Dr. Léger-Abraham received her Ph.D. degree in Biochemistry from Université de Montréal, Montréal, Canada. She completed her postgraduate training at Harvard Medical School in the Department of Biological Chemistry and Molecular Pharmacology.
Publications
1H, 13C, and 15N backbone chemical shift assignments of m7GTP cap-bound Leishmania initiation factor 4E-1. Biomol NMR Assign. 2020 10; 14(2):259-263. View Abstract
A newly identified Leishmania IF4E-interacting protein, Leish4E-IP2, modulates the activity of cap-binding protein paralogs. Nucleic Acids Res. 2020 05 07; 48(8):4405-4417. View Abstract
Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major. Nucleic Acids Res. 2018 04 20; 46(7):3791-3801. View Abstract
1H, 13C, and 15N backbone chemical shift assignments of 4E-BP144-87 and 4E-BP144-87 bound to eIF4E. Biomol NMR Assign. 2017 Oct; 11(2):187-191. View Abstract
Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4036-45. View Abstract
A novel 4E-interacting protein in Leishmania is involved in stage-specific translation pathways. Nucleic Acids Res. 2011 Oct; 39(19):8404-15. View Abstract
Evolutionary changes in the Leishmania eIF4F complex involve variations in the eIF4E-eIF4G interactions. Nucleic Acids Res. 2009 Jun; 37(10):3243-53. View Abstract
The three transfer RNAs occupying the A, P and E sites on the ribosome are involved in viral programmed -1 ribosomal frameshift. Nucleic Acids Res. 2007; 35(16):5581-92. View Abstract
A reassessment of the response of the bacterial ribosome to the frameshift stimulatory signal of the human immunodeficiency virus type 1. RNA. 2004 Aug; 10(8):1225-35. View Abstract
Functional studies of the 900 tetraloop capping helix 27 of 16S ribosomal RNA. J Mol Biol. 2002 Jul 26; 320(5):979-89. View Abstract