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Research Background

Dr. Koichi Yuki obtained his M.D. from the University of Tokyo, Japan. After his initial medical training in Japan, he came to US and completed his surgical internship in the University of Hawaii, anesthesia residency in Massachusetts General Hospital, followed by pediatric anesthesia fellowship and pediatric cardiac anesthesia fellowship in Boston Children’s Hospital. He is currently an Associate Professor of Anaesthesia at Harvard Medical School and an Associate in Cardiac Anesthesia at Boston Children’s Hospital. He did postdoctoral research fellowship under Drs. Timothy Springer and Motomu Shimaoka (Immune Disease Institute), and his laboratory research focuses on elucidation of sepsis pathophysiology and understanding the impact of anesthetics on perioperative immune function. In addition, he is interested in performing risk stratification of noncardiac surgery in patients with congenital heart disease.

 

Education

Medical School

University of Tokyo, Faculty of Medicine
1999 Tokyo Japan

Internship

Surgery Hawaii University Surgical Program
2001 Honolulu HI

Residency

Anesthesia Ichihara Hospital, Teikyo University
1999 Chiba Japan

Graduate School

Anesthesia Massachusetts General Hospital
2002 Boston MA

Fellowship

Pediatric Anesthesia Boston Children's Hospital
2005 Boston MA

Fellowship

Pediatric Cardiac Anesthesia Boston Children's Hospital
2006 Boston MA

Publications

  1. Postoperative mechanical ventilation after corrective Tetralogy of Fallot surgery in infants: Assessment of perioperative factors and radiographic severity scores. Perioper Care Oper Room Manag. 2024 Dec; 37. View Abstract
  2. Perioperative Outcomes in Congenital Heart Disease: A Review of Clinical Factors Associated With Prolonged Ventilation and Length of Stay in Four Common CHD Operations. J Cardiothorac Vasc Anesth. 2024 Nov 14. View Abstract
  3. Neutrophil extracellular traps formation is associated with postoperative complications in congenital cardiac surgery. Pediatr Res. 2024 Nov 11. View Abstract
  4. Postoperative Organ Dysfunction Risk Stratification Using Extracellular Vesicle-Derived circRNAs in Pediatric Congenital Heart Surgery. Cells. 2024 08 25; 13(17). View Abstract
  5. Dexmedetomidine directly binds to and inhibits Toll-like receptor 4. Int Immunopharmacol. 2024 Nov 15; 141:112975. View Abstract
  6. The Fontan Circulation in Pregnancy: Hemodynamic Challenges and Anesthetic Considerations. J Cardiothorac Vasc Anesth. 2024 Nov; 38(11):2770-2782. View Abstract
  7. Toll-like receptors and integrins crosstalk. Front Immunol. 2024; 15:1403764. View Abstract
  8. Ketamine modulates disrupted in schizophrenia-1/glycogen synthase kinase-3ß interaction. Front Mol Neurosci. 2024; 17:1342233. View Abstract
  9. Mechanism of isoflurane-mediated breast cancer growth in vivo. Oncol Lett. 2024 Jun; 27(6):287. View Abstract
  10. The landscape of immune dysregulation in pediatric sepsis at a single-cell resolution. Clin Immunol. 2024 May; 262:110175. View Abstract
  11. Integrin CD11c regulates B cell homeostasis. Front Immunol. 2024; 15:1359608. View Abstract
  12. Cystic Fibrosis Mice Are Highly Susceptible to Repeated Acute Pseudomonas aeruginosa Pneumonia after Intranasal Inoculation. Biomed Res Int. 2024; 2024:4769779. View Abstract
  13. The landscape of immune dysregulation in pediatric sepsis at a single-cell resolution. bioRxiv. 2024 Jan 19. View Abstract
  14. Perioperative Factors and Radiographic Severity Scores for Predicting the Duration of Mechanical Ventilation After Arterial Switch Surgery. J Cardiothorac Vasc Anesth. 2024 Apr; 38(4):992-1005. View Abstract
  15. Neutrophil extracellular traps formation is associated with postoperative complications in neonates and infants undergoing congenital cardiac surgery. bioRxiv. 2023 Dec 23. View Abstract
  16. Volatile anesthetic isoflurane exposure facilitates Enterococcus biofilm infection. FASEB J. 2023 10; 37(10):e23186. View Abstract
  17. Perioperative prophylactic corticosteroids for cardiac surgery in children: A systematic review and meta-analysis. Am Heart J. 2023 12; 266:159-167. View Abstract
  18. CD11a regulates hematopoietic stem and progenitor cells. Front Immunol. 2023; 14:1219953. View Abstract
  19. Age-dependent transcriptomic profiles of leukocytes in pediatric population. Clin Immunol. 2023 10; 255:109728. View Abstract
  20. Trailblazing through the Opioid Epidemic. Will Science Prevail? Transl Perioper Pain Med. 2023; 10(2):530-532. View Abstract
  21. Predictability of Pediatric Sepsis Outcome Using SEPSIS-3 Definition in a Single Tertiary Pediatric Institution. Transl Perioper Pain Med. 2023; 10(2):515-521. View Abstract
  22. Differential effects of dexmedetomidine on Gram-positive and Gram-negative bacterial killing and phagocytosis. Int Immunopharmacol. 2023 Jul; 120:110327. View Abstract
  23. CD11c regulates neutrophil maturation. Blood Adv. 2023 04 11; 7(7):1312-1325. View Abstract
  24. Narrative review of systemic inflammatory response mechanisms in cardiac surgery and immunomodulatory role of anesthetic agents. Ann Card Anaesth. 2023 Apr-Jun; 26(2):133-142. View Abstract
  25. Surgical site infection in pediatric spinal fusion surgery revisited: outcome and risk factors after preventive bundle implementation. Perioper Care Oper Room Manag. 2023 Mar; 30. View Abstract
  26. GltS regulates biofilm formation in methicillin-resistant Staphylococcus aureus. Commun Biol. 2022 11 23; 5(1):1284. View Abstract
  27. aDß2 as a novel target of experimental polymicrobial sepsis. Front Immunol. 2022; 13:1059996. View Abstract
  28. CD11c regulates late-stage T cell development in the thymus. Front Immunol. 2022; 13:1040818. View Abstract
  29. Exploring Noncardiac Surgical Needs From Infancy to Adulthood in Patients With Congenital Heart Disease. J Cardiothorac Vasc Anesth. 2022 12; 36(12):4364-4369. View Abstract
  30. The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis. Immunity. 2022 08 09; 55(8):1354-1369.e8. View Abstract
  31. Propofol directly binds to and inhibits TLR7. FASEB J. 2022 08; 36(8):e22481. View Abstract
  32. Use of clindamycin as an alternative antibiotic prophylaxis. Perioper Care Oper Room Manag. 2022 Sep; 28. View Abstract
  33. The Role of Pulmonary Function Test in Perioperative Management of Patients with Cystic Fibrosis. Transl Perioper Pain Med. 2022; 9(2):438-444. View Abstract
  34. Predictive Factors for Postoperative Intensive Care Unit Admission and Mechanical Ventilation After Cardiac Catheterization for Pediatric Pulmonary Vein Stenosis. J Cardiothorac Vasc Anesth. 2022 08; 36(8 Pt A):2500-2508. View Abstract
  35. Isoflurane attenuates sepsis-associated lung injury. Biochem Biophys Res Commun. 2022 04 09; 599:127-133. View Abstract
  36. CCR6 and CXCR6 Identify the Th17 Cells With Cytotoxicity in Experimental Autoimmune Encephalomyelitis. Front Immunol. 2022; 13:819224. View Abstract
  37. How Should We Care for Patients with Congenital Heart Diseases Undergoing Surgical Procedures in Ambulatory Settings? Transl Perioper Pain Med. 2022; 9(1):416-420. View Abstract
  38. Translational Role of Rodent Models to Study Ventilator-Induced Lung Injury. Transl Perioper Pain Med. 2021 Dec; 8(4):404-415. View Abstract
  39. The Role of General Anesthetic Drug Selection in Cancer Outcome. Biomed Res Int. 2021; 2021:2563093. View Abstract
  40. Neutrophil and T Cell Functions in Patients with Congenital Heart Diseases: A Review. Pediatr Cardiol. 2021 Oct; 42(7):1478-1482. View Abstract
  41. Pattern recognition receptors as therapeutic targets for bacterial, viral and fungal sepsis. Int Immunopharmacol. 2021 Sep; 98:107909. View Abstract
  42. Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA. FASEB J. 2021 06; 35(6):e21501. View Abstract
  43. The Role of Anesthetic Selection in Perioperative Bleeding. Biomed Res Int. 2021; 2021:5510634. View Abstract
  44. The immunomodulatory mechanism of dexmedetomidine. Int Immunopharmacol. 2021 Aug; 97:107709. View Abstract
  45. The Characterization of Postoperative Mechanical Respiratory Requirement in Neonates and Infants Undergoing Cardiac Surgery on Cardiopulmonary Bypass in a Single Tertiary Institution. J Cardiothorac Vasc Anesth. 2022 01; 36(1):215-221. View Abstract
  46. Anesthetics isoflurane and sevoflurane attenuate flagellin-mediated inflammation in the lung. Biochem Biophys Res Commun. 2021 06 11; 557:254-260. View Abstract
  47. Risk factors for pediatric surgical site infection following neurosurgical procedures for hydrocephalus: a retrospective single-center cohort study. BMC Anesthesiol. 2021 04 21; 21(1):124. View Abstract
  48. Surgical Site Infections and Perioperative Optimization of Host Immunity by Selection of Anesthetics. Biomed Res Int. 2021; 2021:5576959. View Abstract
  49. The Use of Regional Catheters in Children Undergoing Repair of Aortic Coarctation. J Cardiothorac Vasc Anesth. 2021 12; 35(12):3694-3699. View Abstract
  50. Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis. Int Immunopharmacol. 2021 Apr; 93:107425. View Abstract
  51. Left Ventricular Outflow Tract Gradient Is Associated With Coronary Artery Obstruction in Children With Williams-Beuren Syndrome. J Cardiothorac Vasc Anesth. 2021 12; 35(12):3677-3680. View Abstract
  52. CD11c regulates hematopoietic stem and progenitor cells under stress. Blood Adv. 2020 12 22; 4(24):6086-6097. View Abstract
  53. The Microbial Flora in an Experimental Polymicrobial Abdominal Sepsis Model Probed by 16S rRNA Sequencing. Transl Perioper Pain Med. 2021; 8(1):305-311. View Abstract
  54. Long QT Syndrome and Perioperative Torsades de Pointes: What the Anesthesiologist Should Know. J Cardiothorac Vasc Anesth. 2022 01; 36(1):286-302. View Abstract
  55. A simple screening test of filtration efficiency for protecting the gas sampling line from coronavirus using fluorescent microspheres. Paediatr Anaesth. 2020 11; 30(11):1269-1274. View Abstract
  56. The Role of Anesthetic Management in Surgical Site Infections After Pediatric Intestinal Surgery. J Surg Res. 2021 03; 259:546-554. View Abstract
  57. Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes. Clin Immunol. 2021 01; 222:108635. View Abstract
  58. The effect of anesthetics on toll like receptor 9. FASEB J. 2020 11; 34(11):14645-14654. View Abstract
  59. Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation. Anesth Analg. 2020 08; 131(2):631-639. View Abstract
  60. SerpinB1 expression in Th17 cells depends on hypoxia-inducible factor 1-alpha. Int Immunopharmacol. 2020 Oct; 87:106826. View Abstract
  61. Role of ß2 Integrins in Neutrophils and Sepsis. Infect Immun. 2020 05 20; 88(6). View Abstract
  62. Intubation precautions in a pediatric patient with severe COVID-19. J Pediatr Surg Case Rep. 2020 Jul; 58:101495. View Abstract
  63. In Vitro Model of Stretch-Induced Lung Injury to Study Different Lung Ventilation Regimens and the Role of Sedatives. Transl Perioper Pain Med. 2020; 7(3):258-264. View Abstract
  64. COVID-19 pathophysiology: A review. Clin Immunol. 2020 06; 215:108427. View Abstract
  65. Anesthetic Management for Heart Transplantation in Adults with Congenital Heart Disease. Transl Perioper Pain Med. 2020; 7(3):248-252. View Abstract
  66. The role of propofol hydroxyl group in 5-lipoxygenase recognition. Biochem Biophys Res Commun. 2020 05 14; 525(4):909-914. View Abstract
  67. Should we Routinely Reverse Neuromuscular Blockade with Sugammadex in Patients with a History of Heart Transplantation? Transl Perioper Pain Med. 2020; 7(2):185-189. View Abstract
  68. Incidence and predictors of postoperative nausea and vomiting in children undergoing electrophysiology ablation procedures. Paediatr Anaesth. 2020 02; 30(2):147-152. View Abstract
  69. Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system. FASEB J. 2019 12; 33(12):14528-14541. View Abstract
  70. SerpinB1 controls encephalitogenic T helper cells in neuroinflammation. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20635-20643. View Abstract
  71. The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction. FASEB J. 2019 11; 33(11):12668-12679. View Abstract
  72. The Outcomes of Pediatric Hematopoietic Stem Cell Transplantation Recipients Requiring Intensive Care Unit Admission- A Single Center Experience. Transl Perioper Pain Med. 2019; 6(3):75-80. View Abstract
  73. Volatile anesthetics affect macrophage phagocytosis. PLoS One. 2019; 14(5):e0216163. View Abstract
  74. The Use of Volatile Anesthetics as Sedatives for Acute Respiratory Distress Syndrome. Transl Perioper Pain Med. 2019; 6(2):27-38. View Abstract
  75. Volatile Anesthetic Attenuates Phagocyte Function and Worsens Bacterial Loads in Wounds. J Surg Res. 2019 01; 233:323-330. View Abstract
  76. Incidence and Risk Factors for Perioperative Cardiovascular and Respiratory Adverse Events in Pediatric Patients With Congenital Heart Disease Undergoing Noncardiac Procedures. Anesth Analg. 2018 09; 127(3):724-729. View Abstract
  77. Induction techniques for pediatric patients with congenital heart disease undergoing noncardiac procedures are influenced by cardiac functional status and residual lesion burden. J Clin Anesth. 2018 Nov; 50:14-17. View Abstract
  78. Volatile Anesthetic Isoflurane Attenuates Liver Injury in Experimental Polymicrobial Sepsis Model. Transl Perioper Pain Med. 2018; 5(3):63-74. View Abstract
  79. Unanticipated hospital admission in pediatric patients with congenital heart disease undergoing ambulatory noncardiac surgical procedures. Paediatr Anaesth. 2018 07; 28(7):607-611. View Abstract
  80. Incidence and Risk Factors of Perioperative Mortality in Pediatric ICU Patients. Transl Perioper Pain Med. 2018; 5(2):49-54. View Abstract
  81. Ligand- and cation-induced structural alterations of the leukocyte integrin LFA-1. J Biol Chem. 2018 04 27; 293(17):6565-6577. View Abstract
  82. Validation of a Mathematical Model of Bidirectional Glenn Circulation With Aortopulmonary Collaterals and the Implications for QP/QS Calculation. J Cardiothorac Vasc Anesth. 2018 02; 32(1):395-401. View Abstract
  83. From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis. Toxicol Sci. 2017 04 01; 156(2):402-411. View Abstract
  84. Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications. Sci Rep. 2017 03 09; 7:44117. View Abstract
  85. The Differential Effects of Anesthetics on Bacterial Behaviors. PLoS One. 2017; 12(1):e0170089. View Abstract
  86. Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production. FASEB J. 2017 04; 31(4):1584-1594. View Abstract
  87. Pediatric Perioperative Stress Responses and Anesthesia. Transl Perioper Pain Med. 2017; 2(1):1-12. View Abstract
  88. The effect of different anesthetics on tumor cytotoxicity by natural killer cells. Toxicol Lett. 2017 Jan 15; 266:23-31. View Abstract
  89. Pausing With the Gauze: Inhibition of Temporary Pacemakers by Radiofrequency Scan During Cardiac Surgery. Anesth Analg. 2016 11; 123(5):1143-1148. View Abstract
  90. Dexmedetomidine-Induced Neuroapoptosis Is Dependent on Its Cumulative Dose. Anesth Analg. 2016 10; 123(4):1008-17. View Abstract
  91. Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review. Anesth Analg. 2016 08; 123(2):326-35. View Abstract
  92. Incidence and risk factors for postoperative vomiting following atrial septal defect repair in children. Paediatr Anaesth. 2016 Jun; 26(6):644-8. View Abstract
  93. Post-Operative Outcomes in Children With and Without Congenital Heart Disease Undergoing Noncardiac Surgery. J Am Coll Cardiol. 2016 Feb 23; 67(7):793-801. View Abstract
  94. A translational consideration of intercellular adhesion molecule-1 biology in the perioperative setting. Transl Perioper Pain Med. 2016; 1(2):17-23. View Abstract
  95. Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis. World J Clin Cases. 2015 Sep 16; 3(9):793-806. View Abstract
  96. Cardiopulmonary bypass in the pediatric population. Best Pract Res Clin Anaesthesiol. 2015 Jun; 29(2):241-56. View Abstract
  97. Differential effects of volatile anesthetics on leukocyte integrin macrophage-1 antigen. J Immunotoxicol. 2016; 13(2):148-56. View Abstract
  98. Sepsis pathophysiology and anesthetic consideration. Cardiovasc Hematol Disord Drug Targets. 2015; 15(1):57-69. View Abstract
  99. The role of macrophage 1 antigen in polymicrobial sepsis. Shock. 2014 Dec; 42(6):532-9. View Abstract
  100. Comparison of actual oxygen delivery kinetics to those predicted by mathematical modeling following stage 1 palliation just prior to superior cavopulmonary anastomosis. Paediatr Anaesth. 2015 Feb; 25(2):174-9. View Abstract
  101. Stereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1. PLoS One. 2014; 9(5):e96649. View Abstract
  102. Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists. Bioorg Med Chem. 2014 Apr 01; 22(7):2353-65. View Abstract
  103. An internal ligand-bound, metastable state of a leukocyte integrin, aXß2. J Cell Biol. 2013 Nov 25; 203(4):629-42. View Abstract
  104. Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1. Anesth Analg. 2013 Oct; 117(4):803-811. View Abstract
  105. Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin aIIbß3. PLoS One. 2013; 8(4):e60415. View Abstract
  106. Cardiac arrest and neuromuscular blockade reversal agents in the transplanted heart. J Cardiothorac Vasc Anesth. 2013 Dec; 27(6):1374-8. View Abstract
  107. Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. J Anesth. 2013 Apr; 27(2):261-8. View Abstract
  108. Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1. FASEB J. 2012 Nov; 26(11):4408-17. View Abstract
  109. A mathematical model of transitional circulation toward biventricular repair in hypoplastic left heart syndrome. Anesth Analg. 2012 Sep; 115(3):618-26. View Abstract
  110. Ventricular-assist device therapy in children. Best Pract Res Clin Anaesthesiol. 2012 Jun; 26(2):247-64. View Abstract
  111. Serial evaluation of left ventricular contraction and relaxation in Takotsubo cardiomyopathy by 2D speckle tracking echocardiography. J Med Ultrason (2001). 2012 Oct; 39(4):265-9. View Abstract
  112. Retrograde intubation during laryngeal cleft repair on cardiopulmonary bypass. J Anesth. 2012 Apr; 26(2):273-4. View Abstract
  113. Improvement of PaO2 during one-lung ventilation with partial left-heart bypass in pediatric patients is caused by increased blood flow to the dependent lung. J Cardiothorac Vasc Anesth. 2013 Jun; 27(3):542-5. View Abstract
  114. Cell-free ligand-binding assays for integrin LFA-1. Methods Mol Biol. 2012; 757:73-8. View Abstract
  115. Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3. FASEB J. 2012 Jan; 26(1):169-80. View Abstract
  116. Anesthetic and cardiopulmonary bypass considerations for cardiac surgery in unique pediatric patient populations: sickle cell disease and cold agglutinin disease. World J Pediatr Congenit Heart Surg. 2011 Jul 01; 2(3):364-70. View Abstract
  117. Blood utilization in neonates and infants undergoing cardiac surgery requiring cardiopulmonary bypass. World J Pediatr Congenit Heart Surg. 2011 Jul 01; 2(3):382-92. View Abstract
  118. Postoperative maladaptive behavioral changes in children. Middle East J Anaesthesiol. 2011 Jun; 21(2):183-9. View Abstract
  119. Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg. 2011 Apr; 112(4):830-8. View Abstract
  120. Anesthetic management of noncardiac surgery for patients with single ventricle physiology. J Anesth. 2011 Apr; 25(2):247-56. View Abstract
  121. Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1. Anesthesiology. 2010 Sep; 113(3):600-9. View Abstract
  122. The effect of left heart bypass on pulmonary blood flow and arterial oxygenation during one-lung ventilation in patients undergoing descending thoracic aortic surgery. J Clin Anesth. 2009 Dec; 21(8):562-6. View Abstract
  123. Management of difficult airway in pediatric patients with right ventricular outflow tract obstruction. J Anesth. 2009; 23(2):281-3. View Abstract
  124. Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis. J Lipid Res. 2009 May; 50(5):860-9. View Abstract
  125. Recent progress on acyl CoA: lysophospholipid acyltransferase research. J Lipid Res. 2009 Apr; 50 Suppl:S46-51. View Abstract
  126. The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB J. 2008 Dec; 22(12):4109-16. View Abstract
  127. Trendelenburg position, simulated Valsalva maneuver, and liver compression do not alter the size of the right internal jugular vein in patients with a bidirectional Glenn shunt. Anesth Analg. 2007 Aug; 105(2):365-8. View Abstract
  128. The perioperative management of a patient with Fontan physiology for pheochromocytoma resection. J Cardiothorac Vasc Anesth. 2008 Oct; 22(5):748-50. View Abstract
  129. Induction of supraventricular tachycardia during transesophageal echocardiography: an unusual complication. J Cardiothorac Vasc Anesth. 2008 Aug; 22(4):592-3. View Abstract

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