Dr. Vajapeyam's research interests are in the areas of MR image and data processing, with special emphasis on brain tumors and diffusion. His research goals include: Developing image and data analysis methods for magnetic resonance imaging and magnetic resonance spectroscopy Studying white matter development of the human brain in infancy and childhood Diffusion tensor imaging and tractography in the human brain Applications of magnetic resonance methods for the characterization, assessment and treatment of human brain neoplasms
Research Background
Dr. Vajapeyam did his undergraduate work in mechanical engineering at the Indian Institute of Technology in Madras, India. He earned his ME and PhD degrees in mechanical engineering from the University of Delaware and completed a 3-year postdoctoral fellowship at Children’s Hospital Boston in 1997.
Publications
Multimodal deep learning improves recurrence risk prediction in pediatric low-grade gliomas. Neuro Oncol. 2025 Jan 12; 27(1):277-290. View Abstract
A foundation model for generalized brain MRI analysis. medRxiv. 2024 Dec 03. View Abstract
Stepwise Transfer Learning for Expert-level Pediatric Brain Tumor MRI Segmentation in a Limited Data Scenario. Radiol Artif Intell. 2024 Jul; 6(4):e230254. View Abstract
Longitudinal risk prediction for pediatric glioma with temporal deep learning. medRxiv. 2024 Jun 28. View Abstract
Noninvasive Molecular Subtyping of Pediatric Low-Grade Glioma with Self-Supervised Transfer Learning. Radiol Artif Intell. 2024 May; 6(3):e230333. View Abstract
Noninvasive molecular subtyping of pediatric low-grade glioma with self-supervised transfer learning. medRxiv. 2023 Nov 22. View Abstract
Automated temporalis muscle quantification and growth charts for children through adulthood. Nat Commun. 2023 11 09; 14(1):6863. View Abstract
Expert-level pediatric brain tumor segmentation in a limited data scenario with stepwise transfer learning. medRxiv. 2023 Sep 18. View Abstract
Correlation between Multiparametric MR Imaging and Molecular Genetics in Pontine Pediatric High-Grade Glioma. AJNR Am J Neuroradiol. 2023 07; 44(7):833-840. View Abstract
Changes in Bone Marrow Adipose Tissue in Transgender and Gender Non-Conforming Youth Undergoing Pubertal Suppression: A Pilot Study. J Clin Densitom. 2022 Oct-Dec; 25(4):485-489. View Abstract
Bone density and bone marrow composition in transgender girls prior to pubertal blockade: A case series. Bone. 2022 09; 162:116454. View Abstract
Bone marrow adiposity in pediatric Crohn's disease. Bone. 2022 09; 162:116453. View Abstract
ADC Histogram Analysis of Pediatric Low-Grade Glioma Treated with Selumetinib: A Report from the Pediatric Brain Tumor Consortium. AJNR Am J Neuroradiol. 2022 03; 43(3):455-461. View Abstract
MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma. AJNR Am J Neuroradiol. 2020 05; 41(5):874-881. View Abstract
Advanced ADC Histogram, Perfusion, and Permeability Metrics Show an Association with Survival and Pseudoprogression in Newly Diagnosed Diffuse Intrinsic Pontine Glioma: A Report from the Pediatric Brain Tumor Consortium. AJNR Am J Neuroradiol. 2020 04; 41(4):718-724. View Abstract
Quantifying radiation therapy response using apparent diffusion coefficient (ADC) parametric mapping of pediatric diffuse intrinsic pontine glioma: a report from the pediatric brain tumor consortium. J Neurooncol. 2019 May; 143(1):79-86. View Abstract
MR Imaging-Based Radiomic Signatures of Distinct Molecular Subgroups of Medulloblastoma. AJNR Am J Neuroradiol. 2019 01; 40(1):154-161. View Abstract
Magnetic resonance imaging and spectroscopy evidence of efficacy for adrenal and gonadal hormone replacement therapy in anorexia nervosa. Bone. 2018 05; 110:335-342. View Abstract
Multiparametric Analysis of Permeability and ADC Histogram Metrics for Classification of Pediatric Brain Tumors by Tumor Grade. AJNR Am J Neuroradiol. 2018 Mar; 39(3):552-557. View Abstract
Bone marrow fat content in 70 adolescent girls with anorexia nervosa: Magnetic resonance imaging and magnetic resonance spectroscopy assessment. Pediatr Radiol. 2017 Jul; 47(8):952-962. View Abstract
Correlation of 18F-FDG PET and MRI Apparent Diffusion Coefficient Histogram Metrics with Survival in Diffuse Intrinsic Pontine Glioma: A Report from the Pediatric Brain Tumor Consortium. J Nucl Med. 2017 08; 58(8):1264-1269. View Abstract
Automated Processing of Dynamic Contrast-Enhanced MRI: Correlation of Advanced Pharmacokinetic Metrics with Tumor Grade in Pediatric Brain Tumors. AJNR Am J Neuroradiol. 2017 Jan; 38(1):170-175. View Abstract
Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor Consortium. Neuro Oncol. 2016 05; 18(5):725-34. View Abstract
A phase I trial and PK study of cediranib (AZD2171), an orally bioavailable pan-VEGFR inhibitor, in children with recurrent or refractory primary CNS tumors. Childs Nerv Syst. 2015 Sep; 31(9):1433-45. View Abstract
Pediatric brain tumor consortium multisite assessment of apparent diffusion coefficient z-axis variation assessed with an ice-water phantom. Acad Radiol. 2015 Mar; 22(3):363-9. View Abstract
White matter microstructure and cognition in adolescents with congenital heart disease. J Pediatr. 2014 Nov; 165(5):936-44.e1-2. View Abstract
18F-FDG PET and MR imaging associations across a spectrum of pediatric brain tumors: a report from the pediatric brain tumor consortium. J Nucl Med. 2014 Sep; 55(9):1473-80. View Abstract
Efficacy of bevacizumab plus irinotecan in children with recurrent low-grade gliomas--a Pediatric Brain Tumor Consortium study. Neuro Oncol. 2014 Jan; 16(2):310-7. View Abstract
Exploratory evaluation of MR permeability with 18F-FDG PET mapping in pediatric brain tumors: a report from the Pediatric Brain Tumor Consortium. J Nucl Med. 2013 Aug; 54(8):1237-43. View Abstract
Adolescents with D-transposition of the great arteries repaired in early infancy demonstrate reduced white matter microstructure associated with clinical risk factors. J Thorac Cardiovasc Surg. 2013 Sep; 146(3):543-9.e1. View Abstract
Lack of efficacy of bevacizumab + irinotecan in cases of pediatric recurrent ependymoma--a Pediatric Brain Tumor Consortium study. Neuro Oncol. 2012 Nov; 14(11):1404-12. View Abstract
The use of magnetic resonance imaging to predict ACL graft structural properties. J Biomech. 2011 Nov 10; 44(16):2843-6. View Abstract
MRI as a central component of clinical trials analysis in brainstem glioma: a report from the Pediatric Brain Tumor Consortium (PBTC). Neuro Oncol. 2011 Apr; 13(4):417-27. View Abstract
Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium. J Nucl Med. 2011 Feb; 52(2):188-95. View Abstract
DTI assessment of the brainstem white matter tracts in pediatric BSG before and after therapy: a report from the Pediatric Brain Tumor Consortium. Childs Nerv Syst. 2011 Jan; 27(1):11-8. View Abstract
Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study. J Clin Oncol. 2010 Jun 20; 28(18):3069-75. View Abstract
Bone marrow changes in adolescent girls with anorexia nervosa. J Bone Miner Res. 2010 Feb; 25(2):298-304. View Abstract
Catheter angiography, MR angiography, and MR perfusion in posterior reversible encephalopathy syndrome. AJNR Am J Neuroradiol. 2009 Feb; 30(2):E19; author reply E20. View Abstract
The Neuroimaging Center of the Pediatric Brain Tumor Consortium-collaborative neuroimaging in pediatric brain tumor research: a work in progress. AJNR Am J Neuroradiol. 2007 Apr; 28(4):603-7. View Abstract
Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme. J Neurooncol. 2007 Mar; 82(1):95-101. View Abstract
Magnetization transfer studies of the fast and slow tissue water diffusion components in the human brain. NMR Biomed. 2005 May; 18(3):186-94. View Abstract
Fat fractions and spectral T2 values in vertebral bone marrow in HIV- and non-HIV-infected men: a 1H spectroscopic imaging study. Magn Reson Med. 2004 Sep; 52(3):552-8. View Abstract
Prolonged T*2 values in newborn versus adult brain: Implications for fMRI studies of newborns. Magn Reson Med. 2004 Jun; 51(6):1287-91. View Abstract
Early experience alters brain function and structure. Pediatrics. 2004 Apr; 113(4):846-57. View Abstract
Biexponential diffusion tensor analysis of human brain diffusion data. Magn Reson Med. 2004 Feb; 51(2):321-30. View Abstract
Normal and ischemic epiphysis of the femur: diffusion MR imaging study in piglets. Radiology. 2003 Jun; 227(3):825-32. View Abstract
A functional magnetic resonance imaging study of paced finger tapping in children. Pediatr Neurol. 2003 Feb; 28(2):89-95. View Abstract
Biexponential apparent diffusion coefficient parametrization in adult vs newborn brain. Magn Reson Imaging. 2001 Jun; 19(5):659-68. View Abstract