Information

Related Research Units

Endocrinology Research
Biddinger Laboratory Research

Publications

  1. The Diabetes Gene Tcf7l2 Organizes Gene Expression in the Liver and Regulates Amino Acid Metabolism. bioRxiv. 2025 Apr 08. View Abstract
  2. Liver specific transgenic expression of CYP7B1 attenuates early western diet-induced MASLD progression. J Lipid Res. 2025 Mar; 66(3):100757. View Abstract
  3. Targeting Liver Epsins Ameliorates Dyslipidemia in Atherosclerosis. bioRxiv. 2024 Aug 27. View Abstract
  4. Gut Microbiota-Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms. Circulation. 2023 04 04; 147(14):1079-1096. View Abstract
  5. Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1. Science. 2022 04 15; 376(6590):eabf8271. View Abstract
  6. Evaluating human genetic support for hypothesized metabolic disease genes. Cell Metab. 2022 05 03; 34(5):661-666. View Abstract
  7. Insulin Prevents Hypercholesterolemia by Suppressing 12a-Hydroxylated Bile Acids. Circulation. 2022 03 29; 145(13):969-982. View Abstract
  8. Triglycerides in Nonalcoholic Fatty Liver Disease: Guilty Until Proven Innocent. Trends Pharmacol Sci. 2021 03; 42(3):183-190. View Abstract
  9. Markers of cholesterol synthesis are elevated in adolescents and young adults with type 2 diabetes. Pediatr Diabetes. 2020 11; 21(7):1126-1131. View Abstract
  10. Type 1 diabetes is associated with an increase in cholesterol absorption markers but a decrease in cholesterol synthesis markers in a young adult population. J Clin Lipidol. 2019 Nov - Dec; 13(6):940-946. View Abstract
  11. Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction. Cell Metab. 2019 12 03; 30(6):1141-1151.e5. View Abstract
  12. Acute suppression of insulin resistance-associated hepatic miR-29 in vivo improves glycemic control in adult mice. Physiol Genomics. 2019 08 01; 51(8):379-389. View Abstract
  13. microRNA-146a-5p association with the cardiometabolic disease risk factor TMAO. Physiol Genomics. 2019 02 01; 51(2):59-71. View Abstract
  14. The beta secretase BACE1 regulates the expression of insulin receptor in the liver. Nat Commun. 2018 04 03; 9(1):1306. View Abstract
  15. FoxO1 Is Required for Most of the Metabolic and Hormonal Perturbations Produced by Hepatic Insulin Receptor Deletion in Male Mice. Endocrinology. 2018 03 01; 159(3):1253-1263. View Abstract
  16. Nonalcoholic fatty liver disease and gastric bypass surgery regulate serum and hepatic levels of pyruvate kinase isoenzyme M2. Am J Physiol Endocrinol Metab. 2018 10 01; 315(4):E613-E621. View Abstract
  17. Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways. J Biol Chem. 2018 02 09; 293(6):2006-2014. View Abstract
  18. YAP suppresses gluconeogenic gene expression through PGC1a. Hepatology. 2017 12; 66(6):2029-2041. View Abstract
  19. PCSK9 Is Increased in Youth With Type 1 Diabetes. Diabetes Care. 2017 07; 40(7):e85-e87. View Abstract
  20. Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis. Cell Rep. 2017 06 06; 19(10):2116-2129. View Abstract
  21. Obesity and type 2 diabetes are associated with elevated PCSK9 levels in young women. Pediatr Diabetes. 2017 Dec; 18(8):755-760. View Abstract
  22. Calorically restricted diets decrease PCSK9 in overweight adolescents. Nutr Metab Cardiovasc Dis. 2017 Apr; 27(4):342-349. View Abstract
  23. The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia. Circulation. 2016 Jul 05; 134(1):61-72. View Abstract
  24. Effect of Leptin Administration on Circulating Apolipoprotein CIII levels in Patients With Lipodystrophy. J Clin Endocrinol Metab. 2016 04; 101(4):1790-7. View Abstract
  25. Effect of Leptin Replacement on PCSK9 in ob/ob Mice and Female Lipodystrophic Patients. Endocrinology. 2016 Apr; 157(4):1421-9. View Abstract
  26. Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation. J Biol Chem. 2016 Jan 15; 291(3):1115-22. View Abstract
  27. Role of Insulin in the Regulation of Proprotein Convertase Subtilisin/Kexin Type 9. Arterioscler Thromb Vasc Biol. 2015 Jul; 35(7):1589-96. View Abstract
  28. Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis. Nat Commun. 2015 Apr 07; 6:6498. View Abstract
  29. PKB/Akt phosphorylation of ERR? contributes to insulin-mediated inhibition of hepatic gluconeogenesis. Diabetologia. 2014 Dec; 57(12):2576-85. View Abstract
  30. MicroRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes. Diabetes. 2014 Sep; 63(9):3141-8. View Abstract
  31. Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins. J Lipid Res. 2014 Apr; 55(4):659-67. View Abstract
  32. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014 Jan 23; 505(7484):559-63. View Abstract
  33. The regulation of ApoB metabolism by insulin. Trends Endocrinol Metab. 2013 Aug; 24(8):391-7. View Abstract
  34. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metab. 2012 Jun 06; 15(6):873-84. View Abstract
  35. PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest. 2011 Jun; 121(6):2504-17. View Abstract
  36. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med. 2011 Mar; 17(3):356-65. View Abstract
  37. Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemia. Arterioscler Thromb Vasc Biol. 2011 Mar; 31(3):513-9. View Abstract
  38. Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab. 2010 Dec 01; 12(6):567-79. View Abstract
  39. You deserve what you eat: lessons learned from the study of the melanin-concentrating hormone (MCH)-deficient mice. Gut. 2010 Dec; 59(12):1625-34. View Abstract
  40. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 04; 464(7285):121-5. View Abstract
  41. Dissecting the role of insulin resistance in the metabolic syndrome. Curr Opin Lipidol. 2009 Jun; 20(3):206-10. View Abstract
  42. Insulin Resistance in Obesity (in press). Metabolic Basis of Obesity. 2009. View Abstract
  43. Chipping away at gallstones. Nat Med. 2008 Jul; 14(7):715-6. View Abstract
  44. Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med. 2008 Jul; 14(7):778-82. View Abstract
  45. Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2. FASEB J. 2008 Jul; 22(7):2579-90. View Abstract
  46. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab. 2008 Feb; 7(2):95-6. View Abstract
  47. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab. 2008 Feb; 7(2):125-34. View Abstract
  48. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem. 2007 Aug 10; 282(32):23672-8. View Abstract
  49. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes. 2006 Jul; 55(7):2032-41. View Abstract
  50. From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol. 2006; 68:123-58. View Abstract
  51. The insulin-like growth factor axis: a potential link between glycemic index and cancer. Am J Clin Nutr. 2005 Aug; 82(2):277-8. View Abstract
  52. Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes. 2005 May; 54(5):1314-23. View Abstract
  53. Characterization of phosphotyrosine containing proteins at the cholinergic synapse. FEBS Lett. 1999; 446(1):95-102. View Abstract
  54. Characterization of the tyrosine phosphorylation and distribution of dystrobrevin isoforms. FEBS Lett. 1998; 432(3):133-40. View Abstract
  55. Rapsyn clusters and activates the synapse-specific receptor tyrosine kinase MuSK. Neuron. 1996; 16(5):953-62. View Abstract

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