Information

Related Research Units

Intellectual and Developmental Disabilities Research Center Research
Neurology Research
Neurosurgery Research
Roberts Laboratory Research
F.M. Kirby Neurobiology Center

Research Overview

Mustafa's research focus is on the development of novel methods to treat brain injury, particularly the type of brain injury that leads to epilepsy, by identifying biological targets which can stop or prevent seizures if manipulated by either brain stimulation or by novel drugs. Currently, he is studying the neurophysiological and molecular mechanisms underlying both congenital and acquired epilepsy and the effect of novel therapeutics on the same.

Research Background

Selected Publications:

  1. MacMullin P, Hodgson N, Damar U, Lee HHC, Hameed MQ, Dhamne SC, Hyde D, Conley GM, Morriss N, Qiu J, Mannix R, Hensch TK, Rotenberg A. Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio. Cereb Cortex. 2020 Nov 3;30(12):6108-6120. doi: 10.1093/cercor/bhaa157. PMID: 32676666; PMCID: PMC8248830.
  2. Klein P, Friedman A, Hameed MQ, Kaminski RM, Bar-Klein G, Klitgaard H, Koepp M, Jozwiak S, Prince DA, Rotenberg A, Twyman R, Vezzani A, Wong M, Löscher W. Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? Epilepsia. 2020 Mar;61(3):359-386. doi: 10.1111/epi.16450. PMID: 32196665; PMCID: PMC8317585.
  3. Hameed MQ, Hsieh TH, Morales-Quezada L, Lee HHC, Damar U, MacMullin PC, Hensch TK, Rotenberg A. Ceftriaxone Treatment Preserves Cortical Inhibitory Interneuron Function via Transient Salvage of GLT-1 in a Rat Traumatic Brain Injury Model. Cereb Cortex. 2019 Dec 17;29(11):4506-4518. doi: 10.1093/cercor/bhy328. PMID: 30590449; PMCID: PMC7150617.
  4. Purtell H, Dhamne SC, Gurnani S, Bainbridge E, Modi ME, Lammers SHT, Super CE, Hameed MQ, Johnson EL 3rd, Sahin M, Rotenberg A. Electrographic spikes are common in wildtype mice. Epilepsy Behav. 2018 Dec;89:94-98. doi: 10.1016/j.yebeh.2018.09.003. Epub 2018 Nov 3. PMID: 30399547; PMCID: PMC7325561.
  5. Dhamne SC, Silverman JL, Super CE, Lammers SHT, Hameed MQ, Modi ME, Copping NA, Pride MC, Smith DG, Rotenberg A, Crawley JN, Sahin M. Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism. Mol Autism. 2017 Jun 15;8:26. doi: 10.1186/s13229-017-0142-z. PMID: 28638591; PMCID: PMC5472997.
  6. Hsieh TH, Lee HHC, Hameed MQ, Pascual-Leone A, Hensch TK, Rotenberg A. Trajectory of Parvalbumin Cell Impairment and Loss of Cortical Inhibition in Traumatic Brain Injury. Cereb Cortex. 2017 Dec 1;27(12):5509-5524. doi: 10.1093/cercor/bhw318. PMID: 27909008; PMCID: PMC6075565.
  7. Petr GT, Sun Y, Frederick NM, Zhou Y, Dhamne SC, Hameed MQ, Miranda C, Bedoya EA, Fischer KD, Armsen W, Wang J, Danbolt NC, Rotenberg A, Aoki CJ, Rosenberg PA. Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. J Neurosci. 2015 Apr 1;35(13):5187-201. doi: 10.1523/JNEUROSCI.4255-14.2015. PMID: 25834045; PMCID: PMC4380995.
  8. Wang Y, Hameed MQ, Rakhade SN, Iglesias AH, Muller PA, Mou DL, Rotenberg A. Hippocampal immediate early gene transcription in the rat fluid percussion traumatic brain injury model. Neuroreport. 2014 Aug 20;25(12):954-9. doi: 10.1097/WNR.0000000000000219. PMID: 24978397.
  9. Hameed MQ, Goodrich GS, Dhamne SC, Amandusson A, Hsieh TH, Mou D, Wang Y, Rotenberg A. A rapid lateral fluid percussion injury rodent model of traumatic brain injury and post-traumatic epilepsy. Neuroreport. 2014 May 7;25(7):532-6. doi: 10.1097/WNR.0000000000000132. PMID: 24553065.
  10. Goodrich GS, Kabakov AY, Hameed MQ, Dhamne SC, Rosenberg PA, Rotenberg A. Ceftriaxone treatment after traumatic brain injury restores expression of the glutamate transporter, GLT-1, reduces regional gliosis, and reduces post- traumatic seizures in the rat. J Neurotrauma. 2013 Aug 15;30(16):1434-41. doi: 10.1089/neu.2012.2712. Epub 2013 Jul 25. PMID: 23510201; PMCID: PMC3741415.

 

Publications

  1. Enhancement of Glutamate Uptake as Novel Antiseizure Approach: Preclinical Proof of Concept. Ann Neurol. 2025 Feb; 97(2):344-357. View Abstract
  2. A comparison of the antiepileptogenic efficacy of two rationally chosen multitargeted drug combinations in a rat model of posttraumatic epilepsy. Exp Neurol. 2024 Dec; 382:114962. View Abstract
  3. Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor. Ann Clin Transl Neurol. 2023 10; 10(10):1790-1801. View Abstract
  4. Depressed glutamate transporter 1 expression in a mouse model of Dravet syndrome. Ann Clin Transl Neurol. 2023 09; 10(9):1695-1699. View Abstract
  5. Editorial: In vitro and in vivo models for neurodevelopmental disorders. Front Neurosci. 2023; 17:1239577. View Abstract
  6. N-acetylcysteine treatment mitigates loss of cortical parvalbumin-positive interneuron and perineuronal net integrity resulting from persistent oxidative stress in a rat TBI model. Cereb Cortex. 2023 03 21; 33(7):4070-4084. View Abstract
  7. Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio. Cereb Cortex. 2020 11 03; 30(12):6108-6120. View Abstract
  8. Diagnostic Accuracy of Non-Invasive Thermal Evaluation of Ventriculoperitoneal Shunt Flow in Shunt Malfunction: A Prospective, Multi-Site, Operator-Blinded Study. Neurosurgery. 2020 10 15; 87(5):939-948. View Abstract
  9. Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? Epilepsia. 2020 03; 61(3):359-386. View Abstract
  10. Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia. Ann Clin Transl Neurol. 2020 03; 7(3):384-389. View Abstract
  11. Ceftriaxone Treatment Preserves Cortical Inhibitory Interneuron Function via Transient Salvage of GLT-1 in a Rat Traumatic Brain Injury Model. Cereb Cortex. 2019 12 17; 29(11):4506-4518. View Abstract
  12. Noninvasive Thermal Evaluation of Ventriculoperitoneal Shunt Patency and Cerebrospinal Fluid Flow Using a Flow Enhancing Device. Neurosurgery. 2019 08 01; 85(2):240-249. View Abstract
  13. Electrographic spikes are common in wildtype mice. Epilepsy Behav. 2018 12; 89:94-98. View Abstract
  14. Trajectory of Parvalbumin Cell Impairment and Loss of Cortical Inhibition in Traumatic Brain Injury. Cereb Cortex. 2017 12 01; 27(12):5509-5524. View Abstract
  15. Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism. Mol Autism. 2017; 8:26. View Abstract
  16. Transcranial Magnetic and Direct Current Stimulation in Children. Curr Neurol Neurosci Rep. 2017 02; 17(2):11. View Abstract
  17. Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus. Sci Rep. 2016 05 31; 6:26794. View Abstract
  18. Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. J Neurosci. 2015 Apr 01; 35(13):5187-201. View Abstract
  19. Hippocampal immediate early gene transcription in the rat fluid percussion traumatic brain injury model. Neuroreport. 2014 Aug 20; 25(12):954-9. View Abstract
  20. A rapid lateral fluid percussion injury rodent model of traumatic brain injury and post-traumatic epilepsy. Neuroreport. 2014 May 07; 25(7):532-6. View Abstract
  21. Ceftriaxone treatment after traumatic brain injury restores expression of the glutamate transporter, GLT-1, reduces regional gliosis, and reduces post-traumatic seizures in the rat. J Neurotrauma. 2013 Aug 15; 30(16):1434-41. View Abstract
  22. VEGF, which is elevated in the CSF of patients with hydrocephalus, causes ventriculomegaly and ependymal changes in rats. Exp Neurol. 2013 Sep; 247:703-9. View Abstract
  23. Evaluation of therapeutic control in a Pakistani population with hypertension. J Eval Clin Pract. 2010 Dec; 16(6):1081-4. View Abstract

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Phone: 617-919-2766
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