Research Overview

Linda Dagi, MD, has contributed substantially to the development and refinement of two new surgical techniques for managing strabismus from sixth nerve palsy, Duane syndrome, and third nerve palsy. She has employed high resolution orbital magnetic resonance imaging to demonstrate the anatomical relationships resulting from these procedures.

Dr. Dagi is Principal Investigator for a series of studies designed to compare the ophthalmic impact on patients with unicoronal synostosis treated by endoscopic strip craniectomy and helmeting (ESCH) rather than by fronto-orbital advancement (FOA). This demonstrated that those patients treated with ESCH had reduced astigmatism, amblyopia, and strabismus and a more favorable craniofacial outcome. She also studies complex strabismus in patients with syndromic craniosynostosis or other craniofacial disorders. Through the use of high resolution orbital imaging and 3D modeling she has demonstrated that exaggerated V-pattern strabismus has its origins at the orbital apex. She has studied surveillance of impending optic neuropathy in this population using OCT and prVEP.

As Director of Quality Assurance, she supervises the development of a goal-determined paradigm to evaluate outcomes of surgery for esotropia and exotropia.

Research Background

Linda Dagi received her MD from Harvard University Medical School. She completed an internship at Georgetown University Hospital and fellowships at The National Eye Institute in Bethesda and here at Boston Children’s Hospital.

Education

Undergraduate School

Harvard College
1978 Camrbidge MA

Medical School

Harvard Medical School
1983 Boston MA

Internship

Georgetown University Hospital
1984 Washington DC

Residency

Georgetown University Hospital
1988 Washington DC

Fellowship

Boston Children's Hospital
1989 Boston MA

Media

Caregiver Profile

Meet Dr. Linda Dagi

Publications

  1. Otitic hydrocephalus and papilloedema-re-evaluating a treatment paradigm. Eye (Lond). 2024 Nov 19. View Abstract
  2. A Comparison of Chemodnervation to Incisional Surgery for Acute, Acquired, Comitant Esotropia: An International Study. Am J Ophthalmol. 2024 07; 263:160-167. View Abstract
  3. Adult Strabismus Preferred Practice Pattern®. Ophthalmology. 2024 Apr; 131(4):P306-P403. View Abstract
  4. The Incidence of Strabismus After Upper and Lower Blepharoplasty in the United States. Ophthalmic Plast Reconstr Surg. 2024 Jul-Aug 01; 40(4):449-452. View Abstract
  5. Optic neuropathy in craniosynostosis. Front Ophthalmol (Lausanne). 2023; 3:1303723. View Abstract
  6. Correlation of Strabismus Surgical Outcomes Graded by Goal-Determined Metric With Patient Satisfaction Survey. Am J Ophthalmol. 2024 04; 260:140-146. View Abstract
  7. Sensitivity, Specificity, and Cutoff Identifying Optic Atrophy by Macular Ganglion Cell Layer Volume in Syndromic Craniosynostosis. Ophthalmology. 2024 Mar; 131(3):341-348. View Abstract
  8. Ophthalmic Manifestations of Unilateral Coronal Synostosis. Curr Eye Res. 2023 10; 48(10):879-886. View Abstract
  9. Orbital and Eyelid Characteristics, Strabismus, and Intracranial Pressure Control in Apert Children Treated by Endoscopic Strip Craniectomy versus Fronto-Orbital Advancement. Plast Reconstr Surg Glob Open. 2023 May; 11(5):e4937. View Abstract
  10. Aberrant regeneration in an international registry of patients with 3rd-nerve palsy. Eur J Ophthalmol. 2023 Nov; 33(6):2154-2161. View Abstract
  11. Two siblings with GAPO syndrome: Ophthalmic presentation and histopathologic findings. Ophthalmic Genet. 2023 Dec; 44(6):598-601. View Abstract
  12. Strategies for managing strabismus from oculomotor nerve palsy. J AAPOS. 2023 02; 27(1):3-9. View Abstract
  13. Extraocular muscle ductions following nasal transposition of the split lateral rectus muscle. Can J Ophthalmol. 2023 12; 58(6):565-569. View Abstract
  14. Relationships among Clinical Factors and Patient-reported Outcome Measures in Adults with Convergence Insufficiency. Optom Vis Sci. 2022 09 01; 99(9):692-701. View Abstract
  15. Nasal Transposition of the Split Lateral Rectus Muscle for Strabismus Associated With Bilateral 3rd-Nerve Palsy. Am J Ophthalmol. 2022 10; 242:165-172. View Abstract
  16. Worldwide outcomes of nasal transposition of the split lateral rectus muscle for strabismus associated with 3rd-nerve palsy. Br J Ophthalmol. 2023 05; 107(5):725-731. View Abstract
  17. Impact of Adding Augmented Superior Rectus Transpositions to Medial Rectus Muscle Recessions When Treating Esotropic Moebius Syndrome. Am J Ophthalmol. 2022 05; 237:83-90. View Abstract
  18. Complication and Management of Optic Nerve Edema Resulting From Nasal Transposition of the Split Lateral Rectus Muscle. J Pediatr Ophthalmol Strabismus. 2021 May-Jun; 58(3):e12-e15. View Abstract
  19. Long-term ophthalmic outcomes in 120 children with unilateral coronal synostosis: a 20-year retrospective analysis. J AAPOS. 2021 04; 25(2):76.e1-76.e5. View Abstract
  20. Definition of successful outcomes after surgery for each type of strabismus: a Delphi study. J AAPOS. 2021 02; 25(1):3.e1-3.e5. View Abstract
  21. Incidence of symptomatic vertical and torsional diplopia after superior rectus transposition for esotropic Duane syndrome and abducens nerve palsy. J AAPOS. 2020 10; 24(5):270.e1-270.e5. View Abstract
  22. Adjustable graded augmentation of superior rectus transposition for treatment of abducens nerve palsy and Duane syndrome. J AAPOS. 2020 10; 24(5):268.e1-268.e7. View Abstract
  23. Self-grading effect of inferior oblique myectomy and recession. J AAPOS. 2020 08; 24(4):218.e1-218.e6. View Abstract
  24. Age at Craniosynostosis Surgery and Its Impact on Ophthalmologic Diagnoses: A Single-Center Retrospective Review. Plast Reconstr Surg. 2020 09; 146(3):375e-376e. View Abstract
  25. Acute, severe dystonia after strabismus surgery in a patient on propofol, ondansetron, and bupropion. J AAPOS. 2020 10; 24(5):312-314. View Abstract
  26. Evaluation and Management of V pattern Strabismus in Craniosynostosis. J Binocul Vis Ocul Motil. 2020 Jan-Mar; 70(1):40-45. View Abstract
  27. Use of the Delphi process for defining successful outcomes for strabismus surgery. J AAPOS. 2019 12; 23(6):309-312. View Abstract
  28. Adult Strabismus Preferred Practice Pattern®. Ophthalmology. 2020 01; 127(1):P182-P298. View Abstract
  29. Unicoronal Synostosis. J Pediatr. 2019 10; 213:243-243.e1. View Abstract
  30. Impact of Obstructive Sleep Apnea on Optic Nerve Function in Patients With Craniosynostosis and Recurrent Intracranial Hypertension. Am J Ophthalmol. 2019 11; 207:356-362. View Abstract
  31. Nonsyndromic Unilateral Coronal Synostosis: A Comparison of Fronto-Orbital Advancement and Endoscopic Suturectomy. Plast Reconstr Surg. 2019 03; 143(3):838-848. View Abstract
  32. "Plugged In". Orbit. 2020 Feb; 39(1):73-74. View Abstract
  33. Commentary: Ernest Codman and the Impact of Quality Improvement in Neurosurgery: A Century Since the Idea of the "End Result". Neurosurgery. 2019 02 01; 84(2):E120-E121. View Abstract
  34. Acquired reversible Brown syndrome caused by focal abscess of the superior oblique muscle. J AAPOS. 2019 06; 23(3):172-174. View Abstract
  35. Consecutive superior oblique palsy after adjustable suture spacer surgery for Brown syndrome: incidence and predicting risk. J AAPOS. 2018 10; 22(5):335-339.e2. View Abstract
  36. Management of graves myopathy: Understanding and managing vertical strabismus from thyroid eye disease. J AAPOS. 2018 08; 22(4):252-255. View Abstract
  37. A case of Graves' ophthalmopathy associated with pembrolizumab (Keytruda) therapy. J AAPOS. 2018 08; 22(4):310-312. View Abstract
  38. A Retrospective Review of Orbital Decompression for Thyroid Orbitopathy with Endoscopic Preservation of the Inferomedial Orbital Bone Strut. Ophthalmic Plast Reconstr Surg. 2017 Sep/Oct; 33(5):334-339. View Abstract
  39. Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura. Dev Cell. 2017 09 11; 42(5):445-461.e5. View Abstract
  40. Central serous chorioretinopathy following medial transposition of split lateral rectus muscle for complete oculomotor nerve palsy. J AAPOS. 2017 12; 21(6):517-518. View Abstract
  41. ACCIDENTAL DUPLICATION: Pericardial patch Graft Repair of Severe Localized Scleral Thinning Encountered during Strabismus Surgery. J AAPOS. 2017 Jun 01. View Abstract
  42. Patient Characteristics and Surgical Approach Impacting Simultaneous to Alternate Prism Cover Test Disparity After Exotropia Surgery: A Quantitative Look at the Difference in Motor Outcomes. J Pediatr Ophthalmol Strabismus. 2017 Jul 01; 54(4):222-230. View Abstract
  43. Management of Small Vertical Deviations. J Pediatr Ophthalmol Strabismus. 2017 May 01; 54(3):134-136. View Abstract
  44. Pericardial patch graft repair of severe localized scleral thinning encountered during strabismus surgery. J AAPOS. 2017 Apr; 21(2):156-156.e1. View Abstract
  45. Rectus muscle excyclorotation and V-pattern strabismus: a quantitative appraisal of clinical relevance in syndromic craniosynostosis. Br J Ophthalmol. 2017 11; 101(11):1560-1565. View Abstract
  46. Visual Field Loss in a Case of Recurrent Cystic Craniopharyngioma During Concomitant Treatment With Pegylated Interferon a-2b. J Pediatr Hematol Oncol. 2016 Jan; 38(1):e26-8. View Abstract
  47. Goal-determined metrics to assess outcomes of exotropia surgery. J AAPOS. 2015 Aug; 19(4):304-10. View Abstract
  48. Using spectral-domain optical coherence tomography to detect optic neuropathy in patients with craniosynostosis. J AAPOS. 2014 Dec; 18(6):543-9. View Abstract
  49. Iatrogenic inferior oblique palsy: intentional disinsertion during transcaruncular approach to orbital fracture repair. J AAPOS. 2014 Oct; 18(5):511-4. View Abstract
  50. Adjustable nasal transposition of split lateral rectus muscle for third nerve palsy. JAMA Ophthalmol. 2014 Aug; 132(8):963-9. View Abstract
  51. Superior rectus transposition vs medial rectus recession for treatment of esotropic Duane syndrome. JAMA Ophthalmol. 2014 Jun; 132(6):669-75. View Abstract
  52. Goal-determined metrics to assess outcomes of esotropia surgery. J AAPOS. 2014 Jun; 18(3):211-6. View Abstract
  53. A 50-year-old man with a long-standing, large-angle exotropia and limitation of adduction in the left eye. Digit J Ophthalmol. 2013; 19(4):64-7. View Abstract
  54. Screw implantation in the globe: the risk of delayed hardware migration from craniofacial repair. J Craniofac Surg. 2013 Sep; 24(5):1650-2. View Abstract
  55. Improving ophthalmic outcomes in children with unilateral coronal synostosis by treatment with endoscopic strip craniectomy and helmet therapy rather than fronto-orbital advancement. J AAPOS. 2013 Jun; 17(3):259-65. View Abstract
  56. Morning glory disc anomaly in association with ipsilateral optic nerve glioma. Arch Ophthalmol. 2012 Aug; 130(8):1082-3. View Abstract
  57. Associated signs, demographic characteristics, and management of dacryocystocele in 64 infants. J AAPOS. 2012 Jun; 16(3):255-60. View Abstract
  58. Superior rectus transposition and medial rectus recession for Duane syndrome and sixth nerve palsy. Arch Ophthalmol. 2012 Feb; 130(2):195-201. View Abstract
  59. Papilledema in the setting of x-linked hypophosphatemic rickets with craniosynostosis. Case Rep Ophthalmol. 2011 Sep; 2(3):376-81. View Abstract
  60. Amniotic membrane implantation to reduce extraocular muscle adhesions to a titanium implant. J AAPOS. 2011 Aug; 15(4):404-6. View Abstract
  61. Effect of age on response to amblyopia treatment in children. Arch Ophthalmol. 2011 Nov; 129(11):1451-7. View Abstract
  62. Thyroid eye disease: honing your skills to improve outcomes. J AAPOS. 2010 Oct; 14(5):425-31. View Abstract
  63. Amblyopia. PIER American College of Physicians . 2010. View Abstract
  64. Thyroid eye disease: Honing your skills to improve outcomes. JAAPOS. 2010; In press. View Abstract
  65. Treatment of unilateral coronal synostosis by endoscopic strip craniectomy or fronto-orbital advancement: Ophthalmologic findings. J AAPOS. 2009 Apr; 13(2):155-60. View Abstract
  66. Outcomes of treatment of nasolacrimal duct obstruction in children with down syndrome. JAAPOS. 2009; 13(1):e21-22. View Abstract
  67. Managing Graves Orbitopathy: Honing Your Skills to Improve Outcomes. JAAPOS. 2009; 13(1):e33. View Abstract
  68. Interobserver reliability of the prism and alternate cover test in children with esotropia. Arch Ophthalmol. 2009; 127(1):59-65. View Abstract
  69. Ocular misalignment in Graves disease may mimic that of superior oblique palsy. J Neuroophthalmol. 2008 Dec; 28(4):302-4. View Abstract
  70. Instability of ocular alignment in childhood esotropia. Ophthalmology. 2008 Dec; 115(12):2266-2274.e4. View Abstract
  71. Pediatric graves' orbitopathy: The pre- and post-pubertal experience. JAAPOS. 2008; 12(4):357-60. View Abstract
  72. Visual Outcomes in Pediatric Pseudotumor Cerebri. American Association of Pediatric Ophthalmology and Strabismus April 2008. 2008. View Abstract
  73. Endoscopic Strip Craniectomy for Unilateral Coronal Synostosis: Impact on the Evolution of Strabismus. American Association of Pediatric Ophthalmology and Strabismus April 2008. 2008. View Abstract
  74. Pediatric Graves' ophthalmopathy: the pre- and postpubertal experience. J AAPOS. 2008 Aug; 12(4):357-60. View Abstract
  75. Transient monocular vision loss from acute rheumatic fever. Pediatr Cardiol. 2008 Sep; 29(5):966-8. View Abstract
  76. The etiology of V pattern strabismus in patients with craniosynostosis. Int Ophthalmol Clin. 2008; 48(2):215-23. View Abstract
  77. Complex Strabismus (Chapter 318). Principals and Practice of Ophthalmology, eds Albert and Miller. 2008; 4(3rd edition):4345-4356. View Abstract
  78. Astigmatism in unilateral coronal synostosis: incidence and laterality. J AAPOS. 2007 Aug; 11(4):367-72. View Abstract
  79. Stability of visual acuity improvement following discontinuation of amblyopia treatment in children 7 to 12 years old. Arch Ophthalmol. 2007; 125:655-659. View Abstract
  80. Visual Outcomes in Pediatric Pseudotumor Cerebri. . American Academy of Ophthalmology November 2006 . 2006. View Abstract
  81. Anterior axial lens subluxation, progressive myopia, and angle-closure glaucoma: recognition and treatment of atypical presentation of ectopia lentis. J AAPOS. 2006 Aug; 10(4):345-50. View Abstract
  82. Preferred Practice Guidelines; Idiopathic Intracranial Hypertension/ Pseudotumor Cerebri. 2006. View Abstract
  83. Incidence and Laterality of Astigmatism in Unilateral Coronal Synostosis . American Association of Pediatric Ophthalmology and Strabismus March 2005. 2005. View Abstract
  84. Randomized trial of treatment of amblyopia in children ages 7 to 17 years. . Arch Ophthalmol. 2005; 123:437-47. View Abstract
  85. Axial Ectopia Lentis with Synechial Angle Closure in a New Connective Tissue Disorder. American Association of Pediatric Ophthalmology and Strabismus March 2002. 2002. View Abstract
  86. Ophthalmic Manifestations of Bear-Stevenson Syndrome. American Association of Pediatric Ophthalmology and Strabismus April 1993. 1993. View Abstract
  87. Perinatal and Early Infantile Presentation of Familial Exudative Vitreo-Retinopathy. American Association of Pediatric Ophthalmology and Strabismus February 1992. 1992. View Abstract
  88. The Evaluation and Treatment of Secondary Optic Atrophy Associated with Craniofacial Abnormalities. Acta, Second International Congress of the Society of Cranio-Maxillo-Facial Surgery. 1991; 449-453. View Abstract
  89. The evaluation and treatment of secondary optic atrophy associated with craniofacial abnormalities. Act, Second International Congress of the Society of Cranio-Maxillo-Facial Surgery. 1991; 449-453. View Abstract
  90. Arrangement of ocular dominance columns in human visual cortex. Arch Ophthalmol. 1990 Jul; 108(7):1025-31. View Abstract
  91. Hyperopia in complicated Leber's congenital amaurosis. Arch Ophthalmol. 1990 May; 108(5):709-12. View Abstract
  92. Hyperopia as a Feature of Complicated and Uncomplicated Leber's Congenital Amaurosis. American Association of Pediatric Ophthalmology and Strabismus April 1989. 1989. View Abstract
  93. Observations on the Tradition of Autoexperimentation in Medicine. The Use of Human Beings in Research with Special Reference to Clinical Trials; eds Spicker,S, Alon, A, DeVries, HT, Englehardt,JR. 1988; 249-260. View Abstract
  94. Ocular Dominance Columns in Human Visual Cortex. NANOS February 1988. 1988. View Abstract
  95. Spasm of the near reflex associated with organic disease. Am J Ophthalmol. 1987 Apr 15; 103(4):582-5. View Abstract
  96. Spasm of the Near Reflex Associated with Organic Disease. Association for Research in Vision and Ophthalmology June 1987. 1987. View Abstract
  97. Branch retinal artery occlusion in the Churg-Strauss syndrome. J Clin Neuroophthalmol. 1985 Dec; 5(4):229-37. View Abstract
  98. Over The Counter Pills that Don't Work. 1983. View Abstract
  99. An Applicant's Guide to the New York City Certificate of Need Process. 1981. View Abstract

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