Information

Related Research Units

Immunology Research
Zanoni Lab Research

Research Overview

Sreya Ghosh is an immunologist working on infectious diseases and cancer. She trained with Dr. Katherine Fitzgerald working on innate immune responses, inflammation, and immune gene regulation. At Boston Children's Hospital, she's a research fellow with Dr. Ivan Zanoni and works on understanding the role of Type III Interferons in diseases. Her research involves deciphering the unique abilities of Type III Interferons in infection, inflammation and tumorigenesis, to facilitate their clinical translation and create effective interventions in diseases such as respiratory infections, IBD and colon cancer.

Research Background

Sreya Ghosh completed her B.Sc. & M.Sc. in Biochemistry from University of Calcutta, India. She received her Ph.D. in Immunology & Microbiology from University of Massachusetts Medical School, USA under the guidance of Dr. Kate Fitzgerald. Currently, Dr. Ghosh is a postdoctoral research fellow in Dr. Ivan Zanoni's group at Harvard Medical School & Boston Children's Hospital.

Formerly the co-chair of the Career Development Committee, since 2020, Dr. Ghosh serves as the Co-President of Boston Children's Postdoc Association. Outside of science, Sreya enjoys experimenting with different cuisines, exploring different cultures, dancing, literature, art, and history.

Publications

  1. Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons. Annu Rev Immunol. 2026 Jan 02. View Abstract
  2. The Dark Knight: Functional Reprogramming of Neutrophils in the Pathogenesis of Colitis-Associated Cancer. Cancer Immunol Res. 2024 Oct 01; 12(10):1311-1319. View Abstract
  3. Origin and evolution of the bread wheat D genome. Nature. 2024 Sep; 633(8031):848-855. View Abstract
  4. Chromosome-scale genome assembly of bread wheat's wild relative Triticum timopheevii. Sci Data. 2024 04 23; 11(1):420. View Abstract
  5. Evaluation of the impact of iPSC differentiation protocols on transcriptomic signatures. Toxicol In Vitro. 2024 Jun; 98:105826. View Abstract
  6. Permanent, Antimicrobial Coating to Rapidly Kill and Prevent Transmission of Bacteria, Fungi, Influenza, and SARS-CoV-2. ACS Appl Mater Interfaces. 2022 Sep 21; 14(37):42483-42493. View Abstract
  7. An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat. Toxicol In Vitro. 2022 Jun; 81:105333. View Abstract
  8. Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement. Nat Biotechnol. 2022 03; 40(3):422-431. View Abstract
  9. Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections. Immunity. 2021 06 08; 54(6):1186-1199.e7. View Abstract
  10. Viral Respiratory Pathogens and Lung Injury. Clin Microbiol Rev. 2021 06 16; 34(3). View Abstract
  11. PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells. Cell Death Dis. 2021 01 14; 12(1):84. View Abstract
  12. The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans. Nat Commun. 2020 12 11; 11(1):6348. View Abstract
  13. Type III interferons disrupt the lung epithelial barrier upon viral recognition. Science. 2020 08 07; 369(6504):706-712. View Abstract
  14. A roadmap for gene functional characterisation in crops with large genomes: Lessons from polyploid wheat. Elife. 2020 03 24; 9. View Abstract
  15. A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1ß Release in Response to a Pathogenic Fungus. J Infect Dis. 2018 01 04; 217(2):329-339. View Abstract
  16. The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression. J Immunol. 2017 11 01; 199(9):3249-3260. View Abstract
  17. Inclusion of Population-specific Reference Panel from India to the 1000 Genomes Phase 3 Panel Improves Imputation Accuracy. Sci Rep. 2017 07 27; 7(1):6733. View Abstract

Contact Sreya Ghosh

Phone: 617-919-2548
Email:
Print Profile