic strip craniectomy in early infancy: the initial five years of anesthesia experience. Anesth Analg. 2011 Feb; 112(2):407-14. View Abstract
Detection of intestinal inflammation by MicroPET imaging using a (64)Cu-labeled anti-beta(7) integrin antibody. Inflamm Bowel Dis. 2010 Sep; 16(9):1458-66. View Abstract
Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. Anesthesiology. 2010 May; 112(5):1155-63. View Abstract
Thinking about the neurotoxic effects of sedatives on the developing brain. Pediatr Crit Care Med. 2010 Mar; 11(2):306-7. View Abstract
Acute intraoperative neurogenic pulmonary edema during endoscopic ventriculoperitoneal shunt revision. Anesth Analg. 2010 Feb 01; 110(2):594-5. View Abstract
Thinking about the neurotoxic effects of sedatives on the developing brain. Pediatric Critical Care Medicine. 2010; in press. View Abstract
Detection of intestinal inflammation by PET imaging using a 64Cu-labeled anti-ƒÒ7 integrin antibody. Inflammatory Bowel Disease. 2010; in press. View Abstract
Is anesthesia bad for the newborn brain? Anesthesiol Clin. 2009 Jun; 27(2):269-84. View Abstract
Clinical research approaches to studying pediatric anesthetic neurotoxicity. Neurotoxicology. 2009 Sep; 30(5):766-71. View Abstract
Prolonged exposure to ketamine increases brain derived neurotrophic factor levels in developing rat brains. Curr Drug Saf. 2009 Jan; 4(1):11-6. View Abstract
Anesthesia for Pediatric Neurosurgery and Traumatic Brain Injury. Smith's Anesthesia for Infants and Children. 2009. View Abstract
The volatile anesthetic agent isoflurane perturbs the conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB. 2008; 22(12):4109-16. View Abstract
SNACC: Basic and Clinical Neurosciences in Perfect Harmony. ASA Newsletter. 2008; 72(9):48-49. View Abstract
The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB J. 2008 Dec; 22(12):4109-16. View Abstract
CON: The toxic effects of anesthetics in the developing brain: the clinical perspective. Anesth Analg. 2008 Jun; 106(6):1664-9. View Abstract
An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function. Anesth Analg. 2008 Jun; 106(6):1681-707. View Abstract
Central nervous system inflammation. Eur J Anaesthesiol Suppl. 2008; 42:154-9. View Abstract
Anesthetic considerations and postoperative ICU care. Pediatric Epilepsy Surgery: Preoperative Assessment and Surgical Treatment, Cataltepe O and Jallo G (eds.). 2008. View Abstract
The Central Nervous System: Pediatric Neuroanesthesia. A Practical Approach to Pediatric Anesthesia, Holzman RS, Mancuso T, Polaner D (eds.). 2008. View Abstract
Pediatric Neuroanesthesia. Anesthesia and Neurosurgery, Cottrell J and Young W eds. 2008. View Abstract
Pediatric Neuroanesthesia. Pediatric Anesthesia, Principles and Practice, Bissonnette, B. (ed.). 2008. View Abstract
Pediatric Neuroanesthesia. A Practice of Anesthesia for Infants and Children Cote CJ and Lerman J(eds.). 2008. View Abstract
Recognition and Alleviation of Pain in Laboratory Animals. 2008. View Abstract
Pediatric Neuroanesthesia. Anesthesia for Neurosurgery in Principles and Practice of Pediatric Neurosurgery Albright AL, Pollack IF, and Adelson D (eds.). 2008. View Abstract
Detection of unanticipated intracranial hemorrhage during intraoperative magnetic resonance image-guided neurosurgery. Report of two cases. J Neurosurg. 2007 May; 106(5 Suppl):398-400. View Abstract
Lidocaine pretreatment for the prevention of propofol-induced transient motor disturbances in children during anesthesia induction: a randomized controlled trial in children undergoing invasive hematologic procedures. Paediatr Anaesth. 2006 Dec; 16(12):1232-7. View Abstract
Anesthesia for epilepsy surgery in children. Childs Nerv Syst. 2006 Aug; 22(8):834-43. View Abstract
Summary proceedings from the neonatal pain-control group. Pediatrics. 2006 Mar; 117(3 Pt 2):S9-S22. View Abstract
Anesthetic management of pial synangiosis and intracranial hemorrhage with a Fontan circulation. Paediatr Anaesth. 2006 Jan; 16(1):72-6. View Abstract
Let's not throw the baby out with the bath water: potential neurotoxicity of anesthetic drugs in infants and children. J Neurosurg Anesthesiol. 2005 Oct; 17(4):207-9. View Abstract
Of mice and men: should we extrapolate rodent experimental data to the care of human neonates? Anesthesiology. 2005 Apr; 102(4):866-8; author reply 868-9. View Abstract
Society of Neurosurgical Anesthesia and Critical Care (SNACC) Problem-based learning discussion: 3 month old boy with saggital craniosynostosis
SNACC Website http://www.snacc.org/ed/casedisc/Craniosynostosis.pdf. 2005. View Abstract
Anesthetic agents and the immature brain: are these toxic or therapeutic? Anesthesiology. 2004 Aug; 101(2):527-30. View Abstract
Perioperative management of diabetes insipidus in children. J Neurosurg Anesthesiol. 2004 Jul; 16(3):220-5. View Abstract
Does anaesthesia harm the developing brain--evidence or speculation? Paediatr Anaesth. 2004 Mar; 14(3):199-200. View Abstract
Long-term outcome in children with moyamoya syndrome after cranial revascularization by pial synangiosis. J Neurosurg. 2004 Feb; 100(2 Suppl Pediatrics):142-9. View Abstract
Perioperative management of diabetes insipidus in children [corrected]. J Neurosurg Anesthesiol. 2004 Jan; 16(1):14-9. View Abstract
Antiepileptic-induced resistance to neuromuscular blockers: mechanisms and clinical significance. Clin Pharmacokinet. 2004; 43(2):71-81. View Abstract
Society for Neurosurgical Anesthesia and Critical Care (SNACC) Bibliography, SNACC website: http://www.snacc.org/ed/bib/StartBIB.html. 2004. View Abstract
Society of Neurosurgical Anesthesia and Critical Care (SNACC) newsletter: report of the 2002 annual meeting, Orlando, Florida. J Neurosurg Anesthesiol. 2003 Apr; 15(2):165-7. View Abstract
Repeated administration of ketamine may lead to neuronal degeneration in the developing rat brain. Paediatr Anaesth. 2002 Nov; 12(9):770-4. View Abstract
Anaesthetic management of children with tuberous sclerosis. Paediatr Anaesth. 2002 Oct; 12(8):700-4. View Abstract
Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury. J Neuroimmunol. 2002 Apr; 125(1-2):59-65. View Abstract
Levels of soluble adhesion molecules are elevated in the cerebrospinal fluid of children with moyamoya syndrome. Neurosurgery. 2002 Mar; 50(3):544-9. View Abstract
Neuroanesthesia. Innovative techniques and monitoring. Anesthesiol Clin North Am. 2002 Mar; 20(1):137-51. View Abstract
Hemostatic changes in pediatric neurosurgical patients as evaluated by thrombelastograph. Anesth Analg. 2001 Oct; 93(4):887-92. View Abstract
Gentle dorsal root retraction and dissection can cause areflexia: implications for intraoperative monitoring during "selective" partial dorsal rhizotomy. Muscle Nerve. 2001 Oct; 24(10):1352-8. View Abstract
Pharmacokinetics and pharmacodynamics of vecuronium in children receiving phenytoin or carbamazepine for chronic anticonvulsant therapy. Br J Anaesth. 2001 Feb; 86(2):223-9. View Abstract
Pediatric Neuroanesthesia. A Practice of Anesthesia for Infants and Children Cote CJ (ed.). 2001; 493-521. View Abstract
The effect of propofol on intraoperative electrocorticography and cortical stimulation during awake craniotomies in children. Paediatr Anaesth. 2000; 10(1):29-34. View Abstract
Onset and duration of action of rocuronium in children receiving chronic anticonvulsant therapy. Paediatr Anaesth. 2000; 10(2):133-6. View Abstract
P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury. Brain Res. 1999 Jul 24; 835(2):360-4. View Abstract
Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury. Stroke. 1999 Jan; 30(1):134-9. View Abstract
Anesthesia for Pediatric Neurosurgery. Pediatric Anesthesia Volume VII, Miller RD (series editor) Atlas of Anesthesia, Greeley WJ (volume ed.). 1999; 7:7-11. View Abstract
Rebound swelling of astroglial cells exposed to hypertonic mannitol. Anesthesiology. 1998 Jun; 88(6):1586-91. View Abstract
Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med. 1998 Feb; 4(2):228-31. View Abstract
ICAM-1 dependent pathway is not involved in the development of neuronal apoptosis after transient focal cerebral ischemia. Brain Res. 1998 Jan 12; 780(2):337-41. View Abstract
Surgical airway, rigid bronchoscopy, and transtracheal jet ventilation in the pediatric patient. Anesthesiol Clin of North America. 1998; 16:827-838. View Abstract
Sevoflurane depresses myocardial contractility less than halothane during induction of anesthesia in children. Anesthesiology. 1996 Dec; 85(6):1260-7. View Abstract
Effects of ondansetron on emesis in the first 24 hours after craniotomy in children. Anesth Analg. 1996 Aug; 83(2):325-8. View Abstract
Cerebral blood flow velocity after mannitol infusion in children. Can J Anaesth. 1996 May; 43(5 Pt 1):461-6. View Abstract
Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury. Ann Neurol. 1996 May; 39(5):618-24. View Abstract
The critical importance of stimulus intensity in intraoperative monitoring for partial dorsal rhizotomy. Muscle Nerve. 1996 Apr; 19(4):415-22. View Abstract
Resection of a massive sacrococcygeal teratoma using hypothermic hypoperfusion: a novel use of extracorporeal membrane oxygenation. J Pediatr Surg. 1995 Nov; 30(11):1557-9. View Abstract
Neuroanesthesia. Neurosurg Clin N Am. 1995 Jul; 6(3):505-20. View Abstract
Anesthesia for stereotactic radiosurgery in children. J Neurosurg Anesthesiol. 1995 Apr; 7(2):100-8. View Abstract
Nitrous oxide depresses the H-reflex in children with cerebral palsy. Anesth Analg. 1995 Feb; 80(2):239-41. View Abstract
Doppler sensor placement during neurosurgical procedures for children in the prone position. J Neurosurg Anesthesiol. 1994 Jul; 6(3):153-5. View Abstract
H reflex studies in cerebral palsy patients undergoing partial dorsal rhizotomy. Muscle Nerve. 1994 May; 17(5):539-49. View Abstract
Anesthetic management of children with moyamoya syndrome. Anesth Analg. 1993 Nov; 77(5):1066-70. View Abstract
EEG power changes are more sensitive than spectral edge frequency variation for detection of cerebral ischemia during carotid artery surgery: a prospective assessment of processed EEG monitoring. J Cardiothorac Vasc Anesth. 1992 Jun; 6(3):292-4. View Abstract
Neonatal surgical emergencies. Seminars in Anesthesia. 1992; 9:309-316. View Abstract
Posterior fossa craniotomy. Common problems in pediatric anesthesia Stehling L, (ed.). 1992; 307-315. View Abstract
A recommendation for reduced lidocaine dosage during intravenous regional bretylium treatment of reflex sympathetic dystrophy. Anesthesiology. 1989 Nov; 71(5):811-2. View Abstract
Osteomalacia in a night nurse. Clinical Orthopedics. 1986; 205:216-221.. View Abstract