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Molecular Medicine Research

Research Overview

Stephen Harrison has made important contributions to structural biology, most notably by determining and analyzing the structures of viruses and viral proteins, by crystallographic analysis of protein/DNA complexes, and by structural studies of protein-kinase switching mechanisms. The initiator of high-resolution virus crystallography, he has moved from his early work on tomato bushy stunt virus ( to the study of more complex human pathogens, including the capsid of human papillomavirus, the envelope of dengue virus, and several components of HIV. He has also turned some his research attention to even more complex assemblies, such as clathrin coated vesicles. Recently the Harrison Laboratory has been studying the structures of viral proteins that mediate entry into cells. These investigations reveal fundamental properties not only of viruses but also of their host cells. The laboratory's current focus is on the study of double-stranded RNA viruses to help determine how nonenveloped viruses (viruses without lipid membranes of their own) enter cells. The structures of entry proteins from reovirus and rotavirus suggest that major conformational rearrangements in the protein oligomers may drive membrane penetration steps. Eludidating the mechanisms of viral entry may reveal targets for antiviral drugs.

 

Research Background

Stephen Harrison received his PhD in biophysics from Harvard University. He completed a postdoctoral fellowship in biophysics at Harvard and was a Helen Hay Whitney Postdoctoral Research Fellow, Children's Cancer Research Foundation, Boston. He is an investigator in the Howard Hughes Medical Institute, a member of the National Academy of Sciences, a fellow of the American Academy of Arts and Sciences, and a member of the American Philosophical Society.. He received the Louisa Gross Horwitz Prize (with Don Wiley and Michael Rossmann) in 1990, the ICN International Prize in Virology in 1998, the Paul Ehrlich and Ludwig Darmstaedter Prize (with Michael Rossmann) in 2001, and the Lewis S. Rosensteil Award in 2019.

Publications

  1. Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases. bioRxiv. 2025 Jan 02. View Abstract
  2. Octahedral small virus-like particles of dengue virus type 2. J Virol. 2024 Dec 31; e0180924. View Abstract
  3. A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores. bioRxiv. 2024 Nov 03. View Abstract
  4. A communication hub for phosphoregulation of kinetochore-microtubule attachment. Curr Biol. 2024 Jun 03; 34(11):2308-2318.e6. View Abstract
  5. The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2. PLoS Pathog. 2024 Apr; 20(4):e1011750. View Abstract
  6. Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin. Proc Natl Acad Sci U S A. 2024 Jan 02; 121(1):e2316964120. View Abstract
  7. Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex. EMBO Rep. 2023 Dec 06; 24(12):e57702. View Abstract
  8. The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2. bioRxiv. 2023 Oct 16. View Abstract
  9. Structure of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface. Open Biol. 2023 03; 13(3):220378. View Abstract
  10. Infant Antibody Repertoires during the First Two Years of Influenza Vaccination. mBio. 2022 12 20; 13(6):e0254622. View Abstract
  11. Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle. Nat Commun. 2022 08 15; 13(1):4802. View Abstract
  12. Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1. Sci Immunol. 2022 08 12; 7(74):eabo3425. View Abstract
  13. Rotavirus VP4 Epitope of a Broadly Neutralizing Human Antibody Defined by Its Structure Bound with an Attenuated-Strain Virion. J Virol. 2022 08 24; 96(16):e0062722. View Abstract
  14. Recall of B cell memory depends on relative locations of prime and boost immunization. Sci Immunol. 2022 05 06; 7(71):eabn5311. View Abstract
  15. Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease. ACS Infect Dis. 2021 09 10; 7(9):2591-2595. View Abstract
  16. Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. Cell. 2021 09 16; 184(19):4969-4980.e15. View Abstract
  17. Differential immune imprinting by influenza virus vaccination and infection in nonhuman primates. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). View Abstract
  18. Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore. J Cell Biol. 2021 08 02; 220(8). View Abstract
  19. A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface. mBio. 2021 06 29; 12(3):e0114421. View Abstract
  20. Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. bioRxiv. 2021 Mar 10. View Abstract
  21. Structural basis of Stu2 recruitment to yeast kinetochores. Elife. 2021 02 16; 10. View Abstract
  22. Functional refolding of the penetration protein on a non-enveloped virus. Nature. 2021 02; 590(7847):666-670. View Abstract
  23. Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses. ACS Infect Dis. 2021 01 08; 7(1):1-5. View Abstract
  24. Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Science. 2021 01 08; 371(6525). View Abstract
  25. The Structural Basis for Kinetochore Stabilization by Cnn1/CENP-T. Curr Biol. 2020 09 07; 30(17):3425-3431.e3. View Abstract
  26. Structure of a nascent membrane protein as it folds on the BAM complex. Nature. 2020 07; 583(7816):473-478. View Abstract
  27. Correction: The structure of the Ctf19c/CCAN from budding yeast. Elife. 2020 Mar 05; 9. View Abstract
  28. Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife. 2020 02 28; 9. View Abstract
  29. The human dimension in contemporary biological research. Nat Struct Mol Biol. 2020 02; 27(2):107-108. View Abstract
  30. Cryoelectron Microscopy Structure of a Yeast Centromeric Nucleosome at 2.7 Å Resolution. Structure. 2020 03 03; 28(3):363-370.e3. View Abstract
  31. Structure of a rabies virus polymerase complex from electron cryo-microscopy. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2099-2107. View Abstract
  32. Cryo-EM Structure of Full-length HIV-1 Env Bound With the Fab of Antibody PG16. J Mol Biol. 2020 02 14; 432(4):1158-1168. View Abstract
  33. Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor. Cell Rep. 2020 01 07; 30(1):53-60.e5. View Abstract
  34. Affinity maturation in a human humoral response to influenza hemagglutinin. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26745-26751. View Abstract
  35. Structure of the Centromere Binding Factor 3 Complex from Kluyveromyces lactis. J Mol Biol. 2019 11 08; 431(22):4444-4454. View Abstract
  36. In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase. J Mol Biol. 2019 08 09; 431(17):3124-3138. View Abstract
  37. The structure of the yeast Ctf3 complex. Elife. 2019 06 13; 8. View Abstract
  38. Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism. Cell. 2019 05 16; 177(5):1124-1135.e16. View Abstract
  39. Self-tolerance curtails the B cell repertoire to microbial epitopes. JCI Insight. 2019 05 16; 4(10). View Abstract
  40. Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies. Sci Rep. 2019 03 05; 9(1):3492. View Abstract
  41. The structure of the Ctf19c/CCAN from budding yeast. Elife. 2019 02 14; 8. View Abstract
  42. Correction: Small-Molecule Inhibitors of Dengue-Virus Entry. PLoS Pathog. 2019 01; 15(1):e1007553. View Abstract
  43. Visualization of Calcium Ion Loss from Rotavirus during Cell Entry. J Virol. 2018 12 15; 92(24). View Abstract
  44. Structure of the membrane proximal external region of HIV-1 envelope glycoprotein. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):E8892-E8899. View Abstract
  45. Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59®-adjuvanted pandemic 2009 H1N1 vaccine. Vaccine. 2018 08 23; 36(35):5325-5332. View Abstract
  46. How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion. Elife. 2018 07 12; 7. View Abstract
  47. Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface. Science. 2018 05 04; 360(6388):552-558. View Abstract
  48. HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope. Nat Commun. 2018 03 16; 9(1):1111. View Abstract
  49. Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires. Immunity. 2018 01 16; 48(1):174-184.e9. View Abstract
  50. Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody. Proc Natl Acad Sci U S A. 2018 01 02; 115(1):168-173. View Abstract
  51. Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations. Nat Commun. 2017 11 23; 8(1):1732. View Abstract
  52. Molecular Structures of Yeast Kinetochore Subcomplexes and Their Roles in Chromosome Segregation. Cold Spring Harb Symp Quant Biol. 2017; 82:83-89. View Abstract
  53. Kinetochore Function from the Bottom Up. Trends Cell Biol. 2018 01; 28(1):22-33. View Abstract
  54. The Kinetochore Receptor for the Cohesin Loading Complex. Cell. 2017 Sep 21; 171(1):72-84.e13. View Abstract
  55. Single-Particle Detection of Transcription following Rotavirus Entry. J Virol. 2017 Sep 15; 91(18). View Abstract
  56. Pictures of the prologue to neurotransmitter release. Proc Natl Acad Sci U S A. 2017 08 22; 114(34):8920-8922. View Abstract
  57. Protein tentacles. J Struct Biol. 2017 12; 200(3):244-247. View Abstract
  58. CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol. 2017 06 16; 429(12):1829-1839. View Abstract
  59. Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer. J Virol. 2017 05 15; 91(10). View Abstract
  60. Antigenicity-defined conformations of an extremely neutralization-resistant HIV-1 envelope spike. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):4477-4482. View Abstract
  61. Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies. Sci Transl Med. 2017 03 15; 9(381). View Abstract
  62. Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial. PLoS Pathog. 2017 02; 13(2):e1006182. View Abstract
  63. Mechanism of membrane fusion induced by vesicular stomatitis virus G protein. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):E28-E36. View Abstract
  64. Conserved Tetramer Junction in the Kinetochore Ndc80 Complex. Cell Rep. 2016 11 15; 17(8):1915-1922. View Abstract
  65. Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nat Med. 2016 12; 22(12):1465-1469. View Abstract
  66. Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Cell. 2016 11 03; 167(4):1014-1027.e12. View Abstract
  67. Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores. Cell. 2016 11 03; 167(4):1028-1040.e15. View Abstract
  68. Molecular Architecture of the Yeast Monopolin Complex. Cell Rep. 2016 10 11; 17(3):929. View Abstract
  69. Immunogenic cross-talk between dengue and Zika viruses. Nat Immunol. 2016 08 19; 17(9):1010-2. View Abstract
  70. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. View Abstract
  71. Complex Antigens Drive Permissive Clonal Selection in Germinal Centers. Immunity. 2016 Mar 15; 44(3):542-552. View Abstract
  72. Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site. Cell Rep. 2016 Jan 05; 14(1):43-54. View Abstract
  73. Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site. Cell Rep. 2015 Dec 29; 13(12):2842-50. View Abstract
  74. Molecular Basis for Antibody-Mediated Neutralization of New World Hemorrhagic Fever Mammarenaviruses. Cell Host Microbe. 2015 Dec 09; 18(6):705-13. View Abstract
  75. Distinct functional determinants of influenza hemagglutinin-mediated membrane fusion. Elife. 2015 Nov 27; 4:e11009. View Abstract
  76. Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy. Cell. 2015 Jul 16; 162(2):314-327. View Abstract
  77. Structural evidence for Scc4-dependent localization of cohesin loading. Elife. 2015 Jun 03; 4:e06057. View Abstract
  78. Correction: Sequential conformational rearrangements in flavivirus membrane fusion. Elife. 2015 May 18; 4. View Abstract
  79. Viral receptor-binding site antibodies with diverse germline origins. Cell. 2015 May 21; 161(5):1026-1034. View Abstract
  80. Viral membrane fusion. Virology. 2015 May; 479-480:498-507. View Abstract
  81. Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage. Proteins. 2015 Apr; 83(4):771-80. View Abstract
  82. Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife. 2015 Feb 20; 4. View Abstract
  83. Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18542-7. View Abstract
  84. Veritas per structuram. Annu Rev Biochem. 2015; 84:37-60. View Abstract
  85. Sequential conformational rearrangements in flavivirus membrane fusion. Elife. 2014 Dec 05; 3:e04389. View Abstract
  86. Structural correlates of rotavirus cell entry. PLoS Pathog. 2014 Sep; 10(9):e1004355. View Abstract
  87. Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10275-80. View Abstract
  88. Molecular structure, function, and dynamics of clathrin-mediated membrane traffic. Cold Spring Harb Perspect Biol. 2014 May 01; 6(5):a016725. View Abstract
  89. An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation. Cell Rep. 2013 Oct 17; 5(1):29-36. View Abstract
  90. Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans. J Infect Dis. 2013 Nov 15; 208(10):1679-87. View Abstract
  91. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res. 2013 Apr; 21(2):101-6. View Abstract
  92. SNP discovery and chromosome anchoring provide the first physically-anchored hexaploid oat map and reveal synteny with model species. PLoS One. 2013; 8(3):e58068. View Abstract
  93. Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates. Elife. 2013 Feb 19; 2:e00333. View Abstract
  94. Structure of a dengue virus envelope protein late-stage fusion intermediate. J Virol. 2013 Feb; 87(4):2287-93. View Abstract
  95. Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion. J Virol. 2013 Feb; 87(3):1554-68. View Abstract
  96. Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):264-9. View Abstract
  97. Location of the dsRNA-dependent polymerase, VP1, in rotavirus particles. J Mol Biol. 2013 Jan 09; 425(1):124-32. View Abstract
  98. Movies of ice-embedded particles enhance resolution in electron cryo-microscopy. Structure. 2012 Nov 07; 20(11):1823-8. View Abstract
  99. Molecular architecture of the yeast monopolin complex. Cell Rep. 2012 Jun 28; 1(6):583-9. View Abstract
  100. B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. Nat Biotechnol. 2012 May 07; 30(5):423-33. View Abstract
  101. Small-molecule inhibitors of dengue-virus entry. PLoS Pathog. 2012; 8(4):e1002627. View Abstract
  102. Kinetics of proton transport into influenza virions by the viral M2 channel. PLoS One. 2012; 7(3):e31566. View Abstract
  103. RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure. EMBO Rep. 2012 Mar 01; 13(3):216-22. View Abstract
  104. Beam-induced motion of vitrified specimen on holey carbon film. J Struct Biol. 2012 Mar; 177(3):630-7. View Abstract
  105. Ndc10 is a platform for inner kinetochore assembly in budding yeast. Nat Struct Mol Biol. 2011 Dec 04; 19(1):48-55. View Abstract
  106. Cross-linking of rotavirus outer capsid protein VP7 by antibodies or disulfides inhibits viral entry. J Virol. 2011 Oct; 85(20):10509-17. View Abstract
  107. Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14216-21. View Abstract
  108. Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching. Nature. 2011 Jul 24; 476(7358):109-13. View Abstract
  109. Recognition of the centromere-specific histone Cse4 by the chaperone Scm3. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9367-71. View Abstract
  110. Molecular structures and interactions in the yeast kinetochore. Cold Spring Harb Symp Quant Biol. 2010; 75:395-401. View Abstract
  111. Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy. Curr Opin Struct Biol. 2011 Apr; 21(2):265-73. View Abstract
  112. Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating. Nat Struct Mol Biol. 2011 Mar; 18(3):295-301. View Abstract
  113. Atomic model of an infectious rotavirus particle. EMBO J. 2011 Jan 19; 30(2):408-16. View Abstract
  114. Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators. J Med Chem. 2011 Jan 13; 54(1):78-94. View Abstract
  115. Mechanistic biology in the next quarter century. Mol Biol Cell. 2010 Nov 15; 21(22):3799-800. View Abstract
  116. Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure. 2010 Oct 13; 18(10):1311-20. View Abstract
  117. Peptide inhibitors of flavivirus entry derived from the E protein stem. J Virol. 2010 Dec; 84(24):12549-54. View Abstract
  118. Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding. Structure. 2010 Sep 08; 18(9):1191-8. View Abstract
  119. Virology. Looking inside adenovirus. Science. 2010 Aug 27; 329(5995):1026-7. View Abstract
  120. Structural biology: Conservation in vesicle coats. Nature. 2010 Aug 26; 466(7310):1048-9. View Abstract
  121. The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell. 2010 Aug 20; 142(4):556-67. View Abstract
  122. CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule. Dev Cell. 2010 Aug 17; 19(2):245-58. View Abstract
  123. Analysis of kinetic intermediates in single-particle dwell-time distributions. Biophys J. 2010 Jul 21; 99(2):360-6. View Abstract
  124. Climate change and the integrity of science. Science. 2010 May 07; 328(5979):689-90. View Abstract
  125. Peptide inhibitors of dengue-virus entry target a late-stage fusion intermediate. PLoS Pathog. 2010 Apr 08; 6(4):e1000851. View Abstract
  126. Effect of mutations in VP5 hydrophobic loops on rotavirus cell entry. J Virol. 2010 Jun; 84(12):6200-7. View Abstract
  127. Subunit interactions in bovine papillomavirus. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6298-303. View Abstract
  128. Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol. 2010 Apr; 17(4):438-44. View Abstract
  129. X-ray crystal structure of the rotavirus inner capsid particle at 3.8 A resolution. J Mol Biol. 2010 Mar 26; 397(2):587-99. View Abstract
  130. Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly. EMBO J. 2010 Feb 03; 29(3):655-65. View Abstract
  131. A rotavirus spike protein conformational intermediate binds lipid bilayers. J Virol. 2010 Feb; 84(4):1764-70. View Abstract
  132. Role of HIV membrane in neutralization by two broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20234-9. View Abstract
  133. Method for measurement of viral fusion kinetics at the single particle level. J Vis Exp. 2009 Sep 07; (31). View Abstract
  134. VP5* rearranges when rotavirus uncoats. J Virol. 2009 Nov; 83(21):11372-7. View Abstract
  135. Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab. Science. 2009 Jun 12; 324(5933):1444-7. View Abstract
  136. Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10644-8. View Abstract
  137. Requirements for the formation of membrane pores by the reovirus myristoylated micro1N peptide. J Virol. 2009 Jul; 83(14):7004-14. View Abstract
  138. Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure. 2008 Nov 12; 16(11):1678-88. View Abstract
  139. The pH sensor for flavivirus membrane fusion. J Cell Biol. 2008 Oct 20; 183(2):177-9. View Abstract
  140. Single-particle kinetics of influenza virus membrane fusion. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15382-7. View Abstract
  141. Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein. Mol Biol Cell. 2008 Oct; 19(10):4480-91. View Abstract
  142. Viral membrane fusion. Nat Struct Mol Biol. 2008 Jul; 15(7):690-8. View Abstract
  143. Peptides released from reovirus outer capsid form membrane pores that recruit virus particles. EMBO J. 2008 Apr 23; 27(8):1289-98. View Abstract
  144. Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1867-72. View Abstract
  145. XMAP215 is a processive microtubule polymerase. Cell. 2008 Jan 11; 132(1):79-88. View Abstract
  146. Three-dimensional intricacies in protein-DNA recognition and transcriptional control. Nat Struct Mol Biol. 2007 Dec; 14(12):1118-9. View Abstract
  147. Comments on the NIGMS PSI. Structure. 2007 Nov; 15(11):1344-6. View Abstract
  148. Crystal structure of the yeast inner kinetochore subunit Cep3p. Structure. 2007 Nov; 15(11):1422-30. View Abstract
  149. Interactions of lipids with aquaporin-0 and other membrane proteins. Pflugers Arch. 2008 Jul; 456(4):651-61. View Abstract
  150. Structure and function of an essential component of the outer membrane protein assembly machine. Science. 2007 Aug 17; 317(5840):961-4. View Abstract
  151. An atomic model of the interferon-beta enhanceosome. Cell. 2007 Jun 15; 129(6):1111-23. View Abstract
  152. Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch. J Biol Chem. 2007 Aug 03; 282(31):22816-22. View Abstract
  153. Protein arms in the kinetochore-microtubule interface of the yeast DASH complex. Mol Biol Cell. 2007 Jul; 18(7):2503-10. View Abstract
  154. Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction. J Mol Biol. 2007 Jun 22; 369(5):1296-306. View Abstract
  155. Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding. Structure. 2007 Mar; 15(3):355-62. View Abstract
  156. Structural analysis of Bub3 interactions in the mitotic spindle checkpoint. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1201-6. View Abstract
  157. The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment. Nat Struct Mol Biol. 2007 Jan; 14(1):54-9. View Abstract
  158. Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol. 2007 Jan 19; 365(3):892-9. View Abstract
  159. Restraining the conformation of HIV-1 gp120 by removing a flexible loop. EMBO J. 2006 Oct 18; 25(20):5026-35. View Abstract
  160. Reovirus mu1 structural rearrangements that mediate membrane penetration. J Virol. 2006 Dec; 80(24):12367-76. View Abstract
  161. Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion. Proc Natl Acad Sci U S A. 2006 Sep 19; 103(38):13938-43. View Abstract
  162. Crystal structure of glycoprotein B from herpes simplex virus 1. Science. 2006 Jul 14; 313(5784):217-20. View Abstract
  163. Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy. J Struct Biol. 2006 Dec; 156(3):453-60. View Abstract
  164. Conformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomain. J Virol. 2006 Jul; 80(14):6794-800. View Abstract
  165. Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure. 2006 Jun; 14(6):1003-9. View Abstract
  166. Stu2p binds tubulin and undergoes an open-to-closed conformational change. J Cell Biol. 2006 Mar 27; 172(7):1009-22. View Abstract
  167. Interactions between SARS coronavirus and its receptor. Adv Exp Med Biol. 2006; 581:229-34. View Abstract
  168. SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. J Biol Chem. 2006 Feb 10; 281(6):3198-203. View Abstract
  169. Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature. 2005 Dec 01; 438(7068):633-8. View Abstract
  170. Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques. J Mol Biol. 2006 Feb 03; 355(5):1048-65. View Abstract
  171. Single particle reconstruction of the human apo-transferrin-transferrin receptor complex. J Struct Biol. 2005 Dec; 152(3):204-10. View Abstract
  172. Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution. Structure. 2005 Oct; 13(10):1545-57. View Abstract
  173. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science. 2005 Sep 16; 309(5742):1864-8. View Abstract
  174. Dissecting the Structure and Function of the Orthoreovirus µ1 ('Penetrini') Protein at 7.0-Å and Higher Resolution. Microsc Microanal. 2005 Aug; 11 Suppl 2:1070-1. View Abstract
  175. The active conformation of the PAK1 kinase domain. Structure. 2005 May; 13(5):769-78. View Abstract
  176. Molecular organization of the Ndc80 complex, an essential kinetochore component. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5363-7. View Abstract
  177. Structure of an unliganded simian immunodeficiency virus gp120 core. Nature. 2005 Feb 24; 433(7028):834-41. View Abstract
  178. Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein. Structure. 2005 Feb; 13(2):197-211. View Abstract
  179. The yeast DASH complex forms closed rings on microtubules. Nat Struct Mol Biol. 2005 Feb; 12(2):138-43. View Abstract
  180. Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein. J Virol. 2005 Jan; 79(2):1223-31. View Abstract
  181. Mechanism of membrane fusion by viral envelope proteins. Adv Virus Res. 2005; 64:231-61. View Abstract
  182. Crystal structure of the spindle assembly checkpoint protein Bub3. J Mol Biol. 2004 Dec 03; 344(4):885-92. View Abstract
  183. Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16268-73. View Abstract
  184. Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. EMBO J. 2004 Nov 10; 23(22):4384-93. View Abstract
  185. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 02; 432(7017):573-9. View Abstract
  186. Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature. 2004 Dec 02; 432(7017):649-53. View Abstract
  187. Crystal structure of the clathrin adaptor protein 1 core. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14108-13. View Abstract
  188. Structural rearrangements in the membrane penetration protein of a non-enveloped virus. Nature. 2004 Aug 26; 430(7003):1053-8. View Abstract
  189. Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13147-51. View Abstract
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