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Research Overview

Research in the Perlmutter Laboratory (Drs. Norma and Craig Gerard) has focused extensively on G protein coupled receptors that play an essential role in activating white blood cells. Many of these receptors and ligands – the molecules that bind to them- have come to be appreciated as a bridge between innate and acquired immunity, as well as being vital to the acute inflammatory response. The bulk of the group’s focus over the last decade has been on elucidating the mechanistic actions of the receptors for the complement anaphylatoxins, C5a and C3a – molecules that mediate inflammatory responses – as well as those for the chemokine superfamily – chemical messengers of the immune system. Their work has moved from cloning the receptors to disrupting receptor genes in order to probe the role of these receptors in disease models in vivo. The lab was the first to show how one pathogen, invasive pneumococcus, exploits the receptor for platelet activating factor to gain access to cells. That discovery was followed by collaborative work defining the chemokine receptors involved as HIV-1 co-receptors.

The specific focus of Norma Gerard’s research leans toward understanding the molecular mechanisms of leukocyte trafficking (the way in which white blood cells mobilize in routine surveillance and during an inflammatory response). Her group is particularly interested in the family of G protein coupled receptors that direct the migration of leukocytes, both at baseline and in response to injury. Such receptors include those for the complement anaphylatoxins, C5a and C3a; neurokinins, including substance P and neurokininA; lipids, including platelet activating factor and leukotrienes; and other peptides, including chemokines and bacterial chemotactic peptides. She uses multiple complementary approaches including genetic models in the mouse, transfection of cultured cells and biochemical analyses, to understand the complex balance between host defense and untoward inflammation that is mediated by these ligands and receptors.

Research Background

Norma Gerard received her PhD from the University of Connecticut. She completed a postdoctoral fellowship at the University of California at San Diego and Scripps Research Institute.

Publications

  1. The oxidation state of cysteine thiols on the ectodomain of TLR2 and TLR4 influences intracellular signaling. Immunobiology. 2020 03; 225(2):151895. View Abstract
  2. Reply. J Allergy Clin Immunol. 2019 09; 144(3):873-874. View Abstract
  3. CFTR regulates B cell activation and lymphoid follicle development. Respir Res. 2019 Jul 01; 20(1):133. View Abstract
  4. Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):13006-13015. View Abstract
  5. Loss of bronchoprotection with ICS plus LABA treatment, ß-receptor dynamics, and the effect of alendronate. J Allergy Clin Immunol. 2019 08; 144(2):416-425.e7. View Abstract
  6. Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Circulation. 2018 05 15; 137(20):2152-2165. View Abstract
  7. The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations. Am J Respir Cell Mol Biol. 2017 12; 57(6):711-720. View Abstract
  8. C5L2, the Second C5a Anaphylatoxin Receptor, Suppresses LPS-Induced Acute Lung Injury. Am J Respir Cell Mol Biol. 2016 11; 55(5):657-666. View Abstract
  9. Loss of Neurokinin-1 Receptor Alters Ocular Surface Homeostasis and Promotes an Early Development of Herpes Stromal Keratitis. J Immunol. 2016 11 15; 197(10):4021-4033. View Abstract
  10. Cloning of the Human C5a Anaphylatoxin Receptor, and More. Front Immunol. 2015; 6:445. View Abstract
  11. Differential Interaction of the Staphylococcal Toxins Panton-Valentine Leukocidin and ?-Hemolysin CB with Human C5a Receptors. J Immunol. 2015 Aug 01; 195(3):1034-43. View Abstract
  12. C5a receptor (CD88) blockade protects against MPO-ANCA GN. J Am Soc Nephrol. 2014 Feb; 25(2):225-31. View Abstract
  13. Biased agonism as a mechanism for differential signaling by chemokine receptors. J Biol Chem. 2013 Dec 06; 288(49):35039-48. View Abstract
  14. Disruption of the complement anaphylatoxin receptor C5L2 exacerbates inflammation in allergic contact dermatitis. J Immunol. 2013 Oct 15; 191(8):4001-9. View Abstract
  15. C5a receptor deficiency alters energy utilization and fat storage. PLoS One. 2013; 8(5):e62531. View Abstract
  16. Intrarectal immunization and IgA antibody-secreting cell homing to the small intestine. J Immunol. 2013 May 01; 190(9):4836-47. View Abstract
  17. Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency. PLoS One. 2013; 8(3):e58787. View Abstract
  18. Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice. J Allergy Clin Immunol. 2013 Feb; 131(2):541-8.e1-9. View Abstract
  19. Diminished pheromone-induced sexual behavior in neurokinin-1 receptor deficient (TACR1(-/-)) mice. Genes Brain Behav. 2012 Jul; 11(5):568-76. View Abstract
  20. Substance P signaling mediates BMP-dependent heterotopic ossification. J Cell Biochem. 2011 Oct; 112(10):2759-72. View Abstract
  21. Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins. J Immunol. 2011 Oct 15; 187(8):4245-55. View Abstract
  22. Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. Endocrinology. 2011 Jun; 152(6):2197-205. View Abstract
  23. C5a receptor enables participation of mast cells in immune complex arthritis independently of Fc? receptor modulation. Arthritis Rheum. 2010 Nov; 62(11):3322-33. View Abstract
  24. A critical role for C5L2 in the pathogenesis of experimental allergic asthma. J Immunol. 2010 Dec 01; 185(11):6741-52. View Abstract
  25. Substance P modulates colitis-associated fibrosis. Am J Pathol. 2010 Nov; 177(5):2300-9. View Abstract
  26. The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction. J Biol Chem. 2010 Mar 05; 285(10):7633-44. View Abstract
  27. Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):628-32. View Abstract
  28. A paradoxical protective role for the proinflammatory peptide substance P receptor (NK1R) in acute hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L687-97. View Abstract
  29. The regulation of liver cell survival by complement. J Immunol. 2009 May 01; 182(9):5412-8. View Abstract
  30. Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia. Am J Pathol. 2009 Mar; 174(3):782-96. View Abstract
  31. Functional roles for C5a receptors in sepsis. Nat Med. 2008 May; 14(5):551-7. View Abstract
  32. FcgammaRIII is protective against Pseudomonas aeruginosa pneumonia. Am J Respir Cell Mol Biol. 2008 Apr; 38(4):401-6. View Abstract
  33. Ventilatory responses to acute hypoxia in neurokinin-1 receptor deficient mice. Respir Physiol Neurobiol. 2007 Nov 15; 159(2):227-31. View Abstract
  34. Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity. J Am Coll Cardiol. 2007 Aug 07; 50(6):528-36. View Abstract
  35. Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury. Free Radic Biol Med. 2007 Aug 15; 43(4):581-9. View Abstract
  36. Neurokinin-1 enables measles virus trans-synaptic spread in neurons. Virology. 2007 May 25; 362(1):235-44. View Abstract
  37. C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression. J Virol. 2007 Jan; 81(2):991-9. View Abstract
  38. Neurokinin-1 receptor blockade and murine lung tumorigenesis. Am J Respir Crit Care Med. 2006 Sep 15; 174(6):674-83. View Abstract
  39. An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. J Biol Chem. 2005 Dec 02; 280(48):39677-80. View Abstract
  40. C5L2 receptor is not involved in C3a / C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12. Leukemia. 2005 Sep; 19(9):1682-3; author reply 1684-5. View Abstract
  41. Lack of neurokinin-1 receptor expression affects tissue mast cell numbers but not their spatial relationship with nerves. Am J Physiol Regul Integr Comp Physiol. 2005 Feb; 288(2):R491-500. View Abstract
  42. A critical role for eosinophils in allergic airways remodeling. Science. 2004 Sep 17; 305(5691):1776-9. View Abstract
  43. Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. J Neurosci. 2004 Jan 28; 24(4):991-8. View Abstract
  44. Basal and activity-induced release of substance P from primary afferent fibres in NK1 receptor knockout mice: evidence for negative feedback. Neuropharmacology. 2003 Dec; 45(8):1101-10. View Abstract
  45. Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse. Gut. 2003 Oct; 52(10):1457-64. View Abstract
  46. Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3-signaling chemokines. Eur J Immunol. 2003 Oct; 33(10):2676-86. View Abstract
  47. The tachykinin NK1 receptor is crucial for the development of non-atopic airway inflammation and hyperresponsiveness. Eur J Pharmacol. 2003 Aug 29; 476(3):249-55. View Abstract
  48. C5L2, a nonsignaling C5A binding protein. Biochemistry. 2003 Aug 12; 42(31):9406-15. View Abstract
  49. Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice. Brain Res. 2003 Aug 08; 980(2):213-20. View Abstract
  50. Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin. J Biol Chem. 2003 Sep 26; 278(39):37902-8. View Abstract
  51. Neurokinin 1 receptors and neprilysin modulation of mouse bladder gene regulation. Physiol Genomics. 2003 Feb 06; 12(3):239-50. View Abstract
  52. Complement in allergy and asthma. Curr Opin Immunol. 2002 Dec; 14(6):705-8. View Abstract
  53. Mast cells mediate substance P-induced bladder inflammation through an NK(1) receptor-independent mechanism. Am J Physiol Renal Physiol. 2002 Oct; 283(4):F616-29. View Abstract
  54. Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms. J Physiol. 2002 Sep 15; 543(Pt 3):1007-14. View Abstract
  55. Tyrosine-sulfated peptides functionally reconstitute a CCR5 variant lacking a critical amino-terminal region. J Biol Chem. 2002 Oct 25; 277(43):40397-402. View Abstract
  56. Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor. Br J Pharmacol. 2002 May; 136(2):271-9. View Abstract
  57. Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res. 2002 May; 43(1):39-56. View Abstract
  58. Secondary lymphoid tissue chemokine (CCL21) activates CXCR3 to trigger a Cl- current and chemotaxis in murine microglia. J Immunol. 2002 Apr 01; 168(7):3221-6. View Abstract
  59. Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice. Gastroenterology. 2002 Mar; 122(3):725-33. View Abstract
  60. The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1479-84. View Abstract
  61. Evidence of a role for NK1 and CGRP receptors in mediating neurogenic vasodilatation in the mouse ear. Br J Pharmacol. 2002 Jan; 135(2):356-62. View Abstract
  62. Interactive contribution of NK(1) and kinin receptors to the acute inflammatory oedema observed in response to noxious heat stimulation: studies in NK(1) receptor knockout mice. Br J Pharmacol. 2001 Dec; 134(8):1805-13. View Abstract
  63. Hemokinin 1 is a full agonist at the substance P receptor. Nat Immunol. 2001 Dec; 2(12):1088. View Abstract
  64. Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A. Am J Physiol Gastrointest Liver Physiol. 2001 Aug; 281(2):G544-51. View Abstract
  65. Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Nat Med. 2001 Jul; 7(7):821-6. View Abstract
  66. Metabolic regulation of brain Abeta by neprilysin. Science. 2001 May 25; 292(5521):1550-2. View Abstract
  67. Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor. J Exp Med. 2001 May 07; 193(9):1059-66. View Abstract
  68. Chemokines: back to the future? Nat Cell Biol. 2001 Feb; 3(2):E53-4. View Abstract
  69. Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis. J Immunol. 2001 Jan 15; 166(2):1285-91. View Abstract
  70. Lack of a significant effect of deletion of the tachykinin neurokinin-1 receptor on wound healing in mouse skin. Neuroscience. 2001; 108(4):695-700. View Abstract
  71. Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain. J Biochem. 2000 Dec; 128(6):897-902. View Abstract
  72. Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med. 2000 Nov 20; 192(10):1515-20. View Abstract
  73. A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry. J Biol Chem. 2000 Oct 27; 275(43):33516-21. View Abstract
  74. A role for the C3a anaphylatoxin receptor in the effector phase of asthma. Nature. 2000 Aug 31; 406(6799):998-1001. View Abstract
  75. Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice. Br J Pharmacol. 2000 Jun; 130(3):505-12. View Abstract
  76. Neurokinin-1 receptor agonists are involved in mediating neutrophil accumulation in the inflamed, but not normal, cutaneous microvasculature: an in vivo study using neurokinin-1 receptor knockout mice. J Immunol. 2000 May 15; 164(10):5424-9. View Abstract
  77. Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. J Immunol. 2000 Apr 01; 164(7):3460-4. View Abstract
  78. Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. Am J Pathol. 2000 Mar; 156(3):775-80. View Abstract
  79. Gene targeting of chemokines and their receptors. Springer Semin Immunopathol. 2000; 22(4):417-32. View Abstract
  80. Nerve-mediated motility of ileal segments isolated from NK(1) receptor knockout mice. Am J Physiol. 1999 12; 277(6):G1173-9. View Abstract
  81. Structure and function of the murine chemokine receptor CXCR3. Eur J Immunol. 1999 11; 29(11):3804-12. View Abstract
  82. Targeted deletion of the neutral endopeptidase gene alters ventilatory responses to acute hypoxia in mice. J Appl Physiol (1985). 1999 Oct; 87(4):1266-71. View Abstract
  83. Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11653-8. View Abstract
  84. Use of NK(1) knockout mice to analyze substance P-induced edema formation. Am J Physiol. 1999 08; 277(2):R476-81. View Abstract
  85. A mismatched-primer polymerase chain reaction-restriction fragment length polymorphism strategy for rapid screening of the polyadenylation signal mutation alpha(T-Saudi) (AATAAA-->AATAAG) in the alpha2-globin gene. Hemoglobin. 1999 Aug; 23(3):213-20. View Abstract
  86. Effects of soluble CD4 on simian immunodeficiency virus infection of CD4-positive and CD4-negative cells. J Virol. 1999 Jul; 73(7):5373-80. View Abstract
  87. The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoni. J Immunol. 1999 May 15; 162(10):6080-5. View Abstract
  88. Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry. Cell. 1999 Mar 05; 96(5):667-76. View Abstract
  89. Cloning and characterization of the guinea pig eosinophil eotaxin receptor, C-C chemokine receptor-3: blockade using a monoclonal antibody in vivo. J Immunol. 1998 Dec 01; 161(11):6139-47. View Abstract
  90. The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques. J Exp Med. 1998 Sep 21; 188(6):1159-71. View Abstract
  91. The orphan seven-transmembrane receptor apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1. J Virol. 1998 Jul; 72(7):6113-8. View Abstract
  92. Structural interactions between chemokine receptors, gp120 Env and CD4. Semin Immunol. 1998 Jun; 10(3):249-57. View Abstract
  93. Neurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritis. J Clin Invest. 1998 Apr 15; 101(8):1547-50. View Abstract
  94. Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury. Proc Natl Acad Sci U S A. 1998 Apr 14; 95(8):4760-5. View Abstract
  95. A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5. J Virol. 1998 Feb; 72(2):1160-4. View Abstract
  96. CD4-independent binding of SIV gp120 to rhesus CCR5. Science. 1997 Nov 21; 278(5342):1470-3. View Abstract
  97. Targeted disruption of the beta-chemokine receptor CCR1 protects against pancreatitis-associated lung injury. J Clin Invest. 1997 Oct 15; 100(8):2022-7. View Abstract
  98. Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. J Exp Med. 1997 Aug 29; 186(5):749-56. View Abstract
  99. Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection. J Exp Med. 1997 Aug 04; 186(3):405-11. View Abstract
  100. The control of microvascular permeability and blood pressure by neutral endopeptidase. Nat Med. 1997 Aug; 3(8):904-7. View Abstract
  101. Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes. J Immunol. 1997 Jul 15; 159(2):905-11. View Abstract
  102. Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1alpha is a ligand for both CXC chemokine receptor-4 isoforms. J Immunol. 1997 Apr 15; 158(8):3561-4. View Abstract
  103. HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5. J Biol Chem. 1997 Mar 14; 272(11):6854-7. View Abstract
  104. Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239. J Virol. 1997 Mar; 71(3):2522-7. View Abstract
  105. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. Nature. 1996 Nov 14; 384(6605):179-83. View Abstract
  106. Neurogenic amplification of immune complex inflammation. Science. 1996 Sep 20; 273(5282):1722-5. View Abstract
  107. The C5a chemoattractant receptor mediates mucosal defence to infection. Nature. 1996 Sep 05; 383(6595):86-9. View Abstract
  108. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell. 1996 Jun 28; 85(7):1135-48. View Abstract
  109. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med. 1996 Jun 01; 183(6):2437-48. View Abstract
  110. Neutral endopeptidase modulates septic shock. Ann N Y Acad Sci. 1996 Mar 22; 780:156-63. View Abstract
  111. Receptor binding specificity and pulmonary gene expression of the neutrophil-activating peptide ENA-78. Am J Respir Cell Mol Biol. 1996 Mar; 14(3):302-8. View Abstract
  112. Rigid fixation of the modified mandibular condylotomy. J Oral Maxillofac Surg. 1996 Mar; 54(3):371-2. View Abstract
  113. Signaling by hemolytically inactive C5b67, an agonist of polymorphonuclear leukocytes. J Immunol. 1996 Jan 15; 156(2):786-92. View Abstract
  114. PAf receptor anchors Streptococcus pneumoniae to activated human endothelial cells. Adv Exp Med Biol. 1996; 416:89-94. View Abstract
  115. Molecular characterization of two murine eosinophil beta chemokine receptors. J Immunol. 1995 Dec 01; 155(11):5299-305. View Abstract
  116. Comparison of the structure and expression of the human and rat neprilysin (endopeptidase 24.11)-encoding genes. Gene. 1995 Oct 27; 164(2):363-6. View Abstract
  117. The role of N-glycosylation for functional expression of the human platelet-activating factor receptor. Glycosylation is required for efficient membrane trafficking. J Biol Chem. 1995 Oct 20; 270(42):25178-84. View Abstract
  118. Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature. 1995 Oct 05; 377(6548):435-8. View Abstract
  119. Probing the "message:address" sites for chemoattractant binding to the C5a receptor. Mutagenesis of hydrophilic and proline residues within the transmembrane segments. J Biol Chem. 1995 Jul 28; 270(30):18077-82. View Abstract
  120. Expression and biologic characterization of the murine chemokine KC. J Immunol. 1995 Jun 01; 154(11):6048-57. View Abstract
  121. Neutral endopeptidase modulation of septic shock. J Exp Med. 1995 Jun 01; 181(6):2271-5. View Abstract
  122. Laser arthroscopy of the temporomandibular joint. Compend Contin Educ Dent. 1995 Apr; 16(4):350, 352-4; QUIZ 356. View Abstract
  123. The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization. J Biol Chem. 1994 Nov 25; 269(47):29355-8. View Abstract
  124. The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors. Mol Pharmacol. 1994 Feb; 45(2):294-9. View Abstract
  125. The pro-inflammatory seven-transmembrane segment receptors of the leukocyte. Curr Opin Immunol. 1994 Feb; 6(1):140-5. View Abstract
  126. Receptor-dependent internalization of platelet-activating factor. J Immunol. 1994 Jan 15; 152(2):793-800. View Abstract
  127. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu Rev Immunol. 1994; 12:775-808. View Abstract
  128. Specific interactions of chemoattractant factor receptors with G-proteins. J Biol Chem. 1993 May 15; 268(14):10139-44. View Abstract
  129. Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene. Biochemistry. 1993 Feb 09; 32(5):1243-50. View Abstract
  130. Molecular aspects of the tachykinin receptors. Regul Pept. 1993 Jan 22; 43(1-2):21-35. View Abstract
  131. Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J Immunol. 1992 Oct 15; 149(8):2600-6. View Abstract
  132. Exon 16 del: a novel form of human neutral endopeptidase (CALLA). Am J Physiol. 1992 Jun; 262(6 Pt 1):L725-9. View Abstract
  133. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. Genomics. 1992 Jun; 13(2):437-40. View Abstract
  134. The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog. J Biol Chem. 1992 May 05; 267(13):9101-6. View Abstract
  135. Functional high efficiency expression of cloned leukocyte chemoattractant receptor cDNAs. FEBS Lett. 1992 Feb 10; 297(3):275-9. View Abstract
  136. Receptor class desensitization of leukocyte chemoattractant receptors. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11564-8. View Abstract
  137. Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. Biochemistry. 1991 Nov 05; 30(44):10640-6. View Abstract
  138. Intradialytic modulation of granulocyte C5a receptors. J Am Soc Nephrol. 1991 Oct; 2(4):920-6. View Abstract
  139. Molecular characterization of the interleukin-8 receptor. Biochem Biophys Res Commun. 1991 Sep 16; 179(2):784-9. View Abstract
  140. Leukotriene receptor on U-937 cells: discriminatory responses to leukotrienes C4 and D4. Am J Physiol. 1991 Aug; 261(2 Pt 1):L164-71. View Abstract
  141. The chemotactic receptor for human C5a anaphylatoxin. Nature. 1991 Feb 14; 349(6310):614-7. View Abstract
  142. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of the cDNA from tracheal and gastric tissues. J Biol Chem. 1991 Jan 15; 266(2):1354. View Abstract
  143. Molecular cloning of the human neurokinin-2 receptor cDNA by polymerase chain reaction and isolation of the gene. Ann N Y Acad Sci. 1991; 632:389-90. View Abstract
  144. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. J Biol Chem. 1990 Nov 25; 265(33):20455-62. View Abstract
  145. Construction and expression of a novel recombinant anaphylatoxin, C5a-N19, as a probe for the human C5a receptor. Biochemistry. 1990 Oct 02; 29(39):9274-81. View Abstract
  146. Peptidase modulation of the pulmonary effects of tachykinins in tracheal superfused guinea pig lungs. J Clin Invest. 1990 Jan; 85(1):170-6. View Abstract
  147. Antigen-dependent leukotriene synthesis and histamine release from IgG1 passively-sensitized guinea pig lungs ex vivo: relationship between serum levels of antigen-specific IgG1 and mediator synthesis/release. Pulm Pharmacol. 1990; 3(4):171-9. View Abstract
  148. Characterization of the substance P receptor in guinea pig lung tissues. Am J Respir Cell Mol Biol. 1989 Oct; 1(4):269-75. View Abstract
  149. Biologic activity of a C2-derived peptide. Demonstration of a specific interaction with guinea pig lung tissues. J Immunol. 1989 Apr 01; 142(7):2401-4. View Abstract
  150. Substance P-induced effects in guinea pig lungs: effects of thiorphan and captopril. J Appl Physiol (1985). 1989 Mar; 66(3):1364-72. View Abstract
  151. Characterization of a receptor for C5a anaphylatoxin on human eosinophils. J Biol Chem. 1989 Jan 25; 264(3):1760-6. View Abstract
  152. Enzymatic degradation of neuropeptides: a possible mechanism of airway hyperresponsiveness. Prog Clin Biol Res. 1989; 297:45-55; discussion 55-6. View Abstract
  153. Studies on the peptide core of human bronchial mucus glycoprotein. Symp Soc Exp Biol. 1989; 43:221-30. View Abstract
  154. Heterogeneity of leukotriene C4 production by eosinophils from asthmatic and from normal subjects. Am Rev Respir Dis. 1988 Oct; 138(4):799-804. View Abstract
  155. Pulmonary responses to bronchoconstrictor agonists in the mouse. J Appl Physiol (1985). 1988 Jun; 64(6):2318-23. View Abstract
  156. Amino acid sequence of guinea pig C3a anaphylatoxin. Protein Seq Data Anal. 1988; 1(6):473-8. View Abstract
  157. Characterization of substance P contractile activity on isolated guinea pig lung tissues. J Pharmacol Exp Ther. 1987 Dec; 243(3):901-6. View Abstract

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