Raif S. Geha

Publications

1. Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature. Sci Immunol. 2025 Jan 10; 10(103):eadq1697. View Abstract
2. Germline mutations in a G protein identify signaling cross-talk in T cells. Science. 2024 Sep 20; 385(6715):eadd8947. View Abstract
3. IL-4 acts on skin-derived dendritic cells to promote the TH2 response to cutaneous sensitization and the development of allergic skin inflammation. J Allergy Clin Immunol. 2024 Dec; 154(6):1462-1471.e3. View Abstract
4. Reflections on a half century of mentoring. J Allergy Clin Immunol. 2024 Oct; 154(4):917-921. View Abstract
5. Phosphodiesterase 4 Inhibitors, Basophils, and Atopic Dermatitis. J Invest Dermatol. 2024 May; 144(5):924-926. View Abstract
6. Clinical, immunological features, treatments, and outcomes of autoimmune hemolytic anemia in patients with RAG deficiency. Blood Adv. 2024 02 13; 8(3):603-607. View Abstract
7. Basophils are important for development of allergic skin inflammation. J Allergy Clin Immunol. 2024 May; 153(5):1344-1354.e5. View Abstract
8. Basophils Play a Protective Role in the Recovery of Skin Barrier Function from Mechanical Injury in Mice. J Invest Dermatol. 2024 Aug; 144(8):1784-1797.e4. View Abstract
9. Regulatory T-cell dysfunction and cutaneous exposure to Staphylococcus aureus underlie eczema in DOCK8 deficiency. J Allergy Clin Immunol. 2024 Jul; 154(1):143-156. View Abstract
10. Ant Venom-Based Ceramide Therapy Is Effective Against Atopic Dermatitis In Vivo. J Drugs Dermatol. 2023 Oct 01; 22(10):1001-1006. View Abstract
11. DOCK8 is essential for neutrophil mediated clearance of cutaneous S. aureus infection. Clin Immunol. 2023 09; 254:109681. View Abstract
12. IL-4 receptor alpha blockade dampens allergic inflammation and upregulates IL-17A expression to promote Saureus clearance in antigen sensitized mouse skin. J Allergy Clin Immunol. 2023 10; 152(4):907-915. View Abstract
13. The IL-4Ra Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice. J Allergy Clin Immunol. 2023 05; 151(5):1296-1306.e7. View Abstract
14. The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children. J Clin Invest. 2023 01 03; 133(1). View Abstract
15. NFKB2 haploinsufficiency identified via screening for IFN-a2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications. J Allergy Clin Immunol. 2023 04; 151(4):926-930.e2. View Abstract
16. Immune dysregulation caused by homozygous mutations in CBLB. J Clin Invest. 2022 10 17; 132(20). View Abstract
17. The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity. J Allergy Clin Immunol Pract. 2023 01; 11(1):158-180.e11. View Abstract
18. A homozygous truncating mutation of FGL2 is associated with immune dysregulation. J Allergy Clin Immunol. 2023 02; 151(2):572-578.e1. View Abstract
19. Clinical, immunological, molecular and therapeutic findings in monogenic immune dysregulation diseases: Middle East and North Africa registry. Clin Immunol. 2022 11; 244:109131. View Abstract
20. Author Correction: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2022 May; 23(5):815. View Abstract
21. Inborn Errors of the Immune System Associated With Atopy. Front Immunol. 2022; 13:860821. View Abstract
22. Linker-Improved Chimeric Endolysin Selectively Kills Staphylococcus aureus In Vitro, on Reconstituted Human Epidermis, and in a Murine Model of Skin Infection. Antimicrob Agents Chemother. 2022 05 17; 66(5):e0227321. View Abstract
23. Notch1-CD22-Dependent Immune Dysregulation in the SARS-CoV2-Associated Multisystem Inflammatory Syndrome in Children. Res Sq. 2022 Apr 11. View Abstract
24. Single-cell transcriptome profile of mouse skin undergoing antigen-driven allergic inflammation recapitulates findings in atopic dermatitis skin lesions. J Allergy Clin Immunol. 2022 08; 150(2):373-384. View Abstract
25. Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection. JCI Insight. 2021 11 08; 6(21). View Abstract
26. Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors. JID Innov. 2021 Sep; 1(3):100059. View Abstract
27. Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor ??B kinase alpha (IKKa). Sci Immunol. 2021 Sep 17; 6(63):eabf6723. View Abstract
28. TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells. JCI Insight. 2021 09 08; 6(17). View Abstract
29. Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C). J Allergy Clin Immunol. 2021 09; 148(3):732-738.e1. View Abstract
30. Basophil: The cell that itches. J Allergy Clin Immunol. 2021 09; 148(3):708-709. View Abstract
31. Author Correction: A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. Nat Immunol. 2021 Jun; 22(6):794-795. View Abstract
32. Consensus Middle East and North Africa Registry on Inborn Errors of Immunity. J Clin Immunol. 2021 08; 41(6):1339-1351. View Abstract
33. Macabre TH2 skewing in DOCK8 deficiency. J Allergy Clin Immunol. 2021 07; 148(1):73-75. View Abstract
34. Multi-kingdom ecological drivers of microbiota assembly in preterm infants. Nature. 2021 03; 591(7851):633-638. View Abstract
35. Combined immunodeficiency due to a mutation in the ?1 subunit of the coat protein I complex. J Clin Invest. 2021 02 01; 131(3). View Abstract
36. Author Correction: A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. Nat Immunol. 2021 Jan; 22(1):100. View Abstract
37. Mast cell-derived IL-13 downregulates IL-12 production by skin dendritic cells to inhibit the TH1 cell response to cutaneous antigen exposure. J Allergy Clin Immunol. 2021 06; 147(6):2305-2315.e3. View Abstract
38. Successful hematopoietic stem cell transplantation in a 4-1BB deficient patient with EBV-induced lymphoproliferation. Clin Immunol. 2021 01; 222:108639. View Abstract
39. DOCK8 Expression in Regulatory T Cells Maintains their Stability and Limits Contact Hypersensitivity. J Invest Dermatol. 2021 06; 141(6):1503-1511.e3. View Abstract
40. Transferrin receptor 1 is a cellular receptor for human heme-albumin. Commun Biol. 2020 10 27; 3(1):621. View Abstract
41. Hematopoietic Stem Cell Transplantation Is a Curative Therapy for Transferrin Receptor 1 (TFRC) Deficiency. J Allergy Clin Immunol Pract. 2021 02; 9(2):753-759.e2. View Abstract
42. A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. Nat Immunol. 2020 11; 21(11):1359-1370. View Abstract
43. Efficacy and economics of targeted panel versus whole-exome sequencing in 878 patients with suspected primary immunodeficiency. J Allergy Clin Immunol. 2021 02; 147(2):723-726. View Abstract
44. Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1. J Allergy Clin Immunol. 2020 11; 146(5):1194-1200.e1. View Abstract
45. APRIL expression is upregulated in atopic dermatitis skin lesions and at sites of antigen driven allergic skin inflammation in mice. Clin Immunol. 2020 10; 219:108556. View Abstract
46. DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers. JCI Insight. 2020 08 06; 5(15). View Abstract
47. Acetaminophen Inhibits the Neutrophil Oxidative Burst: Implications for Diagnostic Testing. J Allergy Clin Immunol Pract. 2020 Nov - Dec; 8(10):3543-3548. View Abstract
48. ITK deficiency presenting as autoimmune lymphoproliferative syndrome. J Allergy Clin Immunol. 2021 02; 147(2):743-745.e1. View Abstract
49. Inherited human IFN-? deficiency underlies mycobacterial disease. J Clin Invest. 2020 06 01; 130(6):3158-3171. View Abstract
50. Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution! Clin Immunol. 2020 07; 216:108459. View Abstract
51. Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome. J Allergy Clin Immunol. 2020 11; 146(5):1165-1179.e11. View Abstract
52. ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation. J Allergy Clin Immunol. 2020 06; 145(6):1606-1614.e4. View Abstract
53. Severe combined immunodeficiency caused by inositol-trisphosphate 3-kinase B (ITPKB) deficiency. J Allergy Clin Immunol. 2020 06; 145(6):1696-1699.e6. View Abstract
54. Genotype and functional correlates of disease phenotype in deficiency of adenosine deaminase 2 (DADA2). J Allergy Clin Immunol. 2020 06; 145(6):1664-1672.e10. View Abstract
55. Hypomorphic variants in AK2 reveal the contribution of mitochondrial function to B-cell activation. J Allergy Clin Immunol. 2020 07; 146(1):192-202. View Abstract
56. Dysregulated actin dynamics in activated PI3Kd syndrome. Clin Immunol. 2020 01; 210:108311. View Abstract
57. A novel truncating mutation in MYD88 in a patient with BCG adenitis, neutropenia and delayed umbilical cord separation. Clin Immunol. 2019 10; 207:40-42. View Abstract
58. Combined immunodeficiency in a patient with c-Rel deficiency. J Allergy Clin Immunol. 2019 08; 144(2):606-608.e4. View Abstract
59. A novel variant in STAT2 presenting with hemophagocytic lymphohistiocytosis. J Allergy Clin Immunol. 2019 08; 144(2):611-613.e3. View Abstract
60. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 05 21; 50(5):1262-1275.e4. View Abstract
61. Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency. J Allergy Clin Immunol Pract. 2019 Jul - Aug; 7(6):1970-1985.e4. View Abstract
62. Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency. J Allergy Clin Immunol. 2019 08; 144(2):574-583.e5. View Abstract
63. Rethinking newborn screening for severe combined immunodeficiency: Lessons from an international partnership for patients with primary immunodeficiencies in Pakistan. Clin Immunol. 2019 05; 202:29-32. View Abstract
64. T-cell mitochondrial dysfunction and lymphopenia in DOCK2-deficient patients. J Allergy Clin Immunol. 2019 07; 144(1):306-309.e2. View Abstract
65. F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects. J Allergy Clin Immunol. 2019 06; 143(6):2317-2321.e12. View Abstract
66. Comprehensive Genetic Results for Primary Immunodeficiency Disorders in a Highly Consanguineous Population. Front Immunol. 2018; 9:3146. View Abstract
67. A monoallelic activating mutation in RAC2 resulting in a combined immunodeficiency. J Allergy Clin Immunol. 2019 04; 143(4):1649-1653.e3. View Abstract
68. Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions". J Allergy Clin Immunol. 2019 03; 143(3):894-913. View Abstract
69. Primary immunodeficiencies caused by mutations in actin regulatory proteins. Immunol Rev. 2019 01; 287(1):121-134. View Abstract
70. Atypical phenotype of an old disease or typical phenotype of a new disease: deficiency of adenosine deaminase 2. Turk J Pediatr. 2019; 61(3):413-417. View Abstract
71. Immunologic reconstitution following hematopoietic stem cell transplantation despite lymph node paucity in NF-?B-inducing kinase deficiency. J Allergy Clin Immunol. 2019 03; 143(3):1240-1243.e4. View Abstract
72. Hematopoietic Stem Cell Transplantation as Treatment for Patients with DOCK8 Deficiency. J Allergy Clin Immunol Pract. 2019 03; 7(3):848-855. View Abstract
73. Human primary immunodeficiency caused by expression of a kinase-dead p110d mutant. J Allergy Clin Immunol. 2019 02; 143(2):797-799.e2. View Abstract
74. Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1a release. J Allergy Clin Immunol. 2019 04; 143(4):1426-1443.e6. View Abstract
75. Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. JCI Insight. 2018 08 23; 3(16). View Abstract
76. Defective TLR9-driven STAT3 activation in B cells of patients with CVID. Clin Immunol. 2018 12; 197:40-44. View Abstract
77. MyD88 signaling in T regulatory cells by endogenous ligands dampens skin inflammation in filaggrin deficient mice. Clin Immunol. 2018 10; 195:88-92. View Abstract
78. Autosomal Recessive Agammaglobulinemia - first case with a novel TCF3 mutation from Pakistan. Clin Immunol. 2019 01; 198:100-101. View Abstract
79. The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses. Cell Rep. 2018 07 17; 24(3):619-629. View Abstract
80. IL-22 promotes allergic airway inflammation in epicutaneously sensitized mice. J Allergy Clin Immunol. 2019 02; 143(2):619-630.e7. View Abstract
81. WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun. 2018 05 03; 9(1):1779. View Abstract
82. RORa-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol. 2018 03 02; 3(21). View Abstract
83. Novel biallelic TRNT1 mutations resulting in sideroblastic anemia, combined B and T cell defects, hypogammaglobulinemia, recurrent infections, hypertrophic cardiomyopathy and developmental delay. Clin Immunol. 2018 03; 188:20-22. View Abstract
84. Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses. Cell Host Microbe. 2017 Nov 08; 22(5):653-666.e5. View Abstract
85. A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations. J Clin Invest. 2017 12 01; 127(12):4415-4420. View Abstract
86. DOCK8 Deficiency Presenting as an IPEX-Like Disorder. J Clin Immunol. 2017 Nov; 37(8):811-819. View Abstract
87. DNA recombination defects in Kuwait: Clinical, immunologic and genetic profile. Clin Immunol. 2018 02; 187:68-75. View Abstract
88. DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs. JCI Insight. 2017 10 05; 2(19). View Abstract
89. A novel mutation in the JH4 domain of JAK3 causing severe combined immunodeficiency complicated by vertebral osteomyelitis. Clin Immunol. 2017 10; 183:198-200. View Abstract
90. Clinical, immunologic, and genetic spectrum of 696 patients with combined immunodeficiency. J Allergy Clin Immunol. 2018 04; 141(4):1450-1458. View Abstract
91. DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells. Clin Immunol. 2017 10; 183:263-265. View Abstract
92. Advances in basic and clinical immunology in 2016. J Allergy Clin Immunol. 2017 Oct; 140(4):959-973. View Abstract
93. Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1. Clin Immunol. 2017 10; 183:142-144. View Abstract
94. Uses of Next-Generation Sequencing Technologies for the Diagnosis of Primary Immunodeficiencies. Front Immunol. 2017; 8:847. View Abstract
95. Cernunnos deficiency associated with BCG adenitis and autoimmunity: First case from the national Iranian registry and review of the literature. Clin Immunol. 2017 10; 183:201-206. View Abstract
96. Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency. J Allergy Clin Immunol. 2018 03; 141(3):1060-1073.e3. View Abstract
97. Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. J Exp Med. 2017 Jul 03; 214(7):1937-1947. View Abstract
98. Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation. J Allergy Clin Immunol. 2018 03; 141(3):1050-1059.e10. View Abstract
99. The LRRC8A Mediated "Swell Activated" Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils. Front Pharmacol. 2017; 8:262. View Abstract
100. Disseminated Mycobacterium malmoense and Salmonella Infections Associated with a Novel Variant in NFKBIA. J Clin Immunol. 2017 07; 37(5):415-418. View Abstract
101. Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function. J Allergy Clin Immunol. 2017 Dec; 140(6):1651-1659.e1. View Abstract
102. Janus kinase 3 deficiency caused by a homozygous synonymous exonic mutation that creates a dominant splice site. J Allergy Clin Immunol. 2017 07; 140(1):268-271.e6. View Abstract
103. Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity. J Clin Invest. 2016 11 01; 126(11):4219-4236. View Abstract
104. A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest. 2016 10 03; 126(10):3837-3851. View Abstract
105. Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice. J Allergy Clin Immunol. 2017 Apr; 139(4):1293-1301.e4. View Abstract
106. Epidermodysplasia verruciformis as a manifestation of ARTEMIS deficiency in a young adult. J Allergy Clin Immunol. 2017 01; 139(1):372-375.e4. View Abstract
107. IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016 09 19; 213(10):2147-66. View Abstract
108. Mutations in pyrin masquerading as a primary immunodeficiency. Clin Immunol. 2016 Oct; 171:65-66. View Abstract
109. IL-22 derived from ?d T cells restricts Staphylococcus aureus infection of mechanically injured skin. J Allergy Clin Immunol. 2016 10; 138(4):1098-1107.e3. View Abstract
110. Rapid molecular diagnostics of severe primary immunodeficiency determined by using targeted next-generation sequencing. J Allergy Clin Immunol. 2016 10; 138(4):1142-1151.e2. View Abstract
111. Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression. J Invest Dermatol. 2016 11; 136(11):2192-2200. View Abstract
112. IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. J Allergy Clin Immunol. 2016 11; 138(5):1356-1366. View Abstract
113. Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation. J Allergy Clin Immunol. 2016 11; 138(5):1384-1394.e2. View Abstract
114. Hyper IgM Syndrome: a Report from the USIDNET Registry. J Clin Immunol. 2016 07; 36(5):490-501. View Abstract
115. Combined immunodeficiency due to a homozygous mutation in ORAI1 that deletes the C-terminus that interacts with STIM 1. Clin Immunol. 2016 05; 166-167:100-2. View Abstract
116. Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2016 09; 138(3):852-859.e3. View Abstract
117. Chronic mucocutaneous candidiasis associated with an SH2 domain gain-of-function mutation that enhances STAT1 phosphorylation. J Allergy Clin Immunol. 2016 07; 138(1):297-299. View Abstract
118. O-008 Aberrant Anti-inflammatory Macrophage Function and Differentiation in Wiskott-Aldrich Syndrome Protein-Deficient Mice and Humans. Inflamm Bowel Dis. 2016 Mar; 22 Suppl 1:S3. View Abstract
119. Thymic stromal lymphopoietin and IL-33 promote skin inflammation and vaccinia virus replication in a mouse model of atopic dermatitis. J Allergy Clin Immunol. 2016 07; 138(1):283-286. View Abstract
120. Spectrum of Phenotypes Associated with Mutations in LRBA. J Clin Immunol. 2016 Jan; 36(1):33-45. View Abstract
121. A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nat Genet. 2016 Jan; 48(1):74-8. View Abstract
122. Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association. J Allergy Clin Immunol. 2016 Mar; 137(3):879-88.e2. View Abstract
123. Autoimmune lymphoproliferative syndrome caused by a homozygous FasL mutation that disrupts FasL assembly. J Allergy Clin Immunol. 2016 Jan; 137(1):324-327.e2. View Abstract
124. Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells. Immunity. 2015 Oct 20; 43(4):660-73. View Abstract
125. Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia. J Allergy Clin Immunol. 2015 Nov; 136(5):1401-4.e1-3. View Abstract
126. Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum. J Allergy Clin Immunol. 2015 Dec; 136(6):1591-1600. View Abstract
127. A novel mutation in NCF2 associated with autoimmune disease and a solitary late-onset infection. Clin Immunol. 2015 Dec; 161(2):128-30. View Abstract
128. Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections. N Engl J Med. 2015 Jun 18; 372(25):2409-22. View Abstract
129. A novel mutation in ORAI1 presenting with combined immunodeficiency and residual T-cell function. J Allergy Clin Immunol. 2015 Aug; 136(2):479-482.e1. View Abstract
130. The Rho GTPase Cdc42 Is Essential for the Activation and Function of Mature B Cells. J Immunol. 2015 May 15; 194(10):4750-8. View Abstract
131. The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2015 Aug; 136(2):402-12. View Abstract
132. A novel mutation in ICOS presenting as hypogammaglobulinemia with susceptibility to opportunistic pathogens. J Allergy Clin Immunol. 2015 Sep; 136(3):794-797.e1. View Abstract
133. Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus. J Allergy Clin Immunol. 2015 Jun; 135(6):1511-8.e6. View Abstract
134. Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in I?Ba. J Exp Med. 2015 Feb 09; 212(2):185-202. View Abstract
135. The microbiota is important for IL-17A expression and neutrophil infiltration in lesional skin of Flg(ft/ft) mice. Clin Immunol. 2015 Feb; 156(2):128-30. View Abstract
136. Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA. J Allergy Clin Immunol. 2015 Jan; 135(1):217-27. View Abstract
137. Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Mol Cell Biol. 2014 Dec 01; 34(23):4343-54. View Abstract
138. Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells. J Allergy Clin Immunol. 2014 Dec; 134(6):1365-1374. View Abstract
139. A novel mutation in FOXN1 resulting in SCID: a case report and literature review. Clin Immunol. 2014 Nov; 155(1):30-32. View Abstract
140. The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency. J Allergy Clin Immunol. 2014 Aug; 134(2):276-84. View Abstract
141. CCL25/CCR9 interactions are not essential for colitis development but are required for innate immune cell protection from chronic experimental murine colitis. Inflamm Bowel Dis. 2014 Jul; 20(7):1165-76. View Abstract
142. Lessons in gene hunting: a RAG1 mutation presenting with agammaglobulinemia and absence of B cells. J Allergy Clin Immunol. 2014 Oct; 134(4):983-5.e1. View Abstract
143. A novel disease-causing CD40L mutation reduces expression of CD40 ligand, but preserves CD40 binding capacity. Clin Immunol. 2014 Aug; 153(2):288-91. View Abstract
144. Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype. J Allergy Clin Immunol. 2014 Jun; 133(6):1667-75. View Abstract
145. Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-a 2b therapy. J Allergy Clin Immunol. 2014 Jun; 133(6):1753-5.e3. View Abstract
146. Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med. 2014 May 05; 211(5):929-42. View Abstract
147. Presence of hypogammaglobulinemia and abnormal antibody responses in GATA2 deficiency. J Allergy Clin Immunol. 2014 Jul; 134(1):223-6. View Abstract
148. Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency. J Allergy Clin Immunol. 2014 Jul; 134(1):221-3. View Abstract
149. TRIF signaling is essential for TLR4-driven IgE class switching. J Immunol. 2014 Mar 15; 192(6):2651-8. View Abstract
150. Food allergy: Insights into etiology, prevention, and treatment provided by murine models. J Allergy Clin Immunol. 2014 Feb; 133(2):309-17. View Abstract
151. Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis. Clin Immunol. 2014 Feb; 150(2):220-4. View Abstract
152. A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency. J Allergy Clin Immunol. 2014 Apr; 133(4):1099-108. View Abstract
153. Gene hunting in the genomic era: approaches to diagnostic dilemmas in patients with primary immunodeficiencies. J Allergy Clin Immunol. 2014 Aug; 134(2):262-8. View Abstract
154. A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency. J Allergy Clin Immunol. 2013 Jul; 132(1):151-8. View Abstract
155. T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation. J Allergy Clin Immunol. 2013 Sep; 132(3):648-655.e1. View Abstract
156. C3a receptor promotes viral containment in mice inoculated with vaccinia virus at sites of allergic skin inflammation. J Allergy Clin Immunol. 2013 Sep; 132(3):746-748.e3. View Abstract
157. A phenotypic approach for IUIS PID classification and diagnosis: guidelines for clinicians at the bedside. J Clin Immunol. 2013 Aug; 33(6):1078-87. View Abstract
158. Development of skin lesions in filaggrin-deficient mice is dependent on adaptive immunity. J Allergy Clin Immunol. 2013 Apr; 131(4):1247-50, 1250.e1. View Abstract
159. Wiskott-Aldrich syndrome: a comprehensive review. Ann N Y Acad Sci. 2013 May; 1285:26-43. View Abstract
160. Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2013 Mar; 131(3):840-8. View Abstract
161. Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. J Allergy Clin Immunol. 2013 Feb; 131(2):451-60.e1-6. View Abstract
162. Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal a-toxin-induced keratinocyte death. J Allergy Clin Immunol. 2013 Feb; 131(2):421-7.e1-2. View Abstract
163. Intronic SH2D1A mutation with impaired SAP expression and agammaglobulinemia. Clin Immunol. 2013 Feb; 146(2):84-9. View Abstract
164. Use of whole exome and genome sequencing in the identification of genetic causes of primary immunodeficiencies. Curr Opin Allergy Clin Immunol. 2012 Dec; 12(6):623-8. View Abstract
165. Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity. 2012 Oct 19; 37(4):747-58. View Abstract
166. Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infect Immun. 2012 Dec; 80(12):4071-7. View Abstract
167. SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils. Int Immunol. 2012 Nov; 24(11):719-27. View Abstract
168. A novel homozygous mutation in recombination activating gene 2 in 2 relatives with different clinical phenotypes: Omenn syndrome and hyper-IgM syndrome. J Allergy Clin Immunol. 2012 Dec; 130(6):1414-6. View Abstract
169. LPS-responsive beige-like anchor (LRBA) gene mutation in a family with inflammatory bowel disease and combined immunodeficiency. J Allergy Clin Immunol. 2012 Aug; 130(2):481-8.e2. View Abstract
170. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2012 May 13; 13(6):612-20. View Abstract
171. Clinical, immunologic and genetic profiles of DOCK8-deficient patients in Kuwait. Clin Immunol. 2012 Jun; 143(3):266-72. View Abstract
172. Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4992-7. View Abstract
173. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22; 119(12):2819-28. View Abstract
174. A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP. J Exp Med. 2012 Jan 16; 209(1):29-34. View Abstract
175. Vaccinia Ig ameliorates eczema vaccinatum in a murine model of atopic dermatitis. J Invest Dermatol. 2012 Apr; 132(4):1299-301. View Abstract
176. Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency. Front Immunol. 2011; 2:54. View Abstract
177. Immunization with modified vaccinia virus Ankara prevents eczema vaccinatum in a murine model of atopic dermatitis. J Allergy Clin Immunol. 2011 Oct; 128(4):890-892.e3. View Abstract
178. Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation. J Allergy Clin Immunol. 2011 Sep; 128(3):601-9.e1-4. View Abstract
179. Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin. J Clin Invest. 2011 Jun; 121(6):2210-20. View Abstract
180. Functional analysis of transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) mutations associated with common variable immunodeficiency. J Allergy Clin Immunol. 2011 Jul; 128(1):226-228.e1. View Abstract
181. A peptide derived from the Wiskott-Aldrich syndrome (WAS) protein-interacting protein (WIP) restores WAS protein level and actin cytoskeleton reorganization in lymphocytes from patients with WAS mutations that disrupt WIP binding. J Allergy Clin Immunol. 2011 Apr; 127(4):998-1005.e1-2. View Abstract
182. Ligation of CD46 to CD40 inhibits CD40 signaling in B cells. Int Immunol. 2011 Mar; 23(3):215-21. View Abstract
183. Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2010 Dec; 126(6):1304-5.e3. View Abstract
184. The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency. J Allergy Clin Immunol. 2010 Dec; 126(6):1234-41.e2. View Abstract
185. Mechanical injury polarizes skin dendritic cells to elicit a T(H)2 response by inducing cutaneous thymic stromal lymphopoietin expression. J Allergy Clin Immunol. 2010 Nov; 126(5):976-84, 984.e1-5. View Abstract
186. Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore). 2010 Nov; 89(6):403-425. View Abstract
187. Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16252-6. View Abstract
188. The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. J Allergy Clin Immunol. 2010 Oct; 126(4):784-90. View Abstract
189. Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients. J Allergy Clin Immunol. 2010 Aug; 126(2):332-7, 337.e1-2. View Abstract
190. Parental consanguinity and the risk of primary immunodeficiency disorders: report from the Kuwait National Primary Immunodeficiency Disorders Registry. Int Arch Allergy Immunol. 2011; 154(1):76-80. View Abstract
191. Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. J Allergy Clin Immunol. 2010 Jul; 126(1):127-32.e7. View Abstract
192. Thymic stromal lymphopoietin. Ann N Y Acad Sci. 2010 Jan; 1183:13-24. View Abstract
193. Primary immunodeficiencies: 2009 update. J Allergy Clin Immunol. 2009 Dec; 124(6):1161-78. View Abstract
194. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. J Allergy Clin Immunol. 2009 Oct; 124(4):761-70.e1. View Abstract
195. Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP. Blood. 2009 Nov 19; 114(21):4729-37. View Abstract
196. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14954-9. View Abstract
197. Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. J Allergy Clin Immunol. 2009 Sep; 124(3):485-93, 493.e1. View Abstract
198. The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function. Blood. 2009 Sep 10; 114(11):2254-62. View Abstract
199. Reply to Narra. J Allergy Clin Immunol. 2009 Jun 01; 123(6):1419-1420. View Abstract
200. Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells. J Allergy Clin Immunol. 2009 Jun; 123(6):1277-86.e5. View Abstract
201. Common variable immunodeficiency. Pediatr Res. 2009 May; 65(5 Pt 2):13R-19R. View Abstract
202. WIP is critical for T cell responsiveness to IL-2. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7519-24. View Abstract
203. Toll-like receptor 2 is important for the T(H)1 response to cutaneous sensitization. J Allergy Clin Immunol. 2009 Apr; 123(4):875-82.e1. View Abstract
204. TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40. Int Immunol. 2009 Apr; 21(4):477-88. View Abstract
205. Cellular and molecular mechanisms in atopic dermatitis. Adv Immunol. 2009; 102:135-226. View Abstract
206. Recent advances in the biology of WASP and WIP. Immunol Res. 2009; 44(1-3):99-111. View Abstract
207. Animal models of atopic dermatitis. J Invest Dermatol. 2009 Jan; 129(1):31-40. View Abstract
208. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest. 2009 Jan; 119(1):47-60. View Abstract
209. Primary immune deficiencies with aberrant IgE production. J Allergy Clin Immunol. 2008 Dec; 122(6):1054-62; quiz 1063-4. View Abstract
210. Transmembrane activator and calcium-modulator and cyclophilin ligand interactor mutations in common variable immunodeficiency. Curr Opin Allergy Clin Immunol. 2008 Dec; 8(6):520-6. View Abstract
211. Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. J Allergy Clin Immunol. 2008 Dec; 122(6):1113-1118.e1. View Abstract
212. A girl with severe hand swelling and abdominal cramps. Clin Chem. 2008 Oct; 54(10):1733-6; discussion 1736-7. View Abstract
213. TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11875-80. View Abstract
214. Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J Immunol. 2008 Mar 15; 180(6):3655-9. View Abstract
215. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell. 2008 Mar 07; 132(5):794-806. View Abstract
216. Distinct regulatory functions of SLP-76 and MIST in NK cell cytotoxicity and IFN-gamma production. Int Immunol. 2008 Mar; 20(3):345-52. View Abstract
217. Heterozygous N-terminal deletion of IkappaBalpha results in functional nuclear factor kappaB haploinsufficiency, ectodermal dysplasia, and immune deficiency. J Allergy Clin Immunol. 2007 Oct; 120(4):900-7. View Abstract
218. Images in immunodeficiency. J Allergy Clin Immunol. 2007 Oct; 120(4):982-4. View Abstract
219. Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. J Allergy Clin Immunol. 2007 Oct; 120(4):776-94. View Abstract
220. B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE. J Allergy Clin Immunol. 2008 Jan; 121(1):191-196.e2. View Abstract
221. Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation. J Allergy Clin Immunol. 2007 Dec; 120(6):1382-8. View Abstract
222. Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15817-22. View Abstract
223. Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation. J Allergy Clin Immunol. 2007 Oct; 120(4):885-91. View Abstract
224. Transcellular diapedesis is initiated by invasive podosomes. Immunity. 2007 Jun; 26(6):784-97. View Abstract
225. Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). J Clin Invest. 2007 Jun; 117(6):1550-7. View Abstract
226. WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP). Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):926-31. View Abstract
227. TACI, isotype switching, CVID and IgAD. Immunol Res. 2007; 38(1-3):102-11. View Abstract
228. A novel anti-WIP monoclonal antibody detects an isoform of WIP that lacks the WASP binding domain. Biochem Biophys Res Commun. 2007 Feb 23; 353(4):875-81. View Abstract
229. Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor-dependent innate antiviral immune responses. J Allergy Clin Immunol. 2006 Dec; 118(6):1357-62. View Abstract
230. CD1d restricted natural killer T cells are not required for allergic skin inflammation. J Allergy Clin Immunol. 2006 Dec; 118(6):1363-8. View Abstract
231. TACI mutation in common variable immunodeficiency and IgA deficiency. Curr Allergy Asthma Rep. 2006 Sep; 6(5):357-62. View Abstract
232. 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. Mol Cell Biol. 2006 Jul; 26(14):5214-25. View Abstract
233. IPEX and the role of Foxp3 in the development and function of human Tregs. J Clin Invest. 2006 Jun; 116(6):1473-5. View Abstract
234. The H1 histamine receptor regulates allergic lung responses. J Clin Invest. 2006 Jun; 116(6):1624-32. View Abstract
235. Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee Meeting in Budapest, 2005. J Allergy Clin Immunol. 2006 Apr; 117(4):883-96. View Abstract
236. A second-site mutation in the initiation codon of WAS (WASP) results in expansion of subsets of lymphocytes in an Wiskott-Aldrich syndrome patient. Hum Mutat. 2006 Apr; 27(4):370-5. View Abstract
237. Molecular basis of common variable immunodeficiency. J Allergy Clin Immunol. 2006 Apr; 117(4):740-6; quiz 747. View Abstract
238. The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen. J Allergy Clin Immunol. 2006 Jun; 117(6):1455-61. View Abstract
239. 2. Update on primary immunodeficiency diseases. J Allergy Clin Immunol. 2006 Feb; 117(2 Suppl Mini-Primer):S435-41. View Abstract
240. Lessons learned from molecular defects in nuclear factor kappaB dependent signaling. Microbes Infect. 2006 Apr; 8(4):1151-6. View Abstract
241. A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19063-8. View Abstract
242. Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome. J Allergy Clin Immunol. 2005 Dec; 116(6):1364-71. View Abstract
243. Charles A. Janeway and Fred S. Rosen: the discovery of gamma globulin therapy and primary immunodeficiency diseases at Boston Children's Hospital. J Allergy Clin Immunol. 2005 Oct; 116(4):937-40. View Abstract
244. WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha. Int Immunol. 2006 Feb; 18(2):221-32. View Abstract
245. COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization. J Allergy Clin Immunol. 2005 Aug; 116(2):390-6. View Abstract
246. Are you immunodeficient? J Allergy Clin Immunol. 2005 Aug; 116(2):423-5. View Abstract
247. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat Genet. 2005 Aug; 37(8):829-34. View Abstract
248. Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J Cell Biol. 2005 Jul 04; 170(1):115-26. View Abstract
249. Role of APRIL in the mucosal Iga antibody response. J Pediatr Gastroenterol Nutr. 2005 Apr; 40 Suppl 1:S27. View Abstract
250. Jun N-terminal kinase is essential for CD40-mediated IgE class switching in B cells. J Allergy Clin Immunol. 2005 Apr; 115(4):856-63. View Abstract
251. Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation. Immunol Rev. 2005 Feb; 203:21-37. View Abstract
252. TACI and BAFF-R mediate isotype switching in B cells. J Exp Med. 2005 Jan 03; 201(1):35-9. View Abstract
253. Characteristics of mycobacterial infection in patients with immunodeficiency and nuclear factor-kappaB essential modulator mutation, with or without ectodermal dysplasia. J Am Acad Dermatol. 2004 Nov; 51(5):718-22. View Abstract
254. Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia. J Allergy Clin Immunol. 2004 Sep; 114(3):650-6. View Abstract
255. Primary immunodeficiency diseases: an update. J Allergy Clin Immunol. 2004 Sep; 114(3):677-87. View Abstract
256. The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. J Clin Invest. 2004 Aug; 114(3):399-407. View Abstract
257. RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. J Exp Med. 2004 Aug 02; 200(3):399-404. View Abstract
258. Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol. 2004 Jun; 24(12):5269-80. View Abstract
259. The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation. J Allergy Clin Immunol. 2004 Apr; 113(4):725-33. View Abstract
260. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol. 2004 Mar; 16(3):395-404. View Abstract
261. Impaired IgA class switching in APRIL-deficient mice. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3903-8. View Abstract
262. WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells. J Exp Med. 2004 Feb 02; 199(3):357-68. View Abstract
263. Allergy and hypersensitivity. Nature versus nurture in allergy and hypersensitivity. Curr Opin Immunol. 2003 Dec; 15(6):603-8. View Abstract
264. Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. Int Immunol. 2003 Dec; 15(12):1431-40. View Abstract
265. The mature activating natural killer cell immunologic synapse is formed in distinct stages. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14151-6. View Abstract
266. The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients. Medicine (Baltimore). 2003 Nov; 82(6):373-84. View Abstract
267. Epicutaneous sensitization with superantigen induces allergic skin inflammation. J Allergy Clin Immunol. 2003 Nov; 112(5):981-7. View Abstract
268. Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. J Exp Med. 2003 Oct 20; 198(8):1189-200. View Abstract
269. Finding NEMO: genetic disorders of NF-[kappa]B activation. J Clin Invest. 2003 Oct; 112(7):983-5. View Abstract
270. IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. J Clin Invest. 2003 Oct; 112(7):1058-66. View Abstract
271. Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells. J Infect Dis. 2003 Oct 01; 188(7):948-53. View Abstract
272. The regulation of immunoglobulin E class-switch recombination. Nat Rev Immunol. 2003 Sep; 3(9):721-32. View Abstract
273. Acute chylothorax in children: selective retention of memory T cells and natural killer cells. J Pediatr. 2003 Aug; 143(2):243-9. View Abstract
274. WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J. 2003 Jul 15; 22(14):3602-12. View Abstract
275. Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma. J Allergy Clin Immunol. 2003 Jul; 112(1):149-58. View Abstract
276. C4b-binding protein (C4BP) activates B cells through the CD40 receptor. Immunity. 2003 Jun; 18(6):837-48. View Abstract
277. WIP participates in actin reorganization and ruffle formation induced by PDGF. J Cell Sci. 2003 Jun 15; 116(Pt 12):2443-51. View Abstract
278. Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells. Mol Cell Biol. 2003 Apr; 23(7):2395-406. View Abstract
279. Primary immunodeficiency diseases: an update. Clin Exp Immunol. 2003 Apr; 132(1):9-15. View Abstract
280. IgG Fc receptor polymorphisms in human disease: implications for intravenous immunoglobulin therapy. J Allergy Clin Immunol. 2003 Apr; 111(4):697-703. View Abstract
281. 12. Primary immunodeficiency diseases. J Allergy Clin Immunol. 2003 Feb; 111(2 Suppl):S571-81. View Abstract
282. Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol Cell. 2002 Dec; 10(6):1269-81. View Abstract
283. The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. Immunity. 2002 Sep; 17(3):265-76. View Abstract
284. X-linked lymphoproliferative disease: genetic lesions and clinical consequences. Curr Allergy Asthma Rep. 2002 Sep; 2(5):361-7. View Abstract
285. Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11351-6. View Abstract
286. Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations. J Clin Invest. 2002 Jun; 109(11):1501-9. View Abstract
287. Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma. J Allergy Clin Immunol. 2002 Jun; 109(6):980-7. View Abstract
288. Aspartame: review of safety. Regul Toxicol Pharmacol. 2002 Apr; 35(2 Pt 2):S1-93. View Abstract
289. CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J Clin Invest. 2002 Mar; 109(5):621-8. View Abstract
290. WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity. 2002 Feb; 16(2):193-204. View Abstract
291. Differential role of SLP-76 domains in T cell development and function. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):884-9. View Abstract
292. Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation. J Allergy Clin Immunol. 2002 Jan; 109(1):106-13. View Abstract
293. IL-3 induces B7.2 (CD86) expression and costimulatory activity in human eosinophils. J Immunol. 2001 Dec 01; 167(11):6097-104. View Abstract
294. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol. 2001 Oct; 3(10):897-904. View Abstract
295. TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice. Immunity. 2001 Oct; 15(4):647-57. View Abstract
296. WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nat Cell Biol. 2001 May; 3(5):484-91. View Abstract
297. Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol. 2001 Apr; 107(4):751-62. View Abstract
298. IgE regulation and roles in asthma pathogenesis. J Allergy Clin Immunol. 2001 Mar; 107(3):429-40. View Abstract
299. Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching. J Clin Invest. 2001 Feb; 107(3):371-8. View Abstract
300. An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis. J Allergy Clin Immunol. 2001 Feb; 107(2):359-66. View Abstract
301. Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex. Blood. 2000 Dec 01; 96(12):3786-92. View Abstract
302. Allergy, a disease of the internal and external environments Curr Opin Immunol. 2000 Dec; 12(6):615-7. View Abstract
303. CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice. Am J Respir Cell Mol Biol. 2000 Nov; 23(5):646-51. View Abstract
304. Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate. J Allergy Clin Immunol. 2000 Nov; 106(5):973-80. View Abstract
305. Identification and characterization of two CD40-inducible enhancers in the mouse TRAF1 gene locus. Mol Immunol. 2000 Nov; 37(16):961-73. View Abstract
306. The role of SLP-76 and LAT in lymphocyte development. Curr Opin Immunol. 2000 Apr; 12(2):173-8. View Abstract
307. Review of alleged reaction to monosodium glutamate and outcome of a multicenter double-blind placebo-controlled study. J Nutr. 2000 04; 130(4S Suppl):1058S-62S. View Abstract
308. Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcgamma receptors I and II/III. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1725-30. View Abstract
309. Molecular mechanisms of IgE regulation. J Allergy Clin Immunol. 2000 Feb; 105(2 Pt 2):S547-58. View Abstract
310. Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein. J Exp Med. 1999 Oct 18; 190(8):1093-102. View Abstract
311. IgE in asthma and atopy: cellular and molecular connections. J Clin Invest. 1999 Oct; 104(7):829-35. View Abstract
312. Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb. Immunity. 1999 Sep; 11(3):339-48. View Abstract
313. The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast. J Biol Chem. 1999 Jun 11; 274(24):17103-8. View Abstract
314. SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. J Clin Invest. 1999 Jun; 103(12):1737-43. View Abstract
315. Structure of the murine TRAF1 gene. Mol Immunol. 1999 Jun; 36(9):611-7. View Abstract
316. Contribution of CD40-CD154-mediated costimulation to an alloresponse in vivo. Transplantation. 1999 May 15; 67(9):1284-7. View Abstract
317. Effect of intravenous immunoglobulin on steroid consumption in patients with severe asthma: a double-blind, placebo-controlled, randomized trial. J Allergy Clin Immunol. 1999 May; 103(5 Pt 1):810-5. View Abstract
318. Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J Clin Invest. 1999 Apr; 103(8):1103-11. View Abstract
319. Regulation of IgE synthesis: the molecular basis and implications for clinical modulation. Allergy Asthma Proc. 1999 Jan-Feb; 20(1):1-8. View Abstract
320. Waltzing with WASP. Trends Cell Biol. 1999 Jan; 9(1):15-9. View Abstract
321. The mouse genome contains two expressed intronless retroposed pseudogenes for the sentrin/sumo-1/PIC1 conjugating enzyme Ubc9. Mol Immunol. 1998 Nov; 35(16):1057-67. View Abstract
322. Role of JAK3 in CD40-mediated signaling. Blood. 1998 Oct 01; 92(7):2435-40. View Abstract
323. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 1998 Oct 01; 395(6701):462-9. View Abstract
324. The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck. J Biol Chem. 1998 Aug 14; 273(33):20992-5. View Abstract
325. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell. 1998 Jul 24; 94(2):229-38. View Abstract
326. IgE-mediated allergy and desensitization to factor IX in hemophilia B. J Allergy Clin Immunol. 1998 Jul; 102(1):113-7. View Abstract
327. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest. 1998 Apr 15; 101(8):1614-22. View Abstract
328. Molecular mechanisms of immunoglobulin E regulation. Int Arch Allergy Immunol. 1998 Apr; 115(4):257-69. View Abstract
329. CD40 ligation and IL-4 use different mechanisms of transcriptional activation of the human lymphotoxin alpha promoter in B cells. Eur J Immunol. 1998 Mar; 28(3):901-6. View Abstract
330. The hyper-IgM (HIM) syndrome. Springer Semin Immunopathol. 1998; 19(4):383-99. View Abstract
331. WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14671-6. View Abstract
332. Targeted gene disruption of murine CD7. Int Immunol. 1997 Dec; 9(12):1875-83. View Abstract
333. Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10844-9. View Abstract
334. Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5866-71. View Abstract
335. Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity. 1997 Apr; 6(4):379-87. View Abstract
336. Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts. J Clin Immunol. 1997 Mar; 17(2):109-26. View Abstract
337. Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40. Int Immunol. 1997 Mar; 9(3):395-405. View Abstract
338. CD30 induction of human immunodeficiency virus gene transcription is mediated by TRAF2. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1390-5. View Abstract
339. HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck. Int Immunol. 1997 Jan; 9(1):53-64. View Abstract
340. Association of human fas (CD95) with a ubiquitin-conjugating enzyme (UBC-FAP). J Biol Chem. 1996 Dec 06; 271(49):31037-43. View Abstract
341. Large-volume leukapheresis in pediatric patients: processing more blood diminishes the apparent magnitude of intra-apheresis recruitment. Transfusion. 1996 Oct; 36(10):879-85. View Abstract
342. The superantigen toxic shock syndrome toxin-1 induces CD40 ligand expression and modulates IgE isotype switching. Int Immunol. 1996 Oct; 8(10):1503-10. View Abstract
343. Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4994-8. View Abstract
344. Mechanisms of inhibition of IgE synthesis by nedocromil sodium: nedocromil sodium inhibits deletional switch recombination in human B cells. J Allergy Clin Immunol. 1996 May; 97(5):1141-50. View Abstract
345. CD40 expression and function in murine B cell ontogeny. Int Immunol. 1996 Mar; 8(3):405-411. View Abstract
346. Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II). Clin Exp Immunol. 1996 Mar; 103(3):408-13. View Abstract
347. The CD40L promoter contains nuclear factor of activated T cells-binding motifs which require AP-1 binding for activation of transcription. J Biol Chem. 1996 Feb 16; 271(7):3763-70. View Abstract
348. Characterization of a 23-kDa protein associated with CD40. Proc Natl Acad Sci U S A. 1995 Dec 05; 92(25):11633-6. View Abstract
349. Cross-linking of Fc gamma receptors activates HIV-1 long terminal repeat-driven transcription in human monocytes. Int Immunol. 1995 Oct; 7(10):1665-70. View Abstract
350. Defective expression of early activation genes in cartilage-hair hypoplasia (CHH) with severe combined immunodeficiency (SCID). Clin Exp Immunol. 1995 Oct; 102(1):6-10. View Abstract
351. CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1). Clin Immunol Immunopathol. 1995 Sep; 76(3 Pt 2):S208-13. View Abstract
352. CD40-mediated lymphotoxin alpha expression in human B cells is tyrosine kinase dependent. Eur J Immunol. 1995 Sep; 25(9):2438-44. View Abstract
353. Bacterial superantigens induce the proliferation of resting gamma/delta receptor bearing T cells. Immunol Invest. 1995 Aug; 24(5):713-24. View Abstract
354. Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells: role of NF-kappa B. J Immunol. 1995 Jul 15; 155(2):902-8. View Abstract
355. CD40 ligand expression is developmentally regulated in human thymocytes. Clin Immunol Immunopathol. 1995 Jul; 76(1 Pt 1):52-8. View Abstract
356. Association of the high-affinity receptor for IgG with the protein tyrosine kinases Hck and Lyn. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):135. View Abstract
357. Activation of tumor necrosis factor-alpha and lymphotoxin-alpha via anti-CD40 in human B cells. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):368-9. View Abstract
358. CD40 ligand/CD40 deficiency. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):37-9. View Abstract
359. Expression of the CD40 ligand in T lymphocytes and induction of IgE isotype switching. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):43-4. View Abstract
360. A point mutation in exon 2 of the CD40 ligand gene causes the simultaneous expression of two defective mRNA species in X-linked hyperimmunoglobulinemia M. Hum Mol Genet. 1995 Apr; 4(4):759-61. View Abstract
361. Interleukin-4 receptor expression by human B cells: functional analysis with a human interleukin-4 toxin, DAB389IL-4. J Allergy Clin Immunol. 1995 Apr; 95(4):893-900. View Abstract
362. gamma/delta T lymphocytes express CD40 ligand and induce isotype switching in B lymphocytes. J Exp Med. 1995 Mar 01; 181(3):1239-44. View Abstract
363. Role of protein tyrosine kinases and phosphatases in isotype switching: crosslinking CD45 to CD40 inhibits IgE isotype switching in human B cells. Immunol Lett. 1995 Feb; 45(1-2):99-106. View Abstract
364. X-linked agammaglobulinemia and immunoglobulin deficiency with normal or elevated IgM: immunodeficiencies of B cell development and differentiation. Adv Immunol. 1995; 60:37-56. View Abstract
365. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):12135-9. View Abstract
366. CD40 ligation induces lymphotoxin alpha gene expression in human B cells. Int Immunol. 1994 Dec; 6(12):1883-90. View Abstract
367. Protein tyrosine kinase activation and protein kinase C translocation are functional components of CD40 signal transduction in resting human B cells. Immunol Invest. 1994 Nov; 23(6-7):437-48. View Abstract
368. A toxic shock syndrome toxin-1 peptide that shows homology to amino acids 180-193 of mycobacterial heat shock protein 65 is presented as conventional antigen. Immunol Invest. 1994 Nov; 23(6-7):381-91. View Abstract
369. Immunosuppressant deoxyspergualin inhibits antigen processing in monocytes. J Immunol. 1994 Nov 01; 153(9):3908-16. View Abstract
370. Role of protein tyrosine kinases in CD40/interleukin-4-mediated isotype switching to IgE. J Allergy Clin Immunol. 1994 Oct; 94(4):784-92. View Abstract
371. MHC class II signaling in B-cell activation. Immunol Today. 1994 Sep; 15(9):418-22. View Abstract
372. Superantigens activate HIV-1 gene expression in monocytic cells. Clin Immunol Immunopathol. 1994 Sep; 72(3):357-61. View Abstract
373. Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. J Exp Med. 1994 Sep 01; 180(3):1165-70. View Abstract
374. Engagement of the common leukocyte antigen CD45 induces homotypic adhesion of activated human T cells. J Immunol. 1994 Aug 15; 153(4):1593-602. View Abstract
375. Decreased expression of the ligand for CD40 in newborn lymphocytes. Eur J Immunol. 1994 Aug; 24(8):1925-8. View Abstract
376. Disodium cromoglycate inhibits S mu-->S epsilon deletional switch recombination and IgE synthesis in human B cells. J Exp Med. 1994 Aug 01; 180(2):663-71. View Abstract
377. Structure of the murine CD40 ligand gene. Mol Immunol. 1994 Aug; 31(12):895-900. View Abstract
378. Molecular pathology of X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1). Immunol Rev. 1994 Apr; 138:87-104. View Abstract
379. Engagement of MHC class II molecules by staphylococcal superantigens activates src-type protein tyrosine kinases. Eur J Immunol. 1994 Mar; 24(3):651-8. View Abstract
380. Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. J Clin Invest. 1994 Mar; 93(3):1315-20. View Abstract
381. Early activation events induced by the staphylococcal superantigen toxic shock syndrome toxin-1 in human peripheral blood monocytes. Clin Immunol Immunopathol. 1994 Feb; 70(2):137-44. View Abstract
382. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2. J Exp Med. 1994 Feb 01; 179(2):673-80. View Abstract
383. Role of CD40-CD40-ligand interaction in Ig-isotype switching. Curr Opin Immunol. 1993 Dec; 5(6):963-7. View Abstract
384. Sequential switching from mu to epsilon via gamma 4 in human B cells stimulated with IL-4 and hydrocortisone. J Immunol. 1993 Nov 01; 151(9):4528-33. View Abstract
385. Physical association between the high-affinity IgG receptor (Fc gamma RI) and the gamma subunit of the high-affinity IgE receptor (Fc epsilon RI gamma). Proc Natl Acad Sci U S A. 1993 Oct 01; 90(19):8847-50. View Abstract
386. Aspartame is no more likely than placebo to cause urticaria/angioedema: results of a multicenter, randomized, double-blind, placebo-controlled, crossover study. J Allergy Clin Immunol. 1993 Oct; 92(4):513-20. View Abstract
387. Activator protein-1 (AP-1) is stimulated by microbial superantigens in human monocytic cells. Eur J Immunol. 1993 Sep; 23(9):2129-35. View Abstract
388. Therapy for patients with recurrent infections and low serum IgG3 levels. J Allergy Clin Immunol. 1993 Aug; 92(2):353-5. View Abstract
389. Deletions in the ligand for CD40 in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1). Int Immunol. 1993 Jul; 5(7):769-73. View Abstract
390. Microbial superantigens induce NF-kappa B in the human monocytic cell line THP-1. J Immunol. 1993 Jun 15; 150(12):5604-13. View Abstract
391. Molecular basis of a multiple lymphokine deficiency in a patient with severe combined immunodeficiency. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4728-32. View Abstract
392. Chromosomal localization of the gene for human B-cell antigen CD40. Somat Cell Mol Genet. 1993 May; 19(3):295-8. View Abstract
393. A protein of the AP-1 family is a component of nuclear factor of activated T cells. J Immunol. 1993 Apr 15; 150(8 Pt 1):3284-90. View Abstract
394. Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2170-3. View Abstract
395. Signal transduction by microbial superantigens via MHC class II molecules. Immunol Rev. 1993 Feb; 131:43-59. View Abstract
396. Severe combined immunodeficiency with selective T-cell cytokine genes. Pediatr Res. 1993 Jan; 33(1 Suppl):S20-2; discussion S22-3. View Abstract
397. Regulation of IgE synthesis: from the membrane to the genes. Springer Semin Immunopathol. 1993; 15(1):5-16. View Abstract
398. Localization of the genetic defect in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1) to the CD40 ligand gene. Trans Assoc Am Physicians. 1993; 106:91-5. View Abstract
399. Regulation of isotype switching. Curr Opin Immunol. 1992 Dec; 4(6):794-7. View Abstract
400. IgE regulation and lymphokine patterns in aging humans. J Allergy Clin Immunol. 1992 Oct; 90(4 Pt 1):630-6. View Abstract
401. Role of protein kinase activation in the induction of B cell adhesion by MHC class II ligands. J Immunol. 1992 Sep 15; 149(6):1853-8. View Abstract
402. Protein tyrosine phosphorylation induced via the IgG receptors Fc gamma Ri and Fc gamma RII in the human monocytic cell line THP-1. J Immunol. 1992 Sep 01; 149(5):1751-7. View Abstract
403. Regulation of IgE synthesis in humans. J Allergy Clin Immunol. 1992 Aug; 90(2):143-50. View Abstract
404. Signals delivered via MHC class II molecules synergize with signals delivered via TCR/CD3 to cause proliferation and cytokine gene expression in T cells. J Immunol. 1992 Jul 01; 149(1):65-70. View Abstract
405. Engagement of MHC class I molecules induces cell adhesion via both LFA-1-dependent and LFA-1-independent pathways. J Immunol. 1992 Apr 01; 148(7):2045-9. View Abstract
406. Role of protein tyrosine phosphorylation in monokine induction by the staphylococcal superantigen toxic shock syndrome toxin-1. J Immunol. 1992 Apr 01; 148(7):2237-41. View Abstract
407. Developmental regulation of transmembrane signaling via the T cell antigen receptor/CD3 complex in human T lymphocytes. J Immunol. 1992 Mar 01; 148(5):1315-21. View Abstract
408. A toxic shock syndrome toxin-1 peptide that shows homology to mycobacterial heat shock protein 18 is presented as conventional antigen to T cells by multiple HLA-DR alleles. J Immunol. 1992 Feb 15; 148(4):1025-30. View Abstract
409. Superantigens. Curr Opin Immunol. 1992 Feb; 4(1):74-8. View Abstract
410. Cellular and molecular mechanisms of immune activation by microbial superantigens: studies using toxic shock syndrome toxin-1. Chem Immunol. 1992; 55:146-71. View Abstract
411. Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen. J Exp Med. 1992 Jan 01; 175(1):289-92. View Abstract
412. Lymphokine profile in bone marrow transplant recipients. Blood. 1991 Dec 01; 78(11):3076-80. View Abstract
413. Cardiotoxicity during treatment of severe childhood asthma. Pediatrics. 1991 Dec; 88(6):1180-6. View Abstract
414. Novel immune deficiencies: defective transcription of lymphokine genes. Clin Immunol Immunopathol. 1991 Nov; 61(2 Pt 2):S16-20. View Abstract
415. Deletional switch recombination occurs in interleukin-4-induced isotype switching to IgE expression by human B cells. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7528-32. View Abstract
416. Staphylococcal exotoxins deliver activation signals to human T-cell clones via major histocompatibility complex class II molecules. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7533-7. View Abstract
417. Regulation of IgE synthesis in humans: a tale of two signals. J Allergy Clin Immunol. 1991 Sep; 88(3 Pt 1):285-95. View Abstract
418. Hydrocortisone and IL-4 induce IgE isotype switching in human B cells. J Immunol. 1991 Sep 01; 147(5):1557-60. View Abstract
419. Engagement of CD14 on human monocytes terminates T cell proliferation by delivering a negative signal to T cells. J Immunol. 1991 Aug 15; 147(4):1134-8. View Abstract
420. Transcriptional activation of IL-1 beta and tumor necrosis factor-alpha genes by MHC class II ligands. J Immunol. 1991 Apr 01; 146(7):2310-5. View Abstract
421. Engagement of MHC-class II molecules by staphylococcal exotoxins delivers a comitogenic signal to human B cells. J Immunol. 1991 Mar 01; 146(5):1661-6. View Abstract
422. Toxic shock syndrome toxin-1, toxic shock, and the immune system. Curr Top Microbiol Immunol. 1991; 174:63-79. View Abstract
423. Induction of human T cell proliferation by a monoclonal antibody to CD5. J Immunol. 1991 Jan 01; 146(1):47-52. View Abstract
424. Novel immune deficiencies: defective transcription of lymphokine genes. Clin Exp Allergy. 1991 Jan; 21 Suppl 1:190-4. View Abstract
425. CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J Exp Med. 1990 Dec 01; 172(6):1861-4. View Abstract
426. Primary combined immunodeficiency resulting from defective transcription of multiple T-cell lymphokine genes. Proc Natl Acad Sci U S A. 1990 Dec; 87(24):10033-7. View Abstract
427. Induction of germ-line and mature C epsilon transcripts in human B cells stimulated with rIL-4 and EBV. J Immunol. 1990 Nov 15; 145(10):3468-73. View Abstract
428. Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule 1-dependent cell adhesion. J Exp Med. 1990 Nov 01; 172(5):1513-6. View Abstract
429. Interleukin 4 down-regulates the expression of CD14 in normal human monocytes. Eur J Immunol. 1990 Nov; 20(11):2375-81. View Abstract
430. Engagement of the monocyte surface antigen CD14 induces lymphocyte function-associated antigen-1/intercellular adhesion molecule-1-dependent homotypic adhesion. J Immunol. 1990 Sep 01; 145(5):1390-4. View Abstract
431. Binding of toxic shock syndrome toxin-1 to murine major histocompatibility complex class II molecules. Eur J Immunol. 1990 Sep; 20(9):1911-6. View Abstract
432. Response to a Haemophilus influenzae type b diphtheria CRM197 conjugate vaccine in children with a defect of antibody production to Haemophilus influenzae type b polysaccharide. J Allergy Clin Immunol. 1990 May; 85(5):948-53. View Abstract
433. Bone marrow transplantation (BMT) for the syndrome of pigmentary dilution and lymphohistiocytosis (Griscelli's syndrome). J Clin Immunol. 1990 May; 10(3):146-53. View Abstract
434. Regulation of immunoglobulin (Ig)E synthesis in the hyper-IgE syndrome. J Clin Invest. 1990 May; 85(5):1666-71. View Abstract
435. Recombinant gamma interferon in treatment of patients with atopic dermatitis and elevated IgE levels. Am J Med. 1990 Apr; 88(4):365-70. View Abstract
436. Signal transduction via leukocyte antigen CD43 (sialophorin). Feedback regulation by protein kinase C. J Immunol. 1990 Feb 15; 144(4):1455-60. View Abstract
437. IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures. J Immunol. 1990 Jan 15; 144(2):570-3. View Abstract
438. Effect of isotypes and allelic polymorphism on the binding of staphylococcal exotoxins to MHC class II molecules. J Immunol. 1990 Jan 01; 144(1):226-30. View Abstract
439. T-cell antigen receptor (TCR)-alpha/beta heterodimer formation is a prerequisite for association of CD3-zeta 2 into functionally competent TCR.CD3 complexes. J Biol Chem. 1989 Dec 05; 264(34):20760-9. View Abstract
440. Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules. J Cell Biol. 1989 Dec; 109(6 Pt 2):3435-44. View Abstract
441. The staphylococcal toxic shock syndrome toxin 1 triggers B cell proliferation and differentiation via major histocompatibility complex-unrestricted cognate T/B cell interaction. J Exp Med. 1989 Dec 01; 170(6):2011-22. View Abstract
442. Staphylococcal enterotoxin B and toxic shock syndrome toxin-1 bind to distinct sites on HLA-DR and HLA-DQ molecules. J Immunol. 1989 Oct 15; 143(8):2583-8. View Abstract
443. Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol. 1989 Aug 15; 143(4):1283-9. View Abstract
444. Endogenous interleukin 6 plays an obligatory role in interleukin 4-dependent human IgE synthesis. Eur J Immunol. 1989 Aug; 19(8):1419-24. View Abstract
445. The evolution of MHC restrictions in antigen recognition by T cells in a haploidentical bone marrow transplant recipient. J Immunol. 1989 Jul 01; 143(1):84-8. View Abstract
446. The IgE system. Ann Allergy. 1989 Jul; 63(1):4-11. View Abstract
447. Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody. J Immunol. 1989 Jun 15; 142(12):4194-200. View Abstract
448. Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules. Proc Natl Acad Sci U S A. 1989 Jun; 86(11):4210-4. View Abstract
449. The B-cell binding site on human immunoglobulin E. Nature. 1989 Apr 20; 338(6217):649-51. View Abstract
450. Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J Exp Med. 1989 Apr 01; 169(4):1295-307. View Abstract
451. An immunodeficiency characterized by defective signal transduction in T lymphocytes. N Engl J Med. 1989 Mar 16; 320(11):696-702. View Abstract
452. Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact. J Clin Immunol. 1989 Mar; 9(2):151-8. View Abstract
453. Regulation of IgE synthesis in humans. J Clin Immunol. 1989 Mar; 9(2):75-83. View Abstract
454. Intracellular cleavage of newly synthesized low affinity Fc epsilon receptor (Fc epsilon R2) provides a second pathway for the generation of the 28-kDa soluble Fc epsilon R2 fragment. J Immunol. 1989 Mar 01; 142(5):1614-20. View Abstract
455. Interleukin 4 dependent induction of IgE synthesis and CD23 expression by the supernatants of a human helper T cell clone. Int Arch Allergy Appl Immunol. 1989; 88(1-2):119-21. View Abstract
456. Hyper immunoglobulin E syndrome. Immunodefic Rev. 1989; 1(2):155-72. View Abstract
457. Regulation of human IgE synthesis. Int Rev Immunol. 1989; 5(2):111-5. View Abstract
458. IgE response and its regulation in allergic diseases. Pediatr Clin North Am. 1988 Oct; 35(5):953-67. View Abstract
459. Phosphorylation of T cell membrane proteins by activators of protein kinase C. J Immunol. 1988 Jun 15; 140(12):4308-14. View Abstract
460. Impaired antibody responses in the hyperimmunoglobulin E syndrome. J Allergy Clin Immunol. 1988 Jun; 81(6):1082-7. View Abstract
461. Antibody deficiency syndromes and novel immunodeficiencies. Pediatr Infect Dis J. 1988 May; 7(5 Suppl):S57-60. View Abstract
462. Recognition by a human alloreactive T-cell clone of an HLA-DP-associated epitope on monocytes and fibroblasts but not on B cells. J Clin Immunol. 1988 May; 8(3):163-70. View Abstract
463. Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes. J Exp Med. 1988 Apr 01; 167(4):1406-16. View Abstract
464. Clinical and immunologic aspects of the hyperimmunoglobulin E syndrome. Hematol Oncol Clin North Am. 1988 Mar; 2(1):81-100. View Abstract
465. Regulation of IgE synthesis in atopic disease. Hosp Pract (Off Ed). 1988 Feb 15; 23(2):91-102. View Abstract
466. Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation, and calcium mobilization in human T cells. J Immunol. 1988 Feb 15; 140(4):1250-5. View Abstract
467. Asthma, recurrent infections and IgG2 deficiency. Ann Allergy. 1988 Feb; 60(2):98, 134-6. View Abstract
468. Fatal varicella in steroid-dependent asthma. J Allergy Clin Immunol. 1988 Jan; 81(1):47-51. View Abstract
469. IgG antibody response to polysaccharides in children with recurrent infections. Monogr Allergy. 1988; 23:97-102. View Abstract
470. Increased in vitro bone resorption by monocytes in the hyper-immunoglobulin E syndrome. J Immunol. 1988 Jan 01; 140(1):84-8. View Abstract
471. Cell cooperation in haploidentical bone marrow transplant recipient. Transplant Proc. 1987 Dec; 19(6 Suppl 7):117-21. View Abstract
472. Requirements for activation of human peripheral blood T cells by mouse monoclonal antibodies to CD3. Clin Immunol Immunopathol. 1987 Apr; 43(1):48-64. View Abstract
473. The presence of IgE on macrophages and dendritic cells infiltrating into the skin lesion of atopic dermatitis. Clin Immunol Immunopathol. 1987 Mar; 42(3):328-37. View Abstract
474. Regulation of the human IgE antibody response. Int Rev Immunol. 1987 Jan; 2(1):75-91. View Abstract
475. Polymerase activity in lymphocyte culture supernatants from patients with Kawasaki disease. Prog Clin Biol Res. 1987; 250:125-30. View Abstract
476. Polymerase activity in lymphocyte culture supernatants from patients with Kawasaki disease. Nature. 1986 Oct 30-Nov 5; 323(6091):814-6. View Abstract
477. Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon. J Clin Invest. 1986 May; 77(5):1428-35. View Abstract
478. Analysis of antigen uptake and presentation by Epstein-Barr virus-transformed human lymphoblastoid B cells. Eur J Immunol. 1984 Apr; 14(4):291-8. View Abstract
479. Mechanisms of the failure of resting B cells to present tetanus toxoid antigen to T cells. J Immunol. 1984 Mar; 132(3):1144-50. View Abstract
480. Immunoregulatory T-cell defects. Immunol Today. 1983 Aug; 4(8):233-6. View Abstract
481. Characterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies. J Allergy Clin Immunol. 1983 Jan; 71(1 Pt 1):47-56. View Abstract
482. Macrophage T-cell interaction in man: handling of tetanus toxoid antigen by human monocytes. J Clin Immunol. 1981 Jan; 1(1):21-9. View Abstract
483. Hyper immunoglobulin M immunodeficiency. (Dysgammaglobulinemia). Presence of immunoglobulin M-secreting plasmacytoid cells in peripheral blood and failure of immunoglobulin M-immunoglobulin G switch in B-cell differentiation. J Clin Invest. 1979 Aug; 64(2):385-91. View Abstract
484. The specificity of T-cell helper factor in man. J Exp Med. 1977 Jun 01; 145(6):1436-48. View Abstract
485. Cooperation between human thymus-derived and bone marrow-derived lymphocytes in the antibody response to ragweed antigen E in vitro. J Clin Invest. 1975 Aug; 56(2):386-90. View Abstract
486. Heterogeneity of "acquired" or common variable agammaglobulinemia. N Engl J Med. 1974 Jul 04; 291(1):1-6. View Abstract
487. Synthesis of an M component by circulating B lymphocytes in severe combined immunodeficiency. N Engl J Med. 1974 Mar 28; 290(13):726-8. View Abstract
488. Interaction of human thymus-derived and non-thymus-derived lymphocytes in vitro. Induction of proliferation and antibody synthesis in B lymphocytes by a soluble factor released from antigen-stimulated T lymphocytes. J Exp Med. 1973 Nov 01; 138(5):1230-47. View Abstract
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