Information

Related Research Units

The Manton Center for Orphan Disease Research
Molecular Medicine Research

Research Overview

Dr. Sliz is a structural biologist with expertise in non-coding RNA regulation, an Associate Professor in Pediatrics and in Biological Chemistry and Molecular Pharmacology at Harvard Medical School. Dr. Sliz has been leading research computing at Boston Children’s Hospital since 2016.

Some of the BCH-wide programs developed under his leadership include Pediatric Scholar, Children’s Rare-Disease Cohorts genomic data initiative, bioinformatics and genomics consulting services, and a Longwood-wide CryoEM computing effort. Dr. Sliz also founded and leads SBGrid - a global structural bioinformatics consortium. He is affiliated with Manton Center for Orphan Disease Research.

Publications

  1. BioStruct-Africa's capacity building workshops as a model for advancing the emerging community of structural biologists in Africa. Commun Chem. 2025 Apr 19; 8(1):118. View Abstract
  2. Zebrafish and cellular models of SELENON-Congenital myopathy exhibit novel embryonic and metabolic phenotypes. Skelet Muscle. 2025 Mar 15; 15(1):7. View Abstract
  3. International Precision Child Health Partnership (IPCHiP): an initiative to accelerate discovery and improve outcomes in rare pediatric disease. NPJ Genom Med. 2025 Feb 27; 10(1):13. View Abstract
  4. Hospital-wide access to genomic data advanced pediatric rare disease research and clinical outcomes. NPJ Genom Med. 2024 Dec 02; 9(1):60. View Abstract
  5. Introduction of the Capsules environment to support further growth of the SBGrid structural biology software collection. Acta Crystallogr D Struct Biol. 2024 Jun 01; 80(Pt 6):439-450. View Abstract
  6. Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway. Int J Mol Sci. 2024 Mar 22; 25(7). View Abstract
  7. Zebrafish and cellular models of SELENON-Related Myopathy exhibit novel embryonic and metabolic phenotypes. bioRxiv. 2024 Feb 26. View Abstract
  8. Toward representative genomic research: the children's rare disease cohorts experience. Ther Adv Rare Dis. 2023 Jan-Dec; 4:26330040231181406. View Abstract
  9. Rethinking Immunological Risk: A Retrospective Cohort Study of Severe SARS-Cov-2 Infections in Individuals With Congenital Immunodeficiencies. J Allergy Clin Immunol Pract. 2023 11; 11(11):3391-3399.e3. View Abstract
  10. Utility of Exome Sequencing for Diagnosis in Unexplained Pediatric-Onset Epilepsy. JAMA Netw Open. 2023 07 03; 6(7):e2324380. View Abstract
  11. Rethinking immunologic risk: a retrospective cohort study of severe SARS-CoV-2 infections in individuals with congenital immunodeficiencies. medRxiv. 2023 Jun 05. View Abstract
  12. Long-Term Characteristics of Human-Derived Biliary Organoids under a Single Continuous Culture Condition. Cells. 2022 Nov 27; 11(23). View Abstract
  13. Clinical Phenotypes and Outcomes in Monogenic Versus Non-monogenic Very Early Onset Inflammatory Bowel Disease. J Crohns Colitis. 2022 Sep 08; 16(9):1380-1396. View Abstract
  14. Structural and functional impact by SARS-CoV-2 Omicron spike mutations. Cell Rep. 2022 04 26; 39(4):110729. View Abstract
  15. Single-cell transcriptome profile of mouse skin undergoing antigen-driven allergic inflammation recapitulates findings in atopic dermatitis skin lesions. J Allergy Clin Immunol. 2022 08; 150(2):373-384. View Abstract
  16. Mendelian etiologies identified with whole exome sequencing in cerebral palsy. Ann Clin Transl Neurol. 2022 02; 9(2):193-205. View Abstract
  17. Corrigendum: Molecular Dissection of the Primase and Polymerase Activities of Deep-Sea Phage NrS-1 Primase-Polymerase. Front Microbiol. 2021; 12:838050. View Abstract
  18. Molecular Dissection of the Primase and Polymerase Activities of Deep-Sea Phage NrS-1 Primase-Polymerase. Front Microbiol. 2021; 12:766612. View Abstract
  19. Congenital X-linked neutropenia with myelodysplasia and somatic tetraploidy due to a germline mutation in SEPT6. Am J Hematol. 2022 01 01; 97(1):18-29. View Abstract
  20. A synonymous coding variant that alters ALAS2 splicing and causes X-linked sideroblastic anemia. Pediatr Blood Cancer. 2022 01; 69(1):e29309. View Abstract
  21. Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C). J Allergy Clin Immunol. 2021 09; 148(3):732-738.e1. View Abstract
  22. Maternal Iron Deficiency Modulates Placental Transcriptome and Proteome in Mid-Gestation of Mouse Pregnancy. J Nutr. 2021 05 11; 151(5):1073-1083. View Abstract
  23. A data-driven architecture using natural language processing to improve phenotyping efficiency and accelerate genetic diagnoses of rare disorders. HGG Adv. 2021 Jul; 2(3). View Abstract
  24. Structural impact on SARS-CoV-2 spike protein by D614G substitution. Science. 2021 04 30; 372(6541):525-530. View Abstract
  25. What Every Reader Should Know About Studies Using Electronic Health Record Data but May Be Afraid to Ask. J Med Internet Res. 2021 03 02; 23(3):e22219. View Abstract
  26. Structural impact on SARS-CoV-2 spike protein by D614G substitution. bioRxiv. 2020 Oct 20. View Abstract
  27. International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium. NPJ Digit Med. 2020; 3:109. View Abstract
  28. Virtual Screening for Ligand Discovery at the s1 Receptor. ACS Med Chem Lett. 2020 Aug 13; 11(8):1555-1561. View Abstract
  29. Children's rare disease cohorts: an integrative research and clinical genomics initiative. NPJ Genom Med. 2020 Jul 06; 5(1):29. View Abstract
  30. Children's rare disease cohorts: an integrative research and clinical genomics initiative. NPJ Genom Med. 2020; 5:29. View Abstract
  31. RiboToolkit: an integrated platform for analysis and annotation of ribosome profiling data to decode mRNA translation at codon resolution. Nucleic Acids Res. 2020 07 02; 48(W1):W218-W229. View Abstract
  32. A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7. Proc Natl Acad Sci U S A. 2020 03 03; 117(9):4653-4663. View Abstract
  33. In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors. ChemMedChem. 2018 12 06; 13(23):2479-2483. View Abstract
  34. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 09; 561(7724):556-560. View Abstract
  35. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 06 05; 23(10):3091-3101. View Abstract
  36. Development of the Precision Link Biobank at Boston Children's Hospital: Challenges and Opportunities. J Pers Med. 2017 Dec 15; 7(4). View Abstract
  37. Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution. RNA Biol. 2017 12 02; 14(12):1756-1765. View Abstract
  38. MightyScreen: An Open-Source Visualization Application for Screening Data Analysis. SLAS Discov. 2018 02; 23(2):218-223. View Abstract
  39. LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation. Cell Rep. 2017 03 14; 18(11):2664-2675. View Abstract
  40. Cryo-EM structure of the replisome reveals multiple interactions coordinating DNA synthesis. Proc Natl Acad Sci U S A. 2017 03 07; 114(10):E1848-E1856. View Abstract
  41. STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1. Structure. 2017 02 07; 25(2):287-294. View Abstract
  42. Pulmonary Vasculopathy Associated with FIGF Gene Mutation. Am J Pathol. 2017 Jan; 187(1):25-32. View Abstract
  43. Extension of research data repository system to support direct compute access to biomedical datasets: enhancing Dataverse to support large datasets. Ann N Y Acad Sci. 2017 01; 1387(1):95-104. View Abstract
  44. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. Cell Stem Cell. 2016 07 07; 19(1):66-80. View Abstract
  45. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. View Abstract
  46. Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides. J Am Chem Soc. 2015 Dec 16; 137(49):15378-81. View Abstract
  47. A Biogenesis Step Upstream of Microprocessor Controls miR-17~92 Expression. Cell. 2015 Aug 13; 162(4):885-99. View Abstract
  48. AppCiter: A Web Application for Increasing Rates and Accuracy of Scientific Software Citation. Structure. 2015 May 05; 23(5):807-808. View Abstract
  49. Science and technology consortia in U.S. biomedical research: a paradigm shift in response to unsustainable academic growth. Bioessays. 2015 Feb; 37(2):119-22. View Abstract
  50. Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res. 2014 Oct; 42(18):11777-91. View Abstract
  51. Chemical interrogation of the malaria kinome. Chembiochem. 2014 Sep 05; 15(13):1920-30. View Abstract
  52. Structural biology computing: Lessons for the biomedical research sciences. Biopolymers. 2013 Nov; 99(11):809-16. View Abstract
  53. Collaboration gets the most out of software. Elife. 2013 Sep 10; 2:e01456. View Abstract
  54. Optimizing peer review of software code. Science. 2013 Jul 19; 341(6143):236-7. View Abstract
  55. A quick guide to software licensing for the scientist-programmer. PLoS Comput Biol. 2012; 8(7):e1002598. View Abstract
  56. Research priorities. Shining light into black boxes. Science. 2012 Apr 13; 336(6078):159-60. View Abstract
  57. Adapting federated cyberinfrastructure for shared data collection facilities in structural biology. J Synchrotron Radiat. 2012 May; 19(Pt 3):462-7. View Abstract
  58. A grid-enabled web service for low-resolution crystal structure refinement. Acta Crystallogr D Biol Crystallogr. 2012 Mar; 68(Pt 3):261-7. View Abstract
  59. Conformational locking upon cooperative assembly of notch transcription complexes. Structure. 2012 Feb 08; 20(2):340-9. View Abstract
  60. A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase. Nat Chem Biol. 2011 Nov 13; 8(1):72-7. View Abstract
  61. Molecular basis for interaction of let-7 microRNAs with Lin28. Cell. 2011 Nov 23; 147(5):1080-91. View Abstract
  62. Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature. 2011 Jan 27; 469(7331):564-7. View Abstract
  63. Protein structure determination by exhaustive search of Protein Data Bank derived databases. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21476-81. View Abstract
  64. Functional and structural analysis of a key region of the cell wall inhibitor moenomycin. ACS Chem Biol. 2010 Jul 16; 5(7):701-11. View Abstract
  65. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2008 Dec 12; 283(50):35078-85. View Abstract
  66. Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design. ACS Chem Biol. 2008 Jul 18; 3(7):429-36. View Abstract
  67. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem. 2008 Aug 01; 283(31):21310-4. View Abstract
  68. Structure and function of an essential component of the outer membrane protein assembly machine. Science. 2007 Aug 17; 317(5840):961-4. View Abstract
  69. Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5348-53. View Abstract
  70. Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2103-8. View Abstract
  71. Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9244-9. View Abstract
  72. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 2006 Mar 10; 124(5):973-83. View Abstract
  73. Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature. 2005 Dec 01; 438(7068):633-8. View Abstract
  74. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 02; 432(7017):573-9. View Abstract
  75. Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature. 2004 May 13; 429(6988):193-7. View Abstract
  76. An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site. Nat Struct Biol. 2003 Oct; 10(10):807-11. View Abstract
  77. How does radiation damage in protein crystals depend on X-ray dose? Structure. 2003 Jan; 11(1):13-9. View Abstract
  78. Crystal structures of two closely related but antigenically distinct HLA-A2/melanocyte-melanoma tumor-antigen peptide complexes. J Immunol. 2001 Sep 15; 167(6):3276-84. View Abstract
  79. Structure, Function and Interactions of Enzyme IIA from the Phosphoenolpyruvate:lactose Phosphotransferase. 2000. View Abstract
  80. The structure of enzyme IIAlactose from Lactococcus lactis reveals a new fold and points to possible interactions of a multicomponent system. Structure. 1997 Jun 15; 5(6):775-88. View Abstract
  81. Crystallization and preliminary structural studies of lactose-specific enzyme IIA from Lactococcus lactis. Acta Crystallogr D Biol Crystallogr. 1996 Nov 01; 52(Pt 6):1199-201. View Abstract

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