Information

Related Research Units

Endocrinology Research

Research Overview

Dr. Kreienkamp's research focuses on the application of genetics to improve the care of individuals with diabetes. Specifically, he is interested in the use of polygenic scores to improve diagnostic accuracy in diabetes care, particularly in pediatrics. Additionally, he uses genetic sequencing in atypical forms of diabetes to discover novel genetic causes for diabetes and advance precision medicine in diabetes care.

Research Background

Dr. Kreienkamp completed his undergraduate studies at Saint Louis University School of Medicine, where he earned a Honors B.A. in Chemistry and a Honors B.S.B.A. in Economics. While in college, he worked in the laboratories of Jeffrey J. Neil, M.D., Ph.D., studying the effects of neonatal ischemia on brain development, and Paul A. Jelliss, Ph.D., studying the utility of inorganic compounds as drug-delivery vehicles. He then entered the M.D./Ph.D. program at Saint Louis University, where he completed his Ph.D. in Biochemistry and Molecular Biology in the laboratory of Susana Gonzalo, Ph.D. studying the molecular mechanisms underlying Hutchinson-Gilford Progeria Syndrome. While there, he had multiple first-author publications and received multiple awards, including the Wendell-Griffith Award for Outstanding Achievement in Biochemistry and Molecular Biology and the William S. Sly Fellowship in Biomedical Sciences. After completing his medical degree, he completed his pediatric residency at St. Louis Children's Hospital/Washington University School of Medicine, before completing his pediatric endocrine fellowship at Boston Children's Hospital. During his fellowship, he authored multiple publications on the application of genetics to improve diabetes care, and he received the Rising Star Award from the Pediatric Endocrine Society.

Education

Undergraduate School

Saint Louis University
2011 St. Louis MO

Graduate School

Saint Louis University
2017 St. Louis MO

Medical School

Saint Louis University
2019 St. Louis MO

Internship

Pediatrics St. Louis Children's Hospital/Washington University School of Medicine
2020 St. Louis MO

Residency

Pediatrics St. Louis Children's Hospital/Washington University School of Medicine
2021 St. Louis MO

Fellowship

Pediatric Endocrinology Boston Children's Hospital
2025 Boston MA

Publications

  1. The Impact of Ancestry on Performance of Type 1 Diabetes Genetic Risk Scores: High Discrimination Performance Is Maintained in African Ancestry Populations, but Population-Specific Thresholds May Improve Risk Prediction. Diabetes Care. 2026 Mar 01; 49(3):e33-e35. View Abstract
  2. Novel Phenotypic Clusters of Youth-Onset Type 2 Diabetes Offer No Added Prognostic Value to Simple Clinical Measures. Diabetes Care. 2026 Jan 01; 49(1):137-146. View Abstract
  3. Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score. Diabetes. 2026 Jan 01; 75(1):205-214. View Abstract
  4. Lonafarnib Clinical Trials Demonstrate Uncoupling of the Muscle-Bone Unit in Hutchinson-Gilford Progeria Syndrome. J Bone Miner Res. 2025 Dec 04. View Abstract
  5. Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries. medRxiv. 2025 Jul 23. View Abstract
  6. The impact of ancestry on performance of type 1 diabetes genetic risk scores: high discrimination performance is maintained in African ancestry populations, but population specific thresholds may improve risk prediction. medRxiv. 2025 Jul 17. View Abstract
  7. Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score. medRxiv. 2025 Jun 22. View Abstract
  8. Type 1 Diabetes Polygenic Scores Improve Diagnostic Accuracy in Pediatric Diabetes Care. Horm Res Paediatr. 2025 May 20; 1-9. View Abstract
  9. Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci. J Am Soc Nephrol. 2025 Oct 01; 36(10):1939-1953. View Abstract
  10. An Atypical Presentation of Cytokine Release Syndrome With Signs of Arthritis During Treatment With Teplizumab in a Pediatric Patient. Diabetes Care. 2025 Apr 01; 48(4):e49-e50. View Abstract
  11. Type 1 Diabetes Polygenic Scores Improve Diagnostic Accuracy in Pediatric Diabetes Care. medRxiv. 2025 Mar 13. View Abstract
  12. Advancing Monogenic Diabetes Research and Clinical Care by Creating a Data Commons: The Precision Diabetes Consortium (PREDICT). J Diabetes Sci Technol. 2026 May; 20(3):1034-1040. View Abstract
  13. MODY Calculator and Clinical Features Routinely Used to Distinguish MODY From Type 2 Diabetes in Adults Perform Poorly for Youth Clinically Diagnosed With Type 2 Diabetes. Diabetes Care. 2025 Jan 01; 48(1):e3-e5. View Abstract
  14. Identification of atypical pediatric diabetes mellitus cases using electronic medical records. BMJ Open Diabetes Res Care. 2024 Nov 07; 12(6). View Abstract
  15. Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine. Nat Med. 2023 10; 29(10):2438-2457. View Abstract
  16. Precision subclassification of type 2 diabetes: a systematic review. Commun Med (Lond). 2023 Oct 05; 3(1):138. View Abstract
  17. Severe Hypercalcemia due to Hypervitaminosis D in a Breastfed Infant. JCEM Case Rep. 2023 May; 1(3):luad049. View Abstract
  18. Systematic review of precision subclassification of type 2 diabetes. medRxiv. 2023 Apr 20. View Abstract
  19. Transmission risk of COVID-19 in high school and college water polo. BMC Infect Dis. 2022 May 11; 22(1):450. View Abstract
  20. A Week of Nightly Fevers in a 10-year-old Girl. Pediatr Rev. 2021 12 01; 42(12):694-697. View Abstract
  21. Vitamin B6 deficiency with normal plasma levels of pyridoxal 5'-phosphate in perinatal hypophosphatasia. Bone. 2021 09; 150:116007. View Abstract
  22. Metabolic Dysfunction in Hutchinson-Gilford Progeria Syndrome. Cells. 2020 02 08; 9(2). View Abstract
  23. Hutchinson-Gilford Progeria Syndrome: Challenges at Bench and Bedside. Subcell Biochem. 2019; 91:435-451. View Abstract
  24. Doubled lifespan and patient-like pathologies in progeria mice fed high-fat diet. Aging Cell. 2019 02; 18(1):e12852. View Abstract
  25. A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin. Cell Rep. 2018 02 20; 22(8):2006-2015. View Abstract
  26. Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response. Nucleus. 2018 01 01; 9(1):258-275. View Abstract
  27. Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations. Ageing Res Rev. 2017 Jan; 33:18-29. View Abstract
  28. Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes. Oncotarget. 2016 May 24; 7(21):30018-31. View Abstract
  29. Methods to Monitor DNA Repair Defects and Genomic Instability in the Context of a Disrupted Nuclear Lamina. Methods Mol Biol. 2016; 1411:419-37. View Abstract
  30. DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome. Curr Opin Cell Biol. 2015 Jun; 34:75-83. View Abstract
  31. Lamin A ?exon9 mutation leads to telomere and chromatin defects but not genomic instability. Nucleus. 2013 Sep-Oct; 4(5):410-9. View Abstract
  32. Differences in 53BP1 and BRCA1 regulation between cycling and non-cycling cells. Cell Cycle. 2013 Dec 01; 12(23):3629-39. View Abstract

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