Information

Related Research Units

Emergency Medicine Research

Research Overview

Dr. Mannix’s research interest is traumatic brain injury. Her clinical research interest is the identification of new serum and imaging biomarkers for diagnosing and managing mild traumatic brain injury. Dr. Mannix also runs a research lab whose focus is on developing new targeted interventions for pediatric traumatic brain injury.

 

Research Background

Rebekah Mannix attended Williams College (undergraduate), University of Massachusetts Medical School (MD, First in Class) and the Harvard School of Public Health (MPH). She did her residency, chief residency and fellowship at Boston Children's Hospital.

Education

Medical School

University of Massachusetts Medical School
1999 Worcester MA

Residency

2002 Boston Children's Hospital
Boston MA

Fellowship

Emergency Medicine Boston Children's Hospital
2005 Boston MA

Graduate School

Harvard School of Public Health
2009 Boston MA

Publications

  1. TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada. BMJ Open. 2025 Apr 22; 15(4):e095292. View Abstract
  2. Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent Treg-microglia crosstalk. Nat Neurosci. 2025 Mar; 28(3):499-516. View Abstract
  3. A Prediction Rule to Identify Children and Young Adults at Low Risk for Myocarditis. Pediatr Emerg Care. 2025 May 01; 41(5):388-394. View Abstract
  4. Concussion and depressive symptoms in high school students: impact of physical activity and substance use. Br J Sports Med. 2025 Feb 06; 59(4):249-256. View Abstract
  5. Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injury. Sci Rep. 2025 Feb 04; 15(1):4189. View Abstract
  6. Health-Promoting Behaviors and Their Associations With Factors Related to Well-Being Among Former National Football League Players: An NFL-LONG Study. J Athl Train. 2025 Feb 01; 60(2):185-197. View Abstract
  7. Changes in Behavioral Health Visits, Operations, and Boarding in a Pediatric Emergency Department. Ann Emerg Med. 2025 May; 85(5):381-392. View Abstract
  8. Progesterone and Estradiol Levels Associated with Concussion and Clinical Outcomes and Recovery in Female Athletes and Cadets. Med Sci Sports Exerc. 2025 Mar 01; 57(3):524-534. View Abstract
  9. Early Targeted Heart Rate Aerobic Exercise Reduces Proportion of Subacute Musculoskeletal Injuries After Recovery From Sport-Related Concussion. Clin J Sport Med. 2024 Nov 01; 34(6):509-516. View Abstract
  10. Baseline Symptoms and Neurocognitive Performance across Collision, Contact, and Noncontact Female High School Athletes. Med Sci Sports Exerc. 2025 Jan 01; 57(1):54-59. View Abstract
  11. Age-Dependent Differences in Blood Levels of Glial Fibrillary Acidic Protein but Not Ubiquitin Carboxy-Terminal Hydrolase L1 in Children. Neurology. 2024 Aug 13; 103(3):e209651. View Abstract
  12. Adolescents With a High Burden of New-Onset Mood Symptoms After Sport-Related Concussion Benefit From Prescribed Aerobic Exercise, a Secondary Analysis of 2 Randomized Controlled Trials. Clin J Sport Med. 2025 Jan 01; 35(1):29-36. View Abstract
  13. Research Letter: Concussion-Related General Startle Suppression in Adolescent Athletes. J Head Trauma Rehabil. 2025 Jan-Feb 01; 40(1):E96-E101. View Abstract
  14. A Pilot Study Investigating the Use of Serum Glial Fibrillary Acidic Protein to Monitor Changes in Brain White Matter Integrity After Repetitive Head Hits During a Single Collegiate Football Game. J Neurotrauma. 2024 07; 41(13-14):1597-1608. View Abstract
  15. Emergency Department Evaluation of Young Infants With Head Injury. Pediatrics. 2024 Jun 01; 153(6). View Abstract
  16. Longitudinal Characterization of Pain Interference and Influential Factors in Former National Football League (NFL) Players Over a 19-Year Period: An NFL-LONG Study. J Pain. 2024 Sep; 25(9):104577. View Abstract
  17. The utility of biomarkers in traumatic brain injuries in children: opportunities and challenges. J Neurosurg Pediatr. 2024 May 17; 34(2):199-203. View Abstract
  18. Time-Dependent Long-Term Effect of Memantine following Repetitive Mild Traumatic Brain Injury. J Neurotrauma. 2024 07; 41(13-14):e1736-e1758. View Abstract
  19. Visual Impairment in Pre-Clinical Models of Mild Traumatic Brain Injury. J Neurotrauma. 2024 08; 41(15-16):1842-1852. View Abstract
  20. Effectiveness of biomedical interventions on the chronic stage of traumatic brain injury: a systematic review of randomized controlled trials. Front Neurol. 2024; 15:1321239. View Abstract
  21. Exposure to potentially lethal weapons and drugs among U.S. adolescents with recent depressive symptoms or suicidality in the Adolescent Behaviors and Experiences Survey. Psychiatry Res. 2024 Apr; 334:115827. View Abstract
  22. The Longitudinal Relationship Between Concussion History, Years of American Football Participation, and Alcohol Use Among Former National Football League Players: an NFL-LONG Study. Arch Clin Neuropsychol. 2024 Feb 19; 39(2):221-226. View Abstract
  23. Pediatric ECG-Based Deep Learning to Predict Left Ventricular Dysfunction and Remodeling. Circulation. 2024 03 19; 149(12):917-931. View Abstract
  24. Addressing State-Based Differences in Suicide Fatalities Among Children and Adolescents-Finding Another Way. JAMA Psychiatry. 2024 Feb 01; 81(2):120-122. View Abstract
  25. Concussion Symptoms and Neurocognitive Performance of Children and Adolescents on Antidepressants. Med Sci Sports Exerc. 2024 Jun 01; 56(6):1018-1025. View Abstract
  26. Non-invasive fluid biomarkers in the diagnosis of mild traumatic brain injury (mTBI): a systematic review. J Neurol Neurosurg Psychiatry. 2024 01 11; 95(2):184-192. View Abstract
  27. Preclinical characterization of macrophage-adhering gadolinium micropatches for MRI contrast after traumatic brain injury in pigs. Sci Transl Med. 2024 01 03; 16(728):eadk5413. View Abstract
  28. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Evaluating Transcranial Photobiomodulation as Treatment for Concussion. Med Sci Sports Exerc. 2024 May 01; 56(5):822-827. View Abstract
  29. Factors Associated with Symptom Resolution after Aerobic Exercise Intervention in Adolescent and Young Adults with Concussion. Med Sci Sports Exerc. 2024 May 01; 56(5):783-789. View Abstract
  30. Firearms Are Now the Leading Cause of Traumatic Brain Injury-Related Mortality in Children. Neurotrauma Rep. 2023; 4(1):823-826. View Abstract
  31. Trends in Pediatric Nonfatal and Fatal Injuries. Pediatrics. 2023 Nov 01; 152(5). View Abstract
  32. Racial & ethnic disparities in geographic access to critical care in the United States: A geographic information systems analysis. PLoS One. 2023; 18(11):e0287720. View Abstract
  33. Contact or Collision Sport History, Repetitive Neurotrauma, and Patient-Reported Outcomes in Early to Midadulthood. J Athl Train. 2023 Nov 01; 58(11-12):952-961. View Abstract
  34. Abortion Restrictiveness and Infant Mortality: An Ecologic Study, 2014-2018. Am J Prev Med. 2024 03; 66(3):418-426. View Abstract
  35. The effects of cytomegalovirus on brain structure following sport-related concussion. Brain. 2023 10 03; 146(10):4262-4273. View Abstract
  36. How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review. J Sport Health Sci. 2024 Jul; 13(4):537-547. View Abstract
  37. Alternative care sites and resident exposure in pediatric emergency medicine: Who, what, and where. AEM Educ Train. 2023 Aug; 7(4):e10903. View Abstract
  38. Subjective and Performance-Based Cognition and Their Associations with Head Injury History in Older Former National Football League Players. Med Sci Sports Exerc. 2023 12 01; 55(12):2170-2179. View Abstract
  39. Joint Injury, Osteoarthritis, and Cardiovascular Disease Risk Factors in Former National Football League Athletes: An NFL-LONG Study. J Athl Train. 2023 Jun 01; 58(6):528-535. View Abstract
  40. Patterns and Predictors of Health Care Utilization After Pediatric Concussion: A Retrospective Cohort Study. Acad Pediatr. 2024 Jan-Feb; 24(1):51-58. View Abstract
  41. Longitudinal Associations of Clinical and Biochemical Head Injury Biomarkers With Head Impact Exposure in Adolescent Football Players. JAMA Netw Open. 2023 05 01; 6(5):e2316601. View Abstract
  42. Adolescents With More Oculomotor and Vestibular Signs of Sport-Related Concussion Benefit from Aerobic Exercise: An Exploratory Analysis. J Neurotrauma. 2023 08; 40(15-16):1718-1729. View Abstract
  43. Editorial: Advancing the representation of minoritized groups and social determinants of health in brain injury research. Front Neurol. 2023; 14:1169445. View Abstract
  44. "At the Breaking Point" Meets Pediatric Patients. Ann Emerg Med. 2023 04; 81(4):518-519. View Abstract
  45. Exercise-Induced Vision Dysfunction Early After Sport-Related Concussion Is Associated With Persistent Postconcussive Symptoms. Clin J Sport Med. 2023 Mar 30. View Abstract
  46. Optimizing Choice and Timing of Behavioral Outcome Tests After Repetitive Mild Traumatic Brain Injury: A Machine Learning-Based Approach on Multiple Pre-Clinical Experiments. J Neurotrauma. 2023 08; 40(15-16):1762-1778. View Abstract
  47. Nutritional Supplement and Dietary Interventions as a Prophylaxis or Treatment of Sub-Concussive Repetitive Head Impact and Mild Traumatic Brain Injury: A Systematic Review. J Neurotrauma. 2023 08; 40(15-16):1557-1566. View Abstract
  48. Association of Posttraumatic Headache With Symptom Burden After Concussion in Children. JAMA Netw Open. 2023 03 01; 6(3):e231993. View Abstract
  49. Incorporation of concussion history as part of the LIfestyle for BRAin Health (LIBRA) modifiable factors risk score and associations with cognition in older former National Football League players. Alzheimers Dement. 2023 07; 19(7):3087-3097. View Abstract
  50. Effects of contact/collision sport history on gait in early- to mid-adulthood. J Sport Health Sci. 2023 05; 12(3):398-405. View Abstract
  51. Relating American Football Age of First Exposure to Patient-Reported Outcomes and Medical Diagnoses Among Former National Football League Players: An NFL-LONG study. Sports Med. 2023 05; 53(5):1073-1084. View Abstract
  52. Effects of Physical Exertion on Early Changes in Blood-Based Brain Biomarkers: Implications for the Acute Point of Care Diagnosis of Concussion. J Neurotrauma. 2023 04; 40(7-8):693-705. View Abstract
  53. No Association Between Processing Speed and Risk of Sport-Related Concussion in Youth Soccer. Clin J Sport Med. 2022 11 01; 32(6):e587-e590. View Abstract
  54. Trends and Disparities in Firearm Fatalities in the United States, 1990-2021. JAMA Netw Open. 2022 11 01; 5(11):e2244221. View Abstract
  55. Understanding the True Effect of Screen Time on Recovery From Concussion. Pediatrics. 2022 11 01; 150(5). View Abstract
  56. Racial and Ethnic Disparities in Access to Pediatric Trauma Centers in the United States: A Geographic Information Systems Analysis. Ann Emerg Med. 2023 03; 81(3):325-333. View Abstract
  57. Examining racial and ethnic disparities in adult emergency department patient visits for concussion in the United States. Front Neurol. 2022; 13:988088. View Abstract
  58. Early analgesic administration and headache presence 7 days post-concussion in children. CJEM. 2022 12; 24(8):876-884. View Abstract
  59. A dominance analysis of subjective cognitive complaint comorbidities in former professional football players with and without mild cognitive impairment. J Int Neuropsychol Soc. 2023 Jul; 29(6):582-593. View Abstract
  60. Measurement implications on the association between self-reported concussion history and depression: An NFL-LONG study. Clin Neuropsychol. 2023 08; 37(6):1136-1153. View Abstract
  61. The stability of self-reported professional football concussion history among former players: A longitudinal NFL-LONG study. Brain Inj. 2022 07 03; 36(8):968-976. View Abstract
  62. Defining an Approach to Monitoring Brain Health in Individuals Exposed to Repetitive Head Impacts: Lessons Learned from Radiation Safety. J Neurotrauma. 2022 07; 39(13-14):897-901. View Abstract
  63. Titrating the Translational Relevance of a Low-Level Repetitive Head Impact Model. Front Neurol. 2022; 13:857654. View Abstract
  64. The bridge. Acad Emerg Med. 2022 10; 29(10):1278-1279. View Abstract
  65. Pediatric Fracture Epidemiology and US Emergency Department Resource Utilization. Pediatr Emerg Care. 2022 Jul 01; 38(7):e1342-e1347. View Abstract
  66. Adolescents with Sport-Related Concussion Who Adhere to Aerobic Exercise Prescriptions Recover Faster. Med Sci Sports Exerc. 2022 09 01; 54(9):1410-1416. View Abstract
  67. Traumatic Brain Injury-Related Optic Nerve Damage. J Neuropathol Exp Neurol. 2022 04 27; 81(5):344-355. View Abstract
  68. Neurocognitive functioning and symptoms across levels of collision and contact in male high school athletes. J Neurol Neurosurg Psychiatry. 2022 Apr 27. View Abstract
  69. Radiculoneuritis due to Lyme disease in a North American child. Am J Emerg Med. 2022 07; 57:234.e1-234.e2. View Abstract
  70. Short-Term Neurologic Manifestations of Repetitive Head Impacts Among Athletes: A Scoping Review. J Head Trauma Rehabil. 2022 Sep-Oct 01; 37(5):318-325. View Abstract
  71. Transition-Related Psychosocial Factors and Mental Health Outcomes in Former National Football League Players: An NFL-LONG Study. J Sport Exerc Psychol. 2022 Jun 01; 44(3):169-176. View Abstract
  72. Paediatric post-concussive symptoms: symptom clusters and clinical phenotypes. Br J Sports Med. 2022 Jul; 56(14):785-791. View Abstract
  73. Need to Clarify Mechanisms Explaining the Effect of Screen Time on Recovery From Concussion-Reply. JAMA Pediatr. 2022 03 01; 176(3):321-322. View Abstract
  74. Mild Cognitive Impairment and Dementia Reported by Former Professional Football Players over 50 yr of Age: An NFL-LONG Study. Med Sci Sports Exerc. 2022 03 01; 54(3):424-431. View Abstract
  75. Cumulative Concussion and Odds of Stroke in Former National Football League Players. Stroke. 2022 01; 53(1):e5-e8. View Abstract
  76. Pediatric Traumatic Injury Emergency Department Visits and Management in US Children's Hospitals From 2010 to 2019. Ann Emerg Med. 2022 03; 79(3):279-287. View Abstract
  77. Subjective Concerns Regarding the Effects of Sport-Related Concussion on Long-Term Brain Health among Former NFL Players: An NFL-LONG Study. Sports Med. 2022 05; 52(5):1189-1203. View Abstract
  78. Effect of Screen Time on Recovery From Concussion: A Randomized Clinical Trial. JAMA Pediatr. 2021 11 01; 175(11):1124-1131. View Abstract
  79. Multiple Past Concussions in High School Hockey Players: Examining Cognitive Functioning and Symptom Reporting. Clin J Sport Med. 2021 11 01; 31(6):e313-e320. View Abstract
  80. Proteomic Discovery of Noninvasive Biomarkers Associated With Sport-Related Concussions. Neurology. 2022 01 11; 98(2):e186-e198. View Abstract
  81. Longitudinal trajectory of depression symptom severity and the influence of concussion history and physical function over a 19-year period among former National Football League (NFL) players: an NFL-LONG Study. J Neurol Neurosurg Psychiatry. 2022 03; 93(3):272-279. View Abstract
  82. Early targeted heart rate aerobic exercise versus placebo stretching for sport-related concussion in adolescents: a randomised controlled trial. Lancet Child Adolesc Health. 2021 11; 5(11):792-799. View Abstract
  83. And so they wait: The other epidemic among United States youth during COVID-19. Acad Emerg Med. 2021 11; 28(11):1347-1348. View Abstract
  84. Visual Dysfunction after Repetitive Mild Traumatic Brain Injury in a Mouse Model and Ramifications on Behavioral Metrics. J Neurotrauma. 2021 10 15; 38(20):2881-2895. View Abstract
  85. Infant mortality, poverty and reproductive justice. Pediatr Res. 2021 11; 90(5):926-929. View Abstract
  86. Persistent CO2 reactivity deficits are associated with neurological dysfunction up to one year after repetitive mild closed head injury in adolescent mice. J Cereb Blood Flow Metab. 2021 12; 41(12):3260-3272. View Abstract
  87. The Male Athlete Triad-A Consensus Statement From the Female and Male Athlete Triad Coalition Part 1: Definition and Scientific Basis. Clin J Sport Med. 2021 07 01; 31(4):335-348. View Abstract
  88. Saliva RNA biomarkers predict concussion duration and detect symptom recovery: a comparison with balance and cognitive testing. J Neurol. 2021 Nov; 268(11):4349-4361. View Abstract
  89. Association of Pharmacological Interventions With Symptom Burden Reduction in Patients With Mild Traumatic Brain Injury: A Systematic Review. JAMA Neurol. 2021 05 01; 78(5):596-608. View Abstract
  90. Association of Clinical Guidelines and Decision Support with Computed Tomography Use in Pediatric Mild Traumatic Brain Injury. J Pediatr. 2021 Aug; 235:178-183.e1. View Abstract
  91. Age and Sex Interactions in Recovery From Mild Traumatic Brain Injury: More Questions Than Answers. JAMA Netw Open. 2021 04 01; 4(4):e213068. View Abstract
  92. Intracranial Traumatic Hematoma Detection in Children Using a Portable Near-infrared Spectroscopy Device. West J Emerg Med. 2021 Mar 24; 22(3):782-791. View Abstract
  93. Plasma PrPC and ADAM-10 as novel biomarkers for traumatic brain injury and concussion: a pilot study. Brain Inj. 2021 05 12; 35(6):734-741. View Abstract
  94. Classification of Comprehensive Neuro-Ophthalmologic Measures of Postacute Concussion. JAMA Netw Open. 2021 03 01; 4(3):e210599. View Abstract
  95. Racial Disparities in Diagnosis of Concussion and Minor Head Trauma and Mechanism of Injury in Pediatric Patients Visiting the Emergency Department. J Pediatr. 2021 06; 233:249-254.e1. View Abstract
  96. Symptoms upon postural change and orthostatic hypotension in adolescents with concussion. Brain Inj. 2021 01 18; 35(2):226-232. View Abstract
  97. BBB pathophysiology-independent delivery of siRNA in traumatic brain injury. Sci Adv. 2021 01; 7(1). View Abstract
  98. Understanding Traumatic Brain Injury in Females: A State-of-the-Art Summary and Future Directions. J Head Trauma Rehabil. 2021 01 01; 36(1):E1-E17. View Abstract
  99. Paediatric ED utilisation in the early phase of the COVID-19 pandemic. Emerg Med J. 2021 Feb; 38(2):100-102. View Abstract
  100. Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients. J Neurotrauma. 2021 01 01; 38(1):1-43. View Abstract
  101. Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio. Cereb Cortex. 2020 11 03; 30(12):6108-6120. View Abstract
  102. Female Sport Participation Effect on Long-Term Health-Related Quality of Life. Clin J Sport Med. 2020 11; 30(6):526-532. View Abstract
  103. Diagnosing mild traumatic brain injury using saliva RNA compared to cognitive and balance testing. Clin Transl Med. 2020 Oct; 10(6):e197. View Abstract
  104. Impact of COVID-19 on professional and personal responsibilities of Massachusetts physicians. Am J Emerg Med. 2020 Nov; 38(11):2365-2367. View Abstract
  105. The Infant Scalp Score: A Validated Tool to Stratify Risk of Traumatic Brain Injury in Infants With Isolated Scalp Hematoma. Acad Emerg Med. 2021 01; 28(1):92-97. View Abstract
  106. Demographics and management of outpatient concussion visits among neurologists and non-neurologists: 2006-2016. Concussion. 2020 Aug 04; 5(3):CNC79. View Abstract
  107. Use of Ondansetron for Vomiting After Head Trauma: Does It Mask Clinically Significant Traumatic Brain Injury? Pediatr Emerg Care. 2020 Aug; 36(8):e433-e437. View Abstract
  108. Are "Other Doctors Are Stupid" Jokes Appropriate? AMA J Ethics. 2020 07 01; 22(7):E583-587. View Abstract
  109. Neurosensory Screening and Symptom Provocation in Pediatric Mild Traumatic Brain Injury. J Head Trauma Rehabil. 2020 Jul/Aug; 35(4):270-278. View Abstract
  110. Fluid Biomarkers of Pediatric Mild Traumatic Brain Injury: A Systematic Review. J Neurotrauma. 2020 10 01; 37(19):2029-2044. View Abstract
  111. What Would You Do, Doctor? JAMA. 2020 05 05; 323(17):1678-1679. View Abstract
  112. Child Access Prevention Firearm Laws and Firearm Fatalities Among Children Aged 0 to 14 Years, 1991-2016. JAMA Pediatr. 2020 05 01; 174(5):463-469. View Abstract
  113. Coronavirus Disease 2019 (COVID-19) and Firearms in the United States: Will an Epidemic of Suicide Follow? Ann Intern Med. 2020 08 04; 173(3):228-229. View Abstract
  114. Prognosis for Persistent Post Concussion Symptoms using a Multifaceted Objective Gait and Balance Assessment Approach. Gait Posture. 2020 06; 79:53-59. View Abstract
  115. Internal Jugular Vein Compression Collar Mitigates Histopathological Alterations after Closed Head Rotational Head Impact in Swine: A Pilot Study. Neuroscience. 2020 06 15; 437:132-144. View Abstract
  116. Managing Pediatric Concussion in the Emergency Department. Ann Emerg Med. 2020 06; 75(6):762-766. View Abstract
  117. A Teenager Presenting With Rash and Visual Disturbance. Pediatr Infect Dis J. 2020 02; 39(2):173. View Abstract
  118. Revisits, readmissions, and outcomes for pediatric traumatic brain injury in California, 2005-2014. PLoS One. 2020; 15(1):e0227981. View Abstract
  119. Automated Quantification of Immunohistochemical Staining of Large Animal Brain Tissue Using QuPath Software. Neuroscience. 2020 03 01; 429:235-244. View Abstract
  120. Biomarkers May Provide Unique Insights Into Neurological Effects Associated With Sport-Related Concussions. JAMA Netw Open. 2020 01 03; 3(1):e1919799. View Abstract
  121. Doctoring While Woman. Acad Emerg Med. 2020 05; 27(5):434-436. View Abstract
  122. The use of opioids in low acuity pediatric trauma patients. PLoS One. 2019; 14(12):e0226433. View Abstract
  123. Longitudinal structural connectomic and rich-club analysis in adolescent mTBI reveals persistent, distributed brain alterations acutely through to one year post-injury. Sci Rep. 2019 12 11; 9(1):18833. View Abstract
  124. Hyperosmolar Therapy in Pediatric Severe Traumatic Brain Injury-A Systematic Review. Crit Care Med. 2019 12; 47(12):e1022-e1031. View Abstract
  125. A Stroke Alert Protocol Decreases the Time to Diagnosis of Brain Attack Symptoms in a Pediatric Emergency Department. J Pediatr. 2020 01; 216:136-141.e6. View Abstract
  126. Memantine Mitigates Oligodendrocyte Damage after Repetitive Mild Traumatic Brain Injury. Neuroscience. 2019 11 21; 421:152-161. View Abstract
  127. Radiologic common data elements rates in pediatric mild traumatic brain injury. Neurology. 2020 01 21; 94(3):e241-e253. View Abstract
  128. Mass School Shootings in the United States: A Novel Root Cause Analysis Using Lay Press Reports. Clin Pediatr (Phila). 2019 11; 58(13):1423-1428. View Abstract
  129. The Buffalo Concussion Bike Test for Concussion Assessment in Adolescents. Sports Health. 2019 Nov/Dec; 11(6):492-497. View Abstract
  130. Concussion Symptom Profiles Among Child, Adolescent, and Young Adult Athletes. Clin J Sport Med. 2019 09; 29(5):391-397. View Abstract
  131. Comparison of Rest to Aerobic Exercise and Placebo-like Treatment of Acute Sport-Related Concussion in Male and Female Adolescents. Arch Phys Med Rehabil. 2019 12; 100(12):2267-2275. View Abstract
  132. Recommendations for the Emergency Department Prevention of Sport-Related Concussion. Ann Emerg Med. 2020 04; 75(4):471-482. View Abstract
  133. Racial and Ethnic Differences in Emergency Department Utilization and Diagnosis for Sports-Related Head Injuries. Front Neurol. 2019; 10:690. View Abstract
  134. Challenges and Progress in Identifying Cervical Spine Injuries in Children. Pediatrics. 2019 07; 144(1). View Abstract
  135. Diffusion Tensor Imaging in Athletes Sustaining Repetitive Head Impacts: A Systematic Review of Prospective Studies. J Neurotrauma. 2019 10 15; 36(20):2831-2849. View Abstract
  136. Practice Patterns in Pharmacological and Non-Pharmacological Therapies for Children with Mild Traumatic Brain Injury: A Survey of 15 Canadian and United States Centers. J Neurotrauma. 2019 10 15; 36(20):2886-2894. View Abstract
  137. Longitudinal Changes in Magnetic Resonance Spectroscopy in Pediatric Concussion: A Pilot Study. Front Neurol. 2019; 10:556. View Abstract
  138. Early Subthreshold Aerobic Exercise for Sport-Related Concussion: A Randomized Clinical Trial. JAMA Pediatr. 2019 04 01; 173(4):319-325. View Abstract
  139. Diagnosis of Concussion in the Pediatric Emergency Department. Semin Pediatr Neurol. 2019 07; 30:35-39. View Abstract
  140. Identifying Persistent Postconcussion Symptom Risk in a Pediatric Sports Medicine Clinic. Am J Sports Med. 2018 11; 46(13):3254-3261. View Abstract
  141. Increasing Fatality Rates From Preventable Deaths in Teenagers and Young Adults. JAMA. 2018 Aug 14; 320(6):543-544. View Abstract
  142. Advanced biomarkers of pediatric mild traumatic brain injury: Progress and perils. Neurosci Biobehav Rev. 2018 11; 94:149-165. View Abstract
  143. Preinjury Migraine History as a Risk Factor for Prolonged Return to School and Sports following Concussion. J Neurotrauma. 2018 Aug 02. View Abstract
  144. And Still We Believed. JAMA. 2018 Jul 17; 320(3):235. View Abstract
  145. Extended Erythropoietin Treatment Prevents Chronic Executive Functional and Microstructural Deficits Following Early Severe Traumatic Brain Injury in Rats. Front Neurol. 2018; 9:451. View Abstract
  146. Etiologies and Yield of Diagnostic Testing in Children Presenting to the Emergency Department with Altered Mental Status. J Pediatr. 2018 09; 200:218-224.e2. View Abstract
  147. Acute concussion: making the diagnosis and state of the art management. Curr Opin Pediatr. 2018 06; 30(3):344-349. View Abstract
  148. Self-reported sleep duration affects tandem gait, but not steady-state gait outcomes among healthy collegiate athletes. Gait Posture. 2018 05; 62:291-296. View Abstract
  149. Neurosensory Deficits Vary as a Function of Point of Care in Pediatric Mild Traumatic Brain Injury. J Neurotrauma. 2018 05 15; 35(10):1178-1184. View Abstract
  150. Behavioral phenotyping and dopamine dynamics in mice with conditional deletion of the glutamate transporter GLT-1 in neurons: resistance to the acute locomotor effects of amphetamine. Psychopharmacology (Berl). 2018 05; 235(5):1371-1387. View Abstract
  151. Investigating Effects of Sex Differences and Prior Concussions on Symptom Reporting and Cognition Among Adolescent Soccer Players. Am J Sports Med. 2018 03; 46(4):961-968. View Abstract
  152. Promise of Salivary MicroRNA for Assessing Concussion. JAMA Pediatr. 2018 01 01; 172(1):14-15. View Abstract
  153. Point-of-care hip ultrasound in a pediatric emergency department. Am J Emerg Med. 2018 Jul; 36(7):1174-1177. View Abstract
  154. Neurocognitive Deficits of Concussed Adolescent Athletes at Self-reported Symptom Resolution in the Zurich Guidelines Era. Orthop J Sports Med. 2017 Nov; 5(11):2325967117737307. View Abstract
  155. Carbon Monoxide Exposure in Youth Ice Hockey. Clin J Sport Med. 2017 Nov; 27(6):536-541. View Abstract
  156. White matter alterations over the course of two consecutive high-school football seasons and the effect of a jugular compression collar: A preliminary longitudinal diffusion tensor imaging study. Hum Brain Mapp. 2018 01; 39(1):491-508. View Abstract
  157. Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae. Nat Commun. 2017 10 17; 8(1):1000. View Abstract
  158. Tribalism in Medicine-Us vs Them. JAMA Pediatr. 2017 09 01; 171(9):831. View Abstract
  159. Concussion: Evaluation and management. Cleve Clin J Med. 2017 Aug; 84(8):623-630. View Abstract
  160. Environmental Enrichment Mitigates Deficits after Repetitive Mild Traumatic Brain Injury. J Neurotrauma. 2017 08 15; 34(16):2445-2455. View Abstract
  161. Memantine improves outcomes after repetitive traumatic brain injury. Behav Brain Res. 2018 03 15; 340:195-204. View Abstract
  162. Complexity and Severity of Pediatric Patients Treated at United States Emergency Departments. J Pediatr. 2017 07; 186:145-149.e1. View Abstract
  163. Burden of USA hospital charges for traumatic brain injury. Brain Inj. 2017; 31(1):24-31. View Abstract
  164. Multiple Past Concussions in High School Football Players: Are There Differences in Cognitive Functioning and Symptom Reporting? Am J Sports Med. 2016 Dec; 44(12):3243-3251. View Abstract
  165. Consistency of Self-Reported Concussion History in Adolescent Athletes. J Neurotrauma. 2017 01 15; 34(2):322-327. View Abstract
  166. Adolescent Mice Demonstrate a Distinct Pattern of Injury after Repetitive Mild Traumatic Brain Injury. J Neurotrauma. 2017 01 15; 34(2):495-504. View Abstract
  167. Microstructural and microglial changes after repetitive mild traumatic brain injury in mice. J Neurosci Res. 2017 04; 95(4):1025-1035. View Abstract
  168. Emergency Department Management of Febrile Respiratory Illness in Children. Pediatr Emerg Care. 2016 Jul; 32(7):429-34. View Abstract
  169. Sports-related concussions - media, science and policy. Nat Rev Neurol. 2016 08; 12(8):486-90. View Abstract
  170. Predictors and Outcomes of Pediatric Firearm Injuries Treated in the Emergency Department: Differences by Mechanism of Intent. Acad Emerg Med. 2016 07; 23(7):790-5. View Abstract
  171. Initial somatic symptoms are associated with prolonged symptom duration following concussion in adolescents. Acta Paediatr. 2016 Sep; 105(9):e426-32. View Abstract
  172. Attribution of Concussion-Like Symptoms and History of Collision Sports Exposure--Reply. JAMA Pediatr. 2016 Apr; 170(4):400. View Abstract
  173. Imaging and serum biomarkers reflecting the functional efficacy of extended erythropoietin treatment in rats following infantile traumatic brain injury. J Neurosurg Pediatr. 2016 Jun; 17(6):739-55. View Abstract
  174. Physical Activity Level and Symptom Duration Are Not Associated After Concussion. Am J Sports Med. 2016 Apr; 44(4):1040-6. View Abstract
  175. Clinical Traumatic Brain Injury in the Preclinical Setting. Methods Mol Biol. 2016; 1462:11-28. View Abstract
  176. Initial symptom burden predicts duration of symptoms after concussion. J Sci Med Sport. 2016 Sep; 19(9):722-5. View Abstract
  177. Factors Associated With Concussion-like Symptom Reporting in High School Athletes. JAMA Pediatr. 2015 Dec; 169(12):1132-40. View Abstract
  178. Outcomes of pediatric patients with persistent midline cervical spine tenderness and negative imaging result after trauma. J Trauma Acute Care Surg. 2015 Nov; 79(5):822-7. View Abstract
  179. Variation and Trends in Charges for Pediatric Care in Massachusetts Emergency Departments, 2000-2011. Acad Emerg Med. 2015 Oct; 22(10):1164-71. View Abstract
  180. Restraint use in motor vehicle crash fatalities in children 0 year to 9 years old. J Trauma Acute Care Surg. 2015 Sep; 79(3 Suppl 1):S55-60. View Abstract
  181. Chronic traumatic encephalopathy and athletes. Neurology. 2015 Oct 27; 85(17):1504-11. View Abstract
  182. Motor Vehicle Crash Fatalities in States With Primary Versus Secondary Seat Belt Laws: A Time-Series Analysis. Ann Intern Med. 2015 Aug 04; 163(3):184-90. View Abstract
  183. Variation in Computed Tomography Imaging for Pediatric Injury-Related Emergency Visits. J Pediatr. 2015 Oct; 167(4):897-904.e3. View Abstract
  184. Division III Collision Sports Are Not Associated with Neurobehavioral Quality of Life. J Neurotrauma. 2016 Jan 15; 33(2):254-9. View Abstract
  185. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature. 2015 Jul 23; 523(7561):431-436. View Abstract
  186. Quality Improvement Effort to Reduce Cranial CTs for Children With Minor Blunt Head Trauma. Pediatrics. 2015 Jul; 136(1):e227-33. View Abstract
  187. Firearm Ownership and Violent Crime in the U.S.: An Ecologic Study. Am J Prev Med. 2015 Aug; 49(2):207-14. View Abstract
  188. Expert consensus document: Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions. Nat Rev Neurol. 2015 04; 11(4):230-44. View Abstract
  189. Change of shift. The blanket. Ann Emerg Med. 2015 Mar; 65(3):336. View Abstract
  190. Risk of athletes with Chiari malformations suffering catastrophic injuries during sports participation is low. Clin J Sport Med. 2015 Mar; 25(2):133-7. View Abstract
  191. Early symptom burden predicts recovery after sport-related concussion. Neurology. 2014 Dec 09; 83(24):2204-10. View Abstract
  192. Pediatric cervical spine injury evaluation after blunt trauma: a clinical decision analysis. Ann Emerg Med. 2015 Mar; 65(3):239-47. View Abstract
  193. Sex differences in the effect of progesterone after controlled cortical impact in adolescent mice: a preliminary study. J Neurosurg. 2014 Dec; 121(6):1337-41. View Abstract
  194. Chronic gliosis and behavioral deficits in mice following repetitive mild traumatic brain injury. J Neurosurg. 2014 Dec; 121(6):1342-50. View Abstract
  195. Complex pattern of interaction between in utero hypoxia-ischemia and intra-amniotic inflammation disrupts brain development and motor function. J Neuroinflammation. 2014 Aug 01; 11:131. View Abstract
  196. Management of pediatric patients with concussion by emergency medicine physicians. Pediatr Emerg Care. 2014 Jul; 30(7):458-61. View Abstract
  197. Multiple prior concussions are associated with symptoms in high school athletes. Ann Clin Transl Neurol. 2014 Jun; 1(6):433-8. View Abstract
  198. Trends in visits for traumatic brain injury to emergency departments in the United States. JAMA. 2014 May 14; 311(18):1917-9. View Abstract
  199. Duration and course of post-concussive symptoms. Pediatrics. 2014 Jun; 133(6):999-1006. View Abstract
  200. Cholesterol testing among children and adolescents during health visits. JAMA. 2014 May 07; 311(17):1804-7. View Abstract
  201. Serum biomarkers predict acute symptom burden in children after concussion: a preliminary study. J Neurotrauma. 2014 Jun 01; 31(11):1072-5. View Abstract
  202. Genetic influences and neuropathological sequelae of repetitive brain injury. Reply. Ann Neurol. 2014 Apr; 75(4):618. View Abstract
  203. A piece of my mind. What would you do, doctor? JAMA. 2014 Mar 05; 311(9):911-2. View Abstract
  204. Management and prevention of sport-related concussion. Clin Pediatr (Phila). 2014 Nov; 53(13):1221-30. View Abstract
  205. Effect of cognitive activity level on duration of post-concussion symptoms. Pediatrics. 2014 Feb; 133(2):e299-304. View Abstract
  206. Epidemiology of paediatric firearm injuries in the USA, 2001-2010. Arch Dis Child. 2014 Apr; 99(4):331-5. View Abstract
  207. Trends in pediatric visits to the emergency department for psychiatric illnesses. Acad Emerg Med. 2014 Jan; 21(1):25-30. View Abstract
  208. Firearm legislation and gun-related fatalities--reply. JAMA Intern Med. 2013 Nov 25; 173(21):2011-2. View Abstract
  209. The prevalence of undiagnosed concussions in athletes. Clin J Sport Med. 2013 Sep; 23(5):339-42. View Abstract
  210. Clinical correlates in an experimental model of repetitive mild brain injury. Ann Neurol. 2013 Jul; 74(1):65-75. View Abstract
  211. Red state blue state. Acad Emerg Med. 2013 Aug; 20(8):858-9. View Abstract
  212. Management strategies and medication use for treating paediatric patients with concussions. Acta Paediatr. 2013 Sep; 102(9):e424-8. View Abstract
  213. The epidemiology of outpatient visits for minor head injury: 2005 to 2009. Neurosurgery. 2013 Jul; 73(1):129-34; discussion 134. View Abstract
  214. Time interval between concussions and symptom duration. Pediatrics. 2013 Jul; 132(1):8-17. View Abstract
  215. Bicycle helmet laws are associated with a lower fatality rate from bicycle-motor vehicle collisions. J Pediatr. 2013 Sep; 163(3):726-9. View Abstract
  216. Firearm legislation and firearm-related fatalities in the United States. JAMA Intern Med. 2013 May 13; 173(9):732-40. View Abstract
  217. A substantial proportion of life-threatening injuries are sport-related. Pediatr Emerg Care. 2013 May; 29(5):624-7. View Abstract
  218. Symptom severity predicts prolonged recovery after sport-related concussion, but age and amnesia do not. J Pediatr. 2013 Sep; 163(3):721-5. View Abstract
  219. Isolated skull fractures: trends in management in US pediatric emergency departments. Ann Emerg Med. 2013 Oct; 62(4):327-31. View Abstract
  220. Beneficial effect of amyloid beta after controlled cortical impact. Brain Inj. 2013 Jun; 27(6):743-8. View Abstract
  221. Uncomfortable. Acad Emerg Med. 2013 Mar; 20(3):325-6. View Abstract
  222. Epidemiology, trends, assessment and management of sport-related concussion in United States high schools. Curr Opin Pediatr. 2012 Dec; 24(6):696-701. View Abstract
  223. Booster seat laws and fatalities in children 4 to 7 years of age. Pediatrics. 2012 Dec; 130(6):996-1002. View Abstract
  224. Increasing recovery time between injuries improves cognitive outcome after repetitive mild concussive brain injuries in mice. Neurosurgery. 2012 Oct; 71(4):885-91. View Abstract
  225. Pediatric traumatic brain injury and radiation risks: a clinical decision analysis. J Pediatr. 2013 Feb; 162(2):392-7. View Abstract
  226. A compassionate care checklist. Acad Emerg Med. 2012 Aug; 19(8):992. View Abstract
  227. Insurance status and the care of adult patients 19 to 64 years of age visiting the emergency department. Acad Emerg Med. 2012 Jul; 19(7):808-15. View Abstract
  228. Traumatic brain injury, microglia, and Beta amyloid. Int J Alzheimers Dis. 2012; 2012:608732. View Abstract
  229. Insurance status and the care of children in the emergency department. J Pediatr. 2012 Sep; 161(3):536-541.e3. View Abstract
  230. Pediatric abdominal pain: use of imaging in the emergency department in the United States from 1999 to 2007. Radiology. 2012 Jun; 263(3):778-85. View Abstract
  231. Detrimental effect of genetic inhibition of B-site APP-cleaving enzyme 1 on functional outcome after controlled cortical impact in young adult mice. J Neurotrauma. 2011 Sep; 28(9):1855-61. View Abstract
  232. Factors associated with the use of cervical spine computed tomography imaging in pediatric trauma patients. Acad Emerg Med. 2011 Sep; 18(9):905-11. View Abstract
  233. Computed tomography for minor head injury: variation and trends in major United States pediatric emergency departments. J Pediatr. 2012 Jan; 160(1):136-9.e1. View Abstract
  234. Pediatric concussions in United States emergency departments in the years 2002 to 2006. J Pediatr. 2010 Dec; 157(6):889-93. View Abstract
  235. Neuroimaging for pediatric head trauma: do patient and hospital characteristics influence who gets imaged? Acad Emerg Med. 2010 Jul; 17(7):694-700. View Abstract
  236. Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2011 Jan; 31(1):351-61. View Abstract
  237. Acute pediatric monoarticular arthritis: distinguishing lyme arthritis from other etiologies. Pediatrics. 2009 Mar; 123(3):959-65. View Abstract
  238. Rheumatologic Emergencies. Essential of Emergency Medicine. Richard V. Aghababian, ED. 2008. View Abstract
  239. Acetaminophen. 2008. View Abstract
  240. Poisoning in Children with Unique Metabolism. Clinical Management of Poisoning and Drug Overdose. 2007. View Abstract
  241. Over-the-Counter Medications / Diabetic Agents. Zaoutis L, Chiang VW, eds. Comprehensive Pediatric Hospital Medicine. 2007. View Abstract
  242. Status asthmaticus in children. Curr Opin Pediatr. 2007 Jun; 19(3):281-7. View Abstract
  243. Acute pediatric rhabdomyolysis: causes and rates of renal failure. Pediatrics. 2006 Nov; 118(5):2119-25. View Abstract
  244. The Boston Marathon Study: a novel approach to research during residency. Pediatrics. 2006 May; 117(5):1818-22. View Abstract
  245. Hyponatremia among runners in the Boston Marathon. N Engl J Med. 2005 Apr 14; 352(15):1550-6. View Abstract
  246. Airway Management in the Poisoned Child.Erickson T, Ahrens W, Aks S, Baum CR and Ling L (eds). Pediatric Toxicology: Diagnosis and Management of the Poisoned Child. 2004; (2004):84-88. View Abstract
  247. PAS Poster Presentation: Etiology and Rate of Acute Renal Failure in Pediatric Rhabdomyolysis. 2004. View Abstract
  248. Effect of sulfur dioxide-sulfate exposure on rat respiratory tract clearance. Am Ind Hyg Assoc J. 1982 Sep; 43(9):679-85. View Abstract

Contact Rebekah Mannix

Print Profile