Multiple Sclerosis and Neuro-immunology
Partners Adult and Pediatric MS Centers, Brigham and Women's Hospital and Massachusetts General Hospital
2008
Boston
MA
Publications
Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis. Mult Scler. 2025 Dec; 31(14):1641-1650. View Abstract
Cognitive Function in People With Pediatric Multiple Sclerosis Over 2 Years. Neurology. 2025 Oct 21; 105(8):e214142. View Abstract
Evaluating Efficacy Outcomes in Pediatric Multiple Sclerosis Patients While Using Avonex or Plegridy via USNPMSC Registry. J Child Neurol. 2025 Sep 16; 8830738251367460. View Abstract
Genetic Landscape of Opsoclonus-Myoclonus-Ataxia Syndrome in Children. Pediatr Neurol. 2025 Dec; 173:33-40. View Abstract
Epigenetic Aging in Pediatric-Onset Multiple Sclerosis. Neurology. 2025 Jun 24; 104(12):e213673. View Abstract
Allele-specific vitamin D receptor binding is associated with pediatric-onset multiple sclerosis. Mult Scler J Exp Transl Clin. 2025 Apr-Jun; 11(2):20552173251335625. View Abstract
Childhood adversity in parents of patients with pediatric multiple sclerosis. Mult Scler Relat Disord. 2025 Jun; 98:106424. View Abstract
Limited early IVIG for the treatment of pediatric myelin oligodendrocyte glycoprotein antibody-associated disease. Mult Scler Relat Disord. 2025 May; 97:106345. View Abstract
Association Between Sun Exposure and Risk of Relapse in Pediatric-Onset Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2025 Mar; 12(2):e200375. View Abstract
Study of the Association Between Menarche and Disease Course in Pediatric Multiple Sclerosis. Neurology. 2025 Feb 25; 104(4):e210213. View Abstract
Predictors of a relapsing course in myelin oligodendrocyte glycoprotein antibody-associated disease. J Neurol Neurosurg Psychiatry. 2024 Dec 16; 96(1):68-75. View Abstract
Epidemiology and Impact of Social Hardships in Children With Multiple Sclerosis in the United States. Neurology. 2024 Dec 10; 103(11):e209991. View Abstract
Patient and family views on research priorities and design of clinical trials and research studies in pediatric multiple sclerosis. Mult Scler. 2024 Oct; 30(11-12):1525-1543. View Abstract
Early Adversity and Socioeconomic Factors in Pediatric Multiple Sclerosis: A Case-Control Study. Neurol Neuroimmunol Neuroinflamm. 2024 09; 11(5):e200282. View Abstract
Association of nutritional intake with clinical and imaging activity in pediatric multiple sclerosis. Mult Scler. 2024 Jul; 30(8):1056-1065. View Abstract
Inaugural Patient-Reported Registry of Pediatric Opsoclonus-Myoclonus-Ataxia Syndrome: Presentation, Diagnosis, and Treatment of 194 Patients. Pediatr Neurol. 2024 Sep; 158:128-134. View Abstract
Clinical and magnetic resonance imaging outcomes in pediatric-onset MS patients on fingolimod and ocrelizumab. Mult Scler Relat Disord. 2024 Jul; 87:105647. View Abstract
Multiomic Analysis of Neuroinflammation and Occult Infection in Sudden Infant Death Syndrome. JAMA Neurol. 2024 03 01; 81(3):240-247. View Abstract
Gene-environment interactions: Epstein-Barr virus infection and risk of pediatric-onset multiple sclerosis. Mult Scler. 2024 Mar; 30(3):308-315. View Abstract
Gene-environment interactions and risk of pediatric-onset multiple sclerosis associated with time spent outdoors. Mult Scler Relat Disord. 2024 Feb; 82:105351. View Abstract
Assessing Needs and Perceptions of Research Participation in Pediatric-Onset Multiple Sclerosis: A Multistakeholder Survey. Pediatr Neurol. 2024 Feb; 151:115-120. View Abstract
Short-chain fatty acid producers in the gut are associated with pediatric multiple sclerosis onset. Ann Clin Transl Neurol. 2024 01; 11(1):169-184. View Abstract
Characteristics and predictors of disease course in children initially presenting with ADEM. Mult Scler Relat Disord. 2023 Oct 15; 80:105075. View Abstract
Disease modifying treatment for pediatric onset multiple sclerosis: Ethical considerations and strategies to navigate parental refusal. Mult Scler Relat Disord. 2023 11; 79:104970. View Abstract
MRI Features and Their Association With Outcomes in Children With Anti-NMDA Receptor Encephalitis. Neurol Neuroimmunol Neuroinflamm. 2023 07; 10(4). View Abstract
An International Pediatric-Onset Opsoclonus-Myoclonus Ataxia Syndrome Registry and Clinical Research Network: Development, Progress, and Vision. Pediatr Neurol. 2023 11; 148:145-147. View Abstract
Demographic Features and Clinical Course of Patients With Pediatric-Onset Multiple Sclerosis on Newer Disease-Modifying Treatments. Pediatr Neurol. 2023 08; 145:125-131. View Abstract
Characteristics of pediatric patients with multiple sclerosis and related disorders infected with SARS-CoV-2. Mult Scler. 2023 04; 29(4-5):576-584. View Abstract
Silent findings: Examination of asymptomatic demyelination in a pediatric US cohort. Mult Scler Relat Disord. 2023 Mar; 71:104573. View Abstract
Mimics of Pediatric Small Vessel Primary Angiitis of the Central Nervous System. Ann Neurol. 2023 01; 93(1):109-119. View Abstract
MOG and AQP4 Antibodies among Children with Multiple Sclerosis and Controls. Ann Neurol. 2023 02; 93(2):271-284. View Abstract
A new look at cognitive functioning in pediatric MS. Mult Scler. 2023 01; 29(1):140-149. View Abstract
Evaluation of white matter microstructure in pediatric onset multiple sclerosis with diffusion compartment imaging. J Neuroimaging. 2022 11; 32(6):1098-1108. View Abstract
An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. J Rheumatol. 2022 Sep; 49(9):1042-1051. View Abstract
Development of a multidisciplinary clinical approach for unexplained regression in Down syndrome. Am J Med Genet A. 2022 08; 188(8):2509-2511. View Abstract
ZSCAN1 Autoantibodies Are Associated with Pediatric Paraneoplastic ROHHAD. Ann Neurol. 2022 08; 92(2):279-291. View Abstract
Novel CAPN1 missense variants in complex hereditary spastic paraplegia with early-onset psychosis. Ann Clin Transl Neurol. 2022 04; 9(4):570-576. View Abstract
Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective. Neurol Neuroimmunol Neuroinflamm. 2022 05; 9(3). View Abstract
A Single Stage Composite Cleft Septorhinoplasty for Correction of the Mature Unilateral Cleft Nose Deformity - The Gujrat Technique. Cleft Palate Craniofac J. 2023 Jul; 60(7):823-832. View Abstract
Gene-environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution. Mult Scler. 2022 08; 28(9):1330-1339. View Abstract
Association Between Time Spent Outdoors and Risk of Multiple Sclerosis. Neurology. 2022 01 18; 98(3):e267-e278. View Abstract
Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis. JAMA Neurol. 2021 11 01; 78(11):1333-1344. View Abstract
Increased Prevalence of Familial Autoimmune Disease in Children With Opsoclonus-Myoclonus Syndrome. Neurol Neuroimmunol Neuroinflamm. 2021 11; 8(6). View Abstract
Gut microbiome is associated with multiple sclerosis activity in children. Ann Clin Transl Neurol. 2021 09; 8(9):1867-1883. View Abstract
Functional analysis of a de novo variant in the neurodevelopment and generalized epilepsy disease gene NBEA. Mol Genet Metab. 2021 Sep-Oct; 134(1-2):195-202. View Abstract
Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2021 09; 8(5). View Abstract
International Consensus Recommendations for the Treatment of Pediatric NMDAR Antibody Encephalitis. Neurol Neuroimmunol Neuroinflamm. 2021 07; 8(5). View Abstract
RCL1 copy number variants are associated with a range of neuropsychiatric phenotypes. Mol Psychiatry. 2021 05; 26(5):1706-1718. View Abstract
Proposal to optimize evaluation and treatment of Febrile infection-related epilepsy syndrome (FIRES): A Report from FIRES workshop. Epilepsia Open. 2021 03; 6(1):62-72. View Abstract
Interleukin-6 Blockade With Tocilizumab in Anakinra-Refractory Febrile Infection-Related Epilepsy Syndrome (FIRES). Child Neurol Open. 2020 Jan-Dec; 7:2329048X20979253. View Abstract
Anakinra usage in febrile infection related epilepsy syndrome: an international cohort. Ann Clin Transl Neurol. 2020 12; 7(12):2467-2474. View Abstract
Improved relapse recovery in paediatric compared to adult multiple sclerosis. Brain. 2020 09 01; 143(9):2733-2741. View Abstract
IQ predictors in pediatric opsoclonus myoclonus syndrome: a large international cohort study. Dev Med Child Neurol. 2020 12; 62(12):1444-1449. View Abstract
Pediatric Multiple Sclerosis Severity Score in a large US cohort. Neurology. 2020 09 29; 95(13):e1844-e1853. View Abstract
Adherence to study drug in a stroke prevention trial"?>. J Stroke Cerebrovasc Dis. 2020 Oct; 29(10):105048. View Abstract
Rituximab in patients with pediatric multiple sclerosis and other demyelinating disorders of the CNS: Practical considerations. Mult Scler. 2021 10; 27(12):1814-1822. View Abstract
Real-World Effectiveness of Initial Disease-Modifying Therapies in Pediatric Multiple Sclerosis. Ann Neurol. 2020 07; 88(1):42-55. View Abstract
Posterior-onset Rasmussen's encephalitis with ipsilateral cerebellar atrophy and uveitis resistant to rituximab. Epilepsy Behav Rep. 2020; 14:100360. View Abstract
Subacute Neuropsychiatric Syndrome in Girls With SHANK3 Mutations Responds to Immunomodulation. Pediatrics. 2020 02; 145(2). View Abstract
Serial vessel wall MR imaging of pediatric tuberculous vasculitis. Neurol Clin Pract. 2019 Dec; 9(6):459-461. View Abstract
Cognitive processing speed in pediatric-onset multiple sclerosis: Baseline characteristics of impairment and prediction of decline. Mult Scler. 2020 12; 26(14):1938-1947. View Abstract
SerpinB1 controls encephalitogenic T helper cells in neuroinflammation. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20635-20643. View Abstract
Exploratory proteomic analysis implicates the alternative complement cascade in primary CNS vasculitis. Neurology. 2019 07 30; 93(5):e433-e444. View Abstract
miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS. Ann Clin Transl Neurol. 2019 Jun; 6(6):1053-1061. View Abstract
Vitamin D genes influence MS relapses in children. Mult Scler. 2020 07; 26(8):894-901. View Abstract
Pioglitazone Therapy in Patients With Stroke and Prediabetes: A Post Hoc Analysis of the IRIS Randomized Clinical Trial. JAMA Neurol. 2019 05 01; 76(5):526-535. View Abstract
Central nervous system-restricted familial hemophagocytic lymphohistiocytosis responds to hematopoietic cell transplantation. Blood Adv. 2019 02 26; 3(4):503-507. View Abstract
Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Pediatr Rheumatol Online J. 2019 Feb 14; 17(1):7. View Abstract
Clinical Subpopulations in a Sample of North American Children Diagnosed With Acute Flaccid Myelitis, 2012-2016. JAMA Pediatr. 2019 02 01; 173(2):134-139. View Abstract
Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry. PLoS Genet. 2019 01; 15(1):e1007808. View Abstract
Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis. J Child Neurol. 2019 03; 34(3):148-152. View Abstract
Scoring System to Optimize Pioglitazone Therapy After Stroke Based on Fracture Risk. Stroke. 2019 Jan; 50(1):95-100. View Abstract
Magnetic resonance imaging in enterovirus-71, myelin oligodendrocyte glycoprotein antibody, aquaporin-4 antibody, and multiple sclerosis-associated myelitis in children. Dev Med Child Neurol. 2019 09; 61(9):1108-1116. View Abstract
Author Correction: Neuroimmune disorders of the central nervous system in children in the molecular era. Nat Rev Neurol. 2018 Dec; 14(12):749. View Abstract
Histopathologic Correlates of Familial Hemophagocytic Lymphohistiocytosis Isolated to the Central Nervous System. J Neuropathol Exp Neurol. 2018 12 01; 77(12):1079-1084. View Abstract
Health-related quality of life in children with inflammatory brain disease. Pediatr Rheumatol Online J. 2018 Nov 20; 16(1):73. View Abstract
Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology. 2019 04 30; 92(18):e2118-e2126. View Abstract
Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US. Neurology. 2018 11 06; 91(19):e1778-e1787. View Abstract
Several household chemical exposures are associated with pediatric-onset multiple sclerosis. Ann Clin Transl Neurol. 2018 Dec; 5(12):1513-1521. View Abstract
Urban air quality and associations with pediatric multiple sclerosis. Ann Clin Transl Neurol. 2018 Oct; 5(10):1146-1153. View Abstract
Heterogeneity in association of remote herpesvirus infections and pediatric MS. Ann Clin Transl Neurol. 2018 Oct; 5(10):1222-1228. View Abstract
Case 27-2018: A 3-Year-Old Boy with Seizures. N Engl J Med. 2018 Aug 30; 379(9):870-878. View Abstract
Neuroimmune disorders of the central nervous system in children in the molecular era. Nat Rev Neurol. 2018 07; 14(7):433-445. View Abstract
Correction to: Impact of an electronic monitoring device and behavioural feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial. Qual Life Res. 2018 04; 27(4):1117. View Abstract
Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis. Mult Scler Relat Disord. 2018 May; 22:103-107. View Abstract
Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice Guideline Update. Ann Surg Oncol. 2018 Feb; 25(2):356-377. View Abstract
Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice Guideline Update. J Clin Oncol. 2018 02 01; 36(4):399-413. View Abstract
Targeting Pioglitazone Hydrochloride Therapy After Stroke or Transient Ischemic Attack According to Pretreatment Risk for Stroke or Myocardial Infarction. JAMA Neurol. 2017 11 01; 74(11):1319-1327. View Abstract
Pioglitazone Prevents Stroke in Patients With a Recent Transient Ischemic Attack or Ischemic Stroke: A Planned Secondary Analysis of the IRIS Trial (Insulin Resistance Intervention After Stroke). Circulation. 2018 01 30; 137(5):455-463. View Abstract
Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis. J Neurol Neurosurg Psychiatry. 2018 01; 89(1):28-33. View Abstract
Genetic risk factors for pediatric-onset multiple sclerosis. Mult Scler. 2018 12; 24(14):1825-1834. View Abstract
Effects of pioglitazone on cognitive function in patients with a recent ischaemic stroke or TIA: a report from the IRIS trial. J Neurol Neurosurg Psychiatry. 2018 01; 89(1):21-27. View Abstract
Smoking cessation and outcome after ischemic stroke or TIA. Neurology. 2017 Oct 17; 89(16):1723-1729. View Abstract
Examining the contributions of environmental quality to pediatric multiple sclerosis. Mult Scler Relat Disord. 2017 Nov; 18:164-169. View Abstract
Dietary factors and pediatric multiple sclerosis: A case-control study. Mult Scler. 2018 07; 24(8):1067-1076. View Abstract
Autoimmune encephalitis in children: clinical phenomenology, therapeutics, and emerging challenges. Curr Opin Neurol. 2017 06; 30(3):334-344. View Abstract
Genetic, Phenotypic, and Interferon Biomarker Status in ADAR1-Related Neurological Disease. Neuropediatrics. 2017 Jun; 48(3):166-184. View Abstract
Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial. Qual Life Res. 2017 09; 26(9):2333-2349. View Abstract
Response to Comment on Inzucchi et al. Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease. Diabetes Care 2016;39:1684-1692. Diabetes Care. 2017 04; 40(4):e47-e48. View Abstract
Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS. Neurology. 2017 Apr 25; 88(17):1623-1629. View Abstract
Pioglitazone and Risk for Bone Fracture: Safety Data From a Randomized Clinical Trial. J Clin Endocrinol Metab. 2017 03 01; 102(3):914-922. View Abstract
Investigations in GABAA receptor antibody-associated encephalitis. Neurology. 2017 Mar 14; 88(11):1012-1020. View Abstract
Risk factors for non-adherence to disease-modifying therapy in pediatric multiple sclerosis. Mult Scler. 2018 02; 24(2):175-185. View Abstract
Distinct effects of obesity and puberty on risk and age at onset of pediatric MS. Ann Clin Transl Neurol. 2016 12; 3(12):897-907. View Abstract
Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease. Diabetes Care. 2016 Oct; 39(10):1684-92. View Abstract
Characteristics of Children and Adolescents With Multiple Sclerosis. Pediatrics. 2016 07; 138(1). View Abstract
Dietary salt intake and time to relapse in paediatric multiple sclerosis. J Neurol Neurosurg Psychiatry. 2016 12; 87(12):1350-1353. View Abstract
A Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack. J Stroke Cerebrovasc Dis. 2016 Jul; 25(7):1705-1712. View Abstract
Clinical features of neuromyelitis optica in children: US Network of Pediatric MS Centers report. Neurology. 2016 Jan 19; 86(3):245-52. View Abstract
Pain and spinal cord imaging measures in children with demyelinating disease. Neuroimage Clin. 2015; 9:338-47. View Abstract
Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis. Mult Scler. 2016 Apr; 22(4):470-82. View Abstract
Reply: To PMID 24907434. Am J Ophthalmol. 2015 Jan; 159(1):211. View Abstract
The Yield of Neuroimaging in Children Presenting to the Emergency Department With Acute Ataxia in the Post-Varicella Vaccine Era. J Child Neurol. 2015 Sep; 30(10):1333-9. View Abstract
Evaluation and treatment of autoimmune neurologic disorders in the pediatric intensive care unit. Semin Pediatr Neurol. 2014 Dec; 21(4):284-90. View Abstract
Impact of MS during the critical window of brain development. Neurology. 2014 Dec 02; 83(23):2106-7. View Abstract
Protective environmental factors for neuromyelitis optica. Neurology. 2014 Nov 18; 83(21):1923-9. View Abstract
The US Network of Pediatric Multiple Sclerosis Centers: Development, Progress, and Next Steps. J Child Neurol. 2015 Sep; 30(10):1381-7. View Abstract
Neuromyelitis optica in an adolescent after bone marrow transplantation. Pediatr Neurol. 2015 Jan; 52(1):119-24. View Abstract
Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: rationale and design of the Insulin Resistance Intervention after Stroke Trial. Am Heart J. 2014 Dec; 168(6):823-9.e6. View Abstract
Utility and safety of rituximab in pediatric autoimmune and inflammatory CNS disease. Neurology. 2014 Jul 08; 83(2):142-50. View Abstract
Visual outcomes in pediatric optic neuritis. Am J Ophthalmol. 2014 Sep; 158(3):503-7.e2. View Abstract
Population-level evidence for an autoimmune etiology of epilepsy. JAMA Neurol. 2014 May; 71(5):569-74. View Abstract
Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study. BMC Neurol. 2013 Nov 13; 13:173. View Abstract
Clinical application and evaluation of the Bien diagnostic criteria for Rasmussen encephalitis. Epilepsia. 2013 Oct; 54(10):1753-60. View Abstract
Elevated relapse rates in pediatric compared to adult MS persist for at least 6 years. Mult Scler Relat Disord. 2014 Mar; 3(2):186-93. View Abstract
Increased Th17 response to myelin peptides in pediatric MS. Clin Immunol. 2013 Mar; 146(3):176-84. View Abstract
Antibody response to common viruses and human leukocyte antigen-DRB1 in pediatric multiple sclerosis. Mult Scler. 2013 Jun; 19(7):891-5. View Abstract
Cognitive impairment occurs in children and adolescents with multiple sclerosis: results from a United States network. J Child Neurol. 2013 Jan; 28(1):102-7. View Abstract
Daclizumab use in patients with pediatric multiple sclerosis. Arch Neurol. 2012 Jan; 69(1):78-81. View Abstract
Multiple sclerosis therapies in pediatric patients with refractory multiple sclerosis. Arch Neurol. 2011 Apr; 68(4):437-44. View Abstract
Update on diagnosis, treatment, and prognosis in opsoclonus-myoclonus-ataxia syndrome. Curr Opin Pediatr. 2010 Dec; 22(6):745-50. View Abstract
Increased relapse rate in pediatric-onset compared with adult-onset multiple sclerosis. Arch Neurol. 2009 Jan; 66(1):54-9. View Abstract
Postvaricella acute transverse myelitis in a previously vaccinated child. Pediatr Neurol. 2008 May; 38(5):370-2. View Abstract
Neonatal hypocalcemic seizures in siblings exposed to topiramate in utero. Pediatr Neurol. 2007 Apr; 36(4):274-6. View Abstract