Information

Related Research Units

Genetics and Genomics Research
Walsh Laboratory Research

Research Overview

Sangita Choudhury obtained her Ph.D. in cell biology and molecular cardiology in the lab of Stephan B Felix from the University of Greifswald, Germany. Sangita studied the mechanism of heart failure and cardiac regeneration during her postdoctoral fellowship. Her primary research interest is to investigate the genetics of human disease from a translational viewpoint by combining her expertise in clinical medicine, basic biology, and bioinformatics. Her research project is being funded by the Boston Children's Hospital's Office of Faculty Development and the American Heart Association.

Publications

  1. Somatic Genomic and Transcriptomic Changes in Single Ischemic Human Heart Cardiomyocytes. Res Sq. 2025 Jan 31. View Abstract
  2. N-cadherin antagonism is bronchoprotective in severe asthma models. Sci Adv. 2024 Nov 29; 10(48):eadp8872. View Abstract
  3. Contributions of Germline and Somatic Mosaic Genetics to Thoracic Aortic Aneurysms in Nonsyndromic Individuals. J Am Heart Assoc. 2024 Jul 16; 13(14):e033232. View Abstract
  4. Single-nucleus multi-omic profiling of polyploid heart nuclei identifies fusion-derived cardiomyocytes in the human heart. Res Sq. 2024 May 30. View Abstract
  5. RASopathies and cardiac manifestations. Front Cardiovasc Med. 2023; 10:1176828. View Abstract
  6. High-quality nuclei isolation from postmortem human heart muscle tissues for single-cell studies. J Mol Cell Cardiol. 2023 06; 179:7-17. View Abstract
  7. High-Quality Nuclei Isolation from Postmortem Human Heart Muscle Tissues for Single-Cell Studies. bioRxiv. 2023 Feb 05. View Abstract
  8. Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity. Nat Aging. 2022 08; 2(8):714-725. View Abstract
  9. Landscape of somatic mutations in aging human heart muscle cells. Nat Aging. 2022 08; 2(8):686-687. View Abstract
  10. Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration. Dev Cell. 2020 04 06; 53(1):42-59.e11. View Abstract
  11. Control of cytokinesis by ß-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment. Sci Transl Med. 2019 10 09; 11(513). View Abstract
  12. Thoracic aortic aneurysm in patients with loss of function Filamin A mutations: Clinical characterization, genetics, and recommendations. Am J Med Genet A. 2018 02; 176(2):337-350. View Abstract
  13. Cover Image, Volume 176A, Number 2, February 2018. Am J Med Genet A. 2018 Feb; 176(2):i. View Abstract
  14. Identification of Novel Non-secosteroidal Vitamin D Receptor Agonists with Potent Cardioprotective Effects and ??devoid of Hypercalcemia. Sci Rep. 2017 08 16; 7(1):8427. View Abstract
  15. Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window. Sci Transl Med. 2015 Apr 01; 7(281):281ra45. View Abstract
  16. Abnormal calcium handling and exaggerated cardiac dysfunction in mice with defective vitamin d signaling. PLoS One. 2014; 9(9):e108382. View Abstract
  17. Antibodies against potassium channel interacting protein 2 induce necrosis in isolated rat cardiomyocytes. J Cell Biochem. 2014 Apr; 115(4):678-89. View Abstract
  18. Moderate and high amounts of tamoxifen in aMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death. Dis Model Mech. 2013 Nov; 6(6):1459-69. View Abstract
  19. Preventing progression of cardiac hypertrophy and development of heart failure by paricalcitol therapy in rats. Cardiovasc Res. 2011 Sep 01; 91(4):632-9. View Abstract
  20. Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusion. Basic Res Cardiol. 2011 May; 106(3):397-407. View Abstract
  21. Delayed activation of caspase-independent apoptosis during heart failure in transgenic mice overexpressing caspase inhibitor CrmA. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1374-81. View Abstract
  22. Role of AIF in cardiac apoptosis in hypertrophic cardiomyocytes from Dahl salt-sensitive rats. Cardiovasc Res. 2010 Jan 01; 85(1):28-37. View Abstract

Contact Sangita Choudhury

Phone: 617-355-8246
Fax: 617-730-0641
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