Leonard Zon

Publications

1. Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP. Cell Stem Cell. 2025 Jan 15. View Abstract
2. Cross-species analyses of thymic mimetic cells reveal evolutionarily ancient origins and both conserved and species-specific elements. Immunity. 2025 01 14; 58(1):108-123.e7. View Abstract
3. Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP. Cell Stem Cell. 2025 Jan 02; 32(1):71-85.e5. View Abstract
4. An attractor state zone precedes neural crest fate in melanoma initiation. bioRxiv. 2024 Oct 25. View Abstract
5. Craters on the melanoma surface facilitate tumor-immune interactions and demonstrate pathologic response to checkpoint blockade in humans. bioRxiv. 2024 Sep 19. View Abstract
6. MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species. Sci Rep. 2024 09 14; 14(1):21527. View Abstract
7. Leukemia-derived apelin selects endothelial niche clones to promote tumorigenesis. bioRxiv. 2024 Sep 13. View Abstract
8. Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells. Science. 2024 Sep 13; 385(6714):eadn1629. View Abstract
9. A conserved transcription factor regulatory program promotes tendon fate. Dev Cell. 2024 Dec 02; 59(23):3106-3123.e12. View Abstract
10. Role of RNA modifications in blood development and regeneration. Exp Hematol. 2024 Oct; 138:104279. View Abstract
11. BF170 hydrochloride enhances the emergence of hematopoietic stem and progenitor cells. Development. 2024 Jul 01; 151(13). View Abstract
12. A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma. Elife. 2024 Jun 14; 13. View Abstract
13. T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation. Cancer Cell. 2024 Jun 10; 42(6):1130-1131. View Abstract
14. Hematopoietic stem cell division is governed by distinct RUNX1 binding partners. bioRxiv. 2024 Jun 08. View Abstract
15. Specific oncogene activation of the cell of origin in mucosal melanoma. bioRxiv. 2024 Apr 26. View Abstract
16. Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev. 2024 Mar 01; 38(5-6):289. View Abstract
17. Colorimetric Barcoding to Track, Isolate, and Analyze Hematopoietic Stem Cell Clones. Methods Mol Biol. 2024; 2707:265-277. View Abstract
18. G-CSF-induced hematopoietic stem cell mobilization from the embryonic hematopoietic niche does not require neutrophils and macrophages. Exp Hematol. 2024 Mar; 131:104147. View Abstract
19. MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species. bioRxiv. 2023 Nov 14. View Abstract
20. Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science. 2023 09 22; 381(6664):1331-1337. View Abstract
21. Transcription factors interact with RNA to regulate genes. Mol Cell. 2023 07 20; 83(14):2449-2463.e13. View Abstract
22. Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C. Cell Rep. 2023 05 30; 42(5):112528. View Abstract
23. PGE2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2220613120. View Abstract
24. Transcription factor induction of vascular blood stem cell niches in vivo. Dev Cell. 2023 06 19; 58(12):1037-1051.e4. View Abstract
25. Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science. 2023 04 21; 380(6642):eabn7625. View Abstract
26. Identification of unique a4 chain structure and conserved antiangiogenic activity of a3NC1 type IV collagen in zebrafish. Dev Dyn. 2023 07; 252(7):1046-1060. View Abstract
27. Transplantation-based screen identifies inducers of muscle progenitor cell engraftment across vertebrate species. Cell Rep. 2023 04 25; 42(4):112365. View Abstract
28. Clonal hematopoiesis and inflammation - the perpetual cycle. Trends Cell Biol. 2023 08; 33(8):695-707. View Abstract
29. The effects of intensive feeding on reproductive performance in laboratory zebrafish (Danio rerio). PLoS One. 2022; 17(11):e0278302. View Abstract
30. Cellular barcoding to decipher clonal dynamics in disease. Science. 2022 10 14; 378(6616):eabm5874. View Abstract
31. Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion. Nat Genet. 2022 12; 54(12):1839-1852. View Abstract
32. Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. Science. 2022 09 23; 377(6613):1413-1419. View Abstract
33. Single-cell analyses reveal early thymic progenitors and pre-B cells in zebrafish. J Exp Med. 2022 09 05; 219(9). View Abstract
34. Modeling Spitz melanoma in zebrafish using sequential mutagenesis. Dis Model Mech. 2022 08 01; 15(8). View Abstract
35. External signals regulate continuous transcriptional states in hematopoietic stem cells. Elife. 2021 12 23; 10. View Abstract
36. Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Science. 2021 Nov 05; 374(6568):768-772. View Abstract
37. Dissecting melanocytes to predict melanoma. Nat Cell Biol. 2021 09; 23(9):930-931. View Abstract
38. In memory of Paul Sylvain Frenette, a pioneering explorer of the hematopoietic stem cell niche who left far too early. Exp Hematol. 2021 Aug 14. View Abstract
39. Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis. Proc Natl Acad Sci U S A. 2021 08 10; 118(32). View Abstract
40. Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 2021 09; 40(38):5718-5729. View Abstract
41. Nucleotide stress responses in neural crest cell fate and melanoma. Cell Cycle. 2021 08; 20(15):1455-1467. View Abstract
42. Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages. Blood Adv. 2021 07 13; 5(13):2673-2686. View Abstract
43. NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021 08 05; 184(16):4268-4283.e20. View Abstract
44. Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials. Nat Rev Drug Discov. 2021 08; 20(8):611-628. View Abstract
45. From development toward therapeutics, a collaborative effort on blood progenitors. Stem Cell Reports. 2021 07 13; 16(7):1674-1685. View Abstract
46. A phase II trial of all-trans retinoic acid (ATRA) in advanced adenoid cystic carcinoma. Oral Oncol. 2021 08; 119:105366. View Abstract
47. Mitochondrial function in development and disease. Dis Model Mech. 2021 06 01; 14(6). View Abstract
48. Cell-specific transcriptional control of mitochondrial metabolism by TIF1? drives erythropoiesis. Science. 2021 05 14; 372(6543):716-721. View Abstract
49. Identification of Basp1 as a novel angiogenesis-regulating gene by multi-model system studies. FASEB J. 2021 05; 35(5):e21404. View Abstract
50. 'Enhancing' red cell fate through epigenetic mechanisms. Curr Opin Hematol. 2021 05 01; 28(3):129-137. View Abstract
51. A uniform format for manuscript submission. Cell. 2021 04 01; 184(7):1654-1656. View Abstract
52. SPRED1 deletion confers resistance to MAPK inhibition in melanoma. J Exp Med. 2021 03 01; 218(3). View Abstract
53. Melanoma models for the next generation of therapies. Cancer Cell. 2021 05 10; 39(5):610-631. View Abstract
54. SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. Elife. 2021 02 02; 10. View Abstract
55. Blood in the water: recent uses of zebrafish to study myeloid biology. Curr Opin Hematol. 2021 01; 28(1):43-49. View Abstract
56. Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits. Nat Genet. 2020 12; 52(12):1333-1345. View Abstract
57. Recurrent co-alteration of HDGF and SETDB1 on chromosome 1q drives cutaneous melanoma progression and poor prognosis. Pigment Cell Melanoma Res. 2021 05; 34(3):641-647. View Abstract
58. Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Sci Transl Med. 2020 10 21; 12(566). View Abstract
59. Impact of COVID-19 Pandemic on Cancer Research. Cancer Cell. 2020 11 09; 38(5):591-593. View Abstract
60. CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23626-23635. View Abstract
61. Cross-species analysis of enhancer logic using deep learning. Genome Res. 2020 12; 30(12):1815-1834. View Abstract
62. A Transgenic System for Rapid Magnetic Enrichment of Rare Embryonic Cells. Zebrafish. 2020 10; 17(5):354-357. View Abstract
63. An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells. Blood. 2020 07 16; 136(3):269-278. View Abstract
64. PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation. Dev Cell. 2020 08 10; 54(3):317-332.e9. View Abstract
65. Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects. Dev Cell. 2020 06 08; 53(5):577-588.e7. View Abstract
66. Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma. Nat Commun. 2020 06 01; 11(1):2718. View Abstract
67. Transcriptome Dynamics of Hematopoietic Stem Cell Formation Revealed Using a Combinatorial Runx1 and Ly6a Reporter System. Stem Cell Reports. 2020 05 12; 14(5):956-971. View Abstract
68. Difference in biophysical properties of cancer-initiating cells in melanoma mutated zebrafish. J Mech Behav Biomed Mater. 2020 07; 107:103746. View Abstract
69. Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis. Cancer Discov. 2020 07; 10(7):980-997. View Abstract
70. Zebrafish patient avatars in cancer biology and precision cancer therapy. Nat Rev Cancer. 2020 05; 20(5):263-273. View Abstract
71. RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Nat Cell Biol. 2020 04; 22(4):372-379. View Abstract
72. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020 01; 577(7792):676-681. View Abstract
73. From blood development to disease: a paradigm for clinical translation. Dis Model Mech. 2020 01 09; 13(1). View Abstract
74. The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development. 2019 12 16; 146(24). View Abstract
75. Use of Zebrafish in Drug Discovery Toxicology. Chem Res Toxicol. 2020 01 21; 33(1):95-118. View Abstract
76. Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. Nat Immunol. 2019 11; 20(11):1481-1493. View Abstract
77. Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment. J Exp Clin Cancer Res. 2019 Sep 13; 38(1):405. View Abstract
78. Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis. ACS Nano. 2019 12 24; 13(12):13853-13865. View Abstract
79. Author Correction: Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 2019 Sep; 573(7772):E1. View Abstract
80. Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1. Immunity. 2019 07 16; 51(1):50-63.e5. View Abstract
81. Modeling Cancer with Flies and Fish. Dev Cell. 2019 05 06; 49(3):317-324. View Abstract
82. AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science. 2019 03 08; 363(6431):1085-1088. View Abstract
83. Improving the visibility of developmental biology: time for induction and specification. Development. 2019 01 16; 146(2). View Abstract
84. Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 2019 05; 156(6):1788-1804.e13. View Abstract
85. Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish. Blood Adv. 2018 12 11; 2(23):3418-3427. View Abstract
86. Stem cell safe harbor: the hematopoietic stem cell niche in zebrafish. Blood Adv. 2018 11 13; 2(21):3063-3069. View Abstract
87. Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Dis Model Mech. 2018 11 05; 11(11). View Abstract
88. Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma. Science. 2018 11 30; 362(6418):1055-1060. View Abstract
89. FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. J Biol Chem. 2018 12 21; 293(51):19797-19811. View Abstract
90. Stu Orkin is a superhero. J Clin Invest. 2018 10 01; 128(10):4213-4217. View Abstract
91. Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma. J Exp Med. 2018 10 01; 215(10):2673-2685. View Abstract
92. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Proc Natl Acad Sci U S A. 2018 09 11; 115(37):9252-9257. View Abstract
93. Making HSCs in vitro: don't forget the hemogenic endothelium. Blood. 2018 09 27; 132(13):1372-1378. View Abstract
94. JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med. 2018 07 02; 215(7):1929-1945. View Abstract
95. Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature. 2018 06; 558(7710):445-448. View Abstract
96. Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion. Dev Biol. 2019 05 15; 449(2):107-114. View Abstract
97. NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells. Nat Commun. 2018 05 08; 9(1):1828. View Abstract
98. Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell. 2018 04 09; 33(4):785. View Abstract
99. RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes. PLoS Genet. 2018 03; 14(3):e1007226. View Abstract
100. Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell. 2018 02 12; 33(2):322-336.e8. View Abstract
101. The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochim Biophys Acta Gene Regul Mech. 2018 Feb; 1861(2):106-116. View Abstract
102. Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis. Br J Haematol. 2018 02; 180(3):420-431. View Abstract
103. PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes. Sci Transl Med. 2017 Nov 15; 9(416). View Abstract
104. Cancer immunotherapy: The dark side of PD-1 receptor inhibition. Nature. 2017 12 07; 552(7683):41-42. View Abstract
105. Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling. Elife. 2017 11 09; 6. View Abstract
106. Loci associated with skin pigmentation identified in African populations. Science. 2017 11 17; 358(6365). View Abstract
107. KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling. Cancer Res. 2017 11 01; 77(21):5820-5830. View Abstract
108. Fishing for answers in precision cancer medicine. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):10306-10308. View Abstract
109. A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. Elife. 2017 08 23; 6. View Abstract
110. Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis. J Exp Med. 2017 Oct 02; 214(10):2817-2827. View Abstract
111. PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo. Exp Hematol. 2017 12; 56:64-68. View Abstract
112. Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment. J Mol Med (Berl). 2017 08; 95(8):809-819. View Abstract
113. Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice. PLoS Genet. 2017 Jun; 13(6):e1006848. View Abstract
114. From fish bowl to bedside: The power of zebrafish to unravel melanoma pathogenesis and discover new therapeutics. Pigment Cell Melanoma Res. 2017 07; 30(4):402-412. View Abstract
115. Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration. Stem Cell Reports. 2017 06 06; 8(6):1465-1471. View Abstract
116. Efficient Transduction of Zebrafish Melanoma Cell Lines and Embryos Using Lentiviral Vectors. Zebrafish. 2017 08; 14(4):379-382. View Abstract
117. Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 2017 05 09; 8(5):1226-1241. View Abstract
118. Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. Elife. 2017 04 07; 6. View Abstract
119. CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. J Exp Med. 2017 04 03; 214(4):1011-1027. View Abstract
120. Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors. Sci Transl Med. 2017 02 08; 9(376). View Abstract
121. EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay. J Exp Med. 2017 03 06; 214(3):623-637. View Abstract
122. Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nat Cell Biol. 2017 01 31; 19(2):142. View Abstract
123. Sorting zebrafish thrombocyte lineage cells with a Cd41 monoclonal antibody enriches hematopoietic stem cell activity. Blood. 2017 03 09; 129(10):1394-1397. View Abstract
124. Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol. 2017; 138:651-679. View Abstract
125. Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet. 2017 Jan 05; 100(1):51-63. View Abstract
126. Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nat Cell Biol. 2017 Jan; 19(1):17-27. View Abstract
127. Aging Hematopoietic Stem Cells Make Their History. Dev Cell. 2016 11 21; 39(4):390-391. View Abstract
128. Development: For cloche the Bell Tolls. Curr Biol. 2016 10 10; 26(19):R890-R892. View Abstract
129. Understanding the regulation of vertebrate hematopoiesis and blood disorders - big lessons from a small fish. FEBS Lett. 2016 Nov; 590(22):4016-4033. View Abstract
130. Transplantation in zebrafish. Methods Cell Biol. 2017; 138:629-647. View Abstract
131. MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell Stem Cell. 2016 12 01; 19(6):784-799. View Abstract
132. Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes. Blood. 2016 10 13; 128(15):1928-1939. View Abstract
133. Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016 07 13; 8(347):347ra93. View Abstract
134. CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development. J Biol Chem. 2016 09 09; 291(37):19558-72. View Abstract
135. Chromatin immunoprecipitation and an open chromatin assay in zebrafish erythrocytes. Methods Cell Biol. 2016; 135:387-412. View Abstract
136. c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Leukemia. 2017 01; 31(1):222-233. View Abstract
137. Generation of Parabiotic Zebrafish Embryos by Surgical Fusion of Developing Blastulae. J Vis Exp. 2016 06 11; (112). View Abstract
138. Engineering Hematopoietic Stem Cells: Lessons from Development. Cell Stem Cell. 2016 06 02; 18(6):707-720. View Abstract
139. Modeling human diseases: an education in interactions and interdisciplinary approaches. Dis Model Mech. 2016 06 01; 9(6):597-600. View Abstract
140. Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies. Dis Model Mech. 2016 07 01; 9(7):811-20. View Abstract
141. Ex vivo tools for the clonal analysis of zebrafish hematopoiesis. Nat Protoc. 2016 May; 11(5):1007-20. View Abstract
142. Tissue-specific gene targeting using CRISPR/Cas9. Methods Cell Biol. 2016; 135:189-202. View Abstract
143. Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Mol Cell. 2016 Apr 07; 62(1):34-46. View Abstract
144. Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4434-9. View Abstract
145. Fish to Learn: Insights into Blood Development and Blood Disorders from Zebrafish Hematopoiesis. Hum Gene Ther. 2016 Apr; 27(4):287-94. View Abstract
146. A Tribute to George Stamatoyannopoulos. Hum Gene Ther. 2016 Apr; 27(4):280-6. View Abstract
147. Embryonic cell culture in zebrafish. Methods Cell Biol. 2016; 133:1-10. View Abstract
148. The Red Light District and Its Effects on Zebrafish Reproduction. Zebrafish. 2016 06; 13(3):226-9. View Abstract
149. GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis. Stem Cell Reports. 2016 Mar 08; 6(3):368-82. View Abstract
150. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science. 2016 Jan 29; 351(6272):aad2197. View Abstract
151. Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. Dev Cell. 2016 Jan 11; 36(1):9-23. View Abstract
152. Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish. Adv Exp Med Biol. 2016; 916:103-24. View Abstract
153. Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells. Cell Stem Cell. 2016 Jan 07; 18(1):73-78. View Abstract
154. Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 2015 Dec 24; 126(26):2811-20. View Abstract
155. Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators. Genom Data. 2015 Dec; 6:199-201. View Abstract
156. Chamber identity programs drive early functional partitioning of the heart. Nat Commun. 2015 Aug 26; 6:8146. View Abstract
157. A Quantitative System for Studying Metastasis Using Transparent Zebrafish. Cancer Res. 2015 10 15; 75(20):4272-4282. View Abstract
158. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug; 17(8):994-1003. View Abstract
159. Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 2015 Jul 23; 523(7561):468-71. View Abstract
160. Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Res. 2015 Aug; 25(8):946-62. View Abstract
161. TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genet. 2015 Jul; 11(7):e1005346. View Abstract
162. A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Leukemia. 2015 Dec; 29(12):2355-65. View Abstract
163. Screening for melanoma resistance genes in vivo. Pigment Cell Melanoma Res. 2015 Jul; 28(4):375-6. View Abstract
164. Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. J Exp Med. 2015 May 04; 212(5):649-63. View Abstract
165. Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. J Exp Med. 2015 May 04; 212(5):633-48. View Abstract
166. A CRISPR/Cas9 vector system for tissue-specific gene disruption in zebrafish. Dev Cell. 2015 Mar 23; 32(6):756-64. View Abstract
167. Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. Elife. 2015 Feb 25; 4. View Abstract
168. DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish. J Hematol Oncol. 2015 Feb 22; 8:15. View Abstract
169. Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. Cell. 2015 Jan 15; 160(1-2):241-52. View Abstract
170. Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood. 2015 Feb 26; 125(9):1418-26. View Abstract
171. A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. Mol Cell Biol. 2015 Mar; 35(5):789-804. View Abstract
172. A comparison of non-integrating reprogramming methods. Nat Biotechnol. 2015 Jan; 33(1):58-63. View Abstract
173. Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res. 2014 Oct; 42(18):11777-91. View Abstract
174. Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2. Exp Cell Res. 2014 Dec 10; 329(2):220-6. View Abstract
175. Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size. Endocrinology. 2014 Oct; 155(10):4069-80. View Abstract
176. From fish tank to bedside in cancer therapy: an interview with Leonard Zon. Dis Model Mech. 2014 Jul; 7(7):735-8. View Abstract
177. Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin. Blood. 2014 Jul 10; 124(2):220-8. View Abstract
178. Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families. Blood. 2014 Jul 03; 124(1):24-32. View Abstract
179. Neural crest development and craniofacial morphogenesis is coordinated by nitric oxide and histone acetylation. Chem Biol. 2014 Apr 24; 21(4):488-501. View Abstract
180. Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Am J Hum Genet. 2014 Apr 03; 94(4):547-58. View Abstract
181. Unexpectedly uneven: posttransplant skeletal distribution of hematopoietic stem cell clones. J Exp Med. 2014 Mar 10; 211(3):384-5. View Abstract
182. Translational research: the path for bringing discovery to patients. Cell Stem Cell. 2014 Feb 06; 14(2):146-8. View Abstract
183. Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development. PLoS Genet. 2014 Jan; 10(1):e1004074. View Abstract
184. A non-canonical function of telomerase RNA in the regulation of developmental myelopoiesis in zebrafish. Nat Commun. 2014; 5:3228. View Abstract
185. Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development. 2014 Jan; 141(1):224-35. View Abstract
186. Of fish and men: using zebrafish to fight human diseases. Trends Cell Biol. 2013 Dec; 23(12):584-6. View Abstract
187. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nat Cell Biol. 2013 Dec; 15(12):1516-25. View Abstract
188. A Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis. Stem Cell Reports. 2013; 1(5):425-36. View Abstract
189. A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species. Cell. 2013 Nov 07; 155(4):909-921. View Abstract
190. zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish. Development. 2013 Dec; 140(24):4988-97. View Abstract
191. The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance. Blood. 2013 Dec 05; 122(24):3918-28. View Abstract
192. Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell. 2013 Oct 03; 13(4):459-70. View Abstract
193. Zebrafish cancer: the state of the art and the path forward. Nat Rev Cancer. 2013 Sep; 13(9):624-36. View Abstract
194. Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood. 2013 Oct 24; 122(17):3074-81. View Abstract
195. Assaying hematopoiesis using zebrafish. Blood Cells Mol Dis. 2013 Dec; 51(4):271-6. View Abstract
196. Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system. Dev Dyn. 2013 Aug; 242(8):949-963. View Abstract
197. Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis. Development. 2013 Jul; 140(14):3040-50. View Abstract
198. Hematopoiesis. Development. 2013 Jun; 140(12):2463-7. View Abstract
199. The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish. PLoS One. 2013; 8(5):e64969. View Abstract
200. A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. Development. 2013 Jun; 140(11):2354-64. View Abstract
201. The zebrafish reference genome sequence and its relationship to the human genome. Nature. 2013 Apr 25; 496(7446):498-503. View Abstract
202. A model for primary melanoma of the CNS implicates NRAS. Cancer Discov. 2013 Apr; 3(4):382-3. View Abstract
203. Ageing: Stem cells on a stress-busting diet. Nature. 2013 Feb 21; 494(7437):317-8. View Abstract
204. The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome Biol. 2013; 14(10):R113. View Abstract
205. Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition. Proc Natl Acad Sci U S A. 2013 Jan 08; 110(2):E141-50. View Abstract
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424. The zebrafish klf gene family. Blood. 2001 Sep 15; 98(6):1792-801. View Abstract
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426. Myelopoiesis in the zebrafish, Danio rerio. Blood. 2001 Aug 01; 98(3):643-51. View Abstract
427. Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins. Development. 2001 Jun; 128(12):2301-8. View Abstract
428. Fishing for lymphoid genes. Trends Immunol. 2001 Jun; 22(6):302-7. View Abstract
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434. Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blood. 2000 Dec 15; 96(13):4178-84. View Abstract
435. Hereditary spherocytosis in zebrafish riesling illustrates evolution of erythroid beta-spectrin structure, and function in red cell morphogenesis and membrane stability. Development. 2000 Dec; 127(23):5123-32. View Abstract
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438. In vivo immunological function of mast cells derived from embryonic stem cells: an approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):9186-90. View Abstract
439. An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Development. 2000 Jul; 127(14):3031-44. View Abstract
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442. Realizing the potential of zebrafish as a model for human disease. Physiol Genomics. 2000 Mar 13; 2(2):49-51. View Abstract
443. Zebrafish: a genetic approach in studying hematopoiesis. Curr Opin Hematol. 2000 Mar; 7(2):79-84. View Abstract
444. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000 Feb 17; 403(6771):776-81. View Abstract
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446. Turning mesoderm into blood: the formation of hematopoietic stem cells during embryogenesis. Curr Top Dev Biol. 2000; 50:45-60. View Abstract
447. The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4. Cytogenet Cell Genet. 2000; 89(3-4):272-5. View Abstract
448. A healthy community through health system partnerships: the approach of Markham Stouffville Hospital. Healthc Pap. 2000; 1(2):96-103; discussion 104-7. View Abstract
449. Dissecting hematopoiesis and disease using the zebrafish. Dev Biol. 1999 Dec 01; 216(1):1-15. View Abstract
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455. Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line. Dev Dyn. 1999 Aug; 215(4):352-70. View Abstract
456. Generation of a zebrafish P1 artificial chromosome library. Genomics. 1999 Jun 01; 58(2):211-3. View Abstract
457. Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. Mol Cell Biol. 1999 Apr; 19(4):2547-55. View Abstract
458. Zebrafish: a new model for human disease. Genome Res. 1999 Feb; 9(2):99-100. View Abstract
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460. Mapping zebrafish mutations by AFLP. Methods Cell Biol. 1999; 60:195-211. View Abstract
461. Zebrafish YAC, BAC, and PAC genomic libraries. Methods Cell Biol. 1999; 60:235-58. View Abstract
462. Genetic backgrounds and some standard stocks and strains used in zebrafish developmental biology and genetics. Methods Cell Biol. 1999; 60:357-9. View Abstract
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464. Collection, storage, and use of zebrafish sperm. Methods Cell Biol. 1999; 60:365-72. View Abstract
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466. Primary fibroblast cell culture. Methods Cell Biol. 1999; 59:39-43. View Abstract
467. Vascular and blood gene expression. Methods Cell Biol. 1999; 59:313-36. View Abstract
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469. Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Nat Genet. 1998 Nov; 20(3):244-50. View Abstract
470. Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins. Proc Natl Acad Sci U S A. 1998 Sep 15; 95(19):11251-6. View Abstract
471. Analysis of the role of MKK-4/Sek-1 in T cell development and apoptosis. Int Immunol. 1998 Aug; 10(8):1077-82. View Abstract
472. Characterization of whole genome radiation hybrid mapping resources for non-mammalian vertebrates. Nucleic Acids Res. 1998 Aug 01; 26(15):3562-6. View Abstract
473. Gene mapping in zebrafish using single-strand conformation polymorphism analysis. Genomics. 1998 Jul 15; 51(2):216-22. View Abstract
474. SCL specifies hematopoietic mesoderm in Xenopus embryos. Development. 1998 Jul; 125(14):2611-20. View Abstract
475. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci U S A. 1998 Jun 09; 95(12):6881-6. View Abstract
476. The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Dev Biol. 1998 May 15; 197(2):248-69. View Abstract
477. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity. 1998 May; 8(5):625-34. View Abstract
478. Development of T-cells during fish embryogenesis. Dev Comp Immunol. 1998 May-Jun; 22(3):253-63. View Abstract
479. Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5121-6. View Abstract
480. Vertebrate genome evolution and the zebrafish gene map. Nat Genet. 1998 Apr; 18(4):345-9. View Abstract
481. Transcriptional regulation of blood formation during Xenopus development. Semin Immunol. 1998 Apr; 10(2):103-9. View Abstract
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484. Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation. Blood. 1998 Jan 15; 91(2):450-7. View Abstract
485. Use of the zebrafish (Danio rerio) to define hematopoiesis. Stem Cells. 1998; 16(2):89-98. View Abstract
486. Cloning and genetic mapping of zebrafish BMP-2. Dev Genet. 1998; 23(2):97-103. View Abstract
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488. The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Development. 1997 Nov; 124(22):4457-66. View Abstract
489. Bipotential primitive-definitive hematopoietic progenitors in the vertebrate embryo. Immunity. 1997 Sep; 7(3):325-34. View Abstract
490. MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. J Biol Chem. 1997 Jun 13; 272(24):15167-73. View Abstract
491. Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK. J Biol Chem. 1997 May 16; 272(20):13229-35. View Abstract
492. Characterization of adult alpha- and beta-globin genes in the zebrafish. Blood. 1997 Jan 15; 89(2):688-700. View Abstract
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495. Induction of cyclin D1 by simian virus 40 small tumor antigen. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):12861-6. View Abstract
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497. Stimulation of the P-450 side chain cleavage enzyme (CYP11A1) promoter through ras- and Ets-2-signaling pathways. Mol Endocrinol. 1996 Sep; 10(9):1084-94. View Abstract
498. Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):9126-31. View Abstract
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502. Genetic regulation of delta-aminolevulinate dehydratase during erythropoiesis. Nucleic Acids Res. 1996 Jul 01; 24(13):2511-8. View Abstract
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504. Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. J Immunol. 1996 Jun 15; 156(12):4535-8. View Abstract
505. The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat. Curr Biol. 1996 May 01; 6(5):606-13. View Abstract
506. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature. 1996 Mar 07; 380(6569):75-9. View Abstract
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509. Stress- and mitogen-activated signal transduction in hematopoietic cells. Curr Opin Hematol. 1996 Jan; 3(1):27-34. View Abstract
510. c-Abl activation regulates induction of the SEK1/stress-activated protein kinase pathway in the cellular response to 1-beta-D-arabinofuranosylcytosine. J Biol Chem. 1995 Dec 22; 270(51):30278-81. View Abstract
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513. Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. Nature. 1995 Oct 26; 377(6551):750-4. View Abstract
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515. Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages. Development. 1995 Oct; 121(10):3141-50. View Abstract
516. Molecular cloning of a cDNA with a novel domain present in the tre-2 oncogene and the yeast cell cycle regulators BUB2 and cdc16. Oncogene. 1995 Sep 21; 11(6):1139-48. View Abstract
517. Cloning and chromosomal localization of a mouse cDNA with homology to the Saccharomyces cerevisiae gene zuotin. Genomics. 1995 Sep 20; 29(2):546-50. View Abstract
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525. Role of interleukin 6 in the growth of myeloma-derived cell lines. Leuk Res. 1992 Oct; 16(10):951-9. View Abstract
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527. The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein. Mol Cell Biol. 1992 Jul; 12(7):2949-57. View Abstract
528. Sequence of the human GATA-1 promoter. Nucleic Acids Res. 1992 Apr 11; 20(7):1812. View Abstract
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540. Pathophysiology and management of HIV-associated hematologic disorders. Blood. 1989 Oct; 74(5):1455-63. View Abstract
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547. Anticardiolipin antibodies associated with HTLV-III infection. Br J Haematol. 1987 Apr; 65(4):495-8. View Abstract
548. Suppression of in vitro haematopoiesis following human immunodeficiency virus infection. Nature. 1987 Mar 12-18; 326(6109):200-3. View Abstract
549. Hemophilus parainfluenzae prostatitis in a homosexual man with chronic lymphadenopathy syndrome and HTLV-III infection. Am J Med. 1987 Jan; 82(1):175-8. View Abstract
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552. Antibodies to human T-lymphotropic virus type III (HTLV-III) in saliva of acquired immunodeficiency syndrome (AIDS) patients and in persons at risk for AIDS. Blood. 1986 Mar; 67(3):831-4. View Abstract
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