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Related Research Units

Endocrinology Research

Research Overview

The main focus of our research is to delineate the underlying molecular mechanisms by which type 2 diabetes and insulin resistance develop in obesity and also understand the cause of obesity. We are dedicated to understanding the insulin signaling pathways and identifying key metabolic molecules that determines the cell's fate and leads to pathophysiology in obesity. Our current work is mainly focused on understanding the role of BRD7 in glucose metabolism and ER homeostasis. The ultimate goal of our research is to identify a therapeutic target for the treatment of type 2 diabetes and obesity.

Publications

  1. BRD7 regulates the insulin-signaling pathway by increasing phosphorylation of GSK3ß. Cell Mol Life Sci. 2018 05; 75(10):1857-1869. View Abstract
  2. Inflammation Improves Glucose Homeostasis through IKKß-XBP1s Interaction. Cell. 2016 11 03; 167(4):1052-1066.e18. View Abstract
  3. The role of BRD7 in embryo development and glucose metabolism. J Cell Mol Med. 2016 08; 20(8):1561-70. View Abstract
  4. High-efficiency lentiviral transduction of primary human CD34? hematopoietic cells with low-dose viral inocula. Biotechnol Lett. 2015 Feb; 37(2):281-8. View Abstract
  5. BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K. Cell Metab. 2014 Jul 01; 20(1):73-84. View Abstract
  6. Potential for therapeutic manipulation of the UPR in disease. Semin Immunopathol. 2013 May; 35(3):351-73. View Abstract
  7. p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nat Med. 2011 Sep 04; 17(10):1251-60. View Abstract
  8. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med. 2011 Mar; 17(3):356-65. View Abstract
  9. Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19320-5. View Abstract
  10. The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat Med. 2010 Apr; 16(4):429-37. View Abstract
  11. Requirement of the JNK-associated Bcl-2 pathway for human lactoferrin-induced apoptosis in the Jurkat leukemia T cell line. Biochimie. 2009 Jan; 91(1):102-8. View Abstract
  12. Long-term expression of von Willebrand Factor by a VSV-G pseudotyped lentivirus enhances the functional activity of secreted B-Domain-deleted Coagulation Factor VIII. Mol Cells. 2007 Aug 31; 24(1):125-31. View Abstract
  13. A stable gene transfer system for hematopoietic progenitor cells from human bone marrow using pseudotyped retroviral vectors. Mol Cells. 2004 Apr 30; 17(2):297-303. View Abstract

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