Research Overview

Dr. Bush's interdisciplinary background as a bioethicist-developmental scientist informs her writings, research, and teaching on the ethical, psychosocial, scientific, and policy challenges of genomic testing and therapies along with other innovative technologies involving fetuses, newborns, infants, children, and women. Her focus is on the complexities, uncertainties, and contextual nuances posed during the prenatal-neonatal "developmental continuum", especially with rare disease, the "diagnostic odyssey continuum", newborn screening, inborn errors of metabolism, neurodevelopment disorders, and novel therapeutics. She is a Collaborator to the YuLab on bioethical aspects of ASO individualized therapies and is Co-PI on an NIH ELSI R01 grant providing ethical guidance for the development genomic medicine as rare as n-of-1.

Research Background

Lynn Wein Bush, PhD MSBioethics MA, is a Bioethicist-Developmental Scientist and Educator, earning degrees from Columbia University in Clinical Psychology, child & neuroscience subspecialty (PhD, MS, Internship and Fellowships); MSBioethics, and MA Developmental Psychology. This foundation, combined with Postgraduate courses in genomics, fetology, neuroscience and decades of experience in NICUs, PICUs, Pediatric specialty units, and MFM clinics informs her writings, research, and teaching on the ethical, psychosocial, scientific, and policy challenges of screening, diagnosis, and therapies involving fetuses, newborns, infants, children, and women.

Dr. Bush is currently Instructor in Pediatrics Harvard Medical School, on faculty BCH Pediatrics, Genetics and Genomics, faculty HMS Genetic Training Program, affiliate faculty RSZ Translational Neuroscience Center, member BCH MFCC Fetal Therapy Board, member HMS Center for Bioethics, and The Academies at BCH and HMS. She is Collaborator to the YuLab on bioethical aspects of ASO individualized therapies as rare as n-of-1. She is a frequent international presenter and has senior policy roles and leadership positions on national-international committees, workgroups, societies, and journals, with recent book chapters, and scholarship co-authored in Pediatrics, Nature, Medical Education, and International J Neonatal Screening, including serving as Special Issue guest-editor. Previously, Dr. Bush was a long-time faculty member at Columbia University Medical Center in Pediatric Clinical Genetics, faculty program in Women and Children's Bioethics, and a member of the Clinical Ethics Committee at Children's Hospital New York.

Education

Graduate School

Columbia University
1989; 2012 New York NY

Publications

  1. Past as Prologue: Predicting Potential Psychosocial-Ethical Burdens of Positive Newborn Screens as Conditions Propagate. Int J Neonatal Screen. 2024 Feb 06; 10(1). View Abstract
  2. NBSTRN Tools to Advance Newborn Screening Research and Support Newborn Screening Stakeholders. Int J Neonatal Screen. 2023 Oct 30; 9(4). View Abstract
  3. When I say … lived curriculum. Med Educ. 2023 07; 57(7):609-611. View Abstract
  4. Experiences of Families Caring for Children with Newborn Screening-Related Conditions: Implications for the Expansion of Genomics in Population-Based Neonatal Public Health Programs. Int J Neonatal Screen. 2022 May 23; 8(2). View Abstract
  5. Pediatric clinical exome/genome sequencing and the engagement process: encouraging active conversation with the older child and adolescent: points to consider-a statement of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2018 07; 20(7):692-694. View Abstract

Contact Lynn Bush