Education

Undergraduate School

University of British Columbia
1968 Vancouver, British Columbia Canada

Medical School

Boston University School of Medicine
1978 Boston MA

Internship

Beth Israel Deaconess Medical Center
1979 Boston MA

Residency

Massachusetts Eye and Ear Infirmary
1982 Boston MA

Fellowship

Boston Children's Hospital
1983 Boston MA

Publications

  1. Association between early postnatal hydrocortisone and retinopathy of prematurity in extremely preterm infants. Neonatology. 2025 Jan 21; 1-20. View Abstract
  2. Platelet characteristics in extremely preterm infants after fatty acid supplementation: a randomized controlled trial. Pediatr Res. 2024 Dec 19. View Abstract
  3. Increased risk of autism in extremely preterm children with a history of retinopathy of prematurity. Acta Paediatr. 2024 Dec 19. View Abstract
  4. Therapeutic Effects of Taurine and Histidine Supplementation in Retinal Diseases. Life (Basel). 2024 Nov 29; 14(12). View Abstract
  5. Correction: Mitochondrial control of hypoxia-induced pathological retinal angiogenesis. Angiogenesis. 2024 Nov; 27(4):701-702. View Abstract
  6. Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity. Angiogenesis. 2024 Nov; 27(4):903-917. View Abstract
  7. Mitochondrial control of hypoxia-induced pathological retinal angiogenesis. Angiogenesis. 2024 Nov; 27(4):691-699. View Abstract
  8. Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3. Angiogenesis. 2024 Nov; 27(4):753-764. View Abstract
  9. Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity. Res Sq. 2024 Jun 25. View Abstract
  10. ROP: 80 Years after Its Detection - Where Do We Stand and How Long Will We Continue to Laser? Neonatology. 2024; 121(5):608-615. View Abstract
  11. Therapeutic Effects of Anti-Inflammatory and Anti-Oxidant Nutritional Supplementation in Retinal Ischemic Diseases. Int J Mol Sci. 2024 May 18; 25(10). View Abstract
  12. Nutritional interventions to prevent retinopathy of prematurity. Pediatr Res. 2024 Sep; 96(4):905-911. View Abstract
  13. Arachidonic acid and docosahexaenoic acid levels correlate with the inflammation proteome in extremely preterm infants. Clin Nutr. 2024 May; 43(5):1162-1170. View Abstract
  14. Visual outcome at 2.5 years of age in ?-3 and ?-6 long-chain polyunsaturated fatty acid supplemented preterm infants: a follow-up of a randomized controlled trial. Lancet Reg Health Eur. 2023 Sep; 32:100696. View Abstract
  15. Prognostic Value of Parenteral Nutrition Duration on Risk of Retinopathy of Prematurity: Development and Validation of the Revised DIGIROP Clinical Decision Support Tool. JAMA Ophthalmol. 2023 08 01; 141(8):716-724. View Abstract
  16. In vivo noninvasive mitochondrial redox assessment of the optic nerve head to predict disease. PNAS Nexus. 2023 May; 2(5):pgad148. View Abstract
  17. Modification of serum fatty acids in preterm infants by parenteral lipids and enteral docosahexaenoic acid/arachidonic acid: A secondary analysis of the Mega Donna Mega trial. Clin Nutr. 2023 06; 42(6):962-971. View Abstract
  18. FGF21 via mitochondrial lipid oxidation promotes physiological vascularization in a mouse model of Phase I ROP. Angiogenesis. 2023 08; 26(3):409-421. View Abstract
  19. Therapeutic activation of endothelial sphingosine-1-phosphate receptor 1 by chaperone-bound S1P suppresses proliferative retinal neovascularization. EMBO Mol Med. 2023 05 08; 15(5):e16645. View Abstract
  20. Retinopathy of prematurity: Metabolic risk factors. Elife. 2022 11 24; 11. View Abstract
  21. Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis. Elife. 2022 Oct 05; 11. View Abstract
  22. Cytochrome P450 oxidase 2J inhibition suppresses choroidal neovascularization in mice. Metabolism. 2022 09; 134:155266. View Abstract
  23. National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity. Acta Paediatr. 2022 08; 111(8):1515-1525. View Abstract
  24. Plasma Levels of Bevacizumab and Vascular Endothelial Growth Factor After Low-Dose Bevacizumab Treatment for Retinopathy of Prematurity in Infants. JAMA Ophthalmol. 2022 04 01; 140(4):337-344. View Abstract
  25. Omega-3/Omega-6 Long-Chain Fatty Acid Imbalance in Phase I Retinopathy of Prematurity. Nutrients. 2022 Mar 23; 14(7). View Abstract
  26. Neurodevelopmental disorders and somatic diagnoses in a national cohort of children born before 24 weeks of gestation. Acta Paediatr. 2022 06; 111(6):1167-1175. View Abstract
  27. Müller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa. Exp Mol Med. 2021 11; 53(11):1748-1758. View Abstract
  28. Association of Docosahexaenoic Acid and Arachidonic Acid Serum Levels With Retinopathy of Prematurity in Preterm Infants. JAMA Netw Open. 2021 10 01; 4(10):e2128771. View Abstract
  29. Insulin-Like Growth Factor 1 in the Preterm Rabbit Pup: Characterization of Cerebrovascular Maturation following Administration of Recombinant Human Insulin-Like Growth Factor 1/Insulin-Like Growth Factor 1-Binding Protein 3. Dev Neurosci. 2021; 43(5):281-295. View Abstract
  30. Development and validation of a new clinical decision support tool to optimize screening for retinopathy of prematurity. Br J Ophthalmol. 2022 11; 106(11):1573-1580. View Abstract
  31. Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Jul; 1866(7):158939. View Abstract
  32. Cellular senescence in pathologic retinal angiogenesis. Trends Endocrinol Metab. 2021 07; 32(7):415-416. View Abstract
  33. Effect of Enteral Lipid Supplement on Severe Retinopathy of Prematurity: A Randomized Clinical Trial. JAMA Pediatr. 2021 04 01; 175(4):359-367. View Abstract
  34. Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration. iScience. 2021 Apr 23; 24(4):102376. View Abstract
  35. Decreased Platelet Counts and Serum Levels of VEGF-A, PDGF-BB, and BDNF in Extremely Preterm Infants Developing Severe ROP. Neonatology. 2021; 118(1):18-27. View Abstract
  36. Fatty acid oxidation and photoreceptor metabolic needs. J Lipid Res. 2021; 62:100035. View Abstract
  37. Vitreous metabolomics profiling of proliferative diabetic retinopathy. Diabetologia. 2021 01; 64(1):70-82. View Abstract
  38. Notice of Withdrawal: Retinal Vasculature in Development and Diseases. Annu Rev Vis Sci. 2020 10 15; 0. View Abstract
  39. Randomized Control Trial of Postnatal rhIGF-1/rhIGFBP-3 Replacement in Preterm Infants: Post-hoc Analysis of Its Effect on Brain Injury. Front Pediatr. 2020; 8:517207. View Abstract
  40. An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis. J Vis Exp. 2020 08 06; (162). View Abstract
  41. Association between low fatty acid levels and platelet count in infants with Retinopathy of Prematurity. Acta Paediatr. 2020 12; 109(12):2547-2548. View Abstract
  42. Validation of the Retinopathy of Prematurity Activity Scale (ROP-ActS) using retrospective clinical data. Acta Ophthalmol. 2021 Mar; 99(2):201-206. View Abstract
  43. Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice. Angiogenesis. 2020 08; 23(3):385-394. View Abstract
  44. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020 03 23; 52(6):779-793.e7. View Abstract
  45. Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models. Int J Mol Sci. 2020 Feb 11; 21(4). View Abstract
  46. Individual Risk Prediction for Sight-Threatening Retinopathy of Prematurity Using Birth Characteristics. JAMA Ophthalmol. 2020 01 01; 138(1):21-29. View Abstract
  47. Pathophysiology of Diabetic Retinopathy: Contribution and Limitations of Laboratory Research. Ophthalmic Res. 2019; 62(4):196-202. View Abstract
  48. Leucocytosis is associated with retinopathy of prematurity in extremely preterm infants. Acta Paediatr. 2019 07; 108(7):1357-1358. View Abstract
  49. Tailored vs Static Oxygen Saturation Targets to Prevent Retinopathy of Prematurity. JAMA Ophthalmol. 2019 04 01; 137(4):423-424. View Abstract
  50. Development of a Retinopathy of Prematurity Activity Scale and Clinical Outcome Measures for Use in Clinical Trials. JAMA Ophthalmol. 2019 03 01; 137(3):305-311. View Abstract
  51. Review shows that donor milk does not promote the growth and development of preterm infants as well as maternal milk. Acta Paediatr. 2019 06; 108(6):998-1007. View Abstract
  52. Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma. JAMA Ophthalmol. 2019 01 01; 137(1):91-95. View Abstract
  53. rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled Trial. J Pediatr. 2019 03; 206:56-65.e8. View Abstract
  54. Erythropoietin serum levels, versus anaemia as risk factors for severe retinopathy of prematurity. Pediatr Res. 2019 08; 86(2):276-282. View Abstract
  55. Retinal Vasculature in Development and Diseases. Annu Rev Vis Sci. 2018 09 15; 4:101-122. View Abstract
  56. A Dosing Study of Bevacizumab for Retinopathy of Prematurity: Late Recurrences and Additional Treatments. Ophthalmology. 2018 12; 125(12):1961-1966. View Abstract
  57. Influence of Human Milk and Parenteral Lipid Emulsions on Serum Fatty Acid Profiles in Extremely Preterm Infants. JPEN J Parenter Enteral Nutr. 2019 01; 43(1):152-161. View Abstract
  58. Relation of Retinopathy of Prematurity to Brain Volumes at Term Equivalent Age and Developmental Outcome at 2 Years of Corrected Age in Very Preterm Infants. Neonatology. 2018; 114(1):46-52. View Abstract
  59. Long-chain polyunsaturated fatty acids decline rapidly in milk from mothers delivering extremely preterm indicating the need for supplementation. Acta Paediatr. 2018 06; 107(6):1020-1027. View Abstract
  60. Association of Retinopathy of Prematurity With Low Levels of Arachidonic Acid: A Secondary Analysis of a Randomized Clinical Trial. JAMA Ophthalmol. 2018 03 01; 136(3):271-277. View Abstract
  61. Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity: A Randomized Clinical Trial. JAMA Pediatr. 2018 03 01; 172(3):278-286. View Abstract
  62. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018 05; 67(5):974-985. View Abstract
  63. PPARa is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017 Nov 28; 15(1):113. View Abstract
  64. Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity. Growth Horm IGF Res. 2018 04; 39:19-24. View Abstract
  65. Implementing higher oxygen saturation targets reduced the impact of poor weight gain as a predictor for retinopathy of prematurity. Acta Paediatr. 2018 05; 107(5):767-773. View Abstract
  66. VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 08 29; 8(1):383. View Abstract
  67. Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3862-3870. View Abstract
  68. Cerebellar Exposure to Cell-Free Hemoglobin Following Preterm Intraventricular Hemorrhage: Causal in Cerebellar Damage? Transl Stroke Res. 2017 Jun 10. View Abstract
  69. Assessment of Lower Doses of Intravitreous Bevacizumab for Retinopathy of Prematurity: A Phase 1 Dosing Study. JAMA Ophthalmol. 2017 06 01; 135(6):654-656. View Abstract
  70. Effects of a lipid emulsion containing fish oil on polyunsaturated fatty acid profiles, growth and morbidities in extremely premature infants: A randomized controlled trial. Clin Nutr ESPEN. 2017 Aug; 20:17-23. View Abstract
  71. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 06 05; 214(6):1753-1767. View Abstract
  72. Special Commentary: Early Clinical Development of Cell Replacement Therapy: Considerations for the National Eye Institute Audacious Goals Initiative. Ophthalmology. 2017 07; 124(7):926-934. View Abstract
  73. Sema3f Protects Against Subretinal Neovascularization In Vivo. EBioMedicine. 2017 Apr; 18:281-287. View Abstract
  74. FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice. Cell Rep. 2017 02 14; 18(7):1606-1613. View Abstract
  75. IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development. Curr Pharm Des. 2017; 23(38):5964-5970. View Abstract
  76. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Nov; 13:201-211. View Abstract
  77. IGF-I in the clinics: Use in retinopathy of prematurity. Growth Horm IGF Res. 2016 Oct - Dec; 30-31:75-80. View Abstract
  78. IGF-1 in retinopathy of prematurity, a CNS neurovascular disease. Early Hum Dev. 2016 11; 102:13-19. View Abstract
  79. Aggressive Posterior Retinopathy of Prematurity Is Associated with Multiple Infectious Episodes and Thrombocytopenia. Neonatology. 2017; 111(1):79-85. View Abstract
  80. Role of Insulinlike Growth Factor 1 in Fetal Development and in the Early Postnatal Life of Premature Infants. Am J Perinatol. 2016 09; 33(11):1067-71. View Abstract
  81. Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications. Am J Physiol Heart Circ Physiol. 2016 09 01; 311(3):H738-49. View Abstract
  82. Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1919-27. View Abstract
  83. Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 06 07; 22(6):692. View Abstract
  84. Review: adiponectin in retinopathy. Biochim Biophys Acta. 2016 08; 1862(8):1392-400. View Abstract
  85. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. View Abstract
  86. Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatr. 2016 Jun; 105(6):576-86. View Abstract
  87. The Eyes Absent Proteins in Developmental and Pathological Angiogenesis. Am J Pathol. 2016 Mar; 186(3):568-78. View Abstract
  88. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94. View Abstract
  89. Serum concentrations of vascular endothelial growth factor in relation to retinopathy of prematurity. Pediatr Res. 2016 Jan; 79(1-1):70-5. View Abstract
  90. Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. View Abstract
  91. Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis. 2015 Oct; 18(4):449-62. View Abstract
  92. Netrin-1 - DCC Signaling Systems and Age-Related Macular Degeneration. PLoS One. 2015; 10(5):e0125548. View Abstract
  93. Effect of Preterm Birth on Postnatal Apolipoprotein and Adipocytokine Profiles. Neonatology. 2015; 108(1):16-22. View Abstract
  94. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. View Abstract
  95. Low birth weight is a risk factor for severe retinopathy of prematurity depending on gestational age. PLoS One. 2014; 9(10):e109460. View Abstract
  96. Insulin-like growth factor-1 and anti-vascular endothelial growth factor in retinopathy of prematurity: has the time come? Neonatology. 2014; 106(3):254-60. View Abstract
  97. Omega-3 supplementation combined with anti-vascular endothelial growth factor lowers vitreal levels of vascular endothelial growth factor in wet age-related macular degeneration. Am J Ophthalmol. 2014 Nov; 158(5):1071-78. View Abstract
  98. Weight at first detection of retinopathy of prematurity predicts disease severity. Br J Ophthalmol. 2014 Nov; 98(11):1565-9. View Abstract
  99. Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):581-6. View Abstract
  100. Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. PLoS One. 2014; 9(1):e85031. View Abstract
  101. WINROP identifies severe retinopathy of prematurity at an early stage in a nation-based cohort of extremely preterm infants. PLoS One. 2013; 8(9):e73256. View Abstract
  102. Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis. 2013 Oct; 16(4):985-92. View Abstract
  103. Choroid sprouting assay: an ex vivo model of microvascular angiogenesis. PLoS One. 2013; 8(7):e69552. View Abstract
  104. Retinopathy of prematurity. Lancet. 2013 Oct 26; 382(9902):1445-57. View Abstract
  105. The biology of retinopathy of prematurity: how knowledge of pathogenesis guides treatment. Clin Perinatol. 2013 Jun; 40(2):201-14. View Abstract
  106. Semaphorin 3F forms an anti-angiogenic barrier in outer retina. FEBS Lett. 2013 Jun 05; 587(11):1650-5. View Abstract
  107. Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration. Cell Metab. 2013 Apr 02; 17(4):471-2. View Abstract
  108. Nutrition, insulin-like growth factor-1 and retinopathy of prematurity. Semin Fetal Neonatal Med. 2013 Jun; 18(3):136-142. View Abstract
  109. DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ?-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways. PLoS One. 2013; 8(1):e53155. View Abstract
  110. Author response: Different efficacy of propranolol in mice with oxygen-induced retinopathy: could differential effects of propranolol be related to differences in mouse strains? Invest Ophthalmol Vis Sci. 2012 Nov 19; 53(12):7728-9. View Abstract
  111. Longitudinal infusion of a complex of insulin-like growth factor-I and IGF-binding protein-3 in five preterm infants: pharmacokinetics and short-term safety. Pediatr Res. 2013 Jan; 73(1):68-74. View Abstract
  112. Importance of early postnatal weight gain for normal retinal angiogenesis in very preterm infants: a multicenter study analyzing weight velocity deviations for the prediction of retinopathy of prematurity. Arch Ophthalmol. 2012 Aug; 130(8):992-9. View Abstract
  113. LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. PLoS One. 2012; 7(7):e41596. View Abstract
  114. SOCS3 is an endogenous inhibitor of pathologic angiogenesis. Blood. 2012 Oct 04; 120(14):2925-9. View Abstract
  115. Propranolol inhibition of ß-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 May 17; 53(6):2968-77. View Abstract
  116. Protective inflammasome activation in AMD. Nat Med. 2012 May 04; 18(5):658-60. View Abstract
  117. Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice. PLoS One. 2012; 7(1):e30203. View Abstract
  118. Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation. 2011 Oct 25; 124(17):1871-81. View Abstract
  119. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15231-6. View Abstract
  120. Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a. Invest Ophthalmol Vis Sci. 2011 Jul 23; 52(8):5376-86. View Abstract
  121. Maternal and neonatal factors associated with poor early weight gain and later retinopathy of prematurity. Acta Paediatr. 2011 Dec; 100(12):1528-33. View Abstract
  122. Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2809-16. View Abstract
  123. Current update on retinopathy of prematurity: screening and treatment. Curr Opin Pediatr. 2011 Apr; 23(2):173-8. View Abstract
  124. Lipid metabolites in the pathogenesis and treatment of neovascular eye disease. Br J Ophthalmol. 2011 Nov; 95(11):1496-501. View Abstract
  125. Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Blood. 2011 Jun 02; 117(22):6024-35. View Abstract
  126. 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ?-3 polyunsaturated fatty acids. Sci Transl Med. 2011 Feb 09; 3(69):69ra12. View Abstract
  127. Analysis of candidate genes for macular telangiectasia type 2. Mol Vis. 2010 Dec 14; 16:2718-26. View Abstract
  128. Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy. Am J Pathol. 2010 Dec; 177(6):2715-23. View Abstract
  129. Predicting proliferative retinopathy in a Brazilian population of preterm infants with the screening algorithm WINROP. Arch Ophthalmol. 2010 Nov; 128(11):1432-6. View Abstract
  130. Vitreal levels of erythropoietin are increased in patients with retinal vein occlusion and correlate with vitreal VEGF and the extent of macular edema. Retina. 2010 Oct; 30(9):1524-9. View Abstract
  131. Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion. Biochim Biophys Acta. 2011 Apr; 1812(4):549-57. View Abstract
  132. Moderate GSK-3ß inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy. Angiogenesis. 2010 Sep; 13(3):269-77. View Abstract
  133. An eye for discovery. J Clin Invest. 2010 Sep; 120(9):3008-11. View Abstract
  134. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010 Jul 21; 30(29):9695-707. View Abstract
  135. Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy. Circ Res. 2010 Aug 20; 107(4):495-500. View Abstract
  136. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):2813-26. View Abstract
  137. High or low oxygen saturation and severe retinopathy of prematurity: a meta-analysis. Pediatrics. 2010 Jun; 125(6):e1483-92. View Abstract
  138. Longitudinal postnatal weight measurements for the prediction of retinopathy of prematurity. Arch Ophthalmol. 2010 Apr; 128(4):443-7. View Abstract
  139. Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc. 2009; 4(11):1565-73. View Abstract
  140. Validation of a new retinopathy of prematurity screening method monitoring longitudinal postnatal weight and insulinlike growth factor I. Arch Ophthalmol. 2009 May; 127(5):622-7. View Abstract
  141. A pharmacokinetic and dosing study of intravenous insulin-like growth factor-I and IGF-binding protein-3 complex to preterm infants. Pediatr Res. 2009 May; 65(5):574-9. View Abstract
  142. Early weight gain predicts retinopathy in preterm infants: new, simple, efficient approach to screening. Pediatrics. 2009 Apr; 123(4):e638-45. View Abstract
  143. Retinopathy of prematurity: current concepts in molecular pathogenesis. Semin Ophthalmol. 2009 Mar-Apr; 24(2):77-81. View Abstract
  144. Emerging treatments for retinopathy of prematurity. Semin Ophthalmol. 2009 Mar-Apr; 24(2):82-6. View Abstract
  145. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature. 2009 Feb 26; 457(7233):1103-8. View Abstract
  146. Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1831-7. View Abstract
  147. Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1329-35. View Abstract
  148. Use of Bayesian networks to probabilistically model and improve the likelihood of validation of microarray findings by RT-PCR. J Biomed Inform. 2009 Apr; 42(2):287-95. View Abstract
  149. Through the eyes of a child: understanding retinopathy through ROP the Friedenwald lecture. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5177-82. View Abstract
  150. A double-edged sword: erythropoietin eyed in retinopathy of prematurity. J AAPOS. 2008 Jun; 12(3):221-2. View Abstract
  151. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest. 2008 Feb; 118(2):526-33. View Abstract
  152. Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration. J Clin Invest. 2007 Oct; 117(10):2758-62. View Abstract
  153. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007 Jul; 13(7):868-873. View Abstract
  154. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10589-94. View Abstract
  155. Retinopathy of prematurity. Angiogenesis. 2007; 10(2):133-40. View Abstract
  156. Longitudinal postnatal weight and insulin-like growth factor I measurements in the prediction of retinopathy of prematurity. Arch Ophthalmol. 2006 Dec; 124(12):1711-8. View Abstract
  157. Postnatal head growth deficit among premature infants parallels retinopathy of prematurity and insulin-like growth factor-1 deficit. Pediatrics. 2006 Jun; 117(6):1930-8. View Abstract
  158. Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis. 2006 May 23; 12:532-80. View Abstract
  159. A radically twisted lipid regulates vascular death. Nat Med. 2005 Dec; 11(12):1275-6. View Abstract
  160. Quantitative multi-gene transcriptional profiling using real-time PCR with a master template. Exp Mol Pathol. 2005 Aug; 79(1):14-22. View Abstract
  161. Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia. Invest Ophthalmol Vis Sci. 2005 Aug; 46(8):2736-47. View Abstract
  162. IGF-1 and retinopathy of prematurity in the preterm infant. Biol Neonate. 2005; 88(3):237-44. View Abstract
  163. Periorbital lymphatic malformation: clinical course and management in 42 patients. Plast Reconstr Surg. 2005 Jan; 115(1):22-30. View Abstract
  164. Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells. Physiol Genomics. 2004 Dec 15; 20(1):36-44. View Abstract
  165. Bone marrow-derived stem cells preserve cone vision in retinitis pigmentosa. J Clin Invest. 2004 Sep; 114(6):755-7. View Abstract
  166. Can we restore aspects of the in utero environment in premature infants to prevent disease? Pediatrics. 2004 Aug; 114(2):491. View Abstract
  167. Pathogenesis of retinopathy of prematurity. Growth Horm IGF Res. 2004 Jun; 14 Suppl A:S140-4. View Abstract
  168. Transforming growth factor beta1 induction of vascular endothelial growth factor receptor 1: mechanism of pericyte-induced vascular survival in vivo. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15859-64. View Abstract
  169. Pathogenesis of retinopathy of prematurity. Semin Neonatol. 2003 Dec; 8(6):469-73. View Abstract
  170. Adipose tissue growth and regression are regulated by angiopoietin-1. Biochem Biophys Res Commun. 2003 Nov 21; 311(3):563-71. View Abstract
  171. Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth. Pediatrics. 2003 Nov; 112(5):1016-20. View Abstract
  172. Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity. J Clin Invest. 2003 Jul; 112(1):50-7. View Abstract
  173. Inhibition of the mammary carcinoma angiogenic switch in C3(1)/SV40 transgenic mice by a mutated form of human endostatin. Int J Cancer. 2002 Sep 20; 101(3):224-34. View Abstract
  174. Stem cells go for the eyes. Nat Med. 2002 Sep; 8(9):932-4. View Abstract
  175. Molecular profiling of angiogenesis markers. Am J Pathol. 2002 Jul; 161(1):35-41. View Abstract
  176. IGF-I is critical for normal vascularization of the human retina. J Clin Endocrinol Metab. 2002 Jul; 87(7):3413-6. View Abstract
  177. RP-forme fruste. J Perinatol. 2002 Apr-May; 22(3):257; author reply 257-8. View Abstract
  178. Pathogenesis of retinopathy of prematurity. Acta Paediatr Suppl. 2002; 91(437):26-8. View Abstract
  179. Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5804-8. View Abstract
  180. Nonvascular role for VEGF: VEGFR-1, 2 activity is critical for neural retinal development. FASEB J. 2001 May; 15(7):1215-7. View Abstract
  181. Heat shock protein 90 in retinal ganglion cells: association with axonally transported proteins. Vis Neurosci. 2001 May-Jun; 18(3):429-36. View Abstract
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