Dr. Nurko's research focuses on Gastrointestinal Motility Disorders in children. His main interest is in the areas of mechanisms of defecation and fecal continence, constipation, non-acid reflux , functional bowel disorders, pseudo-obstruction, postoperative problems after GI surgery and Hirschsprung's disease. He is actively involved in a number of clinical trials and outcomes research studies .
The main goals of Dr. Nurko's research, is to:
Determine the mechanisms for fecal continence in children
Determine the role that non-acid reflux plays in children with gastroesophageal reflux disease
Find better treatments for children with motility disorders
Genetic mutations in children with gastroparesis and pseudobstruction
mRNA patterns in gastric mucosa of children with gastroparesis, pseudobstruction and constipation
Validation of new methods to establish gastric emptying
New methods for the study of intestinal motility
Use of high resolution manometry in children with motility disorders
Research Background
Dr. Nurko was awarded his MD from the Universidad Nacional Autonoma de Mexico. Residency and fellowship was completed at Children's Hospital, Boston.
Education
Medical School
University Nacional Autonoma de Mexico
1981
Mexico City
Mexico
Internship
Boston City Hospital
1982
Boston
MA
Residency
Massachusetts General Hospital
1984
Boston
MA
Fellowship
Boston Children's Hospital
1987
Boston
MA
Media
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Nuestros Médicos
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Publications
Rome Foundation Working Team Report on overlap in disorders of gut-brain interaction. Nat Rev Gastroenterol Hepatol. 2025 Jan 27. View Abstract
Disorders of secondary peristalsis are associated with the development of esophagitis. Neurogastroenterol Motil. 2024 Dec; 36(12):e14943. View Abstract
Achieving Enteral Autonomy in Children with Intestinal Failure Following Inpatient Admission: A Case Series. J Pediatr. 2024 Dec; 275:114226. View Abstract
Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility. Neurogastroenterol Motil. 2024 Oct; 36(10):e14869. View Abstract
Safety and efficacy of linaclotide in children aged 2-5 years with functional constipation: Phase 2, randomized study. J Pediatr Gastroenterol Nutr. 2024 Sep; 79(3):510-518. View Abstract
Impact of Coronavirus disease 2019 pandemic in children with functional abdominal pain disorders: Data from long-term follow-up. J Pediatr Gastroenterol Nutr. 2024 Jul; 79(1):26-34. View Abstract
Randomized controlled trial of linaclotide in children aged 6-17 years with functional constipation. J Pediatr Gastroenterol Nutr. 2024 May; 78(5):1059-1068. View Abstract
A multicenter registry study on percutaneous electrical nerve field stimulation for pediatric disorders of gut-brain interaction. J Pediatr Gastroenterol Nutr. 2024 Apr; 78(4):817-826. View Abstract
Efficacy and safety of linaclotide in treating functional constipation in paediatric patients: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial. Lancet Gastroenterol Hepatol. 2024 Mar; 9(3):238-250. View Abstract
Safety and efficacy of linaclotide in children aged 7-17 years with irritable bowel syndrome with constipation. J Pediatr Gastroenterol Nutr. 2024 Mar; 78(3):539-547. View Abstract
The utility of balloon-based and standard impedance technology to diagnose esophageal mucosal diseases in children. Neurogastroenterol Motil. 2024 Mar; 36(3):e14726. View Abstract
The Effect of Dexmedetomidine Sedation on Lower Gastrointestinal Motility in Children-Is It Suitable for Anorectal Manometry? J Clin Med. 2023 Dec 04; 12(23). View Abstract
The Clinical Utility of Antroduodenal Manometry in the Evaluation of Children with Upper Gastrointestinal Symptoms. J Pediatr Gastroenterol Nutr. 2023 12 01; 77(6):734-740. View Abstract
Simultaneous Colonic Pressure Waves in Children and Young Adults with Gastrointestinal Motility Disorders: Artefact or Colonic Physiology? J Clin Med. 2023 Sep 06; 12(18). View Abstract
First study to assess the reliability of commonly used pain scales in children with disorders of gut-brain interaction. Neurogastroenterol Motil. 2023 09; 35(9):e14636. View Abstract
Award Recipients for Pediatric Gastroenterology: A Descriptive Analysis of Gender Distribution. J Pediatr Gastroenterol Nutr. 2023 12 01; 77(6):e99-e103. View Abstract
Clinical Utility of Ileal Motility in Children With Defecation Disorders and Children With Chronic Intestinal Pseudo-Obstruction. J Pediatr Gastroenterol Nutr. 2023 09 01; 77(3):327-331. View Abstract
Efficacy of Oral Psyllium in Pediatric Irritable Bowel Syndrome: A Double-Blind Randomized Control Trial. J Pediatr Gastroenterol Nutr. 2023 08 01; 77(2):e49-e50. View Abstract
Clinical utility of colonic low-amplitude propagating contractions in children with functional constipation. Neurogastroenterol Motil. 2023 05; 35(5):e14543. View Abstract
Differences in rectoanal inhibitory reflex duration between patients with refractory functional constipationand myelomeningocele. Arch Argent Pediatr. 2023 04 01; 121(2):e202202598. View Abstract
Airway Impedance: A Novel Diagnostic Tool to Predict Extraesophageal Airway Inflammation. J Pediatr. 2023 05; 256:5-10.e2. View Abstract
Author response to letter to the editor. Neurogastroenterol Motil. 2022 Dec; 34(12):e14478. View Abstract
A Quality Improvement Initiative to Reduce Abdominal X-ray use in Pediatric Patients Presenting with Constipation. J Pediatr. 2022 12; 251:127-133. View Abstract
Diverting Ileostomy in Children With Functional Constipation: A Study Evaluating the Utility of Colon Manometry. J Pediatr Gastroenterol Nutr. 2022 11 01; 75(5):578-583. View Abstract
A prospective study of intrapyloric botulinum toxin and EndoFLIP in children with nausea and vomiting. Neurogastroenterol Motil. 2022 Nov; 34(11):e14428. View Abstract
Pediatric Aspects of Nutrition Interventions for Disorders of Gut-Brain Interaction. Am J Gastroenterol. 2022 06 01; 117(6):995-1009. View Abstract
Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial. JAMA Pediatr. 2022 04 01; 176(4):349-356. View Abstract
International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature. Clin Gastroenterol Hepatol. 2022 11; 20(11):2474-2484.e3. View Abstract
The Utility of Functional Luminal Imaging Probes Measurements to Diagnose Dysmotility and Their Relationship to Impaired Bolus Clearance. J Pediatr Gastroenterol Nutr. 2022 04 01; 74(4):523-528. View Abstract
Autoimmune gastrointestinal dysmotility following SARS-CoV-2 infection successfully treated with intravenous immunoglobulin. Neurogastroenterol Motil. 2022 07; 34(7):e14314. View Abstract
Can Propofol Be Used to Assess the Presence of the Rectoanal Inhibitory Reflex During Anorectal Manometry Studies? J Pediatr Gastroenterol Nutr. 2022 01 01; 74(1):33-37. View Abstract
Prucalopride for Treatment of Upper Gastrointestinal Symptoms in Children. Paediatr Drugs. 2022 Jan; 24(1):73-81. View Abstract
Impact of Coronavirus Disease 2019 on the Pediatric Population with Aerodigestive Disease. J Pediatr. 2022 04; 243:14-20.e1. View Abstract
Overall Impact of Coronavirus Disease 2019 Outbreak in Children With Functional Abdominal Pain Disorders: Results From the First Pandemic Phase. J Pediatr Gastroenterol Nutr. 2021 12 01; 73(6):689-694. View Abstract
Bile Acid Diarrhea in Adults and Adolescents. Neurogastroenterol Motil. 2022 04; 34(4):e14287. View Abstract
Melanosis Coli Is Not Associated with Colonic Dysmotility Nor Severity of Pediatric Functional Constipation. Dig Dis Sci. 2022 08; 67(8):3922-3928. View Abstract
Pharmacogenomics fail to explain proton pump inhibitor refractory esophagitis in pediatric esophageal atresia. Neurogastroenterol Motil. 2022 01; 34(1):e14217. View Abstract
A Collaborative Effort to Advance Drug Development in Pediatric Constipation and Irritable Bowel Syndrome. J Pediatr Gastroenterol Nutr. 2021 08 01; 73(2):145-149. View Abstract
A Review of the Evidence and Recommendations on Communication Skills and the Patient-Provider Relationship: A Rome Foundation Working Team Report. Gastroenterology. 2021 11; 161(5):1670-1688.e7. View Abstract
Duodenal and proximal jejunal motility inhibition associated with bisacodyl-induced colonic high-amplitude propagating contractions. Am J Physiol Gastrointest Liver Physiol. 2021 09 01; 321(3):G325-G334. View Abstract
Response to Febo-Rodriguez et al. Am J Gastroenterol. 2021 07 01; 116(7):1553. View Abstract
Markers of Bile Acid Metabolism in Pediatric Diarrhea Predominant Irritable Bowel Syndrome and Healthy Controls. J Pediatr Gastroenterol Nutr. 2021 06 01; 72(6):859-865. View Abstract
Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-Blind Study With Long-term Extension. Clin Gastroenterol Hepatol. 2022 03; 20(3):602-610.e5. View Abstract
Healthcare spending and utilization for pediatric Irritable Bowel Syndrome in a commercially insured population. Neurogastroenterol Motil. 2021 11; 33(11):e14147. View Abstract
Evaluation of Fecal Incontinence in Pediatric Functional Constipation: Clinical Utility of Anorectal and Colon Manometry. J Pediatr Gastroenterol Nutr. 2021 03 01; 72(3):361-365. View Abstract
Development of Entrustable Professional Activities and Standards in Training in Pediatric Neurogastroenterology and Motility: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and American Neurogastroenterology and Motility Society Position Paper. J Pediatr Gastroenterol Nutr. 2021 01 01; 72(1):168-180. View Abstract
The Golden Half Hour in Chronic Pediatric Pain-Feedback as the First Intervention. JAMA Pediatr. 2021 01 01; 175(1):7-8. View Abstract
Diagnostic and clinical utility of the wireless motility capsule in children: A study in patients with functional gastrointestinal disorders. Neurogastroenterol Motil. 2021 04; 33(4):e14032. View Abstract
Pediatric Solid Gastric Emptying Scintigraphy: Normative Value Guidelines and Nonstandard Meal Alternatives. Am J Gastroenterol. 2020 11; 115(11):1830-1839. View Abstract
Comparison of longitudinal and radial characteristics of intra-anal pressures using 3D high-definition anorectal manometry between children with anoretal malformations and functional constipation. Neurogastroenterol Motil. 2021 02; 33(2):e13971. View Abstract
Long-term Use of Bisacodyl in Pediatric Functional Constipation Refractory to Conventional Therapy. J Pediatr Gastroenterol Nutr. 2020 09; 71(3):288-291. View Abstract
Pediatric Solid Gastric Emptying Scintigraphy: Normative Value Guidelines and Nonstandard Meal Alternatives. Am J Gastroenterol. 2020 Aug 19. View Abstract
Proceedings of the 2018 Advances In Motility and In NeuroGastroenterology: AIMING for the Future Single Topic Symposium. J Pediatr Gastroenterol Nutr. 2020 08; 71(2):e59-e67. View Abstract
Perceptions of Pain Treatment in Pediatric Patients With Functional Gastrointestinal Disorders. Clin J Pain. 2020 07; 36(7):550-557. View Abstract
Botulinum Toxin as a Treatment for Feeding Difficulties in Young Children. J Pediatr. 2020 11; 226:228-235. View Abstract
Interleukin-10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study. JPEN J Parenter Enteral Nutr. 2020 11; 44(8):1407-1416. View Abstract
Characterization of the colonic response to bisacodyl in children with treatment-refractory constipation. Neurogastroenterol Motil. 2020 08; 32(8):e13851. View Abstract
Omeprazole inhibits IgE-mediated mast cell activation and allergic inflammation induced by ingested allergen in mice. J Allergy Clin Immunol. 2020 10; 146(4):884-893.e5. View Abstract
Utility of Colon Manometry in Guiding Therapy and Predicting Need for Surgery in Children With Defecation Disorders. J Pediatr Gastroenterol Nutr. 2020 02; 70(2):232-237. View Abstract
It Is Ok to Be Negative! J Pediatr Gastroenterol Nutr. 2019 10; 69(4):393-394. View Abstract
Utility of Colon Manometry in Guiding Therapy and Predicting Need for Surgery in Children With Defecation Disorders. J Pediatr Gastroenterol Nutr. 2019 Sep 17. View Abstract
Gastrointestinal Dysmotility and the Implications for Respiratory Disease. Curr Treat Options Pediatr. 2019 Jun; 5(2):197-214. View Abstract
Chronic Acalculous Cholecystitis in Children With Biliary Symptoms: Usefulness of Hepatocholescintigraphy. J Pediatr Gastroenterol Nutr. 2019 01; 68(1):68-73. View Abstract
Same day versus next day antroduodenal manometry results in children with upper gastrointestinal symptoms: A prospective study. Neurogastroenterol Motil. 2019 03; 31(3):e13521. View Abstract
A Distinct Esophageal mRNA Pattern Identifies Eosinophilic Esophagitis Patients With Food Impactions. Front Immunol. 2018; 9:2059. View Abstract
Primary placement of a skin-level Cecostomy Tube for Antegrade Colonic Enema Administration Using a Modification of the Laparoscopic-Assisted Percutaneous Endoscopic Cecostomy (LAPEC). J Pediatr Surg. 2019 Mar; 54(3):486-490. View Abstract
Focus on the use of antidepressants to treat pediatric functional abdominal pain: current perspectives. Clin Exp Gastroenterol. 2018; 11:365-372. View Abstract
Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference. Gastroenterology. 2018 10; 155(4):1022-1033.e10. View Abstract
Microstructural White Matter Abnormalities in the Dorsal Cingulum of Adolescents with IBS. eNeuro. 2018 Jul-Aug; 5(4). View Abstract
Multidisciplinary Treatment Reduces Pain and Increases Function in Children With Functional Gastrointestinal Disorders. Clin Gastroenterol Hepatol. 2019 04; 17(5):994-996. View Abstract
Thoracoscopic esophagomyotomy for achalasia in the pediatric population: A retrospective cohort study. J Pediatr Surg. 2019 Mar; 54(3):572-576. View Abstract
Educational needs in the diagnosis and management of pediatric functional constipation: a US survey of specialist and primary care clinicians. Postgrad Med. 2018 May; 130(4):428-435. View Abstract
Prevalence of Pediatric Functional Gastrointestinal Disorders Utilizing the Rome IV Criteria. J Pediatr. 2018 04; 195:134-139. View Abstract
Novel Pressure-Impedance Parameters for Evaluating Esophageal Function in Pediatric Achalasia. J Pediatr Gastroenterol Nutr. 2018 01; 66(1):37-42. View Abstract
An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning. J Allergy Clin Immunol. 2018 04; 141(4):1354-1364.e9. View Abstract
Are We Using Abdominal Radiographs Appropriately in the Management of Pediatric Constipation? J Pediatr. 2017 12; 191:179-183. View Abstract
An ANMS-NASPGHAN consensus document on esophageal and antroduodenal manometry in children. Neurogastroenterol Motil. 2018 03; 30(3). View Abstract
Perceived medication adherence barriers mediating effects between gastrointestinal symptoms and health-related quality of life in pediatric inflammatory bowel disease. Qual Life Res. 2018 01; 27(1):195-204. View Abstract
Rectal Suction Biopsy in Patients With Previous Anorectal Surgery for Hirschsprung Disease. J Pediatr Gastroenterol Nutr. 2017 08; 65(2):173-178. View Abstract
Spontaneous food allergy in Was-/- mice occurs independent of FceRI-mediated mast cell activation. Allergy. 2017 Dec; 72(12):1916-1924. View Abstract
The Prevalence of Rome IV Nonerosive Esophageal Phenotypes in Children. J Pediatr. 2017 10; 189:86-91. View Abstract
Motility Disorders in Children. Pediatr Clin North Am. 2017 06; 64(3):593-612. View Abstract
Patient Health Communication Mediating Effects Between Gastrointestinal Symptoms and Gastrointestinal Worry in Pediatric Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017 05; 23(5):704-711. View Abstract
Empirically Derived Patterns of Pain, Stooling, and Incontinence and Their Relations to Health-Related Quality of Life Among Youth With Chronic Constipation. J Pediatr Psychol. 2017 Apr 01; 42(3):325-334. View Abstract
Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation. Neurogastroenterol Motil. 2017 Jul; 29(7). View Abstract
The pediatric Rome IV criteria: what's new? Expert Rev Gastroenterol Hepatol. 2017 Mar; 11(3):193-201. View Abstract
Pediatric rumination subtypes: A study using high-resolution esophageal manometry with impedance. Neurogastroenterol Motil. 2017 05; 29(5). View Abstract
Gastrointestinal Symptoms Predictors of Health-Related Quality of Life in Patients With Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2016 12; 63(6):e186-e192. View Abstract
Gastrointestinal symptoms predictors of health-related quality of life in pediatric patients with functional gastrointestinal disorders. Qual Life Res. 2017 04; 26(4):1015-1025. View Abstract
Utility of Octreotide in Advancing Enteral Feeds in Children with Chronic Intestinal Pseudo-Obstruction. Paediatr Drugs. 2016 Oct; 18(5):387-92. View Abstract
Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models. World Allergy Organ J. 2016; 9:23. View Abstract
Abdominal Pain, the Adolescent and Altered Brain Structure and Function. PLoS One. 2016; 11(5):e0156545. View Abstract
Allergic skin sensitization promotes eosinophilic esophagitis through the IL-33-basophil axis in mice. J Allergy Clin Immunol. 2016 11; 138(5):1367-1380.e5. View Abstract
Simultaneous urodynamic and anorectal manometry studies in children: insights into the relationship between the lower gastrointestinal and lower urinary tracts. Neurogastroenterol Motil. 2016 06; 28(6):924-33. View Abstract
Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls. J Pediatr Gastroenterol Nutr. 2015 Sep; 61(3):323-9. View Abstract
Effect of anesthesia on gastroesophageal reflux in children: a study using BRAVO wireless pH study measurements. Neurogastroenterol Motil. 2015 Nov; 27(11):1553-8. View Abstract
Accuracy of digital mRNA profiling of oesophageal biopsies as a novel diagnostic approach to eosinophilic oesophagitis. Clin Exp Allergy. 2015 Aug; 45(8):1317-1327. View Abstract
High-resolution manometry combined with impedance measurements discriminates the cause of dysphagia in children. Eur J Pediatr. 2015 Dec; 174(12):1629-37. View Abstract
Validation of a bowel dysfunction instrument for adolescents with spina bifida. J Pediatr Urol. 2015 Aug; 11(4):199.e1-7. View Abstract
A multicenter study on childhood constipation and fecal incontinence: effects on quality of life. J Pediatr. 2015 Jun; 166(6):1482-7.e1. View Abstract
PedsQL gastrointestinal symptoms scales and gastrointestinal worry scales in pediatric patients with inflammatory bowel disease in comparison with healthy controls. Inflamm Bowel Dis. 2015 May; 21(5):1115-24. View Abstract
Shared care: a quality improvement initiative to optimize primary care management of constipation. Pediatrics. 2015 May; 135(5):e1300-7. View Abstract
Measuring Health-Related Quality of Life With the Parental Opinions of Pediatric Constipation Questionnaire. J Pediatr Psychol. 2015 Sep; 40(8):814-24. View Abstract
Emergency department burden of constipation in the United States from 2006 to 2011. Am J Gastroenterol. 2015 Apr; 110(4):572-9. View Abstract
Inpatient burden of childhood functional GI disorders in the USA: an analysis of national trends in the USA from 1997 to 2009. Neurogastroenterol Motil. 2015 May; 27(5):684-92. View Abstract
Interpretability of the PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in Pediatric Patients With Functional and Organic Gastrointestinal Diseases. J Pediatr Psychol. 2015 Jul; 40(6):591-601. View Abstract
Treating constipation with prucalopride: one size does not fit all. Gastroenterology. 2014 Dec; 147(6):1214-6. View Abstract
Health-related quality of life in pediatric patients with functional and organic gastrointestinal diseases. J Pediatr. 2015 Jan; 166(1):85-90. View Abstract
PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with functional and organic gastrointestinal diseases in comparison to healthy controls. Qual Life Res. 2015 Feb; 24(2):363-78. View Abstract
Evaluation and treatment of constipation in children and adolescents. Am Fam Physician. 2014 Jul 15; 90(2):82-90. View Abstract
Persistent pain in chronically ill children without detectable disease activity. Pain Manag. 2014 May; 4(3):211-9. View Abstract
Functional dyspepsia in children. Pediatr Ann. 2014 Apr; 43(4):e101-5. View Abstract
Involvement of the iNKT cell pathway is associated with early-onset eosinophilic esophagitis and response to allergen avoidance therapy. Am J Gastroenterol. 2014 May; 109(5):646-57. View Abstract
Intraesophageal pressure recording improves the detection of cough during multichannel intraluminal impedance testing in children. J Pediatr Gastroenterol Nutr. 2014 Jan; 58(1):22-6. View Abstract
Assessment of abdominal pain through global outcomes and recent FDA recommendations in children: are we ready for change? J Pediatr Gastroenterol Nutr. 2014 Jan; 58(1):46-50. View Abstract
The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing. Pediatr Pulmonol. 2014 Nov; 49(11):1090-6. View Abstract
Longitudinal and radial characteristics of intra-anal pressures in children using 3D high-definition anorectal manometry: new observations. Am J Gastroenterol. 2013 Dec; 108(12):1918-28. View Abstract
Review of organic causes of fecal incontinence in children: evaluation and treatment. Expert Rev Gastroenterol Hepatol. 2013 Sep; 7(7):657-67. View Abstract
Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. Clin Exp Allergy. 2013 Aug; 43(8):902-13. View Abstract
The overlap of functional abdominal pain in pediatric Crohn's disease. Inflamm Bowel Dis. 2013 Mar-Apr; 19(4):826-31. View Abstract
Relationship between postprandial metabolomics and colon motility in children with constipation. Neurogastroenterol Motil. 2013 May; 25(5):420-6, e299. View Abstract
Safety and efficacy of cyproheptadine for treating dyspeptic symptoms in children. J Pediatr. 2013 Jul; 163(1):261-7. View Abstract
Factors associated with successful decrease and discontinuation of antegrade continence enemas (ACE) in children with defecation disorders: a study evaluating the effect of ACE on colon motility. Neurogastroenterol Motil. 2013 Feb; 25(2):140-e81. View Abstract
Accuracy of pain recall in children. J Pediatr Gastroenterol Nutr. 2012 Sep; 55(3):288-91. View Abstract
Fc-epsilon-RI, the high affinity IgE-receptor, is robustly expressed in the upper gastrointestinal tract and modulated by mucosal inflammation. PLoS One. 2012; 7(7):e42066. View Abstract
Internal anal sphincter relaxation associated with bisacodyl-induced colonic high amplitude propagating contractions in children with constipation: a colo-anal reflex? Neurogastroenterol Motil. 2012 Nov; 24(11):1023-e545. View Abstract
Endoscopic intrapyloric injection of botulinum toxin A in the treatment of children with gastroparesis: a retrospective, open-label study. Gastrointest Endosc. 2012 Feb; 75(2):302-9. View Abstract
Heterogeneity of lower esophageal sphincter function in children with achalasia. J Pediatr Gastroenterol Nutr. 2012 Jan; 54(1):34-40. View Abstract
The presence of pepsin in the lung and its relationship to pathologic gastro-esophageal reflux. Neurogastroenterol Motil. 2012 Feb; 24(2):129-33, e84-5. View Abstract
Extra-esophageal symptoms: how do we treat them? J Pediatr Gastroenterol Nutr. 2011 Dec; 53 Suppl 2:S22-3. View Abstract
Anorectal manometry may identify children with spinal cord lesions. J Pediatr Gastroenterol Nutr. 2011 Nov; 53(5):507-11. View Abstract
50 years ago in the journal of pediatrics achalasia in children as a cause of recurrent pulmonary disease. J Pediatr. 2011 Oct; 159(4):632. View Abstract
Esophageal disease in pediatrics. Ann N Y Acad Sci. 2011 Sep; 1232:401-4. View Abstract
Development and validation of a standardized ELISA for the detection of soluble Fc-epsilon-RI in human serum. J Immunol Methods. 2011 Oct 28; 373(1-2):192-9. View Abstract
Higher rate of bronchoalveolar lavage culture positivity in children with nonacid reflux and respiratory disorders. J Pediatr. 2011 Sep; 159(3):504-6. View Abstract
Defecation disorders in children after surgery for Hirschsprung disease. J Pediatr Gastroenterol Nutr. 2011 Jul; 53(1):75-9. View Abstract
Diagnosis of supra-esophageal gastric reflux: correlation of oropharyngeal pH with esophageal impedance monitoring for gastro-esophageal reflux. Neurogastroenterol Motil. 2011 Aug; 23(8):717-e326. View Abstract
Long-term follow-up of patients after antegrade continence enema procedure. J Pediatr Gastroenterol Nutr. 2011 May; 52(5):574-80. View Abstract
Cisapride improves enteral tolerance in pediatric short-bowel syndrome with dysmotility. J Pediatr Gastroenterol Nutr. 2011 May; 52(5):590-4. View Abstract
Functional abdominal pain and irritable bowel syndrome in children and adolescents. Therapy. 2011 May 01; 8(3):315-331. View Abstract
A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum. PLoS One. 2011 Apr 22; 6(4):e19098. View Abstract
Beliefs and attitudes of general pediatricians and pediatric gastroenterologists regarding functional gastrointestinal disorders: a survey study. Clin Pediatr (Phila). 2011 Oct; 50(10):891-6. View Abstract
Effect of different pH criteria on dual-sensor pH monitoring in the evaluation of supraesophageal gastric reflux in children. J Pediatr Gastroenterol Nutr. 2011 Apr; 52(4):399-403. View Abstract
Does reflux monitoring with multichannel intraluminal impedance change clinical decision making? J Pediatr Gastroenterol Nutr. 2011 Apr; 52(4):404-7. View Abstract
Coexistence of constipation and incontinence in children and adults. Best Pract Res Clin Gastroenterol. 2011 Feb; 25(1):29-41. View Abstract
Comparative analysis of FceRI expression patterns in patients with eosinophilic and reflux esophagitis. J Pediatr Gastroenterol Nutr. 2010 Nov; 51(5):584-92. View Abstract
Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. PLoS One. 2010 Aug 16; 5(8):e12204. View Abstract
Lack of utility of abdominal x-rays in the evaluation of children with constipation: comparison of different scoring methods. J Pediatr Gastroenterol Nutr. 2010 Aug; 51(2):155-9. View Abstract
Management of functional abdominal pain and irritable bowel syndrome in children and adolescents. Expert Rev Gastroenterol Hepatol. 2010 Jun; 4(3):293-304. View Abstract
Reflux events detected by pH-MII do not determine fundoplication outcome. J Pediatr Gastroenterol Nutr. 2010 Mar; 50(3):251-5. View Abstract
Esophageal dysmotility in children with eosinophilic esophagitis: a study using prolonged esophageal manometry. Am J Gastroenterol. 2009 Dec; 104(12):3050-7. View Abstract
Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders. Gastroenterology. 2009 Oct; 137(4):1261-9. View Abstract
Long-term clinical outcome after botulinum toxin injection in children with nonrelaxing internal anal sphincter. Am J Gastroenterol. 2009 Apr; 104(4):976-83. View Abstract
The tip of the iceberg: the prevalence of functional gastrointestinal diseases in children. J Pediatr. 2009 Mar; 154(3):313-5. View Abstract
Preservation of intestinal motility after the serial transverse enteroplasty procedure in a large animal model of short bowel syndrome. J Pediatr Surg. 2009 Jan; 44(1):229-35; discussion 235. View Abstract
Functional abdominal pain: time to get together and move forward. J Pediatr Gastroenterol Nutr. 2008 Nov; 47(5):679-80. View Abstract
Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. J Allergy Clin Immunol. 2008 Dec; 122(6):1113-1118.e1. View Abstract
Approach to the child who has persistent dysphagia after surgical treatment for esophageal achalasia. J Pediatr Gastroenterol Nutr. 2008 Jul; 47(1):92-7. View Abstract
Opioid side effects--mechanism-based therapy. N Engl J Med. 2008 May 29; 358(22):2400-2. View Abstract
Role of acid and nonacid reflux in children with eosinophilic esophagitis compared with patients with gastroesophageal reflux and control patients. J Pediatr Gastroenterol Nutr. 2008 May; 46(5):520-3. View Abstract
Lipid-laden macrophage index is not an indicator of gastroesophageal reflux-related respiratory disease in children. Pediatrics. 2008 Apr; 121(4):e879-84. View Abstract
PEG3350 in the treatment of childhood constipation: a multicenter, double-blinded, placebo-controlled trial. J Pediatr. 2008 Aug; 153(2):254-61, 261.e1. View Abstract
Pediatric gastrointestinal motility disorders: challenges and a clinical update. Gastroenterol Hepatol (N Y). 2008 Feb; 4(2):140-8. View Abstract
Esophageal dysmotility in patients who have eosinophilic esophagitis. Gastrointest Endosc Clin N Am. 2008 Jan; 18(1):73-89; ix. View Abstract
The sensitivity of multichannel intraluminal impedance and the pH probe in the evaluation of gastroesophageal reflux in children. Clin Gastroenterol Hepatol. 2006 Feb; 4(2):167-72. View Abstract
What's the value of diagnostic tools in defecation disorders? J Pediatr Gastroenterol Nutr. 2005 Sep; 41 Suppl 1:S53-5. View Abstract
Use of multi-channel intraluminal impedance (MII) in the evaluation of children with respiratory symptoms: a new phenomenon? J Pediatr Gastroenterol Nutr. 2005 Aug; 41(2):166-8. View Abstract
The Paris Consensus on Childhood Constipation Terminology (PACCT) Group. J Pediatr Gastroenterol Nutr. 2005 Mar; 40(3):273-5. View Abstract
Esophageal motor activity in children with gastro-esophageal reflux disease and esophagitis. J Pediatr Gastroenterol Nutr. 2005 Jan; 40(1):70-5. View Abstract
The importance of multichannel intraluminal impedance in the evaluation of children with persistent respiratory symptoms. Am J Gastroenterol. 2004 Dec; 99(12):2452-8. View Abstract
Management of Fecal Incontinence in Children Without Functional Fecal Retention. Curr Treat Options Gastroenterol. 2004 Oct; 7(5):381-390. View Abstract
Incidence of spinal cord lesions in patients with intractable constipation. J Pediatr. 2004 Sep; 145(3):409-11. View Abstract
Increased prevalence of constipation and fecal soiling in a population of obese children. J Pediatr. 2004 Aug; 145(2):253-4. View Abstract
The importance of gut motility in the metabolic control of propionic acidemia. J Pediatr. 2004 Apr; 144(4):532-5. View Abstract
Association of Schatzki ring with eosinophilic esophagitis in children. J Pediatr Gastroenterol Nutr. 2004 Apr; 38(4):436-41. View Abstract
Prolonged monitoring of esophageal motor function in healthy children. J Pediatr Gastroenterol Nutr. 2004 Feb; 38(2):192-7. View Abstract
Acute myeloid leukemia presenting as non-neutropenic colitis in an infant. J Pediatr Gastroenterol Nutr. 2003 Nov; 37(5):631-3. View Abstract
Impeding gastroesophageal refluxate: a new application of an old medication. Gastroenterology. 2003 Sep; 125(3):984-5; discussion 985-6. View Abstract
Internal anal sphincter achalasia in children: clinical characteristics and treatment with Clostridium botulinum toxin. J Pediatr Gastroenterol Nutr. 2003 Sep; 37(3):315-9. View Abstract
Stimulation with fatty meal (Lipomul) to assess gallbladder emptying in children with chronic acalculous cholecystitis. J Pediatr Gastroenterol Nutr. 2003 Aug; 37(2):178-82. View Abstract
Rectal manometry in patients with isolated sacral agenesis. J Pediatr Gastroenterol Nutr. 2003 Jul; 37(1):47-52. View Abstract
Trends in referral to a single encopresis clinic over 20 years. Pediatrics. 2003 May; 111(5 Pt 1):e604-7. View Abstract
Abnormalities in gastrointestinal motility are associated with diseases of oxidative phosphorylation in children. Am J Gastroenterol. 2003 Apr; 98(4):871-7. View Abstract
Serial transverse enteroplasty (STEP): a novel bowel lengthening procedure. J Pediatr Surg. 2003 Mar; 38(3):425-9. View Abstract
Isolated neonatal swallowing dysfunction: a case series and review of the literature. Dig Dis Sci. 2003 Jan; 48(1):30-5. View Abstract
High-resolution EUS in children with eosinophilic "allergic" esophagitis. Gastrointest Endosc. 2003 Jan; 57(1):30-6. View Abstract
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Eosinophilic esophagitis: it's not just kid's stuff. Gastrointest Endosc. 2002 Aug; 56(2):260-70. View Abstract
Manometry studies in children: minimum standards for procedures. Neurogastroenterol Motil. 2002 Aug; 14(4):411-20. View Abstract
The infant with chronic vomiting: the value of the upper GI series. Pediatr Radiol. 2002 Aug; 32(8):549-50; discussion 551. View Abstract
Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations. J Clin Invest. 2002 Jun; 109(11):1501-9. View Abstract
Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology. 2002 May; 122(5):1216-25. View Abstract
Early constipation and toilet training in children with encopresis. J Pediatr Gastroenterol Nutr. 2002 Apr; 34(4):385-8. View Abstract
Cysteine metabolism and whole blood glutathione synthesis in septic pediatric patients. Crit Care Med. 2001 Apr; 29(4):870-7. View Abstract
Nonfixation of an atretic colon predicts Hirschsprung's disease. J Pediatr Surg. 2001 Jan; 36(1):202-4. View Abstract
The spectrum of pediatric gastroesophageal reflux. JAMA. 2000 Dec 27; 284(24):3125-6. View Abstract
The barium enema in constipation: comparison with rectal manometry and biopsy to exclude Hirschsprung's disease after the neonatal period. Pediatr Radiol. 2000 Oct; 30(10):681-4. View Abstract
Advances in the management of pediatric constipation. Curr Gastroenterol Rep. 2000 Jun; 2(3):234-40. View Abstract
The efficacy of cisapride: what is needed for digestion? J Pediatr Gastroenterol Nutr. 2000 Mar; 30(3):230-1. View Abstract
Cisapride for the treatment of constipation in children: A double-blind study. J Pediatr. 2000 Jan; 136(1):35-40. View Abstract
Constipation in infants and children: evaluation and treatment. A medical position statement of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 1999 Nov; 29(5):612-26. View Abstract
Barrett's esophagus in a teenager with a ringed esophagus. Pediatr Radiol. 1999 Aug; 29(8):641. View Abstract
Cisapride for the treatment of gastroesophageal reflux disease in children. J Pediatr Gastroenterol Nutr. 1999 Jul; 29(1):7. View Abstract
Allergic colitis: a mimic of Hirschsprung disease. Pediatr Radiol. 1999 Jan; 29(1):37-41. View Abstract
Intraduodenal hematoma complicating intestinal biopsy: case reports and review of the literature. Am J Gastroenterol. 1998 Dec; 93(12):2547-50. View Abstract
Schatzki ring in children and young adults: clinical and radiologic findings. Pediatr Radiol. 1998 Nov; 28(11):884-6. View Abstract
Benefit of uncooked cornstarch in the management of children with dumping syndrome fed exclusively by gastrostomy. Am J Gastroenterol. 1998 May; 93(5):814-8. View Abstract
Use of octreotide for the treatment of severe gastrointestinal bleeding in children. J Pediatr Gastroenterol Nutr. 1998 Mar; 26(3):356-9. View Abstract
"Feeding the gut": the scientific basis for continued enteral nutrition during acute diarrhea. J Pediatr. 1997 Dec; 131(6):801-8. View Abstract
Successful use of a chicken-based diet for the treatment of severely malnourished children with persistent diarrhea: a prospective, randomized study. J Pediatr. 1997 Sep; 131(3):405-12. View Abstract
Botulinum toxin for achalasia: are we witnessing the birth of a new era? J Pediatr Gastroenterol Nutr. 1997 Apr; 24(4):447-9. View Abstract
Treatment of intractable constipation in children: experience with cisapride. J Pediatr Gastroenterol Nutr. 1996 Jan; 22(1):38-44. View Abstract
Anorectal function in children after ileoanal pull-through. J Pediatr Surg. 1994 Feb; 29(2):329-32; discussion 332-3. View Abstract
Role of neuropeptide Y in opossum internal anal sphincter. Am J Physiol. 1990 Jan; 258(1 Pt 1):G59-64. View Abstract
Peptide histidine isoleucine and vasoactive intestinal polypeptide cause relaxation of opossum internal anal sphincter via two distinct receptors. Gastroenterology. 1989 Feb; 96(2 Pt 1):403-13. View Abstract
Role of vasoactive intestinal polypeptide in the internal anal sphincter relaxation of the opossum. J Clin Invest. 1988 Apr; 81(4):1146-53. View Abstract
Pectus carinatum and pectus excavatum: are they the same disease? Am Surg. 1981 May; 47(5):215-8. View Abstract
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