Dr. Kreienkamp's research focuses on the application of genetics to improve the care of individuals with diabetes. Specifically, he is interested in the use of polygenic scores to improve diagnostic accuracy in diabetes care, particularly in pediatrics. Additionally, he uses genetic sequencing in atypical forms of diabetes to discover novel genetic causes for diabetes and advance precision medicine in diabetes care.
Research Background
Dr. Kreienkamp completed his undergraduate studies at Saint Louis University School of Medicine, where he earned a Honors B.A. in Chemistry and a Honors B.S.B.A. in Economics. While in college, he worked in the laboratories of Jeffrey J. Neil, M.D., Ph.D., studying the effects of neonatal ischemia on brain development, and Paul A. Jelliss, Ph.D., studying the utility of inorganic compounds as drug-delivery vehicles. He then entered the M.D./Ph.D. program at Saint Louis University, where he completed his Ph.D. in Biochemistry and Molecular Biology in the laboratory of Susana Gonzalo, Ph.D. studying the molecular mechanisms underlying Hutchinson-Gilford Progeria Syndrome. While there, he had multiple first-author publications and received multiple awards, including the Wendell-Griffith Award for Outstanding Achievement in Biochemistry and Molecular Biology and the William S. Sly Fellowship in Biomedical Sciences. After completing his medical degree, he completed his pediatric residency at St. Louis Children's Hospital/Washington University School of Medicine, before completing his pediatric endocrine fellowship at Boston Children's Hospital. During his fellowship, he authored multiple publications on the application of genetics to improve diabetes care, and he received the Rising Star Award from the Pediatric Endocrine Society.
Education
Undergraduate School
Saint Louis University
2011
St. Louis
MO
Graduate School
Saint Louis University
2017
St. Louis
MO
Medical School
Saint Louis University
2019
St. Louis
MO
Internship
Pediatrics
St. Louis Children's Hospital/Washington University School of Medicine
2020
St. Louis
MO
Residency
Pediatrics
St. Louis Children's Hospital/Washington University School of Medicine
2021
St. Louis
MO
Fellowship
Pediatric Endocrinology
Boston Children's Hospital
2025
Boston
MA
Publications
Type 1 Diabetes Polygenic Scores Improve Diagnostic Accuracy in Pediatric Diabetes Care. Horm Res Paediatr. 2025 May 20; 1-17. View Abstract
Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci. J Am Soc Nephrol. 2025 May 05. View Abstract
An Atypical Presentation of Cytokine Release Syndrome With Signs of Arthritis During Treatment With Teplizumab in a Pediatric Patient. Diabetes Care. 2025 Apr 01; 48(4):e49-e50. View Abstract
Type 1 Diabetes Polygenic Scores Improve Diagnostic Accuracy in Pediatric Diabetes Care. medRxiv. 2025 Mar 13. View Abstract
Advancing Monogenic Diabetes Research and Clinical Care by Creating a Data Commons: The Precision Diabetes Consortium (PREDICT). J Diabetes Sci Technol. 2025 Jan 09; 19322968241310896. View Abstract
MODY Calculator and Clinical Features Routinely Used to Distinguish MODY From Type 2 Diabetes in Adults Perform Poorly for Youth Clinically Diagnosed With Type 2 Diabetes. Diabetes Care. 2025 Jan 01; 48(1):e3-e5. View Abstract
Identification of atypical pediatric diabetes mellitus cases using electronic medical records. BMJ Open Diabetes Res Care. 2024 Nov 07; 12(6). View Abstract
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine. Nat Med. 2023 Oct; 29(10):2438-2457. View Abstract
Severe Hypercalcemia due to Hypervitaminosis D in a Breastfed Infant. JCEM Case Rep. 2023 May; 1(3):luad049. View Abstract
Systematic review of precision subclassification of type 2 diabetes. medRxiv. 2023 Apr 20. View Abstract
Vitamin B6 deficiency with normal plasma levels of pyridoxal 5'-phosphate in perinatal hypophosphatasia. Bone. 2021 09; 150:116007. View Abstract
