Information

Related Research Units

Emergency Medicine Research

Research Overview

Dr. Lise Nigrovic’s research focus has been in the approach to diagnosis and management of children with infectious emergencies. Her significant research contributions include the development and multi-center validation of a clinical prediction model to distinguish between bacterial from viral meningitis. Her current research is focused on the diagnosis and management of children with acute Lyme disease. She is the founding chair of the only pediatric Lyme disease clinical research network, Pedi Lyme Net with associated pediatric biorepository and more than 5000 children enrolled. Currently she is the PI for a NIAID funded 21-center comparative effectiveness study comparing doxycycline to ceftriaxone for children with Lyme meningitis. Previously she served as the site principal investigator for the Pediatric Emergency Medicine Applied Research Network (PECARN) and past chair of the Pediatric Emergency Medicine Clinical Research Collaborative (PEM CRC).

Research Background

Lise Nigrovic received her MD in Medicine from Harvard Medical School and her MPH in clinical effectiveness from the Harvard School of Public Health. She completed her residency, chief residency and clinical fellowship in Pediatric Emergency Medicine at Boston Children's Hospital and then joined the faculty in the Division of Emergency Medicine at Boston Children’s Hospital. She now serves as the site PI for Harvard Catalyst at Boston Children’s Hospital.

Education

Medical School

Harvard Medical School
1997 Boston MA

Residency

Boston Children's Hospital
2002 Boston MA

Fellowship

Boston Children's Hospital
2005 Boston MA

Graduate School

MPH Harvard School of Public Health
2005 Boston MA

Publications

  1. Evaluation of Lyme serologic quantitative test indexes: High first-tier test index values predict positive second-tier result in standard and modified 2-tier Lyme testing algorithms. Am J Clin Pathol. 2024 Sep 03. View Abstract
  2. Comparative Evaluation of Commercial Test Kits Cleared for Use in Modified Two-Tiered Testing Algorithms for Serodiagnosis of Lyme Disease. J Infect Dis. 2024 Aug 14; 230(Supplement_1):S76-S81. View Abstract
  3. Managing the Swollen Knee in a Child. Ann Emerg Med. 2024 Nov; 84(5):500-507. View Abstract
  4. Mapping the distribution of Lyme disease at a mid-Atlantic site in the United States using electronic health data. PLoS One. 2024; 19(5):e0301530. View Abstract
  5. Increased usage of doxycycline for young children with Lyme disease. Front Antibiot. 2024; 3:1388039. View Abstract
  6. Utility of Synovial Fluid Biomarkers for Culture-Positive Septic Arthritis in a Lyme Disease-Endemic Region. Pediatr Emerg Care. 2024 Jul 01; 40(7):e82-e88. View Abstract
  7. Predictors of Invasive Bacterial Infection in Febrile Infants Aged 2 to 6 Months in the Emergency Department. J Pediatr. 2024 Jul; 270:114017. View Abstract
  8. Diagnostic Stewardship in the Evaluation of a Child With a Potential Central Nervous System Infection. Pediatr Infect Dis J. 2024 Jun 01; 43(6):e204-e206. View Abstract
  9. Impact of COVID-19 and the cancellation of the 2020 PAS Meeting on abstract publications. Pediatr Res. 2024 Jun; 95(7):1668-1669. View Abstract
  10. Radiographic pneumonia in young febrile infants presenting to the emergency department: secondary analysis of a prospective cohort study. Emerg Med J. 2023 Dec 22; 41(1):13-19. View Abstract
  11. Rehydration Rates and Outcomes in Overweight Children With Diabetic Ketoacidosis. Pediatrics. 2023 Dec 01; 152(6). View Abstract
  12. Sensitivity of Two-Tiered Lyme Disease Serology in Children With an Erythema Migrans Lesion. J Pediatric Infect Dis Soc. 2023 Oct 28; 12(10):553-555. View Abstract
  13. Biomarkers for Pediatric Bacterial Musculoskeletal Infections in Lyme Disease-Endemic Regions. Pediatrics. 2023 Aug 01; 152(2). View Abstract
  14. Impact of the COVID-19 pandemic on pediatric faculty: a report from nine academic institutions. Pediatr Res. 2024 Feb; 95(3):775-784. View Abstract
  15. Clinical and Laboratory Predictors of Dehydration Severity in Children With Diabetic Ketoacidosis. Ann Emerg Med. 2023 08; 82(2):167-178. View Abstract
  16. Racial Differences in the Diagnosis of Lyme Disease in Children. Clin Infect Dis. 2023 03 21; 76(6):1129-1131. View Abstract
  17. Multiplex High-Definition Polymerase Chain Reaction Assay for the Diagnosis of Tick-borne Infections in Children. Open Forum Infect Dis. 2023 Apr; 10(4):ofad121. View Abstract
  18. Comparative effectiveness and complications of intravenous ceftriaxone compared with oral doxycycline in Lyme meningitis in children: a multicentre prospective cohort study. BMJ Open. 2023 02 28; 13(2):e071141. View Abstract
  19. Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes. Endocrinol Diabetes Metab. 2023 05; 6(3):e412. View Abstract
  20. Relationships among biochemical measures in children with diabetic ketoacidosis. J Pediatr Endocrinol Metab. 2023 Mar 28; 36(3):313-318. View Abstract
  21. Trends in the Use of Procalcitonin at US Children's Hospital Emergency Departments. Hosp Pediatr. 2023 01 01; 13(1):24-30. View Abstract
  22. Serious Bacterial Infections in Young Febrile Infants With Positive Urinalysis Results. Pediatrics. 2022 10 01; 150(4). View Abstract
  23. Pyuria in Children with Diabetic Ketoacidosis. J Pediatr. 2023 01; 252:204-207.e2. View Abstract
  24. Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis. J Pediatr. 2022 11; 250:100-104. View Abstract
  25. Prevalence and Management of Invasive Bacterial Infections in Febrile Infants Ages 2 to 6 Months. Ann Emerg Med. 2022 12; 80(6):499-506. View Abstract
  26. Comprehensiveness of Testing Among Herpes Simplex Virus Infected Infants: A Multicenter Cohort Study. Pediatr Infect Dis J. 2022 10 01; 41(10):851-853. View Abstract
  27. Empiric antibiotics for children with suspected Lyme disease. Ticks Tick Borne Dis. 2022 09; 13(5):101989. View Abstract
  28. A Clinical Prediction Rule for Bacterial Musculoskeletal Infections in Children with Monoarthritis in Lyme Endemic Regions. Ann Emerg Med. 2022 09; 80(3):225-234. View Abstract
  29. Validation of Septic Knee Monoarthritis Prediction Rule in a Lyme Disease Endemic Area. Pediatr Emerg Care. 2022 Feb 01; 38(2):e881-e885. View Abstract
  30. Multisystem Inflammatory-like Syndrome in a Child Following COVID-19 mRNA Vaccination. Vaccines (Basel). 2021 Dec 30; 10(1). View Abstract
  31. Seasonality of Acute Lyme Disease in Children. Trop Med Infect Dis. 2021 Nov 09; 6(4). View Abstract
  32. Attending-Provider Handoffs and Pediatric Emergency Department Revisits. Pediatr Emerg Care. 2021 Nov 01; 37(11):e679-e685. View Abstract
  33. Two-Tier Lyme Disease Serology in Children with Previous Lyme Disease. Vector Borne Zoonotic Dis. 2021 11; 21(11):839-842. View Abstract
  34. The Pediatric Emergency Research Network: a decade old and growing. Eur J Emerg Med. 2021 10 01; 28(5):341-343. View Abstract
  35. Changes in Antibiotic Treatment for Children With Lyme Meningitis 2015-2020. Hosp Pediatr. 2021 10; 11(10):e243-e248. View Abstract
  36. Predictors of Invasive Herpes Simplex Virus Infection in Young Infants. Pediatrics. 2021 09; 148(3). View Abstract
  37. Serologic Response to Borrelia Antigens Varies with Clinical Phenotype in Children and Young Adults with Lyme Disease. J Clin Microbiol. 2021 10 19; 59(11):e0134421. View Abstract
  38. Serum Sodium Concentration and Mental Status in Children With Diabetic Ketoacidosis. Pediatrics. 2021 09; 148(3). View Abstract
  39. Environmental Correlates of Lyme Disease Emergence in Southwest Virginia, 2005-2014. J Med Entomol. 2021 07 16; 58(4):1680-1685. View Abstract
  40. Electrocardiogram as a Lyme Disease Screening Test. J Pediatr. 2021 Nov; 238:228-232.e1. View Abstract
  41. The Pediatric Emergency Research Network (PERN): A decade of global research cooperation in paediatric emergency care. Emerg Med Australas. 2021 10; 33(5):900-910. View Abstract
  42. The Pediatric Emergency Research Network: A Decade of Global Research Cooperation in Pediatric Emergency Care. Pediatr Emerg Care. 2021 07 01; 37(7):389-396. View Abstract
  43. Effects of Fluid Rehydration Strategy on Correction of Acidosis and Electrolyte Abnormalities in Children With Diabetic Ketoacidosis. Diabetes Care. 2021 09; 44(9):2061-2068. View Abstract
  44. Managing Diabetic Ketoacidosis in Children. Ann Emerg Med. 2021 09; 78(3):340-345. View Abstract
  45. Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days. Pediatr Emerg Care. 2021 May 01; 37(5):e227-e229. View Abstract
  46. Validation of the Rule of 7's for Identifying Children at Low-risk for Lyme Meningitis. Pediatr Infect Dis J. 2021 04 01; 40(4):306-309. View Abstract
  47. Research environment and resources to support pediatric emergency medicine fellow research. AEM Educ Train. 2021 Jul; 5(3):e10585. View Abstract
  48. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. Clin Infect Dis. 2021 01 23; 72(1):e1-e48. View Abstract
  49. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. Clin Infect Dis. 2021 01 23; 72(1):1-8. View Abstract
  50. Characteristics of Afebrile Infants =60 Days of Age With Invasive Bacterial Infections. Hosp Pediatr. 2021 01; 11(1):100-105. View Abstract
  51. Invasive Bacterial Infections in Afebrile Infants Diagnosed With Acute Otitis Media. Pediatrics. 2021 01; 147(1). View Abstract
  52. Febrile Infants =60 Days Old With Positive Urinalysis Results and Invasive Bacterial Infections. Hosp Pediatr. 2020 12; 10(12):1120-1125. View Abstract
  53. Pediatric Lyme Disease Biobank, United States, 2015-2020. Emerg Infect Dis. 2020 12; 26(12):3099-3101. View Abstract
  54. Frequency and Risk Factors of Acute Kidney Injury During Diabetic Ketoacidosis in Children and Association With Neurocognitive Outcomes. JAMA Netw Open. 2020 12 01; 3(12):e2025481. View Abstract
  55. Clinical Practice Guidelines by the Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology: 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Neurology. 2021 02 09; 96(6):262-273. View Abstract
  56. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Arthritis Care Res (Hoboken). 2021 01; 73(1):1-9. View Abstract
  57. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Arthritis Rheumatol. 2021 01; 73(1):12-20. View Abstract
  58. Kicking it through the uprights: getting it published after presenting at PAS. Pediatr Res. 2021 05; 89(7):1598-1600. View Abstract
  59. Cognitive Function Following Diabetic Ketoacidosis in Children With New-Onset or Previously Diagnosed Type 1 Diabetes. Diabetes Care. 2020 11; 43(11):2768-2775. View Abstract
  60. Time to Positive Blood and Cerebrospinal Fluid Cultures in Febrile Infants =60 Days of Age. Hosp Pediatr. 2020 09; 10(9):719-727. View Abstract
  61. The Infant Scalp Score: A Validated Tool to Stratify Risk of Traumatic Brain Injury in Infants With Isolated Scalp Hematoma. Acad Emerg Med. 2021 01; 28(1):92-97. View Abstract
  62. Use of Ondansetron for Vomiting After Head Trauma: Does It Mask Clinically Significant Traumatic Brain Injury? Pediatr Emerg Care. 2020 Aug; 36(8):e433-e437. View Abstract
  63. Marked Escalation in Journal Submissions During COVID-19 Pandemic. Ann Emerg Med. 2021 01; 77(1):130-131. View Abstract
  64. Hypertension during Diabetic Ketoacidosis in Children. J Pediatr. 2020 08; 223:156-163.e5. View Abstract
  65. Two-Tier Lyme Disease Serology Test Results Can Vary According to the Specific First-Tier Test Used. J Pediatric Infect Dis Soc. 2020 Apr 30; 9(2):128-133. View Abstract
  66. The Champagne Tap: Time to Pop the Cork? Acad Emerg Med. 2020 11; 27(11):1194-1198. View Abstract
  67. Performance of the Modified Boston and Philadelphia Criteria for Invasive Bacterial Infections. Pediatrics. 2020 04; 145(4). View Abstract
  68. Development of a pediatric Lyme meningitis symptom measurement instrument using a Delphi technique. Ticks Tick Borne Dis. 2020 07; 11(4):101418. View Abstract
  69. Research Interest in Pediatric Emergency Medicine Fellows. Pediatr Emerg Care. 2020 Feb; 36(2):e38-e42. View Abstract
  70. Application of the Bacterial Meningitis Score for Infants Aged 0 to 60 Days. J Pediatric Infect Dis Soc. 2019 Dec 27; 8(6):559-562. View Abstract
  71. Diagnostic Performance of C6 Enzyme Immunoassay for Lyme Arthritis. Pediatrics. 2020 01; 145(1). View Abstract
  72. The Lyme Disease Polymerase Chain Reaction Test Has Low Sensitivity. Vector Borne Zoonotic Dis. 2020 04; 20(4):310-313. View Abstract
  73. A Bayesian Spatiotemporal Analysis of Pediatric Group A Streptococcal Infections. Open Forum Infect Dis. 2019 Dec; 6(12):ofz524. View Abstract
  74. Children With Minor Blunt Head Trauma Presenting to the Emergency Department. Pediatrics. 2019 12; 144(6). View Abstract
  75. What is the effect of a decision aid in potentially vulnerable parents? Insights from the head CT choice randomized trial. Health Expect. 2020 02; 23(1):63-74. View Abstract
  76. Provider-Level and Hospital-Level Factors and Process Measures of Quality Care Delivered in Pediatric Emergency Departments. Acad Pediatr. 2020 May - Jun; 20(4):524-531. View Abstract
  77. Cerebrospinal Fluid Profiles of Infants =60 Days of Age With Bacterial Meningitis. Hosp Pediatr. 2019 12; 9(12):979-982. View Abstract
  78. Evaluation of the Modified Two-Tiered Testing Method for Diagnosis of Lyme Disease in Children. J Clin Microbiol. 2019 10; 57(10). View Abstract
  79. Parenteral Antibiotic Therapy Duration in Young Infants With Bacteremic Urinary Tract Infections. Pediatrics. 2019 09; 144(3). View Abstract
  80. State of the Journal: Women First Authors, Peer Reviewers, and Editorial Board Members at Annals of Emergency Medicine. Ann Emerg Med. 2019 12; 74(6):731-735. View Abstract
  81. A Prediction Model to Identify Febrile Infants =60 Days at Low Risk of Invasive Bacterial Infection. Pediatrics. 2019 07; 144(1). View Abstract
  82. Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants =60 Days of Age Undergoing Evaluation for Meningitis. J Hosp Med. 2019 08 01; 14(8):492-495. View Abstract
  83. Positive 2-Tiered Lyme Disease Serology is Uncommon in Asymptomatic Children Living in Endemic Areas of the United States. Pediatr Infect Dis J. 2019 05; 38(5):e105-e107. View Abstract
  84. Systematic review and meta-analysis found significant risk of brain injury and neurosurgery in alert children after a post-traumatic seizure. Acta Paediatr. 2019 10; 108(10):1841-1849. View Abstract
  85. A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections. JAMA Pediatr. 2019 04 01; 173(4):342-351. View Abstract
  86. A minority of children diagnosed with Lyme disease recall a preceding tick bite. Ticks Tick Borne Dis. 2019 04; 10(3):694-696. View Abstract
  87. Impact of a Resident Research Grant on Scholarly Output During Pediatric Residency. Acad Pediatr. 2019 May - Jun; 19(4):477-479. View Abstract
  88. Application of the Rochester Criteria to Identify Febrile Infants With Bacteremia and Meningitis. Pediatr Emerg Care. 2019 Jan; 35(1):22-27. View Abstract
  89. Higher C6 enzyme immunoassay index values correlate with a diagnosis of noncutaneous Lyme disease. Diagn Microbiol Infect Dis. 2019 Jun; 94(2):160-164. View Abstract
  90. Pediatric Emergency Care Research Networks: A Research Agenda. Acad Emerg Med. 2018 12; 25(12):1336-1344. View Abstract
  91. Oral Ondansetron to Reduce Intravenous Fluid Rehydration: Context Matters. Ann Emerg Med. 2019 03; 73(3):266-268. View Abstract
  92. Risk Stratification of Febrile Infants =60 Days Old Without Routine Lumbar Puncture. Pediatrics. 2018 12; 142(6). View Abstract
  93. C-reactive protein or erythrocyte sedimentation rate results reliably exclude invasive bacterial infections. Am J Emerg Med. 2019 08; 37(8):1510-1515. View Abstract
  94. Validating a Clinical Prediction Rule for Ventricular Shunt Malfunction. Pediatr Emerg Care. 2018 Nov; 34(11):751-756. View Abstract
  95. Effect of the Head Computed Tomography Choice Decision Aid in Parents of Children With Minor Head Trauma: A Cluster Randomized Trial. JAMA Netw Open. 2018 09 07; 1(5):e182430. View Abstract
  96. A Brush with Danger. Clin Pract Cases Emerg Med. 2018 Nov; 2(4):373-374. View Abstract
  97. Time to Pathogen Detection for Non-ill Versus Ill-Appearing Infants =60 Days Old With Bacteremia and Meningitis. Hosp Pediatr. 2018 07; 8(7):379-384. View Abstract
  98. A method to identify pediatric high-risk diagnoses missed in the emergency department. Diagnosis (Berl). 2018 Jun 27; 5(2):63-69. View Abstract
  99. Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis. N Engl J Med. 2018 Jun 14; 378(24):2275-2287. View Abstract
  100. Accuracy of Herpes Simplex Virus Polymerase Chain Reaction Testing of the Blood for Central Nervous System Herpes Simplex Virus Infections in Infants. J Pediatr. 2018 09; 200:274-276.e1. View Abstract
  101. Epidemiology and Etiology of Invasive Bacterial Infection in Infants =60 Days Old Treated in Emergency Departments. J Pediatr. 2018 09; 200:210-217.e1. View Abstract
  102. Would Parents Consent to a Comparative Effectiveness Trial of Oral Doxycycline Versus Intravenous Ceftriaxone for the Treatment of Children with Lyme Meningitis? Pediatr Infect Dis J. 2018 05; 37(5):e140-e142. View Abstract
  103. Hip Synovial Fluid Cell Counts in Children From a Lyme Disease Endemic Area. Pediatrics. 2018 05; 141(5). View Abstract
  104. Teaching Incision and Drainage: Perceived Educational Value of Abscess Models. Pediatr Emerg Care. 2018 Mar; 34(3):174-178. View Abstract
  105. Evaluation of a sequential enzyme immunoassay testing algorithm for Lyme disease demonstrates lack of test independence but high diagnostic specificity. Diagn Microbiol Infect Dis. 2018 Jul; 91(3):217-219. View Abstract
  106. Cerebrospinal Fluid Reference Values for Young Infants Undergoing Lumbar Puncture. Pediatrics. 2018 03; 141(3). View Abstract
  107. Herpes Simplex Virus Infection in Infants Undergoing Meningitis Evaluation. Pediatrics. 2018 02; 141(2). View Abstract
  108. Patient-level Factors and the Quality of Care Delivered in Pediatric Emergency Departments. Acad Emerg Med. 2018 03; 25(3):301-309. View Abstract
  109. Accuracy of Clinician Suspicion of Lyme Disease in the Emergency Department. Pediatrics. 2017 Dec; 140(6). View Abstract
  110. A Systematic Review and Meta-Analysis of the Management and Outcomes of Isolated Skull Fractures in Children. Ann Emerg Med. 2018 06; 71(6):714-724.e2. View Abstract
  111. Implicit Review Instrument to Evaluate Quality of Care Delivered by Physicians to Children in Emergency Departments. Health Serv Res. 2018 06; 53(3):1316-1334. View Abstract
  112. Accuracy of Complete Blood Cell Counts to Identify Febrile Infants 60 Days or Younger With Invasive Bacterial Infections. JAMA Pediatr. 2017 11 06; 171(11):e172927. View Abstract
  113. Managing Peripheral Facial Palsy. Ann Emerg Med. 2018 May; 71(5):618-624. View Abstract
  114. Educational Initiative to Standardize Concussion Management in Pediatric Primary Care. Clin Pediatr (Phila). 2018 06; 57(7):806-814. View Abstract
  115. X Marks the Spot (or Does It?): Ultrasonography-Assisted Site Marking for Lumbar Puncture in Children: Answers to the May 2017 Journal Club Questions. Ann Emerg Med. 2017 Oct; 70(4):592-596. View Abstract
  116. Correction of Cerebrospinal Fluid Protein in Infants With Traumatic Lumbar Punctures. Pediatr Infect Dis J. 2017 Oct; 36(10):1006-1008. View Abstract
  117. Concomitant Bacterial Meningitis in Infants With Urinary Tract Infection. Pediatr Infect Dis J. 2017 09; 36(9):908-910. View Abstract
  118. Utility of Lumbar Puncture in Children Presenting With Status Epilepticus. Pediatr Emerg Care. 2017 Aug; 33(8):544-547. View Abstract
  119. Empiric Antibiotic Use and Susceptibility in Infants With Bacterial Infections: A Multicenter Retrospective Cohort Study. Hosp Pediatr. 2017 Jul 20. View Abstract
  120. Impact of Enteroviral Polymerase Chain Reaction Testing on Length of Stay for Infants 60 Days Old or Younger. J Pediatr. 2017 10; 189:169-174.e2. View Abstract
  121. The Yale Observation Scale Score and the Risk of Serious Bacterial Infections in Febrile Infants. Pediatrics. 2017 Jul; 140(1). View Abstract
  122. The Yale Observation Scale Score and the Risk of Serious Bacterial Infections in Febrile Infants. Pediatrics. 2017 Jun 06. View Abstract
  123. Diagnostic Lumbar Puncture Among Children With Facial Palsy in a Lyme Disease Endemic Area. J Pediatric Infect Dis Soc. 2017 Jun 01; 6(2):205-208. View Abstract
  124. X Marks the Spot (or Does It?): Ultrasonography-Assisted Site Marking for Lumbar Puncture in Children: May 2017 Annals of Emergency Medicine Journal Club. Ann Emerg Med. 2017 May; 69(5):657-658. View Abstract
  125. Research priorities for a multi-center child abuse network: Lessons learned from pediatric emergency medicine networks. Child Abuse Negl. 2017 08; 70:414-416. View Abstract
  126. Evaluation of Modified 2-Tiered Serodiagnostic Testing Algorithms for Early Lyme Disease. Clin Infect Dis. 2017 04 15; 64(8):1074-1080. View Abstract
  127. Complexity and Severity of Pediatric Patients Treated at United States Emergency Departments. J Pediatr. 2017 07; 186:145-149.e1. View Abstract
  128. Geographic Expansion of Lyme Disease in Michigan, 2000-2014. Open Forum Infect Dis. 2017; 4(1):ofw269. View Abstract
  129. Interpretation of Cerebrospinal Fluid White Blood Cell Counts in Young Infants With a Traumatic Lumbar Puncture. Ann Emerg Med. 2017 May; 69(5):622-631. View Abstract
  130. Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger. JAMA. 2016 Aug 23-30; 316(8):846-57. View Abstract
  131. Evaluation of the C6 Lyme Enzyme Immunoassay for the Diagnosis of Lyme Disease in Children and Adolescents. Clin Infect Dis. 2016 10 01; 63(7):922-8. View Abstract
  132. Diagnosis of Lyme disease in the pediatric acute care setting. Curr Opin Pediatr. 2016 06; 28(3):287-93. View Abstract
  133. A QI Initiative to Reduce Hospitalization for Children With Isolated Skull Fractures. Pediatrics. 2016 06; 137(6). View Abstract
  134. False Positive Lyme Disease IgM Immunoblots in Children. J Pediatr. 2016 Jul; 174:267-269.e1. View Abstract
  135. Efficacy of an Interinstitutional Mentoring Program Within Pediatric Rheumatology. Arthritis Care Res (Hoboken). 2016 05; 68(5):645-51. View Abstract
  136. Validation of the bacterial meningitis score in adults presenting to the ED with meningitis. Am J Emerg Med. 2016 Jul; 34(7):1265-7. View Abstract
  137. Yield of emergent neuroimaging in children with new-onset seizure and status epilepticus. Seizure. 2016 Feb; 35:4-10. View Abstract
  138. The Positive Predictive Value of Lyme Elisa for the Diagnosis of Lyme Disease in Children. Pediatr Infect Dis J. 2015 Nov; 34(11):1260-2. View Abstract
  139. Pediatric Emergency Care Applied Research Network head injury clinical prediction rules are reliable in practice. Postgrad Med J. 2015 Nov; 91(1081):634-8. View Abstract
  140. Geographic Expansion of Lyme Disease in the Southeastern United States, 2000-2014. Open Forum Infect Dis. 2015 Dec; 2(4):ofv143. View Abstract
  141. Accuracy of diagnosis codes to identify febrile young infants using administrative data. J Hosp Med. 2015 Dec; 10(12):787-93. View Abstract
  142. Motor Vehicle Crash Fatalities in States With Primary Versus Secondary Seat Belt Laws: A Time-Series Analysis. Ann Intern Med. 2015 Aug 04; 163(3):184-90. View Abstract
  143. Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence. Clin Infect Dis. 2015 Nov 01; 61(9):1374-80. View Abstract
  144. Quality Improvement Effort to Reduce Cranial CTs for Children With Minor Blunt Head Trauma. Pediatrics. 2015 Jul; 136(1):e227-33. View Abstract
  145. Trends in Ambulatory Care for Children with Concussion and Minor Head Injury from Eastern Massachusetts between 2007 and 2013. J Pediatr. 2015 Sep; 167(3):738-44. View Abstract
  146. Radiographic evaluation of pediatric cerebrospinal fluid shunt malfunction in the emergency setting. Pediatr Emerg Care. 2015 Jun; 31(6):435-40; quiz 441-3. View Abstract
  147. Association of clinical practice guidelines with emergency department management of febrile infants =56 days of age. J Hosp Med. 2015 Jun; 10(6):358-65. View Abstract
  148. The effect of traumatic lumbar puncture on hospitalization rate for febrile infants 28 to 60 days of age. Acad Emerg Med. 2015 Feb; 22(2):240-3. View Abstract
  149. The Yield of Neuroimaging in Children Presenting to the Emergency Department With Acute Ataxia in the Post-Varicella Vaccine Era. J Child Neurol. 2015 Sep; 30(10):1333-9. View Abstract
  150. Sick kids look sick. Ann Emerg Med. 2015 Jun; 65(6):633-5. View Abstract
  151. Variation in care of the febrile young infant <90 days in US pediatric emergency departments. Pediatrics. 2014 Oct; 134(4):667-77. View Abstract
  152. Comparison of rapid cranial MRI to CT for ventricular shunt malfunction. Pediatrics. 2014 Jul; 134(1):e47-54. View Abstract
  153. Incorrect classification in articles about traumatic brain injuries in children with minor blunt head trauma. JAMA Pediatr. 2014 Jun; 168(6):585-6. View Abstract
  154. Pediatric status epilepticus: how common is cerebrospinal fluid pleocytosis in the absence of infection? Seizure. 2014 Aug; 23(7):573-5. View Abstract
  155. Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children. Int J Emerg Med. 2014 Feb 27; 7(1):14. View Abstract
  156. Pediatric Emergency Care Applied Research Network head injury clinical prediction rules are reliable in practice. Arch Dis Child. 2014 May; 99(5):427-31. View Abstract
  157. Synovial fluid findings in children with knee monoarthritis in lyme disease endemic areas. Pediatr Emerg Care. 2014 Jan; 30(1):16-9. View Abstract
  158. Spinal cord injury without radiologic abnormality in children imaged with magnetic resonance imaging. J Trauma Acute Care Surg. 2013 Nov; 75(5):843-7. View Abstract
  159. Characteristics of the pediatric patients treated by the Pediatric Emergency Care Applied Research Network's affiliated EMS agencies. Prehosp Emerg Care. 2014 Jan-Mar; 18(1):52-9. View Abstract
  160. Validation of anaphylaxis in the Food and Drug Administration's Mini-Sentinel. Pharmacoepidemiol Drug Saf. 2013 Nov; 22(11):1205-13. View Abstract
  161. The bacterial meningitis score to distinguish bacterial from aseptic meningitis in children from Sao Paulo, Brazil. Pediatr Infect Dis J. 2013 Sep; 32(9):1026-9. View Abstract
  162. Nurse and physician agreement in the assessment of minor blunt head trauma. Pediatrics. 2013 Sep; 132(3):e689-94. View Abstract
  163. Effect of the duration of emergency department observation on computed tomography use in children with minor blunt head trauma. Ann Emerg Med. 2013 Dec; 62(6):597-603. View Abstract
  164. Informing the design of clinical decision support services for evaluation of children with minor blunt head trauma in the emergency department: a sociotechnical analysis. J Biomed Inform. 2013 Oct; 46(5):905-13. View Abstract
  165. The effect of recommending cognitive rest on recovery from sport-related concussion. Brain Inj. 2013; 27(7-8):839-42. View Abstract
  166. Isolated skull fractures: trends in management in US pediatric emergency departments. Ann Emerg Med. 2013 Oct; 62(4):327-31. View Abstract
  167. Enteroviral testing and length of hospital stay for children evaluated for lyme meningitis. J Emerg Med. 2013 Jun; 44(6):1196-200. View Abstract
  168. Trends in the management of viral meningitis at United States children's hospitals. Pediatrics. 2013 Apr; 131(4):670-6. View Abstract
  169. Distinguishing Lyme from septic knee monoarthritis in Lyme disease-endemic areas. Pediatrics. 2013 Mar; 131(3):e695-701. View Abstract
  170. Aseptic meningitis. Handb Clin Neurol. 2013; 112:1153-6. View Abstract
  171. Booster seat laws and fatalities in children 4 to 7 years of age. Pediatrics. 2012 Dec; 130(6):996-1002. View Abstract
  172. The prevalence of traumatic brain injuries after minor blunt head trauma in children with ventricular shunts. Ann Emerg Med. 2013 Apr; 61(4):389-93. View Abstract
  173. Treatment complications in children with lyme meningitis. Pediatr Infect Dis J. 2012 Oct; 31(10):1032-5. View Abstract
  174. Pediatric traumatic brain injury and radiation risks: a clinical decision analysis. J Pediatr. 2013 Feb; 162(2):392-7. View Abstract
  175. Electrocardiograph Abnormalities in Children With Lyme Meningitis. J Pediatric Infect Dis Soc. 2012 Dec; 1(4):293-8. View Abstract
  176. Meta-analysis of bacterial meningitis score validation studies. Arch Dis Child. 2012 Sep; 97(9):799-805. View Abstract
  177. Impact of in-hospital enteroviral polymerase chain reaction testing on the clinical management of children with meningitis. J Hosp Med. 2012 Sep; 7(7):517-20. View Abstract
  178. Predictors of ventricular shunt infection among children presenting to a pediatric emergency department. Pediatr Emerg Care. 2012 May; 28(5):405-9. View Abstract
  179. Utility of plain radiographs in detecting traumatic injuries of the cervical spine in children. Pediatr Emerg Care. 2012 May; 28(5):426-32. View Abstract
  180. Factors influencing neurological outcome of children with bacterial meningitis at the emergency department. Eur J Pediatr. 2012 Sep; 171(9):1365-71. View Abstract
  181. Rapid sequence intubation for pediatric emergency patients: higher frequency of failed attempts and adverse effects found by video review. Ann Emerg Med. 2012 Sep; 60(3):251-9. View Abstract
  182. Adjustment of cerebrospinal fluid protein for red blood cells in neonates and young infants. J Hosp Med. 2012 Apr; 7(4):325-8. View Abstract
  183. Relationship between cerebrospinal fluid glucose and serum glucose. N Engl J Med. 2012 Feb 09; 366(6):576-8. View Abstract
  184. Validation of a clinical prediction rule to distinguish Lyme meningitis from aseptic meningitis. Pediatrics. 2012 Jan; 129(1):e46-53. View Abstract
  185. Prevalence of clinically important traumatic brain injuries in children with minor blunt head trauma and isolated severe injury mechanisms. Arch Pediatr Adolesc Med. 2012 Apr; 166(4):356-61. View Abstract
  186. Factors associated with the use of cervical spine computed tomography imaging in pediatric trauma patients. Acad Emerg Med. 2011 Sep; 18(9):905-11. View Abstract
  187. The effect of observation on cranial computed tomography utilization for children after blunt head trauma. Pediatrics. 2011 Jun; 127(6):1067-73. View Abstract
  188. Correction of cerebrospinal fluid protein for the presence of red blood cells in children with a traumatic lumbar puncture. J Pediatr. 2011 Jul; 159(1):158-9. View Abstract
  189. Integrating spatial epidemiology into a decision model for evaluation of facial palsy in children. Arch Pediatr Adolesc Med. 2011 Jan; 165(1):61-7. View Abstract
  190. Low risk of bacterial meningitis in children with a positive enteroviral polymerase chain reaction test result. Clin Infect Dis. 2010 Nov 15; 51(10):1221-2. View Abstract
  191. Factors associated with cervical spine injury in children after blunt trauma. Ann Emerg Med. 2011 Aug; 58(2):145-55. View Abstract
  192. Use of population health data to refine diagnostic decision-making for pertussis. J Am Med Inform Assoc. 2010 Jan-Feb; 17(1):85-90. View Abstract
  193. Diagnostic value of immature neutrophils (bands) in the cerebrospinal fluid of children with cerebrospinal fluid pleocytosis. Pediatrics. 2009 Jun; 123(6):e967-71. View Abstract
  194. Cerebrospinal fluid pleocytosis in children in the era of bacterial conjugate vaccines: distinguishing the child with bacterial and aseptic meningitis. Pediatr Emerg Care. 2009 Feb; 25(2):112-7; quiz 118-20. View Abstract
  195. Clinical predictors of Lyme disease among children with a peripheral facial palsy at an emergency department in a Lyme disease-endemic area. Pediatrics. 2008 Nov; 122(5):e1080-5. View Abstract
  196. Effect of antibiotic pretreatment on cerebrospinal fluid profiles of children with bacterial meningitis. Pediatrics. 2008 Oct; 122(4):726-30. View Abstract
  197. Tularemia. Infect Dis Clin North Am. 2008 Sep; 22(3):489-504, ix. View Abstract
  198. Children with bacterial meningitis presenting to the emergency department during the pneumococcal conjugate vaccine era. Acad Emerg Med. 2008 Jun; 15(6):522-8. View Abstract
  199. Cerebrospinal fluid xanthochromia in newborns is related to maternal labor before delivery. Pediatrics. 2007 Nov; 120(5):e1212-6. View Abstract
  200. Lumbar puncture success rate is not influenced by family-member presence. Pediatrics. 2007 Oct; 120(4):e777-82. View Abstract
  201. Letter in response. Clinical decision rule to identify patients at very low risk of bacterial meningitis. JAMA. 2007; 297(15):1653-1655. View Abstract
  202. Risk factors for traumatic or unsuccessful lumbar punctures in children. Ann Emerg Med. 2007 Jun; 49(6):762-71. View Abstract
  203. Linking surveillance to action: incorporation of real-time regional data into a medical decision rule. J Am Med Inform Assoc. 2007 Mar-Apr; 14(2):206-11. View Abstract
  204. Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis. JAMA. 2007 Jan 03; 297(1):52-60. View Abstract
  205. Patients with juvenile psoriatic arthritis comprise two distinct populations. Arthritis Rheum. 2006 Nov; 54(11):3564-72. View Abstract
  206. The Lyme vaccine: a cautionary tale. Epidemiol Infect. 2007 Jan; 135(1):1-8. View Abstract
  207. Extreme thrombocytosis predicts Kawasaki disease in infants. Clin Pediatr (Phila). 2006 Jun; 45(5):446-52. View Abstract
  208. Cerebrospinal latex agglutination fails to contribute to the microbiologic diagnosis of pretreated children with meningitis. Pediatr Infect Dis J. 2004 Aug; 23(8):786-8. View Abstract
  209. Evaluation of the febrile child 3 to 36 months old in the era of the pneumococcal conjugate vaccine: focus on occult bacteremia. Clin Pediatr Emerg Med. 2004; 49:13-19. View Abstract
  210. Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era. Pediatrics. 2002 Oct; 110(4):712-9. View Abstract
  211. Rotavirus cerebellitis? Clin Infect Dis. 2002 Jan 01; 34(1):130. View Abstract
  212. Introduction. Curr Opin Pediatr. 2001 Feb; 13(1):81. View Abstract
  213. What's new with enteroviral infections? Curr Opin Pediatr. 2001 Feb; 13(1):89-94. View Abstract
  214. Oral and airway sequelae after hair relaxer ingestion. Pediatr Emerg Care. 2001 Feb; 17(1):36-7. View Abstract
  215. Cost analysis of enteroviral polymerase chain reaction in infants with fever and cerebrospinal fluid pleocytosis. Arch Pediatr Adolesc Med. 2000 Aug; 154(8):817-21. View Abstract

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