Research Overview

1. Ongoing intraoperative TXA study

2. Ongoing pharmacogenetic of morphine

3. Ongoing Psychophysical, psychological and pain genetic trial on adolescents with idiopathic scoliosis

4. Ongoing Healthcare Utiliation Study for children undergoing rehabilitation therapy at Boston Children's Hospital

Education

Medical School

University of Baghdad College of Medicine
1976 Baghdad Iraq

Internship

University of Baghdad Hospital, Affiliated Teaching Hospitals
1980 Baghdad Iraq

Residency

Surgery Al-Quassimi Hospital
Sharjah United Arab Emirates

Residency

Department of Accident and Emergency Al-Quassimi Hospital
Sharjah United Arab Emirates

Residency

Anesthesia Brookdale Hospital Medical Center, State University of NY
Brooklyn NY

Residency

Surgery Brookdale Hospital Medical Center, State University of NY
Brooklyn NY

Fellowship

Pediatric Anesthesia Boston Children's Hospital
Boston MA

Fellowship

Clinical Trials Research - Clinical Associate in Neurobiology and Anesthesiology Branch National Institute of Dental Research, National Institute of Health
Bethesda MD

Media

Caregiver Profile

Meet Dr. Navil Sethna

Clinic Tour

A look inside the Pediatric Pain Rehabilitation Center

Clinic Tour

A look inside the Young Adult Pain Rehabilitation Center

Publications

  1. Characterization of pain and somatization and its relationship with psychopathology in early onset psychosis. J Psychiatr Res. 2024 Nov; 179:77-82. View Abstract
  2. Quantitative somatosensory testing of the abdomen: establishing initial reference values across developmental age and biological sex. Pain. 2024 Jan 01; 165(1):115-125. View Abstract
  3. Alterations of pain pathways by experimental sleep disturbances in humans: central pain-inhibitory, cyclooxygenase, and endocannabinoid pathways. Sleep. 2023 06 13; 46(6). View Abstract
  4. Signs and symptoms of pediatric complex regional pain syndrome - type 1: A retrospective cohort study. Can J Pain. 2023; 7(1):2179917. View Abstract
  5. Clinical Assessment of Mechanical Allodynia in Youth With Complex Regional Pain Syndrome: Development and Preliminary Validation of the Pediatric Tactile Sensitivity Test of Allodynia (Pedi-Sense). J Pain. 2023 04; 24(4):706-715. View Abstract
  6. Pilot Investigation of Somatosensory Functioning and Pain Catastrophizing in Pediatric Spinal Fusion Surgery. Pain Manag Nurs. 2023 02; 24(1):27-34. View Abstract
  7. Pediatric pain rehabilitation during the COVID-19 pandemic: exploring the effectiveness of a hybrid intensive interdisciplinary pain treatment model. Disabil Rehabil. 2023 09; 45(19):3079-3086. View Abstract
  8. Alterations in the structure and function of the brain in adolescents with new daily persistent headache: A pilot MRI study. Headache. 2022 07; 62(7):858-869. View Abstract
  9. The First Hybrid International Educational Comprehensive Cleft Care Workshop. Cleft Palate Craniofac J. 2023 10; 60(10):1189-1198. View Abstract
  10. Nusinersen for Patients With Spinal Muscular Atrophy: 1415 Doses via an Interdisciplinary Institutional Approach. Pediatr Neurol. 2022 07; 132:33-40. View Abstract
  11. Efficacy and safety of pharmacological, physical, and psychological interventions for the management of chronic pain in children: a WHO systematic review and meta-analysis. Pain. 2022 Jan 01; 163(1):e1-e19. View Abstract
  12. Pain stickiness in pediatric complex regional pain syndrome: A role for the nucleus accumbens. Neurobiol Pain. 2021 Jan-Jul; 9:100062. View Abstract
  13. Antinociceptive effect of vapocoolant medium stream spray on hotplate latency in rat pups. Paediatr Anaesth. 2021 03; 31(3):330-337. View Abstract
  14. Offset analgesia identifies impaired endogenous pain modulation in pediatric chronic pain disorders. Pain. 2020 12; 161(12):2852-2859. View Abstract
  15. Variation Between and Within Hospitals in Single Injection Caudal Local Anesthetic Dose: A Report From the Pediatric Regional Anesthesia Network. Anesth Analg. 2020 06; 130(6):1693-1701. View Abstract
  16. Does intensive interdisciplinary pain treatment improve pediatric headache-related disability? Disabil Rehabil. 2022 Jan; 44(2):194-201. View Abstract
  17. Pharmacological interventions for chronic pain in children: an overview of systematic reviews. Pain. 2019 08; 160(8):1698-1707. View Abstract
  18. Shifting brain circuits in pain chronicity. Hum Brain Mapp. 2019 10 15; 40(15):4381-4396. View Abstract
  19. Pharmacological interventions for chronic pain in children: an overview of systematic reviews. Pain. 2019 Jun 19. View Abstract
  20. Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications. Neuropsychopharmacology. 2020 01; 45(1):205-216. View Abstract
  21. The Society for Pediatric Anesthesia recommendations for the use of opioids in children during the perioperative period. Paediatr Anaesth. 2019 06; 29(6):547-571. View Abstract
  22. Youth With Chronic Pain and a History of Adverse Childhood Experiences in the Context of Multidisciplinary Pain Rehabilitation. Clin J Pain. 2019 05; 35(5):420-427. View Abstract
  23. Physical Therapy Outcome Measures for Assessment of Lower Extremity Chronic Pain-Related Function in Pediatrics. Pediatr Phys Ther. 2019 04; 31(2):200-207. View Abstract
  24. Tranexamic Acid Is Efficacious at Decreasing the Rate of Blood Loss in Adolescent Scoliosis Surgery: A Randomized Placebo-Controlled Trial. J Bone Joint Surg Am. 2018 Dec 05; 100(23):2024-2032. View Abstract
  25. Back to Living: Long-term Functional Status of Pediatric Patients Who Completed Intensive Interdisciplinary Pain Treatment. Clin J Pain. 2018 10; 34(10):890-899. View Abstract
  26. Complications in Pediatric Regional Anesthesia: An Analysis of More than 100,000 Blocks from the Pediatric Regional Anesthesia Network. Anesthesiology. 2018 10; 129(4):721-732. View Abstract
  27. Chronic exposure to insufficient sleep alters processes of pain habituation and sensitization. Pain. 2018 01; 159(1):33-40. View Abstract
  28. Children With Chronic Pain: Response Trajectories After Intensive Pain Rehabilitation Treatment. J Pain. 2018 02; 19(2):207-218. View Abstract
  29. Perioperative management of gastrostomy tube placement in Duchenne muscular dystrophy adolescent and young adult patients: A role for a perioperative surgical home. Paediatr Anaesth. 2018 02; 28(2):127-133. View Abstract
  30. Antiepileptic drugs for chronic non-cancer pain in children and adolescents. Cochrane Database Syst Rev. 2017 08 05; 8:CD012536. View Abstract
  31. Opioids for chronic non-cancer pain in children and adolescents. Cochrane Database Syst Rev. 2017 07 26; 7:CD012538. View Abstract
  32. Changes in Maternal and Paternal Pain-Related Attitudes, Behaviors, and Perceptions across Pediatric Pain Rehabilitation Treatment: A Multilevel Modeling Approach. J Pediatr Psychol. 2017 01 01; 42(1):52-64. View Abstract
  33. Changes in Maternal and Paternal Pain-Related Attitudes, Behaviors, and Perceptions across Pediatric Pain Rehabilitation Treatment: A Multilevel Modeling Approach. J Pediatr Psychol. 2016 Jun 20. View Abstract
  34. Anesthetic management of 877 pediatric patients undergoing muscle biopsy for neuromuscular disorders: a 20-year review. Paediatr Anaesth. 2016 Jul; 26(7):710-21. View Abstract
  35. Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. J Child Neurol. 2016 06; 31(7):899-906. View Abstract
  36. Fear and Reward Circuit Alterations in Pediatric CRPS. Front Hum Neurosci. 2015; 9:703. View Abstract
  37. Sensory and Thermal Quantitative Testing in Children With Sickle Cell Disease. J Pediatr Hematol Oncol. 2015 Apr; 37(3):185-9. View Abstract
  38. The analgesic effect of a vapocoolant stream spray in reducing heat nociception on the glabrous skin of rat pups. Anesth Analg. 2014 Dec; 119(6):1367-72. View Abstract
  39. Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study. Pediatr Rheumatol Online J. 2014; 12:39. View Abstract
  40. Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome. Neuroimage Clin. 2014; 6:347-69. View Abstract
  41. Pain management following major intracranial surgery in pediatric patients: a prospective cohort study in three academic children's hospitals. Paediatr Anaesth. 2014 Nov; 24(11):1132-40. View Abstract
  42. Changes in sleep habits in adolescents during intensive interdisciplinary pediatric pain rehabilitation. J Youth Adolesc. 2015 Feb; 44(2):543-55. View Abstract
  43. Review of outcomes in pediatric patients undergoing anterior cruciate ligament repairs with regional nerve blocks. J Pediatr Nurs. 2014 Nov-Dec; 29(6):670-8. View Abstract
  44. The responsive amygdala: treatment-induced alterations in functional connectivity in pediatric complex regional pain syndrome. Pain. 2014 Sep; 155(9):1727-1742. View Abstract
  45. Pain prevalence and trajectories following pediatric spinal fusion surgery. J Pain. 2013 Dec; 14(12):1694-702. View Abstract
  46. A single institution's effort to translate codeine knowledge into specific clinical practice. J Pain Symptom Manage. 2014 Jul; 48(1):119-26. View Abstract
  47. Population pharmacokinetics of tranexamic acid in paediatric patients undergoing craniosynostosis surgery. Clin Pharmacokinet. 2013 Apr; 52(4):267-76. View Abstract
  48. Parents' perspective of their journey caring for a child with chronic neuropathic pain. Pain Manag Nurs. 2014 Mar; 15(1):246-57. View Abstract
  49. A day-hospital approach to treatment of pediatric complex regional pain syndrome: initial functional outcomes. Clin J Pain. 2012 Nov-Dec; 28(9):766-74. View Abstract
  50. Hemodynamic changes during spinal anesthesia in premature infants with congenital heart disease undergoing inguinal hernia correction. Paediatr Anaesth. 2012 Sep; 22(9):865-70. View Abstract
  51. Pain sensitivity and modulation in primary insomnia. Eur J Pain. 2012 Apr; 16(4):522-33. View Abstract
  52. Adult cleft lip repair under local anesthesia: an effective technique in resource-poor settings. Cleft Palate Craniofac J. 2013 Jan; 50(1):59-63. View Abstract
  53. Unilateral hemiparesis with thoracic epidural in an adolescent. Case Rep Anesthesiol. 2012; 2012:732584. View Abstract
  54. Sympathetic nerve blocks, pragmatic trials, and responder analysis. Anesthesiology. 2012 Jan; 116(1):12-4. View Abstract
  55. Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology. 2011 Apr; 114(4):862-71. View Abstract
  56. Successful resuscitation after inadvertent intravenous injection of bupivacaine in an adolescent. Paediatr Anaesth. 2010 Oct; 20(10):958-9. View Abstract
  57. Incidence of epidural catheter-associated infections after continuous epidural analgesia in children. Anesthesiology. 2010 Jul; 113(1):224-32. View Abstract
  58. Accuracy of preoperative electrocardiographic and chest radiographic screening for prediction of left ventricular dysfunction in patients with suspected neuromuscular disorders. Anesth Analg. 2010 Apr 01; 110(4):1116-20. View Abstract
  59. Ganglion impar block for management of chronic coccydynia in an adolescent. Paediatr Anaesth. 2009 Nov; 19(11):1137-8. View Abstract
  60. Acupuncture management of pain and emergence agitation in children after bilateral myringotomy and tympanostomy tube insertion. Paediatr Anaesth. 2009 Nov; 19(11):1096-101. View Abstract
  61. Lumbar sympathetic blockade in children with complex regional pain syndromes: a double blind placebo-controlled crossover trial. Anesthesiology. 2009 Aug; 111(2):372-80. View Abstract
  62. Anesthesia and perioperative medical management of children with spinal muscular atrophy. Paediatr Anaesth. 2009 Nov; 19(11):1054-63. View Abstract
  63. Combined use of infraorbital and external nasal nerve blocks for effective perioperative pain control during and after cleft lip repair. Cleft Palate Craniofac J. 2009 Nov; 46(6):629-35. View Abstract
  64. Core outcome domains and measures for pediatric acute and chronic/recurrent pain clinical trials: PedIMMPACT recommendations. J Pain. 2008 Sep; 9(9):771-83. View Abstract
  65. Tranexamic acid diminishes intraoperative blood loss and transfusion in spinal fusions for duchenne muscular dystrophy scoliosis. Spine (Phila Pa 1976). 2007 Sep 15; 32(20):2278-83. View Abstract
  66. Cutaneous sensory abnormalities in children and adolescents with complex regional pain syndromes. Pain. 2007 Sep; 131(1-2):153-61. View Abstract
  67. Value of bispectral index monitor in differentiating between moderate and deep Ramsay Sedation Scores in children. Paediatr Anaesth. 2006 Dec; 16(12):1226-31. View Abstract
  68. Complex regional pain syndromes in children and adolescents: regional and systemic signs and symptoms and hemodynamic response to tilt table testing. Clin J Pain. 2006 May; 22(4):399-406. View Abstract
  69. Do results from studies of a simulated epidural test dose improve our ability to detect unintentional epidural vascular puncture in children? Paediatr Anaesth. 2005 Sep; 15(9):711-5. View Abstract
  70. Transdermal analgesia with local anesthetics in children: review, update and future directions. Expert Rev Neurother. 2005 Sep; 5(5):625-34. View Abstract
  71. Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery. Anesthesiology. 2005 Apr; 102(4):727-32. View Abstract
  72. A randomized controlled trial to evaluate S-Caine patch for reducing pain associated with vascular access in children. Anesthesiology. 2005 Feb; 102(2):403-8. View Abstract
  73. Blood loss in pediatric spine surgery. Eur Spine J. 2004 Oct; 13 Suppl 1:S6-17. View Abstract
  74. Analgesics for the treatment of pain in children. N Engl J Med. 2002 Oct 03; 347(14):1094-103. View Abstract
  75. Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes. J Pediatr. 2002 Jul; 141(1):135-40. View Abstract
  76. Prolonged sensory and motor deficit following short-term lumbar epidural analgesia in a patient with mixed connective tissue disease. J Pain Symptom Manage. 2002 Feb; 23(2):89-92. View Abstract
  77. Quantitative assessment of cutaneous thermal and vibration sensation and thermal pain detection thresholds in healthy children and adolescents. Muscle Nerve. 2001 Oct; 24(10):1339-45. View Abstract
  78. The pharmacokinetics of epidural ropivacaine in infants and young children. Anesth Analg. 2001 Oct; 93(4):893-7. View Abstract
  79. Use of the Bispectral Index monitor to aid titration of propofol during a drug-assisted interview. Paediatr Anaesth. 2001 Mar; 11(2):245-8. View Abstract
  80. Efficacy of simulated epinephrine-containing epidural test dose after intravenous atropine during isoflurane anesthesia in children. Reg Anesth Pain Med. 2000 Nov-Dec; 25(6):566-72. View Abstract
  81. Ketorolac suppresses postoperative bladder spasms after pediatric ureteral reimplantation. Anesth Analg. 2000 Jul; 91(1):11-5. View Abstract
  82. The substance P receptor antagonist CP-99,994 reduces acute postoperative pain. Clin Pharmacol Ther. 1998 Nov; 64(5):562-8. View Abstract
  83. Regional anesthesia and analgesia. Semin Perinatol. 1998 Oct; 22(5):380-9. View Abstract
  84. Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects. Anesth Analg. 1998 Jun; 86(6):1250-6. View Abstract
  85. The response of patients with Duchenne's muscular dystrophy to neuromuscular blockade with vecuronium. Anesthesiology. 1998 Feb; 88(2):351-4. View Abstract
  86. Pethidine-associated seizure in a healthy adolescent receiving pethidine for postoperative pain control. Paediatr Anaesth. 1998; 8(4):349-52. View Abstract
  87. Unexpected interaction of methylphenidate (Ritalin) with anaesthetic agents. Paediatr Anaesth. 1997; 7(1):69-72. View Abstract
  88. Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system. J Pediatr. 1996 Aug; 129(2):292-6. View Abstract
  89. Regional anesthesia for pain associated with terminal pediatric malignancy. Pain. 1996 Apr; 65(1):63-69. View Abstract
  90. Anesthetic management of children with moyamoya syndrome. Anesth Analg. 1993 Nov; 77(5):1066-70. View Abstract
  91. Venous air embolism during identification of the epidural space in children. Anesth Analg. 1993 May; 76(5):925-7. View Abstract
  92. Continuous caudal anesthesia for inguinal hernia repair in former preterm infants. J Clin Anesth. 1993 Mar-Apr; 5(2):129-33. View Abstract
  93. Intravenous isoproterenol as a marker for epidural test-dosing in children. Anesth Analg. 1993 Jan; 76(1):178-81. View Abstract
  94. Latex anaphylaxis in a child with a history of multiple anesthetic drug allergies. Anesthesiology. 1992 Aug; 77(2):372-5. View Abstract
  95. Spinal fusion in Duchenne muscular dystrophy: a multidisciplinary approach. Muscle Nerve. 1992 May; 15(5):604-14. View Abstract
  96. Pediatric regional anesthesia equipment. Int Anesthesiol Clin. 1992; 30(3):163-76. View Abstract
  97. Laser Doppler measurements of skin blood flow before, during, and after lumbar sympathetic blockade in children and young adults with reflex sympathetic dystrophy syndrome. J Clin Monit. 1992 Jan; 8(1):16-9. View Abstract
  98. Continuous subarachnoid analgesia in two adolescents with severe scoliosis and impaired pulmonary function. Reg Anesth. 1991 Nov-Dec; 16(6):333-6. View Abstract
  99. Epidural analgesia in patients with congenital lumbosacral spinal anomalies. Anesthesiology. 1991 Aug; 75(2):370-4. View Abstract
  100. Comparison of morphine and methadone for prevention of postoperative pain in 3- to 7-year-old children. J Pediatr. 1991 Jul; 119(1 Pt 1):136-41. View Abstract
  101. Patient-controlled analgesia in children and adolescents: a randomized, prospective comparison with intramuscular administration of morphine for postoperative analgesia. J Pediatr. 1991 Mar; 118(3):460-6. View Abstract
  102. Celiac plexus blockade for a 3-year-old boy with hepatoblastoma and refractory pain. Pediatrics. 1990 Nov; 86(5):779-81. View Abstract
  103. Subarachnoid bupivacaine analgesia for seven months for a patient with a spinal cord tumor. Anesthesiology. 1990 Jun; 72(6):1094-6. View Abstract
  104. Chest wall motion of infants during spinal anesthesia. J Appl Physiol (1985). 1990 May; 68(5):2087-91. View Abstract
  105. Meningococcal purpura fulminans: treatment of vascular insufficiency in a 2-yr-old child with lumbar epidural sympathetic blockade. Anesthesiology. 1989 Sep; 71(3):463-4. View Abstract
  106. Pediatric pain clinics: recommendations for their development. Pediatrician. 1989; 16(1-2):94-102. View Abstract
  107. Regional analgesia on pediatric medical and surgical wards. Intensive Care Med. 1989; 15 Suppl 1:S40-3. View Abstract
  108. Anesthesia-related complications in children with Duchenne muscular dystrophy. Anesthesiology. 1988 Mar; 68(3):462-5. View Abstract
  109. Cardiac arrest following inhalation induction of anaesthesia in a child with Duchenne's muscular dystrophy. Can Anaesth Soc J. 1986 Nov; 33(6):799-802. View Abstract

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