Ofer Levy

Publications

1. Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients. Nat Commun. 2025 Jan 10; 16(1):586. View Abstract
2. Protocol for measuring anti-fentanyl antibodies in mouse serum by enzyme-linked immunosorbent assay. STAR Protoc. 2024 Dec 20; 5(4):103402. View Abstract
3. Biomarkers of vaccine safety and efficacy in vulnerable populations: Lessons from the fourth international precision vaccines conference. Vaccine. 2025 Jan 01; 43(Pt 2):126477. View Abstract
4. Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping. bioRxiv. 2024 Nov 25. View Abstract
5. Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19. bioRxiv. 2024 Nov 16. View Abstract
6. Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation. EBioMedicine. 2024 Dec; 110:105411. View Abstract
7. Safety and implementation of a phase 1 randomized GLA-SE-adjuvanted CH505TF gp120 HIV vaccine trial in newborns. medRxiv. 2024 Oct 17. View Abstract
8. The BNT162b2 mRNA vaccine demonstrates reduced age-associated TH1 support in vitro and in vivo. iScience. 2024 Nov 15; 27(11):111055. View Abstract
9. Plasma adenosine deaminase-1 and -2 activities are lower at birth in Papua New Guinea than in The Gambia but converge over the first weeks of life. Front Immunol. 2024; 15:1425349. View Abstract
10. Social complexity of a fentanyl vaccine to prevent opioid overdose conference proceedings: Radcliffe Institute for Advanced Study conference proceedings. Vaccine. 2025 Jan 12; 44:126324. View Abstract
11. DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life. Nat Commun. 2024 Sep 17; 15(1):8167. View Abstract
12. Precision adjuvants for pediatric vaccines. Sci Transl Med. 2024 Sep 04; 16(763):eabq7378. View Abstract
13. Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70. Sci Transl Med. 2024 Jul 24; 16(757):eadm8451. View Abstract
14. Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human Life. J Immunol Res. 2024; 2024:1117796. View Abstract
15. Need for strategic communications and stakeholder engagement to advance acceptability of an overdose preventing vaccine targeting fentanyl. Vaccine. 2024 Oct 24; 42(24):126082. View Abstract
16. From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation. Sci Adv. 2024 Jul 05; 10(27):eadg3747. View Abstract
17. Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways. Clin Epigenetics. 2024 Jul 03; 16(1):85. View Abstract
18. Network Analysis Reveals Protein Modules Associated with Childhood Respiratory Diseases. bioRxiv. 2024 Jun 17. View Abstract
19. BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice. Res Sq. 2024 Jun 11. View Abstract
20. Heterologous SARS-CoV-2 booster vaccine for individuals with hematological malignancies after a primary SARS-CoV-2 mRNA vaccine series. Vaccine. 2024 Sep 17; 42(22):126054. View Abstract
21. Immune profiling of age and adjuvant-specific activation of human blood mononuclear cells in vitro. Commun Biol. 2024 06 08; 7(1):709. View Abstract
22. Longitudinal plasma proteomic analysis of 1117 hospitalized patients with COVID-19 identifies features associated with severity and outcomes. Sci Adv. 2024 May 24; 10(21):eadl5762. View Abstract
23. Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality. J Clin Invest. 2024 May 01; 134(9). View Abstract
24. Editorial: Precision vaccinology for infectious diseases. Front Immunol. 2024; 15:1400443. View Abstract
25. Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology. Sci Transl Med. 2024 Apr 17; 16(743):eadj5154. View Abstract
26. Respiratory Infection- and Asthma-prone, Low Vaccine Responder Children Demonstrate Distinct Mononuclear Cell DNA Methylation Pathways. Res Sq. 2024 Apr 03. View Abstract
27. Human In vitro Modeling Identifies Adjuvant Combinations that Unlock Antigen Cross-presentation and Promote T-helper 1 Development in Newborns, Adults and Elders. J Mol Biol. 2024 02 15; 436(4):168446. View Abstract
28. Author Correction: Co-adjuvanting DDA/TDB liposomes with a TLR7 agonist allows for IgG2a/c class-switching in the absence of Th1 cells. NPJ Vaccines. 2024 Jan 11; 9(1):13. View Abstract
29. Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study. Nat Commun. 2024 Jan 03; 15(1):216. View Abstract
30. Co-adjuvanting DDA/TDB liposomes with a TLR7 agonist allows for IgG2a/c class-switching in the absence of Th1 cells. NPJ Vaccines. 2023 Dec 22; 8(1):189. View Abstract
31. Modeling human immune responses to vaccination in vitro. Trends Immunol. 2024 01; 45(1):32-47. View Abstract
32. Host-Microbe Multi-omic Profiling Identifies a Unique Program of COVID-19 Inflammatory Dysregulation in Solid Organ Transplant Recipients. Res Sq. 2023 Dec 20. View Abstract
33. Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants. bioRxiv. 2023 Nov 06. View Abstract
34. Early cellular and molecular signatures correlate with severity of West Nile virus infection. iScience. 2023 Dec 15; 26(12):108387. View Abstract
35. Corrigendum to "Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study" [eBioMedicine 83 (2022) 104208]. EBioMedicine. 2023 Dec; 98:104860. View Abstract
36. Human in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen. NPJ Vaccines. 2023 Oct 26; 8(1):163. View Abstract
37. Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance. J Allergy Clin Immunol. 2023 11; 152(5):1107-1120.e6. View Abstract
38. Severe congenital neutropenia due to jagunal homolog 1 (JAGN1) mutation: a case report and literature review. Front Pediatr. 2023; 11:1223191. View Abstract
39. A protocol for high-throughput screening for immunomodulatory compounds using human primary cells. STAR Protoc. 2023 Sep 15; 4(3):102405. View Abstract
40. Elevated third trimester corticosteroid levels are associated with fewer offspring infections. Sci Rep. 2023 06 28; 13(1):10461. View Abstract
41. Precision Vaccinology Approaches for the Development of Adjuvanted Vaccines Targeted to Distinct Vulnerable Populations. Pharmaceutics. 2023 Jun 19; 15(6). View Abstract
42. Effective early antiretroviral therapy in perinatal-HIV infection reduces subsequent plasma inflammatory profile. Pediatr Res. 2023 11; 94(5):1667-1674. View Abstract
43. Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients. Cell Rep Med. 2023 06 20; 4(6):101079. View Abstract
44. Integrative systems biology characterizes immune-mediated neurodevelopmental changes in murine Zika virus microcephaly. iScience. 2023 Jul 21; 26(7):106909. View Abstract
45. A simple, time- and cost-effective, high-throughput depletion strategy for deep plasma proteomics. Sci Adv. 2023 03 29; 9(13):eadf9717. View Abstract
46. Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. 2023 Mar 03; 8(1):30. View Abstract
47. Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. 2023 Feb 14; 8(1):18. View Abstract
48. The mRNA vaccine BNT162b2 demonstrates impaired TH1 immunogenicity in human elders in vitro and aged mice in vivo. Res Sq. 2022 Dec 21. View Abstract
49. Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection. Front Immunol. 2022; 13:1012824. View Abstract
50. Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance. bioRxiv. 2022 Dec 07. View Abstract
51. Reduced Steroid Metabolites Identify Infection-Prone Children in Two Independent Pre-Birth Cohorts. Metabolites. 2022 Nov 13; 12(11). View Abstract
52. A single birth dose of Hepatitis B vaccine induces polyfunctional CD4+ T helper cells. Front Immunol. 2022; 13:1043375. View Abstract
53. Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses. Nat Immunol. 2022 12; 23(12):1788-1798. View Abstract
54. Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination. Nat Immunol. 2022 12; 23(12):1777-1787. View Abstract
55. The Immune Signatures data resource, a compendium of systems vaccinology datasets. Sci Data. 2022 10 20; 9(1):635. View Abstract
56. Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination. Sci Rep. 2022 10 18; 12(1):16860. View Abstract
57. A Parallelization Strategy for the Time Efficient Analysis of Thousands of LC/MS Runs in High-Performance Computing Environment. J Proteome Res. 2022 11 04; 21(11):2810-2814. View Abstract
58. Ruxolitinib for Refractory Macrophage Activation Syndrome Complicating Adult-Onset Still's Disease. Eur J Rheumatol. 2022 Oct; 9(4):217-220. View Abstract
59. Shaping Neonatal Immunization by Tuning the Delivery of Synergistic Adjuvants via Nanocarriers. ACS Chem Biol. 2022 09 16; 17(9):2559-2571. View Abstract
60. Immunogenicity of a Three-Dose Primary Series of mRNA COVID-19 Vaccines in Patients With Lymphoid Malignancies. Open Forum Infect Dis. 2022 Aug; 9(8):ofac417. View Abstract
61. Advancing the Science of Vaccine Safety During the Coronavirus Disease 2019 (COVID-19) Pandemic and Beyond: Launching an International Network of Special Immunization Services. Clin Infect Dis. 2022 08 15; 75(Suppl 1):S11-S17. View Abstract
62. Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity. Clin Infect Dis. 2022 08 15; 75(Suppl 1):S51-S60. View Abstract
63. Precision Vaccine Adjuvants for Older Adults: A Scoping Review. Clin Infect Dis. 2022 08 15; 75(Suppl 1):S72-S80. View Abstract
64. A Precision Adjuvant Approach to Enhance Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines Optimized for Immunologically Distinct Vulnerable Populations. Clin Infect Dis. 2022 08 15; 75(Suppl 1):S30-S36. View Abstract
65. Precision Vaccines: Lessons Learned From the Coronavirus Pandemic. Clin Infect Dis. 2022 08 15; 75(Suppl 1):S1. View Abstract
66. Pediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines: Perceptions and Attitudes From the Food and Drug Administration Public Commentary. Clin Infect Dis. 2022 08 15; 75(Suppl 1):S46-S50. View Abstract
67. Acceptability of a Fentanyl Vaccine to Prevent Opioid Overdose and Need for Personalized Decision-Making. Clin Infect Dis. 2022 08 15; 75(Suppl 1):S98-S109. View Abstract
68. Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study. EBioMedicine. 2022 Sep; 83:104208. View Abstract
69. mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant. Commun Biol. 2022 08 06; 5(1):790. View Abstract
70. CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns. Nat Commun. 2022 08 02; 13(1):4234. View Abstract
71. Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells. bioRxiv. 2022 Jul 11. View Abstract
72. Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro. Cell Rep. 2022 05 03; 39(5):110772. View Abstract
73. Determinants of B-Cell Compartment Hyperactivation in European Adolescents Living With Perinatally Acquired HIV-1 After Over 10 Years of Suppressive Therapy. Front Immunol. 2022; 13:860418. View Abstract
74. Waning effectiveness of SARS-CoV-2 mRNA vaccines in older adults: a rapid review. Hum Vaccin Immunother. 2022 11 30; 18(5):2045857. View Abstract
75. An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity. Cell. 2022 02 17; 185(4):614-629.e21. View Abstract
76. An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice. Sci Transl Med. 2022 Jan 26; 14(629):eabj5305. View Abstract
77. BCG vaccine's off-target effects on allergic, inflammatory, and autoimmune diseases: Worth another shot? J Allergy Clin Immunol. 2022 01; 149(1):51-54. View Abstract
78. Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life. Cytokine. 2021 12; 148:155704. View Abstract
79. SARS-CoV-2 mRNA Vaccine Attitudes as Expressed in U.S. FDA Public Commentary: Need for a Public-Private Partnership in a Learning Immunization System. Front Public Health. 2021; 9:695807. View Abstract
80. Human Newborn Monocytes Demonstrate Distinct BCG-Induced Primary and Trained Innate Cytokine Production and Metabolic Activation In Vitro. Front Immunol. 2021; 12:674334. View Abstract
81. Bell's palsy and SARS-CoV-2 vaccines-an unfolding story - Authors' reply. Lancet Infect Dis. 2021 09; 21(9):1211-1212. View Abstract
82. Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life. Front Immunol. 2021; 12:578700. View Abstract
83. Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity. bioRxiv. 2021 May 21. View Abstract
84. Human Blood Plasma Shapes Distinct Neonatal TLR-Mediated Dendritic Cell Activation via Expression of the MicroRNA Let-7g. Immunohorizons. 2021 04 30; 5(4):246-256. View Abstract
85. Considering Mandatory Vaccination of Children for COVID-19. Pediatrics. 2021 06; 147(6). View Abstract
86. Bell's palsy and SARS-CoV-2 vaccines. Lancet Infect Dis. 2021 04; 21(4):450-452. View Abstract
87. The Fifth International Neonatal and Maternal Immunization Symposium (INMIS 2019): Securing Protection for the Next Generation. mSphere. 2021 01 27; 6(1). View Abstract
88. Vaccination of Term and Preterm Infants. Neoreviews. 2020 12; 21(12):e817-e827. View Abstract
89. Integrative Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections. Metabolites. 2020 Nov 30; 10(12). View Abstract
90. Corrigendum: Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea. Front Pediatr. 2020; 8:610461. View Abstract
91. Ensuring vaccine safety. Science. 2020 12 11; 370(6522):1274-1275. View Abstract
92. Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model. Sci Rep. 2020 10 20; 10(1):17836. View Abstract
93. Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life. Front Immunol. 2020; 11:578505. View Abstract
94. Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference. Front Immunol. 2020; 11:590373. View Abstract
95. A Neonatal Murine Escherichia coli Sepsis Model Demonstrates That Adjunctive Pentoxifylline Enhances the Ratio of Anti- vs. Pro-inflammatory Cytokines in Blood and Organ Tissues. Front Immunol. 2020; 11:577878. View Abstract
96. A cloud-based bioinformatic analytic infrastructure and Data Management Core for the Expanded Program on Immunization Consortium. J Clin Transl Sci. 2020 Sep 22; 5(1):e52. View Abstract
97. Posterior shoulder fracture-dislocation: A systematic review of the literature and current aspects of management. Chin J Traumatol. 2021 Feb; 24(1):18-24. View Abstract
98. Electromyographic analysis of selected shoulder muscles during a series of exercises commonly used in patients with symptomatic degenerative rotator cuff tears. J Shoulder Elbow Surg. 2020 Oct; 29(10):e361-e373. View Abstract
99. BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis. Sci Transl Med. 2020 05 06; 12(542). View Abstract
100. Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea. Front Pediatr. 2020; 8:197. View Abstract
101. Staphylococcus epidermidis Sensitizes Perinatal Hypoxic-Ischemic Brain Injury in Male but Not Female Mice. Front Immunol. 2020; 11:516. View Abstract
102. Early antiretroviral therapy-treated perinatally HIV-infected seronegative children demonstrate distinct long-term persistence of HIV-specific T-cell and B-cell memory. AIDS. 2020 04 01; 34(5):669-680. View Abstract
103. Phosphoric Metabolites Link Phosphate Import and Polysaccharide Biosynthesis for Candida albicans Cell Wall Maintenance. mBio. 2020 03 17; 11(2). View Abstract
104. BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny. Front Microbiol. 2020; 11:332. View Abstract
105. Vancomycin Is Protective in a Neonatal Mouse Model of Staphylococcus epidermidis-Potentiated Hypoxic-Ischemic Brain Injury. Antimicrob Agents Chemother. 2020 02 21; 64(3). View Abstract
106. The TLR5 Agonist Flagellin Shapes Phenotypical and Functional Activation of Lung Mucosal Antigen Presenting Cells in Neonatal Mice. Front Immunol. 2020; 11:171. View Abstract
107. Toward precision adjuvants: optimizing science and safety. Curr Opin Pediatr. 2020 02; 32(1):125-138. View Abstract
108. Licensed Bacille Calmette-Guérin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation. Vaccine. 2020 02 24; 38(9):2229-2240. View Abstract
109. Immunological mechanisms of inducing HIV immunity in infants. Vaccine. 2020 01 16; 38(3):411-415. View Abstract
110. Immunometabolic approaches to prevent, detect, and treat neonatal sepsis. Pediatr Res. 2020 01; 87(2):399-405. View Abstract
111. Cyclic AMP in human preterm infant blood is associated with increased TLR-mediated production of acute-phase and anti-inflammatory cytokines in vitro. Pediatr Res. 2020 11; 88(5):717-725. View Abstract
112. Vascular Endothelium in Neonatal Sepsis: Basic Mechanisms and Translational Opportunities. Front Pediatr. 2019; 7:340. View Abstract
113. AIDS Vaccine Research Subcommittee (AVRS) Consultation: Early-Life Immunization Strategies against HIV Acquisition. mSphere. 2019 07 17; 4(4). View Abstract
114. OMIC Technologies and Vaccine Development: From the Identification of Vulnerable Individuals to the Formulation of Invulnerable Vaccines. J Immunol Res. 2019; 2019:8732191. View Abstract
115. Dynamic molecular changes during the first week of human life follow a robust developmental trajectory. Nat Commun. 2019 03 12; 10(1):1092. View Abstract
116. PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function. Cancer Immunol Res. 2019 02; 7(2):257-268. View Abstract
117. Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro. Antimicrob Agents Chemother. 2018 12; 62(12). View Abstract
118. Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro. Vaccine. 2019 01 03; 37(1):80-89. View Abstract
119. Microphysiologic Human Tissue Constructs Reproduce Autologous Age-Specific BCG and HBV Primary Immunization in vitro. Front Immunol. 2018; 9:2634. View Abstract
120. The Fourth International Neonatal and Maternal Immunization Symposium (INMIS 2017): Toward Integrating Maternal and Infant Immunization Programs. mSphere. 2018 11 07; 3(6). View Abstract
121. First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines. mSphere. 2018 08 01; 3(4). View Abstract
122. Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future. Front Pediatr. 2018; 6:199. View Abstract
123. Early Life HIV-1 Immunization: Providing a Window for Protection Before Sexual Debut. AIDS Res Hum Retroviruses. 2018 10; 34(10):823-827. View Abstract
124. Antimicrobial peptide LL-37 and recombinant human mannose-binding lectin express distinct age- and pathogen-specific antimicrobial activity in human newborn cord blood in vitro. F1000Res. 2018; 7:616. View Abstract
125. Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. PLoS One. 2018; 13(5):e0196352. View Abstract
126. A Cost-Effective High-Throughput Plasma and Serum Proteomics Workflow Enables Mapping of the Molecular Impact of Total Pancreatectomy with Islet Autotransplantation. J Proteome Res. 2018 05 04; 17(5):1983-1992. View Abstract
127. Neonatal Immunization: Rationale, Current State, and Future Prospects. Front Immunol. 2018; 9:532. View Abstract
128. Hepatic Legionella pneumophila Infection in an Infant With Severe Combined Immunodeficiency. Pediatr Infect Dis J. 2018 04; 37(4):356-358. View Abstract
129. Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn. Front Immunol. 2018; 9:29. View Abstract
130. Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization. Front Immunol. 2017; 8:1772. View Abstract
131. Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation. Front Immunol. 2017; 8:1531. View Abstract
132. Stemless Prosthesis for Total Shoulder Arthroplasty. J Am Acad Orthop Surg. 2017 Dec; 25(12):e291-e300. View Abstract
133. The "Parachute" Technique: A Simple and Effective Single-Row Procedure to Achieve an Increased Contact Area Between the Cuff-Tendon and Its Footprint. Arthrosc Tech. 2017 Oct; 6(5):e1903-e1909. View Abstract
134. The "Purse String" Procedure for Recurrent Anterior Glenohumeral Instability: A Simple Technique to Achieve Bankart Repair, Capsular Shift, and a Good Labral Bumper. Arthrosc Tech. 2017 Aug; 6(4):e1245-e1251. View Abstract
135. Waning Immunity and Microbial Vaccines-Workshop of the National Institute of Allergy and Infectious Diseases. Clin Vaccine Immunol. 2017 Jul; 24(7). View Abstract
136. Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis. PLoS One. 2017; 12(4):e0175936. View Abstract
137. Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses. J Allergy Clin Immunol. 2017 Nov; 140(5):1339-1350. View Abstract
138. TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth. JCI Insight. 2017 03 23; 2(6):e91020. View Abstract
139. Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny. Immunity. 2017 03 21; 46(3):350-363. View Abstract
140. The "Purse-string" Technique for Shoulder Stabilization, Description of the Technique, Long term Results and Literature Review. Open Orthop J. 2017; 11:183-188. View Abstract
141. Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns. Pediatr Res. 2017 May; 81(5):806-816. View Abstract
142. A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity. Front Immunol. 2016; 7:562. View Abstract
143. Human newborn B cells mount an interferon-a/ß receptor-dependent humoral response to respiratory syncytial virus. J Allergy Clin Immunol. 2017 06; 139(6):1997-2000.e4. View Abstract
144. Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization. J Immunol. 2016 12 01; 197(11):4413-4424. View Abstract
145. Antimicrobial Proteins and Peptides in Early Life: Ontogeny and Translational Opportunities. Front Immunol. 2016; 7:309. View Abstract
146. "Owl" Technique for All-Arthroscopic Augmentation of a Massive or Large Rotator Cuff Tear With Extracellular Matrix Graft. Arthrosc Tech. 2016 Aug; 5(4):e717-e724. View Abstract
147. Complications of Hip Arthroscopy: Patient Perspectives. Orthop Nurs. 2016 Jul-Aug; 35(4):208-13. View Abstract
148. Heterologous vaccine effects. Vaccine. 2016 07 25; 34(34):3923-30. View Abstract
149. Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells. Innate Immun. 2016 08; 22(6):433-43. View Abstract
150. Harnessing the beneficial heterologous effects of vaccination. Nat Rev Immunol. 2016 06; 16(6):392-400. View Abstract
151. Use of cidofovir in pediatric patients with adenovirus infection. F1000Res. 2016; 5:758. View Abstract
152. In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. Cytokine. 2016 07; 83:99-109. View Abstract
153. The impact of concomitant fibromyalgia on visual analogue scales of pain, fatigue and function in patients with various rheumatic disorders. Clin Exp Rheumatol. 2016 Mar-Apr; 34(2 Suppl 96):S120-4. View Abstract
154. Circulating Human Neonatal Naïve B Cells are Deficient in CD73 Impairing Purine Salvage. Front Immunol. 2016; 7:121. View Abstract
155. Changing oral vaccine to inactivated polio vaccine might increase mortality. Lancet. 2016 Mar 12; 387(10023):1054-1055. View Abstract
156. Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures. Mol Cell Proteomics. 2016 06; 15(6):1877-94. View Abstract
157. Pilot experience with opebacan/rBPI 21 in myeloablative hematopoietic cell transplantation. F1000Res. 2015; 4:1480. View Abstract
158. Pediatric Vaccine Adjuvants: Components of the Modern Vaccinologist's Toolbox. Pediatr Infect Dis J. 2015 Dec; 34(12):1395-8. View Abstract
159. Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs. Innate Immun. 2016 Jan; 22(1):51-62. View Abstract
160. The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes. PLoS One. 2015; 10(8):e0134640. View Abstract
161. Systems vaccinology: a promise for the young and the poor. Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19; 370(1671). View Abstract
162. Staphylococcus epidermidis Bacteremia Induces Brain Injury in Neonatal Mice via Toll-like Receptor 2-Dependent and -Independent Pathways. J Infect Dis. 2015 Nov 01; 212(9):1480-90. View Abstract
163. Ready to benefit from training: heterologous effects of early life immunization. Trans R Soc Trop Med Hyg. 2015 Jan; 109(1):3-4. View Abstract
164. Soluble mediators regulating immunity in early life. Front Immunol. 2014; 5:457. View Abstract
165. The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells. Biomaterials. 2014 Oct; 35(31):8876-8886. View Abstract
166. Thoracoscapular Fusion for Winging of the Scapula with Screw Fixation for Fascioscapulohumeral Dystrophy (Modified Copeland-Howard Procedure). JBJS Essent Surg Tech. 2014 Jun; 4(2):e12. View Abstract
167. Infection-induced inflammation and cerebral injury in preterm infants. Lancet Infect Dis. 2014 Aug; 14(8):751-762. View Abstract
168. Ontogeny of early life immunity. Trends Immunol. 2014 Jul; 35(7):299-310. View Abstract
169. Tocilizumab in adult-onset Still's disease: the Israeli experience. J Rheumatol. 2014 Feb; 41(2):244-7. View Abstract
170. A prime time for trained immunity: innate immune memory in newborns and infants. Neonatology. 2014; 105(2):136-41. View Abstract
171. Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity. Rev Med Virol. 2014 Jan; 24(1):55-70. View Abstract
172. Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines. Pediatr Res. 2014 Jan; 75(1-2):184-8. View Abstract
173. Identification of single nucleotide polymorphisms in hematopoietic cell transplant patients affecting early recognition of, and response to, endotoxin. Innate Immun. 2014 Oct; 20(7):697-711. View Abstract
174. Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine. J Biol Chem. 2013 Sep 20; 288(38):27315-27326. View Abstract
175. Neonatal host defense against Staphylococcal infections. Clin Dev Immunol. 2013; 2013:826303. View Abstract
176. Vaccine-induced immunity in early life. Vaccine. 2013 May 17; 31(21):2481-2. View Abstract
177. Management of first-time dislocations of the shoulder in patients older than 40 years: the prevalence of iatrogenic fracture. J Orthop Trauma. 2013 Apr; 27(4):190-3. View Abstract
178. The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes. PLoS One. 2013; 8(3):e58164. View Abstract
179. Role of innate immunity in neonatal infection. Am J Perinatol. 2013 Feb; 30(2):105-12. View Abstract
180. Plasma-mediated immune suppression: a neonatal perspective. Pediatr Allergy Immunol. 2013 Mar; 24(2):102-13. View Abstract
181. Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly. Immunity. 2012 Nov 16; 37(5):771-83. View Abstract
182. Immune response to vaccine adjuvants during the first year of life. Vaccine. 2013 May 17; 31(21):2500-5. View Abstract
183. A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses. PLoS One. 2012; 7(9):e43897. View Abstract
184. Innate immune activation in neonatal tracheal aspirates suggests endotoxin-driven inflammation. Pediatr Res. 2012 Aug; 72(2):203-11. View Abstract
185. Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways. J Allergy Clin Immunol. 2012 Jul; 130(1):195-204.e9. View Abstract
186. Responsiveness of human monocytes to the commensal bacterium Staphylococcus epidermidis develops late in gestation. Pediatr Res. 2012 Jul; 72(1):10-8. View Abstract
187. Neonatal plasma polarizes TLR4-mediated cytokine responses towards low IL-12p70 and high IL-10 production via distinct factors. PLoS One. 2012; 7(3):e33419. View Abstract
188. Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death. Sci Transl Med. 2011 Nov 23; 3(110):110ra118. View Abstract
189. Toll2011 at Lago di Garda: studying danger sensors by the guard towers at the lake. Nat Immunol. 2011 Aug 18; 12(9):805-8. View Abstract
190. Deficient expression of bactericidal/permeability-increasing protein in immunocompromised hosts: translational potential of replacement therapy. Biochem Soc Trans. 2011 Aug; 39(4):994-9. View Abstract
191. Development of newborn and infant vaccines. Sci Transl Med. 2011 Jul 06; 3(90):90ps27. View Abstract
192. 17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. J Leukoc Biol. 2011 Sep; 90(3):459-70. View Abstract
193. Systemic stimulation of TLR2 impairs neonatal mouse brain development. PLoS One. 2011 May 06; 6(5):e19583. View Abstract
194. "Put your 'extended' finger on the bleeder": the use of direct pressure from the shaver blade to achieve hemostasis. Arthroscopy. 2011 Jun; 27(6):867-9. View Abstract
195. Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants. PLoS One. 2011 Apr 13; 6(4):e18185. View Abstract
196. Challenges in infant immunity: implications for responses to infection and vaccines. Nat Immunol. 2011 Mar; 12(3):189-94. View Abstract
197. Adenosine modulates Toll-like receptor function: basic mechanisms and translational opportunities. Expert Rev Anti Infect Ther. 2011 Feb; 9(2):261-9. View Abstract
198. Human neonatal peripheral blood leukocytes demonstrate pathogen-specific coordinate expression of TLR2, TLR4/MD2, and MyD88 during bacterial infection in vivo. Pediatr Res. 2010 Dec; 68(6):479-83. View Abstract
199. Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore). 2010 Nov; 89(6):403-425. View Abstract
200. Method of bacterial killing differentially affects the human innate immune response to Staphylococcus epidermidis. Innate Immun. 2011 Dec; 17(6):508-16. View Abstract
201. Role of innate host defenses in susceptibility to early-onset neonatal sepsis. Clin Perinatol. 2010 Jun; 37(2):307-37. View Abstract
202. TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia. PLoS One. 2010 Apr 09; 5(4):e10111. View Abstract
203. Neonatal innate immunity in allergy development. Curr Opin Pediatr. 2009 Dec; 21(6):762-9. View Abstract
204. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17858-63. View Abstract
205. Neonatal vaccination: a once in a lifetime opportunity. Pediatr Infect Dis J. 2009 Sep; 28(9):833-5. View Abstract
206. Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):13797-801. View Abstract
207. Endotoxin-directed innate immunity in tracheal aspirates of mechanically ventilated human neonates. Pediatr Res. 2009 Aug; 66(2):191-6. View Abstract
208. The active elevation lag sign and the triangle sign: new clinical signs of trapezius palsy. J Shoulder Elbow Surg. 2009 Jul-Aug; 18(4):573-6. View Abstract
209. Developmental biology of the innate immune response: implications for neonatal and infant vaccine development. Pediatr Res. 2009 May; 65(5 Pt 2):98R-105R. View Abstract
210. Safety and efficacy of neonatal vaccination. Eur J Immunol. 2009 Jan; 39(1):36-46. View Abstract
211. Novel vaccines: bridging research, development and production. Expert Rev Vaccines. 2008 Nov; 7(9):1321-4. View Abstract
212. Bactericidal/permeability-increasing protein (BPI) and BPI homologs at mucosal sites. Trends Immunol. 2008 Nov; 29(11):541-7. View Abstract
213. Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. J Allergy Clin Immunol. 2008 Dec; 122(6):1113-1118.e1. View Abstract
214. The role of anterior deltoid reeducation in patients with massive irreparable degenerative rotator cuff tears. J Shoulder Elbow Surg. 2008 Nov-Dec; 17(6):863-70. View Abstract
215. Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood. 2008 Sep 01; 112(5):1750-8. View Abstract
216. Immunostimulatory activity of Toll-like receptor 8 agonists towards human leucocytes: basic mechanisms and translational opportunities. Biochem Soc Trans. 2007 Dec; 35(Pt 6):1485-91. View Abstract
217. Evidence of a bactericidal permeability increasing protein in an invertebrate, the Crassostrea gigas Cg-BPI. Proc Natl Acad Sci U S A. 2007 Nov 06; 104(45):17759-64. View Abstract
218. Bactericidal/permeability-increasing protein in host defense and its efficacy in the treatment of bacterial sepsis. Curr Infect Dis Rep. 2007 Oct; 3(5):407-12. View Abstract
219. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med. 2007 Oct 01; 204(10):2407-22. View Abstract
220. Neonatal immune responses to coagulase-negative staphylococci. Curr Opin Infect Dis. 2007 Aug; 20(4):370-5. View Abstract
221. Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat Rev Immunol. 2007 May; 7(5):379-90. View Abstract
222. Recombinant bactericidal/permeability-increasing protein rBPI21 protects against pneumococcal disease. Infect Immun. 2007 Jan; 75(1):342-9. View Abstract
223. Subacromial plica as a cause of impingement in the shoulder. J Shoulder Elbow Surg. 2006 Nov-Dec; 15(6):697-700. View Abstract
224. TCR zeta down-regulation under chronic inflammation is mediated by myeloid suppressor cells differentially distributed between various lymphatic organs. J Immunol. 2006 Oct 01; 177(7):4763-72. View Abstract
225. The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn. J Immunol. 2006 Aug 01; 177(3):1956-66. View Abstract
226. Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo. Pediatr Res. 2006 Aug; 60(2):205-9. View Abstract
227. Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells. Blood. 2006 Aug 15; 108(4):1284-90. View Abstract
228. Neonatal babesiosis: case report and review of the literature. Pediatr Infect Dis J. 2006 Feb; 25(2):169-73. View Abstract
229. Functional and biochemical characterization of epithelial bactericidal/permeability-increasing protein. Am J Physiol Gastrointest Liver Physiol. 2006 Mar; 290(3):G557-67. View Abstract
230. Posttraumatic locked dislocation of congenital pseudarthrosis of the clavicle. J Shoulder Elbow Surg. 2005 May-Jun; 14(3):336-7. View Abstract
231. Geometrical analysis of Copeland surface replacement shoulder arthroplasty in relation to normal anatomy. J Shoulder Elbow Surg. 2005 Mar-Apr; 14(2):186-92. View Abstract
232. Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation. Immunol Rev. 2005 Feb; 203:21-37. View Abstract
233. Innate immunity of the human newborn: distinct cytokine responses to LPS and other Toll-like receptor agonists. J Endotoxin Res. 2005; 11(2):113-6. View Abstract
234. Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848. J Immunol. 2004 Oct 01; 173(7):4627-34. View Abstract
235. Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia. J Allergy Clin Immunol. 2004 Sep; 114(3):650-6. View Abstract
236. Antimicrobial proteins and peptides: anti-infective molecules of mammalian leukocytes. J Leukoc Biol. 2004 Nov; 76(5):909-25. View Abstract
237. Cementless surface replacement arthroplasty (Copeland CSRA) for osteoarthritis of the shoulder. J Shoulder Elbow Surg. 2004 May-Jun; 13(3):266-71. View Abstract
238. Copeland surface replacement arthroplasty of the shoulder in rheumatoid arthritis. J Bone Joint Surg Am. 2004 Mar; 86(3):512-8. View Abstract
239. Genetic screening for susceptibility to infection in the NICU setting. Pediatr Res. 2004 Apr; 55(4):546-8. View Abstract
240. Mechanical properties of regenerated coracoacromial ligament after subacromial decompression. J Shoulder Elbow Surg. 2004 Jan-Feb; 13(1):51-6. View Abstract
241. Critical role of the complement system in group B streptococcus-induced tumor necrosis factor alpha release. Infect Immun. 2003 Nov; 71(11):6344-53. View Abstract
242. Endotoxemia and elevation of lipopolysaccharide-binding protein after hematopoietic stem cell transplantation. Pediatr Infect Dis J. 2003 Nov; 22(11):978-81. View Abstract
243. Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells. J Infect Dis. 2003 Oct 01; 188(7):948-53. View Abstract
244. Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function. J Immunol. 2003 Aug 01; 171(3):1343-51. View Abstract
245. Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia. Biochem Soc Trans. 2003 Aug; 31(Pt 4):795-800. View Abstract
246. Disseminated varicella infection due to vaccine (Oka) strain varicella zoster virus in a patient with a novel deficiency in natural killer T cells. Journal of Infectious Diseases. 2003; 188:948-953. View Abstract
247. Endotoxemia and elevation of lipopolysachharide-binding protein after hematopoietic stem cell transplantation. Pediatric Infectious Disease Journal. 2003; 22:978-981. View Abstract
248. Newborn cord blood demonstrates impaired TNF responses to multiple pathogen-assocaited molecular pattern molecules (PAMPs) despite normal expression of monocyte Toll-like receptos 1 and 2, MD-2, MyD88 and TIRAP. Pediatric Research: Abstracts of the Pediatric Academic Societies' Annual Meeting. 2003; 350A. View Abstract
249. Journeys in the study of antibacterial host defenses: Conserved mechanisms, evolving insights and potential therapeutic opportunities [review]. Recent Research Developments in Antimicrobial Agents & Chemotherapy. 2003; 6:1-38. View Abstract
250. Expression of BPI by human mucosal epithelia [review]. Biochemical Society Transactions. 2003; 31:795-800. View Abstract
251. Simple, minimally invasive surgical technique for treatment of type 2 fractures of the distal clavicle. J Shoulder Elbow Surg. 2003 Jan-Feb; 12(1):24-8. View Abstract
252. The vertical-apical suture Bankart lesion repair for anteroinferior glenohumeral instability. J Shoulder Elbow Surg. 2002 Sep-Oct; 11(5):481-5. View Abstract
253. Impaired innate immunity at birth: deficiency of bactericidal/permeability-increasing protein (BPI) in the neutrophils of newborns. Pediatr Res. 2002 Jun; 51(6):667-9. View Abstract
254. Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils. Transplantation. 2002 May 15; 73(9):1522-6. View Abstract
255. The role of arthroscopy for the problem shoulder arthroplasty. J Shoulder Elbow Surg. 2002 May-Jun; 11(3):230-4. View Abstract
256. Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3902-7. View Abstract
257. Fatal disseminated Candida lusitaniae infection in an infant with chronic granulomatous disease. Pediatr Infect Dis J. 2002 Mar; 21(3):262-4. View Abstract
258. Therapeutic potential of the bactericidal/permeability-increasing protein. Expert Opin Investig Drugs. 2002 Feb; 11(2):159-67. View Abstract
259. Lipid-mediator-induced expression of bactericidal/permeability-increasing protein (BPI) in human mucosal epithelia. Proceedings of the National Academy of Sciences. 2002; 99:3902-3907. View Abstract
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263. Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents. Blood. 2000 Oct 15; 96(8):2664-72. View Abstract
264. Enhancement of neonatal innate defense: effects of adding an N-terminal recombinant fragment of bactericidal/permeability-increasing protein on growth and tumor necrosis factor-inducing activity of gram-negative bacteria tested in neonatal cord blood ex vivo. Infect Immun. 2000 Sep; 68(9):5120-5. View Abstract
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267. Oxygen-independent antimicrobial systems of phagocytes. Inflammation: Basic Principles and Clinical Correlates. 1999; 801-817. View Abstract
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270. Antibacterial 15 kDa protein isoforms (p15s) of rabbit polymorphonuclear leukocytes. 1996. View Abstract
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272. Extracellular accumulation of potently microbicidal bactericidal/permeability-increasing protein (BPI) and p15s in an evolving sterile rabbit peritoneal inflammatory exudate. Journal of Clinical Investigation. 1995; 95:1916-1924. View Abstract
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276. Structural characterization of BPI-modulating 15 kDa proteins from rabbit polymorphonuclear leukocytes: identification of a novel family of leukocyte proteins. Agents Actions. 1993; 39 Spec No:C207-10. View Abstract
277. Isolation of two isoforms of a novel 15 kDa protein from rabbit polymorphonuclear leukocytes that modulates the antibacterial actions of other leukocyte proteins. Journal of Biological Chemistry. 1990; 265:15956-15962. View Abstract
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