One goal of Leonard Rappaport's work is to gain a better understanding of the effects of medical and surgical interventions on development and neurological status later in childhood. He seeks to use that information to improve developmental and behavioral outcome after infant cardiac surgery.
His lab is also collaborating with Children's Genomics Center and MIT's Department of Brain and Cognitive Sciences to better understand the etiology of developmental disorders. One of the goals of this work is to improve the methods of diagnosing and treating autism spectrum disorders. Rappaport and colleagues are also investigating the etiology and treatment of elimination disorders such as encopresis and enuresis.
Research Background
Leonard Rappaport received his MD from Yale University School of Medicine. He completed an internship, residency, and fellowship at Childrens Hospital Boston. Dr. Rappaport serves on the Executive Board for NIH-NHLBI trials in infant heart surgery.
Education
Medical School
Yale University School of Medicine
1977
New Haven
CT
Internship
Boston Children's Hospital
1978
Boston
MA
Residency
Boston Children's Hospital
1980
Boston
MA
Fellowship
Boston Children's Hospital
1982
Boston
MA
Publications
Twelve-Month Outcomes of Stand-Alone Excisional Goniotomy in Mild to Severe Glaucoma. Clin Ophthalmol. 2020; 14:1891-1897. View Abstract
Reintroducing Dyslexia: Early Identification and Implications for Pediatric Practice. Pediatrics. 2020 07; 146(1). View Abstract
Updating the neurodevelopmental profile of Alazami syndrome: Illustrating the role of developmental assessment in rare genetic disorders. Am J Med Genet A. 2019 08; 179(8):1565-1569. View Abstract
Six-Month Outcomes of Goniotomy Performed with the Kahook Dual Blade as a Stand-Alone Glaucoma Procedure. Adv Ther. 2018 11; 35(11):2093-2102. View Abstract
Longitudinal Associations between Neurodevelopment and Psychosocial Health Status in Patients with Repaired D-Transposition of the Great Arteries. J Pediatr. 2019 01; 204:38-45.e1. View Abstract
Congenital Zika Virus Infection: A Developmental-Behavioral Perspective. J Dev Behav Pediatr. 2017 01; 38(1):65-66. View Abstract
Neurodevelopmental outcome in children with congenital heart disease: a work in progress. Pediatrics. 2015 May; 135(5):926-7. View Abstract
Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome. Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):4596-601. View Abstract
Peripheral blood gene expression signature differentiates children with autism from unaffected siblings. Neurogenetics. 2013 May; 14(2):143-52. View Abstract
Using whole-exome sequencing to identify inherited causes of autism. Neuron. 2013 Jan 23; 77(2):259-73. View Abstract
Characteristics and predictive value of blood transcriptome signature in males with autism spectrum disorders. PLoS One. 2012; 7(12):e49475. View Abstract
The co-morbidity burden of children and young adults with autism spectrum disorders. PLoS One. 2012; 7(4):e33224. View Abstract
Adolescents with d-transposition of the great arteries corrected with the arterial switch procedure: neuropsychological assessment and structural brain imaging. Circulation. 2011 Sep 20; 124(12):1361-9. View Abstract
Pediatrician-psychiatrist collaboration to care for children with attention deficit hyperactivity disorder, depression, and anxiety. Clin Pediatr (Phila). 2011 Jan; 50(1):37-43. View Abstract
Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders. Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 05; 153B(4):937-47. View Abstract
Clinical genetic testing for patients with autism spectrum disorders. Pediatrics. 2010 Apr; 125(4):e727-35. View Abstract
Behaviour at eight years in children with surgically corrected transposition: The Boston Circulatory Arrest Trial. Cardiol Young. 2009 Feb; 19(1):86-97. View Abstract
Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery. J Thorac Cardiovasc Surg. 2008 Feb; 135(2):347-54, 354.e1-4. View Abstract
Encopresis. Oski's Pediatrics. DeAngelis C. 2005. View Abstract
Prediction of IQ and achievement at age 8 years from neurodevelopmental status at age 1 year in children with D-transposition of the great arteries. Pediatrics. 2004 Nov; 114(5):e572-6. View Abstract
Consultation with the specialist: encopresis: assessment and management. Pediatr Rev. 2004 Aug; 25(8):278-83. View Abstract
Effect of prenatal diagnosis on outcomes in D-transposition of the great arteries. Pediatrics. 2004 Apr; 113(4):e335-40. View Abstract
Enuresis. Behavioral and Developmental Pediatrics: A Handbook for Primary Care. Zuckerman B and Parker S, Eds. 2004. View Abstract
Recurrent abdominal pain. Behavioral and Developmental Pediatrics: A Handbook for Primary Care. Zuckerman B and Parker S, Eds. 2004. View Abstract
Encopresis. Behavioral and Developmental Pediatrics: A Handbook for Primary Care. 2004. View Abstract
The influence of hemodilution on outcome after hypothermic cardiopulmonary bypass: results of a randomized trial in infants. J Thorac Cardiovasc Surg. 2003 Dec; 126(6):1765-74. View Abstract
Neurodevelopmental status at eight years in children with dextro-transposition of the great arteries: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg. 2003 Nov; 126(5):1385-96. View Abstract
The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg. 2003 Nov; 126(5):1397-403. View Abstract
Neurobehavioral factors associated with referral for learning problems in a community sample: evidence for an adaptational model for learning disorders. J Learn Disabil. 2003 Sep-Oct; 36(5):467-83. View Abstract
Length of stay after infant heart surgery is related to cognitive outcome at age 8 years. J Pediatr. 2003 Jul; 143(1):67-73. View Abstract
Visual-spatial skills in children after open-heart surgery. J Dev Behav Pediatr. 2003 Jun; 24(3):169-79. View Abstract
Trends in referral to a single encopresis clinic over 20 years. Pediatrics. 2003 May; 111(5 Pt 1):e604-7. View Abstract
Complementary and alternative therapies in childhood attention and hyperactivity problems. J Dev Behav Pediatr. 2003 Feb; 24(1):4-8. View Abstract
Influence of parental stress and social support on the behavioral adjustment of children with transposition of the great arteries. J Dev Behav Pediatr. 2002 Oct; 23(5):314-21. View Abstract
Measuring quality of life in children with attention-deficit/hyperactivity disorder and their families: development and evaluation of a new tool. Arch Pediatr Adolesc Med. 2002 Apr; 156(4):384-91. View Abstract
Early constipation and toilet training in children with encopresis. J Pediatr Gastroenterol Nutr. 2002 Apr; 34(4):385-8. View Abstract
Development assessment and interventions. Managing Elevated Lead Levels Among Young Children, Recommendations from the Advisory Committee on Childhood Lead Poinoning Prevention. 2002. View Abstract
Recurrent abdominal pain. Behavioral and Developmental Pediatrics: A Handbook for Primary Care. Zuckerman B and Parker S, Eds. 2002. View Abstract
Recurrent abdominal pain. Pain Management in Children, Schecter N, Berde C, Yaster M Eds. 2002. View Abstract
General health status of children with D-transposition of the great arteries after the arterial switch operation. Circulation. 2001 Sep 18; 104(12 Suppl 1):I138-42. View Abstract
Book Reviews. J Dev Behav Pediatr. 2001 Feb; 22(1):77-78. View Abstract
Developmental and neurologic effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants. J Thorac Cardiovasc Surg. 2001 Feb; 121(2):374-83. View Abstract
An evaluation of an innovative multimedia educational software program for asthma management: report of a randomized, controlled trial. Pediatrics. 2000 Jul; 106(1 Pt 2):210-5. View Abstract
Comparison of the effects of fetal cardiomyocyte and skeletal myoblast transplantation on postinfarction left ventricular function. J Thorac Cardiovasc Surg. 2000 Jun; 119(6):1169-75. View Abstract
Reliability and validity of a DSM-IV based ADHD screener. Child Neuropsychol. 2000 Mar; 6(1):3-23. View Abstract
Epidemiologic perspectives on neuropsychological disorders in children. Handbook of Neuropsycholygy, Rapin I, Segalowitz S (Eds). 2000. View Abstract
Infant colic and childhood recurrent abdominal pain syndromes: is there a relationship? J Dev Behav Pediatr. 1999 Oct; 20(5):315-7. View Abstract
Developmental and neurological status of children at 4 years of age after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass. Circulation. 1999 Aug 03; 100(5):526-32. View Abstract
Addressing sexual abuse in the primary care setting. Pediatrics. 1999 Aug; 104(2 Pt 1):270-5. View Abstract
Recurrent pains in children. Ambulatory Pediatrics. M Green, R Haggerty and M Weitzman. 1999. View Abstract
Attention-Deficit/Hyperactivity Disorder (ADHD) in adolescents: Special considerations. Contemporary Pediatrics. 1999. View Abstract
Cellular distribution of Ca2+ pumps and Ca2+ release channels in rat cardiac hypertrophy induced by aortic stenosis. Circulation. 1998 Dec 01; 98(22):2477-86. View Abstract
Can cellular transplantation improve function in doxorubicin-induced heart failure? Circulation. 1998 Nov 10; 98(19 Suppl):II151-5; discussion II155-6. View Abstract
Relation of seizures after cardiac surgery in early infancy to neurodevelopmental outcome. Boston Circulatory Arrest Study Group. Circulation. 1998 Mar 03; 97(8):773-9. View Abstract
Encopresis. Ambulatory Pediatric Care. R Derchewitz, Ed. 1998. View Abstract
Does transplantation of cardiomyocytes improve function of infarcted myocardium? Circulation. 1997 Nov 04; 96(9 Suppl):II-188-93. View Abstract
Patterns of developmental dysfunction after surgery during infancy to correct transposition of the great arteries. J Dev Behav Pediatr. 1997 Apr; 18(2):75-83. View Abstract
Encopresis in adolescents. Adolescent Medicine. Friedman S, Fisher M, Schonberg SK, eds. 1997. View Abstract
Can grafted cardiomyocytes colonize peri-infarct myocardial areas? Circulation. 1996 Nov 01; 94(9 Suppl):II337-40. View Abstract
Recurrent abdominal pain; Keeping it simple. Amb Child Health. 1996; 1:370-378. View Abstract
Pediatric compliance and the roles of distinct treatment characteristics, treatment attitudes, and family stress: a preliminary report. J Dev Behav Pediatr. 1995 Oct; 16(5):350-8. View Abstract
Accumulation of fetal fibronectin mRNAs after balloon denudation of rabbit arteries. Circulation. 1995 Aug 15; 92(4):904-11. View Abstract
Developmental and neurologic status of children after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass. N Engl J Med. 1995 Mar 02; 332(9):549-55. View Abstract
Infants tolerate spinal anesthesia with minimal overall autonomic changes: analysis of heart rate variability in former premature infants undergoing hernia repair. Anesth Analg. 1995 Jan; 80(1):20-7. View Abstract
Bowel and bladder control. Behavioral and Developmental Pediatrics Chapter, Boyce T, Shonkoff J, eds. Rudolph's Textrbook of Pediatrics. 1995. View Abstract
A comparison of the developmental and neurologic status at one year of children who underwent heart surgery using hypothermic ciculatory arrest or low-flow cardiopulmonary bypass: The Boston Ciculatory Arrest Study. Brain Injury and Infant Cardiac Surgery. Jonas R, Newburger J, Volpe J, Eds. 1995. View Abstract
Enuresis. Behavioral and Developmental Pediatrics: A Handbook for Primary Care. Zuckerman B and Parker S, eds. 1995. View Abstract
Developmental testing in outcome studies. Brain Injury and Infant Cardiac Surgery. Jonas R, Newburger J, Volpe J Eds. 1995. View Abstract
Recurrent abdominal pain. Behavioral and Developmental Pediatrics: A Handbook for Primary Care. Zuckerman B and Parker S, Eds. 1995. View Abstract
Enuresis in adolescents. Adolescent Medicine, Friedman S,Fisher M, Schonberg SK,Eds. 1992. View Abstract
Cognitive development of children following early repair of transposition of the great arteries using deep hypothermic circulatory arrest. Pediatrics. 1991 May; 87(5):701-7. View Abstract
Stimulant medication and attention deficit-hyperactivity disorder. The child's perspective. Am J Dis Child. 1991 Mar; 145(3):291-5. View Abstract
Asthma self-management programs: A guide to proper selection. J All Imm. 1990; 4:8-13. View Abstract
The school-age child: putting it all together. Curr Probl Pediatr. 1989 Jun; 19(6):285-323. View Abstract
School functioning and disease severity in boys with hemophilia. J Dev Behav Pediatr. 1989 Apr; 10(2):81-5. View Abstract
Effects of theophylline on behavior and learning in children with asthma. Am J Dis Child. 1989 Mar; 143(3):368-72. View Abstract
Neurodevelopmental readiness for adolescence: studies of an assessment instrument for 9- to 14-year-old children. J Dev Behav Pediatr. 1988 Aug; 9(4):181-8. View Abstract
School placement. Pediatr Rev. 1987 Mar; 8(9):261-71. View Abstract
Concurrence of congenital ocular motor apraxia and other motor problems: an expanded syndrome. Dev Med Child Neurol. 1987 Feb; 29(1):85-90. View Abstract
Locus of control as predictor of compliance and outcome in treatment of encopresis. J Pediatr. 1986 Dec; 109(6):1061-4. View Abstract
The prevention of constipation and encopresis: a developmental model and approach. Pediatr Clin North Am. 1986 Aug; 33(4):859-69. View Abstract
Locus of control and self-esteem in children with encopresis. J Dev Behav Pediatr. 1986 Apr; 7(2):111-3. View Abstract
Recurrent abdominal pain in school children: The loneliness of the long-distance pediatrician. Pediatr Clin N Amer. 1986; 33:969-991. View Abstract
Pediatric management of severe treatment-resistant encopresis. J Dev Behav Pediatr. 1985 Dec; 6(6):349-51. View Abstract
Recurrent abdominal pain in school children: the loneliness of the long-distance physician. Pediatr Clin North Am. 1984 Oct; 31(5):969-91. View Abstract
A study of treatment resistance among children referred for encopresis. Clin Pediatr (Phila). 1984 Aug; 23(8):449-52. View Abstract
Behavioral Pediatrics, In Graef,J . and ConeT(eds). Manual of Pediatric Therapeutics. 1984. View Abstract
Children's descriptions of their developmental dysfunctions. Field testing of a self-administered student profile. Am J Dis Child. 1983 Apr; 137(4):369-74. View Abstract