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Research Overview

Dr. Nandivada is a pediatric general surgeon with a focus in congenital colorectal malformations and disease. She is interested in improving the care for children with Hirschsprung disease, who continue to suffer from enterocolitis and chronic constipation despite resection of the aganglionic segment of bowel and an uncomplicated pull-through procedure. Her research aims to identify abnormalities in the expression and/or function of tight junction proteins in children with Hirshsprung Disease and develop small molecule therapeutics that can maintain barrier function and reduce the risk of postoperative complications.

Research Background

Dr. Nandivada has a degree in Chemistry from the Massachusetts Institute of Technology (MIT) and began her research training with the Besmer lab in Developmental Biology. She then received her MD from the State University of New York at Stony Brook and was a William J. von Liebig Fellow of Vascular Surgery Research in the Furie Lab at the Beth Israel Deaconess Medical Center (BIDMC). She completed her general surgical training at BIDMC and her pediatric surgical and research training at Boston Children's Hospital (BCH). She is dual boarded in general and pediatric surgery and focuses within the Colorectal and Pelvic Malformation Center at BCH.

Education

Undergraduate School

Massachusetts Institute of Technology
Boston MA

Medical School

State University of New York
Stony Brook MA

Residency

Beth Israel Deaconess Medical Center
Boston MA

Fellowship

Boston Children's Hospital
Boston MA

Publications

  1. Surgical management of short-segment Hirschsprung disease. World J Pediatr Surg. 2024; 7(4):e000916. View Abstract
  2. Mullerian and vaginal anomalies. Curr Opin Pediatr. 2024 Dec 01; 36(6):710-719. View Abstract
  3. Evaluation and Management of Total Colonic Hirschsprung Disease: A Comprehensive Review From the American Pediatric Surgical Association (APSA) Hirschsprung Disease Interest Group. J Pediatr Surg. 2024 Nov; 59(11):161677. View Abstract
  4. WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production. Cell Mol Gastroenterol Hepatol. 2024; 18(2):101349. View Abstract
  5. Robotic-assisted laparoscopic Malone appendicostomy: a 6-year perspective. Pediatr Surg Int. 2024 Feb 24; 40(1):58. View Abstract
  6. Late Diagnosis of Hirschsprung Disease: Clinical Presentation and Long-Term Functional Outcomes. J Pediatr Surg. 2024 Feb; 59(2):220-224. View Abstract
  7. Influence of Initial Treatment Strategy on Outcomes for Children With Rectal Prolapse. J Pediatr Gastroenterol Nutr. 2023 11 01; 77(5):603-609. View Abstract
  8. Invited Commentary: Persistence Pays Off- Pursuing NED Status in Hepatoblastoma Improves Survival: An Observational Study by Fleming A, et al. J Pediatr Surg. 2023 06; 58(6):1088-1089. View Abstract
  9. Saving the perineal body-A modification of the posterior sagittal anorectoplasty. Pediatr Surg Int. 2023 Jan 02; 39(1):71. View Abstract
  10. Primary and secondary vaginal reconstruction with autologous buccal mucosa and intravaginal wound vacuum therapy. J Pediatr Surg. 2022 Aug; 57(8):1687-1693. View Abstract
  11. Technical Considerations in Primary Repair of a Congenital Prostatic Rectourethral Fistula in an Adult-Sized Patient. European J Pediatr Surg Rep. 2022 Jan; 10(1):e20-e24. View Abstract
  12. The Surgical Program in Innovation (SPIN): A Design and Prototyping Curriculum for Surgical Trainees. Acad Med. 2021 09 01; 96(9):1306-1310. View Abstract
  13. Optimizing Duration of Empiric Management of Suspected Central Line-Associated Bloodstream Infections in Pediatric Patients with Intestinal Failure. J Pediatr. 2020 12; 227:69-76.e3. View Abstract
  14. Alpha-tocopherol in intravenous lipid emulsions imparts hepatic protection in a murine model of hepatosteatosis induced by the enteral administration of a parenteral nutrition solution. PLoS One. 2019; 14(7):e0217155. View Abstract
  15. Omega-3 fatty acids are protective in hepatic ischemia reperfusion injury in the absence of GPR120 signaling. J Pediatr Surg. 2019 Nov; 54(11):2392-2397. View Abstract
  16. Fish oil protects the liver from parenteral nutrition-induced injury via GPR120-mediated PPAR? signaling. Prostaglandins Leukot Essent Fatty Acids. 2019 04; 143:8-14. View Abstract
  17. A Diet With Docosahexaenoic and Arachidonic Acids as the Sole Source of Polyunsaturated Fatty Acids Is Sufficient to Support Visual, Cognitive, Motor, and Social Development in Mice. Front Neurosci. 2019; 13:72. View Abstract
  18. Vascular Endothelial Growth Factor Enhances Compensatory Lung Growth in Piglets. Surgery. 2018 12; 164(6):1279-1286. View Abstract
  19. Effects of dietary omega-3 fatty acids on bones of healthy mice. Clin Nutr. 2019 10; 38(5):2145-2154. View Abstract
  20. Vascular endothelial growth factor accelerates compensatory lung growth by increasing the alveolar units. Pediatr Res. 2018 06; 83(6):1182-1189. View Abstract
  21. Pretreatment with intravenous fish oil reduces hepatic ischemia reperfusion injury in a murine model. Surgery. 2018 05; 163(5):1035-1039. View Abstract
  22. Parenteral Soybean Oil Induces Hepatosteatosis Despite Addition of Fish Oil in a Mouse Model of Intestinal Failure-Associated Liver Disease. JPEN J Parenter Enteral Nutr. 2018 02; 42(2):403-411. View Abstract
  23. Technique and perioperative management of left pneumonectomy in neonatal piglets. J Surg Res. 2017 05 15; 212:146-152. View Abstract
  24. Methods to Reduce Medication Errors in a Clinical Trial of an Investigational Parenteral Medication. Contemp Clin Trials Commun. 2016 Dec 15; 4:64-67. View Abstract
  25. Risk of post-procedural bleeding in children on intravenous fish oil. Am J Surg. 2017 Oct; 214(4):733-737. View Abstract
  26. Predictors of failure of fish-oil therapy for intestinal failure-associated liver disease in children. Am J Clin Nutr. 2016 09; 104(3):663-70. View Abstract
  27. A Comparison of Fish Oil Sources for Parenteral Lipid Emulsions in a Murine Model. JPEN J Parenter Enteral Nutr. 2017 02; 41(2):181-187. View Abstract
  28. Eucaloric Ketogenic Diet Reduces Hypoglycemia and Inflammation in Mice with Endotoxemia. Lipids. 2016 06; 51(6):703-14. View Abstract
  29. Long-Term Fish Oil Lipid Emulsion Use in Children With Intestinal Failure-Associated Liver Disease [Formula: see text]. JPEN J Parenter Enteral Nutr. 2017 08; 41(6):930-937. View Abstract
  30. Lipid emulsions in the treatment and prevention of parenteral nutrition-associated liver disease in infants and children. Am J Clin Nutr. 2016 Feb; 103(2):629S-34S. View Abstract
  31. Intravenous Lipid Emulsions in Parenteral Nutrition. Adv Nutr. 2015 Sep; 6(5):600-10. View Abstract
  32. Clinically Relevant Mechanisms of Lipid Synthesis, Transport, and Storage. JPEN J Parenter Enteral Nutr. 2015 Sep; 39(1 Suppl):8S-17S. View Abstract
  33. Challenging the 48-Hour Rule-Out for Central Line-Associated Bloodstream Infections in the Pediatric Intestinal Failure Population: A Retrospective Pilot Study. JPEN J Parenter Enteral Nutr. 2016 05; 40(4):567-73. View Abstract
  34. The natural history of cirrhosis from parenteral nutrition-associated liver disease after resolution of cholestasis with parenteral fish oil therapy. Ann Surg. 2015 Jan; 261(1):172-9. View Abstract
  35. The addition of medium-chain triglycerides to a purified fish oil-based diet alters inflammatory profiles in mice. Metabolism. 2015 Feb; 64(2):274-82. View Abstract
  36. Elevated Alkaline Phosphatase in Infants With Parenteral Nutrition-Associated Liver Disease Reflects Bone Rather Than Liver Disease. JPEN J Parenter Enteral Nutr. 2015 Nov; 39(8):973-6. View Abstract
  37. Surgical therapies for fecal incontinence. Curr Opin Gastroenterol. 2014 Jan; 30(1):69-74. View Abstract
  38. Treatment of parenteral nutrition-associated liver disease: the role of lipid emulsions. Adv Nutr. 2013 Nov; 4(6):711-7. View Abstract
  39. Neonatal intestinal physiology and failure. Semin Pediatr Surg. 2013 Nov; 22(4):190-4. View Abstract
  40. Role of parenteral lipid emulsions in the preterm infant. Early Hum Dev. 2013 Oct; 89 Suppl 2:S45-9. View Abstract
  41. Mechanisms for the effects of fish oil lipid emulsions in the management of parenteral nutrition-associated liver disease. Prostaglandins Leukot Essent Fatty Acids. 2013 Sep; 89(4):153-8. View Abstract
  42. Fish oil-based lipid emulsion in the treatment of parenteral nutrition-associated liver disease. Curr Opin Pediatr. 2013 Apr; 25(2):193-200. View Abstract
  43. Prosthetic graft infections involving the femoral artery. J Vasc Surg. 2013 Mar; 57(3):700-5. View Abstract
  44. The impact of endovascular procedures on fellowship training in lower extremity revascularization. J Vasc Surg. 2012 Jun; 55(6):1814-20. View Abstract
  45. Advances in the surgical management of inflammatory bowel disease. Curr Opin Gastroenterol. 2012 Jan; 28(1):47-51. View Abstract
  46. Stroke of the posterior cerebral circulation. Int Angiol. 2011 Apr; 30(2):105-14. View Abstract
  47. Laser-induced endothelial cell activation supports fibrin formation. Blood. 2010 Nov 25; 116(22):4675-83. View Abstract
  48. Prevalence and impact of the subclavian steal syndrome. Ann Surg. 2010 Jul; 252(1):166-70. View Abstract

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