Information

Related Research Units

Dana Farber Boston Childrens Cancer and Blood Disorders Center Research

Research Overview

Dr. Peter E. Newburger is a physician-scientist focused on caring for patients with non-malignant hematologic disorders with a special interest in diseases of white blood cell number and function. Dr. Newburger’s laboratory uses human and mouse genetics to understand white blood cell production and function, how this goes awry in disease, and how to correct genetic disorders by gene therapy.

Education

Medical School

Harvard Medical School
1974 Boston MA

Residency

Boston Children's Hospital
1976 Boston MA

Fellowship

Dana-Farber/Boston Children's Cancer and Blood Disorders Center
1979 Boston MA

Publications

  1. High symptom burden in female X-linked chronic granulomatous disease carriers. Clin Immunol. 2024 Nov; 268:110364. View Abstract
  2. Absence of Neutropenia in Patients With Early Exon Nonsense Mutations in ELANE : Clinical Evidence to Support Gene Therapy Approaches for Severe Congenital Neutropenia. J Pediatr Hematol Oncol. 2024 Aug 01; 46(6):e463-e465. View Abstract
  3. Clinical Remission of Severe Crohn's Disease with Empagliflozin Monotherapy in a Pediatric Patient with Glycogen Storage Disease Type 1b. JPGN Rep. 2023 Nov; 4(4):e356. View Abstract
  4. The European Guidelines on Diagnosis and Management of Neutropenia in Adults and Children: A Consensus Between the European Hematology Association and the EuNet-INNOCHRON COST Action. Hemasphere. 2023 Apr; 7(4):e872. View Abstract
  5. Reply to: Stand with Ukraine. Pediatr Blood Cancer. 2023 Jul; 70(7):e30300. View Abstract
  6. Outcomes for patients with severe chronic neutropenia treated with granulocyte colony-stimulating factor. Blood Adv. 2022 07 12; 6(13):3861-3869. View Abstract
  7. Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease. JAMA Cardiol. 2021 04 01; 6(4):457-462. View Abstract
  8. Dissecting ELANE neutropenia pathogenicity by human HSC gene editing. Cell Stem Cell. 2021 05 06; 28(5):833-845.e5. View Abstract
  9. Genotype-phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency. Am J Hematol. 2020 05; 95(5):472-482. View Abstract
  10. Lentiviral gene therapy for X-linked chronic granulomatous disease. Nat Med. 2020 02; 26(2):200-206. View Abstract
  11. Gene Editing ELANE in Human Hematopoietic Stem and Progenitor Cells Reveals Disease Mechanisms and Therapeutic Strategies for Severe Congenital Neutropenia. Blood. 2019 Nov 13; 134(Supplement_1):3. View Abstract
  12. Benign ethnic neutropenia. Blood Rev. 2019 09; 37:100586. View Abstract
  13. Aberrant splicing contributes to severe a-spectrin-linked congenital hemolytic anemia. J Clin Invest. 2019 04 30; 129(7):2878-2887. View Abstract
  14. The Genetic Landscape of Diamond-Blackfan Anemia. Am J Hum Genet. 2019 Feb 07; 104(2):356. View Abstract
  15. Neutropenia in the age of genetic testing: Advances and challenges. Am J Hematol. 2019 03; 94(3):384-393. View Abstract
  16. Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro. Nat Commun. 2018 12 05; 9(1):5180. View Abstract
  17. The Genetic Landscape of Diamond-Blackfan Anemia. Am J Hum Genet. 2018 12 06; 103(6):930-947. View Abstract
  18. How we approach: Severe congenital neutropenia and myelofibrosis due to mutations in VPS45. Pediatr Blood Cancer. 2019 01; 66(1):e27473. View Abstract
  19. Gene expression in chronic granulomatous disease and interferon-? receptor-deficient cells treated in vitro with interferon-?. J Cell Biochem. 2019 03; 120(3):4321-4332. View Abstract
  20. Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study. Haematologica. 2019 02; 104(2):e51-e53. View Abstract
  21. Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study. Blood. 2018 05 17; 131(20):2183-2192. View Abstract
  22. "How I approach…"-A new series in Pediatric Blood & Cancer. Pediatr Blood Cancer. 2018 06; 65(6):e26994. View Abstract
  23. Comment on: Phenotypic Prenatal Diagnosis of Chronic Granulomatous Disease: A Useful Tool in the Absence of Molecular Diagnosis. Scand J Immunol. 2018 01; 87(1):57. View Abstract
  24. Long-Term Effects of G-CSF Therapy in Cyclic Neutropenia. N Engl J Med. 2017 12 07; 377(23):2290-2292. View Abstract
  25. A novel homozygous VPS45 p.P468L mutation leading to severe congenital neutropenia with myelofibrosis. Pediatr Blood Cancer. 2017 Sep; 64(9). View Abstract
  26. Laurence A. Boxer, MD, 1940-2017. Pediatr Blood Cancer. 2017 06; 64(6). View Abstract
  27. Autoimmune and other acquired neutropenias. Hematology Am Soc Hematol Educ Program. 2016 Dec 02; 2016(1):38-42. View Abstract
  28. An oral HemokineTM, a-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo. Blood Cells Mol Dis. 2017 03; 63:1-8. View Abstract
  29. Mild Microcytic Anemia in an Infant with a Compound Heterozygosity for Hb C (HBB: c.19G?>?A) and Hb Osu Christiansborg (HBB: c.157G?>?A). Hemoglobin. 2016 Jun; 40(3):208-9. View Abstract
  30. Frontline Science: Splenic progenitors aid in maintaining high neutrophil numbers at sites of sterile chronic inflammation. J Leukoc Biol. 2016 08; 100(2):253-60. View Abstract
  31. Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9. Blood. 2015 Dec 17; 126(25):2734-8. View Abstract
  32. Neutrophil Responses to Sterile Implant Materials. PLoS One. 2015; 10(9):e0137550. View Abstract
  33. Regulation of CYBB Gene Expression in Human Phagocytes by a Distant Upstream NF-?B Binding Site. J Cell Biochem. 2015 Sep; 116(9):2008-17. View Abstract
  34. In memoriam: Robert J. Arceci. Pediatr Blood Cancer. 2015 Aug; 62(8):iii. View Abstract
  35. Use of granulocyte colony-stimulating factor during pregnancy in women with chronic neutropenia. Obstet Gynecol. 2015 Jan; 125(1):197-203. View Abstract
  36. The diversity of mutations and clinical outcomes for ELANE-associated neutropenia. Curr Opin Hematol. 2015 Jan; 22(1):3-11. View Abstract
  37. Phagocyte nicotinamide adenine dinucleotide phosphate oxidase activity in patients with inherited IFN-?R1 or IFN-?R2 deficiency. J Allergy Clin Immunol. 2015 May; 135(5):1393-5.e1. View Abstract
  38. Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells. RNA Biol. 2014; 11(6):777-87. View Abstract
  39. HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells. J Cell Biochem. 2013 Oct; 114(10):2375-83. View Abstract
  40. Evaluation and management of patients with isolated neutropenia. Semin Hematol. 2013 Jul; 50(3):198-206. View Abstract
  41. Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia. Hum Genet. 2013 Nov; 132(11):1265-74. View Abstract
  42. Advances in understanding the pathogenesis of HLH. Br J Haematol. 2013 Jun; 161(5):609-622. View Abstract
  43. Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. Hum Mutat. 2012 Jul; 33(7):1037-44. View Abstract
  44. The human NADPH oxidase: primary and secondary defects impairing the respiratory burst function and the microbicidal ability of phagocytes. Scand J Immunol. 2011 May; 73(5):420-7. View Abstract
  45. Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease. Nat Immunol. 2011 Mar; 12(3):213-21. View Abstract
  46. Hemophagocytic lymphohistiocytosis with MUNC13-4 gene mutation or reduced natural killer cell function prior to onset of childhood leukemia. Pediatr Blood Cancer. 2011 May; 56(5):856-8. View Abstract
  47. Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for phenotype determination by modifying genes. Pediatr Blood Cancer. 2010 Aug; 55(2):314-7. View Abstract
  48. Local arterial nanoparticle delivery of siRNA for NOX2 knockdown to prevent restenosis in an atherosclerotic rat model. Gene Ther. 2010 Oct; 17(10):1279-87. View Abstract
  49. Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy. Br J Haematol. 2010 Jul; 150(2):196-9. View Abstract
  50. X chromosome-wide analyses of genomic DNA methylation states and gene expression in male and female neutrophils. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3704-9. View Abstract
  51. Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. Am J Hum Genet. 2010 Feb 12; 86(2):222-8. View Abstract
  52. Comment on "Impaired priming and activation of the neutrophil NADPH oxidase in patients with IRAK4 or NEMO deficiency". J Immunol. 2009 Sep 15; 183(6):3559. View Abstract
  53. Dynamics of alpha-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34(+) cells in culture. Exp Hematol. 2009 Oct; 37(10):1143-1156.e3. View Abstract
  54. Use of rituximab for refractory cytopenias associated with autoimmune lymphoproliferative syndrome (ALPS). Pediatr Blood Cancer. 2009 Jul; 52(7):847-52. View Abstract
  55. Cyclic neutropenia in animals. Am J Hematol. 2009 Apr; 84(4):258; author reply 258. View Abstract
  56. A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. Blood. 2009 Mar 12; 113(11):2526-34. View Abstract
  57. Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. Am J Hum Genet. 2008 Dec; 83(6):769-80. View Abstract
  58. Toll-like receptor-mediated activation of neutrophils by influenza A virus. Blood. 2008 Sep 01; 112(5):2028-34. View Abstract
  59. Essential role of nuclear factor-kappaB for NADPH oxidase activity in normal and anhidrotic ectodermal dysplasia leukocytes. Blood. 2008 Aug 15; 112(4):1453-60. View Abstract
  60. The American Society of Pediatric Hematology/Oncology distinguished career award goes to Laurence A. Boxer, MD. Pediatr Blood Cancer. 2008 Jun; 50(6):1121-2. View Abstract
  61. IL6 to the rescue. Blood. 2008 Apr 15; 111(8):3914-5. View Abstract
  62. Mosaic tetraploidy and transient GFI1 mutation in a patient with severe chronic neutropenia. Pediatr Blood Cancer. 2008 Mar; 50(3):630-2. View Abstract
  63. Up-regulation of NADPH oxidase components and increased production of interferon-gamma by leukocytes from sickle cell disease patients. Am J Hematol. 2008 Jan; 83(1):41-5. View Abstract
  64. Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia. Br J Haematol. 2008 Jan; 140(2):210-3. View Abstract
  65. A molecular classification of congenital neutropenia syndromes. Pediatr Blood Cancer. 2007 Oct 15; 49(5):609-14. View Abstract
  66. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 Jun 14; 447(7146):799-816. View Abstract
  67. Temporal evolution of gene expression in rat carotid artery following balloon angioplasty. J Cell Biochem. 2007 May 15; 101(2):399-410. View Abstract
  68. RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. Blood. 2007 Jul 15; 110(2):640-50. View Abstract
  69. A limited number of genes are involved in the differentiation of germinal center B cells. J Cell Biochem. 2006 Dec 01; 99(5):1308-25. View Abstract
  70. Nuclease sensitive element binding protein 1 gene disruption results in early embryonic lethality. J Cell Biochem. 2006 Sep 01; 99(1):140-5. View Abstract
  71. Nuclease sensitive element binding protein 1 associates with the selenocysteine insertion sequence and functions in mammalian selenoprotein translation. J Cell Physiol. 2006 Jun; 207(3):775-83. View Abstract
  72. Acute lymphocytic leukemia with eosinophilia and unusual karyotype. Leuk Lymphoma. 2006 Jun; 47(6):1176-9. View Abstract
  73. Chronic granulomatous disease in Latin American patients: clinical spectrum and molecular genetics. Pediatr Blood Cancer. 2006 Feb; 46(2):243-52. View Abstract
  74. Novel transcribed regions in the human genome. Cold Spring Harb Symp Quant Biol. 2006; 71:111-6. View Abstract
  75. Disorders of neutrophil number and function. Hematology Am Soc Hematol Educ Program. 2006; 104-10. View Abstract
  76. The effect of IFN-gamma and TNF-alpha on the NADPH oxidase system of human colostrum macrophages, blood monocytes, and THP-1 cells. J Interferon Cytokine Res. 2005 Sep; 25(9):540-6. View Abstract
  77. Hematology and oncology. Curr Opin Pediatr. 2005 Feb; 17(1):1-2. View Abstract
  78. The role of toll-like receptors in herpes simplex infection in neonates. J Infect Dis. 2005 Mar 01; 191(5):746-8. View Abstract
  79. A panorama of lineage-specific transcription in hematopoiesis. Bioessays. 2004 Dec; 26(12):1276-87. View Abstract
  80. Superoxide release and cellular gluthatione peroxidase activity in leukocytes from children with persistent asthma. Braz J Med Biol Res. 2004 Nov; 37(11):1607-13. View Abstract
  81. p47(phox) PX domain of NADPH oxidase targets cell membrane via moesin-mediated association with the actin cytoskeleton. J Cell Biochem. 2004 Jul 01; 92(4):795-809. View Abstract
  82. Lineage specificity of gene expression patterns. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6508-13. View Abstract
  83. Association of glucose-6-phosphate dehydrogenase deficiency and X-linked chronic granulomatous disease in a child with anemia and recurrent infections. Am J Hematol. 2004 Mar; 75(3):151-6. View Abstract
  84. Hematology and oncology. Curr Opin Pediatr. 2004 Feb; 16(1):1-2. View Abstract
  85. The effect of IFN-gamma and TNF-alpha on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells. J Interferon Cytokine Res. 2003 Dec; 23(12):737-44. View Abstract
  86. Gene expression in mature neutrophils: early responses to inflammatory stimuli. J Leukoc Biol. 2004 Feb; 75(2):358-72. View Abstract
  87. BARCODE-ALL: accelerated and cost-effective genetic risk stratification in acute leukemia using spectrally addressable liquid bead microarrays. Leukemia. 2003 Jul; 17(7):1404-10. View Abstract
  88. BARCODE-ALL: accelerated and cost-effective genetic risk stratification in acute leukemia using spectrally addressable liquid bead microarrays. Leukemia. 2003 Jul; 17(7):1411-3. View Abstract
  89. Gene expression in human neutrophils during activation and priming by bacterial lipopolysaccharide. J Cell Biochem. 2003 Jul 01; 89(4):848-61. View Abstract
  90. Hematology and oncology. Curr Opin Pediatr. 2003 Feb; 15(1):1-2. View Abstract
  91. Genomic and proteomic analysis of the myeloid differentiation program: global analysis of gene expression during induced differentiation in the MPRO cell line. Blood. 2002 Nov 01; 100(9):3209-20. View Abstract
  92. Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils. Blood. 2002 Sep 01; 100(5):1860-8. View Abstract
  93. Adolescents with cancer: access to clinical trials and age-appropriate care. Curr Opin Pediatr. 2002 Feb; 14(1):1-4. View Abstract
  94. An unusual intronic mutation in the CYBB gene giving rise to chronic granulomatous disease. Biochim Biophys Acta. 2001 Sep 28; 1537(2):125-31. View Abstract
  95. Genomic and proteomic analysis of the myeloid differentiation program. Blood. 2001 Aug 01; 98(3):513-24. View Abstract
  96. RNA expression patterns change dramatically in human neutrophils exposed to bacteria. Blood. 2001 Apr 15; 97(8):2457-68. View Abstract
  97. Autosomal recessive chronic granulomatous disease caused by defects in NCF-1, the gene encoding the phagocyte p47-phox: mutations not arising in the NCF-1 pseudogenes. Blood. 2001 Jan 01; 97(1):305-11. View Abstract
  98. Interferon-gamma improves splicing efficiency of CYBB gene transcripts in an interferon-responsive variant of chronic granulomatous disease due to a splice site consensus region mutation. Blood. 2000 Jun 01; 95(11):3548-54. View Abstract
  99. Recognition and binding of the human selenocysteine insertion sequence by nucleolin. J Cell Biochem. 2000 Apr; 77(3):507-16. View Abstract
  100. Global analysis of neutrophil gene expression. Curr Opin Hematol. 2000 Jan; 7(1):16-20. View Abstract
  101. Hematology and oncology. Curr Opin Pediatr. 1999 Feb; 11(1):31-2. View Abstract
  102. A modified method for the display of 3'-end restriction fragments of cDNAs: molecular profiling of gene expression in neutrophils. Methods Enzymol. 1999; 303:272-97. View Abstract
  103. NADPH oxidase activity and cytochrome b558 content of human Epstein-Barr-virus-transformed B lymphocytes correlate with expression of genes encoding components of the oxidase system. Arch Biochem Biophys. 1998 Dec 15; 360(2):158-64. View Abstract
  104. Differential expression of Id genes in multipotent myeloid progenitor cells: Id-1 is induced by early-and late-acting cytokines while Id-2 is selectively induced by cytokines that drive terminal granulocytic differentiation. J Cell Biochem. 1998 Nov 01; 71(2):277-85. View Abstract
  105. Dexamethasone but not indomethacin inhibits human phagocyte nicotinamide adenine dinucleotide phosphate oxidase activity by down-regulating expression of genes encoding oxidase components. J Immunol. 1998 Nov 01; 161(9):4960-7. View Abstract
  106. X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase. Am J Hum Genet. 1998 Jun; 62(6):1320-31. View Abstract
  107. Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47PHOX on serine 303 or 304. J Biol Chem. 1998 Apr 17; 273(16):9539-43. View Abstract
  108. Identification and molecular cloning of a human selenocysteine insertion sequence-binding protein. A bifunctional role for DNA-binding protein B. J Biol Chem. 1998 Mar 06; 273(10):5443-6. View Abstract
  109. Hematology and oncology. Curr Opin Pediatr. 1998 Feb; 10(1):47-8. View Abstract
  110. Laminin promotes differentiation of NB4 promyelocytic leukemia cells with all-trans retinoic acid. Blood. 1996 Jul 01; 88(1):261-7. View Abstract
  111. Selenium-regulated translation control of heterologous gene expression: normal function of selenocysteine-substituted gene products. J Cell Biochem. 1996 Jun 01; 61(3):410-9. View Abstract
  112. Expression of basic helix-loop-helix transcription factors in explant hematopoietic progenitors. J Cell Biochem. 1996 Jun 01; 61(3):478-88. View Abstract
  113. Partial reconstitution of the respiratory burst oxidase in lymphoblastoid B cell lines lacking p67-phox after transfection with an expression vector containing wild-type and mutant p67 -phox cDNAs: Deletions of the carboxy and amino terminal residues of p67-phox are not required for activity. Exp Hematol. 1996 Mar; 24(4):531-6. View Abstract
  114. Umbilical cord blood as a new and promising source of unrelated-donor hematopoietic stem cells for transplantation. Curr Opin Pediatr. 1996 Feb; 8(1):29-32. View Abstract
  115. RNA-binding proteins that specifically recognize the selenocysteine insertion sequence of human cellular glutathione peroxidase mRNA. J Biol Chem. 1995 Dec 22; 270(51):30448-52. View Abstract
  116. Structure and function of the selenium translation element in the 3'-untranslated region of human cellular glutathione peroxidase mRNA. RNA. 1995 Jul; 1(5):519-25. View Abstract
  117. A new X-linked variant of chronic granulomatous disease characterized by the existence of a normal clone of respiratory burst-competent phagocytic cells. Blood. 1995 Jan 01; 85(1):231-41. View Abstract
  118. Chronic granulomatous disease and glutathione peroxidase deficiency, revisited. Blood. 1994 Dec 01; 84(11):3861-9. View Abstract
  119. Regulation of the human cellular glutathione peroxidase gene during in vitro myeloid and monocytic differentiation. Blood. 1994 Dec 01; 84(11):3902-8. View Abstract
  120. An in-frame trinucleotide repeat in the coding region of the human cellular glutathione peroxidase (GPX1) gene: in vivo polymorphism and in vitro instability. Genomics. 1994 Sep 01; 23(1):292-4. View Abstract
  121. Mutations in the promoter region of the gene for gp91-phox in X-linked chronic granulomatous disease with decreased expression of cytochrome b558. J Clin Invest. 1994 Sep; 94(3):1205-11. View Abstract
  122. Restitution of superoxide generation in autosomal cytochrome-negative chronic granulomatous disease (A22(0) CGD)-derived B lymphocyte cell lines by transfection with p22phax cDNA. J Exp Med. 1993 Dec 01; 178(6):2047-53. View Abstract
  123. Selenium regulation of glutathione peroxidase in human hepatoma cell line Hep3B. Arch Biochem Biophys. 1993 Jul; 304(1):53-7. View Abstract
  124. Chemotactic peptide-induced cytoplasmic pH changes in incubated human monocytes. J Leukoc Biol. 1993 Jun; 53(6):673-8. View Abstract
  125. Sequences in the 3'-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon. J Biol Chem. 1993 May 25; 268(15):11463-9. View Abstract
  126. Human immunodeficiency virus type 1-infected HL-60 cells are capable of both monocytic and granulocytic differentiation. J Gen Virol. 1992 Dec; 73 ( Pt 12):3257-61. View Abstract
  127. O2- production by B lymphocytes lacking the respiratory burst oxidase subunit p47phox after transfection with an expression vector containing a p47phox cDNA. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10174-7. View Abstract
  128. Chronic granulomatous disease presenting in a 69-year-old man. N Engl J Med. 1991 Dec 19; 325(25):1786-90. View Abstract
  129. In vitro regulation of human phagocyte cytochrome b heavy and light chain gene expression by bacterial lipopolysaccharide and recombinant human cytokines. J Biol Chem. 1991 Aug 25; 266(24):16171-7. View Abstract
  130. Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell. Blood. 1990 Dec 15; 76(12):2443-8. View Abstract
  131. Measurement of superoxide release in the phagovacuoles of immune complex-stimulated human neutrophils. J Immunol Methods. 1990 Jul 03; 130(2):223-33. View Abstract
  132. Simultaneous flow cytometric measurements of cytoplasmic Ca++ and membrane potential changes upon FMLP exposure as HL-60 cells mature into granulocytes: using [Ca++]in as an indicator of granulocyte maturity. J Leukoc Biol. 1990 Mar; 47(3):265-74. View Abstract
  133. Isolation and chromosomal localization of the human glutathione peroxidase gene. Genomics. 1990 Feb; 6(2):268-71. View Abstract
  134. Relationships between the cell cycle and the expression of c-myc and transferrin receptor genes during induced myeloid differentiation. Exp Cell Res. 1990 Jan; 186(1):1-5. View Abstract
  135. Post-transcriptional regulation of glutathione peroxidase gene expression by selenium in the HL-60 human myeloid cell line. Blood. 1989 Nov 15; 74(7):2535-41. View Abstract
  136. Differentiation of human hematopoietic cells increases expression of a gene transferred by a retroviral vector. J Leukoc Biol. 1989 Sep; 46(3):221-9. View Abstract
  137. Infection of hematopoietic and stromal cells in human continuous bone marrow cultures by a retroviral vector containing the neomycin resistance gene. Acta Haematol. 1989; 82(3):136-43. View Abstract
  138. New perspectives in chronic granulomatous disease. J Clin Immunol. 1988 Nov; 8(6):419-25. View Abstract
  139. Partial correction of the phagocyte defect in patients with X-linked chronic granulomatous disease by subcutaneous interferon gamma. N Engl J Med. 1988 Jul 21; 319(3):146-51. View Abstract
  140. Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5215-9. View Abstract
  141. Expression of the X-CGD gene during induced differentiation of myeloid leukemia cell line HL-60. Mol Cell Biol. 1988 Jul; 8(7):2804-10. View Abstract
  142. Cellular and molecular effects of recombinant interferon gamma in chronic granulomatous disease. Hematol Oncol Clin North Am. 1988 Jun; 2(2):267-76. View Abstract
  143. Marrow donors and international cooperation. Lancet. 1988 Jan 16; 1(8577):117-8. View Abstract
  144. Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease. J Clin Invest. 1987 Oct; 80(4):1009-16. View Abstract
  145. Biochemical and morphological characterization of basophilic leukocytes from two patients with myelogenous leukemia. J Immunol. 1987 Apr 15; 138(8):2616-25. View Abstract
  146. Changes in superoxide dismutase, catalase, and the glutathione cycle during induced myeloid differentiation. Arch Biochem Biophys. 1986 Dec; 251(2):551-7. View Abstract
  147. Neutrophil defect associated with malignant infantile osteopetrosis. J Lab Clin Med. 1986 Nov; 108(5):498-505. View Abstract
  148. Variant chronic granulomatous disease: modulation of the neutrophil defect by severe infection. Blood. 1986 Oct; 68(4):914-9. View Abstract
  149. Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location. Nature. 1986 Jul 3-9; 322(6074):32-8. View Abstract
  150. Characterization of a spontaneous mutation to a beta-thalassemia allele. Am J Hum Genet. 1986 Jun; 38(6):860-7. View Abstract
  151. Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activity. J Clin Invest. 1986 Apr; 77(4):1402-4. View Abstract
  152. Cloning the gene for the inherited disorder chronic granulomatous disease on the basis of its chromosomal location. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 1:177-83. View Abstract
  153. Long-term culture of human granulocytes and granulocyte progenitor cells. Prog Clin Biol Res. 1986; 211:159-85. View Abstract
  154. Pseudomonas cepacia pneumonia in chronic granulomatous disease. Pediatr Infect Dis. 1986 Jan-Feb; 5(1):111. View Abstract
  155. Relationships between in vitro selenium supply, glutathione peroxidase activity, and phagocytic function in the HL-60 human myeloid cell line. J Biol Chem. 1985 Jul 25; 260(15):8951-5. View Abstract
  156. Modulation of mononuclear phagocyte cytotoxicity by alpha-tocopherol (vitamin E). J Leukoc Biol. 1985 Apr; 37(4):449-59. View Abstract
  157. Chediak-Higashi syndrome: studies in long-term bone marrow culture. Exp Hematol. 1985 Feb; 13(2):117-22. View Abstract
  158. Development of the superoxide-generating system during differentiation of the HL-60 human promyelocytic leukemia cell line. J Biol Chem. 1984 Mar 25; 259(6):3771-6. View Abstract
  159. Studies on low-dose hydroxyethyl starch leukapheresis. Rate of elimination of HES in vivo and function of the harvested granulocytes in vitro. Vox Sang. 1984; 47(5):325-9. View Abstract
  160. Impaired granulocyte superoxide production and prolongation of the respiratory burst due to a low-affinity NADPH-dependent oxidase. Blood. 1983 Sep; 62(3):564-71. View Abstract
  161. Human neutrophil dysfunction with giant granules and defective activation of the respiratory burst. Blood. 1983 Jun; 61(6):1247-57. View Abstract
  162. Eosinophilic cytoplasmic inclusions in fetal leukocytes: are Auer bodies a recapitulation of fetal morphology? Blood. 1983 Mar; 61(3):593-5. View Abstract
  163. Chronic granulomatous disease due to granulocytes with abnormal NADPH oxidase activity and deficient cytochrome-b. Blood. 1983 Mar; 61(3):423-8. View Abstract
  164. Allogeneic bone marrow transplantation for chronic granulomatous disease. J Pediatr. 1982 Dec; 101(6):952-5. View Abstract
  165. Con-A-stimulated superoxide production by granulocytes: reversible activation of NADPH oxidase. Blood. 1982 Nov; 60(5):1188-94. View Abstract
  166. Heterogeneous pathways of oxidizing radical production in human neutrophils and the HL-60 cell line. Pediatr Res. 1982 Oct; 16(10):856-60. View Abstract
  167. Superoxide generation by human fetal granulocytes. Pediatr Res. 1982 May; 16(5):373-6. View Abstract
  168. Opsonized zymosan-stimulated granulocytes-activation and activity of the superoxide-generating system and membrane potential changes. Blood. 1981 Nov; 58(5):975-82. View Abstract
  169. Human granulocytes generated in continuous bone marrow culture are physiologically normal. Blood. 1981 Oct; 58(4):724-32. View Abstract
  170. The effects of irradiation on blood components. Transfusion. 1981 Jul-Aug; 21(4):419-26. View Abstract
  171. Functionally deficient differentiation of HL-60 promyelocytic leukemia cells induced by phorbol myristate acetate. Cancer Res. 1981 May; 41(5):1861-5. View Abstract
  172. Leukemia relapse in donor cells after allogeneic bone-marrow transplantation. N Engl J Med. 1981 Mar 19; 304(12):712-4. View Abstract
  173. Chronic pain: principles of management. J Pediatr. 1981 Feb; 98(2):180-9. View Abstract
  174. Corticosteroid dependence of continuous hemopoiesis in vitro with murine or human bone marrow. Haematol Blood Transfus. 1981; 26:289-93. View Abstract
  175. Chronic granulomatous disease. Expression of the metabolic defect by in vitro culture of bone marrow progenitors. J Clin Invest. 1980 Sep; 66(3):599-602. View Abstract
  176. Phorbol myristate acetate stimulates macrophage differentiation and replication and alters granulopoiesis and leukemogenesis in long-term bone marrow cultures. Blood. 1980 Sep; 56(3):368-79. View Abstract
  177. NAD(P)H-dependent superoxide production by phagocytic vesicles from guinea pig and human granulocytes. J Biol Chem. 1980 Jul 25; 255(14):6584-8. View Abstract
  178. Dissociation of opsonized particle phagocytosis and respiratory burst activity in an Epstein-Barr virus-infected myeloid cell line. J Cell Biol. 1980 Jun; 85(3):549-57. View Abstract
  179. Correction of infantile agranulocytosis (Kostmann's syndrome) by allogeneic bone marrow transplantation. Am J Med. 1980 Apr; 68(4):605-9. View Abstract
  180. Virus and cell requirements for Friend virus granulocytic leukemogenesis in long-term bone marrow cultures of NIH swiss [N:NIH(S)] mice. J Natl Cancer Inst. 1980 Apr; 64(4):867-78. View Abstract
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  189. Hapten-specific IgE antibody responses in mice. 3. Establishment of parameters for generation of helper T cell function regulating the primary and secondary responses of IgE and IgG B lymphocytes. J Immunol. 1974 Sep; 113(3):958-73. View Abstract
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