I have expertise in neuroimage analysis using structural and diffusion magnetic resonance imaging (MRI) and I have been focused on development and analysis of quantitative neuroimaging features of normal and abnormal brain development. I have developed methodologies for quantifying and investigating early cortical structural development, and for examining white matter connectivity patterns based on individual’s cortical gyral patterns. My long-term goal is to provide a novel and unique imaging biomarker for genetic brain disorders, and develop my career as a pioneer in a translational research filed of the developmental neuroimaging. To that end, I have been studying various developmental brain disorders using my original MRI analysis techniques and showing the potential to really diagnose developmental problems in multiple disorders (polymicrogyria, developmental dyslexia, tuberous sclerosis complex, and TUBB3 syndromes).
Publications
Impact of high maternal body mass index on fetal cerebral cortical and cerebellar volumes. J Perinat Med. 2025 Jan 06. View Abstract
Noncoding variants and sulcal patterns in congenital heart disease: Machine learning to predict functional impact. iScience. 2025 Feb 21; 28(2):111707. View Abstract
Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo. bioRxiv. 2024 Jun 28. View Abstract
Meta-regression of sulcal patterns, clinical and environmental factors on neurodevelopmental outcomes in participants with multiple CHD types. Cereb Cortex. 2024 06 04; 34(6). View Abstract
Automatic cortical surface parcellation in the fetal brain using attention-gated spherical U-net. Front Neurosci. 2024; 18:1410936. View Abstract
The role of cortical structural variance in deep learning-based prediction of fetal brain age. Front Neurosci. 2024; 18:1411334. View Abstract
Publisher Correction to: Morphological Features of Language Regions in Individuals with Tuberous Sclerosis Complex. J Autism Dev Disord. 2024 Mar; 54(3):1232. View Abstract
A Prospective Multi-Institutional Study Comparing the Brain Development in the Third Trimester between Opioid-Exposed and Nonexposed Fetuses Using Advanced Fetal MR Imaging Techniques. AJNR Am J Neuroradiol. 2024 02 07; 45(2):218-223. View Abstract
Association between placental oxygen transport and fetal brain cortical development: a study in monochorionic diamniotic twins. Cereb Cortex. 2024 01 14; 34(1). View Abstract
Association of genetic and sulcal traits with executive function in congenital heart disease. Ann Clin Transl Neurol. 2024 02; 11(2):278-290. View Abstract
Maternal pre-pregnancy obesity affects the uncinate fasciculus white matter tract in preterm infants. Front Pediatr. 2023; 11:1225960. View Abstract
Morphological Features of Language Regions in Individuals with Tuberous Sclerosis Complex. J Autism Dev Disord. 2024 Aug; 54(8):3155-3175. View Abstract
Comprehensive quantitative analyses of fetal magnetic resonance imaging in isolated cerebral ventriculomegaly. Neuroimage Clin. 2023; 37:103357. View Abstract
Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis. Dev Cell. 2022 10 24; 57(20):2381-2396.e13. View Abstract
Quantification of sulcal emergence timing and its variability in early fetal life: Hemispheric asymmetry and sex difference. Neuroimage. 2022 11; 263:119629. View Abstract
Regional brain development in fetuses with Dandy-Walker malformation: A volumetric fetal brain magnetic resonance imaging study. PLoS One. 2022; 17(2):e0263535. View Abstract
Optimal Method for Fetal Brain Age Prediction Using Multiplanar Slices From Structural Magnetic Resonance Imaging. Front Neurosci. 2021; 15:714252. View Abstract
Abnormal Right-Hemispheric Sulcal Patterns Correlate with Executive Function in Adolescents with Tetralogy of Fallot. Cereb Cortex. 2021 08 26; 31(10):4670-4680. View Abstract
Association between Quantitative MR Markers of Cortical Evolving Organization and Gene Expression during Human Prenatal Brain Development. Cereb Cortex. 2021 07 05; 31(8):3610-3621. View Abstract
Abnormal Left-Hemispheric Sulcal Patterns in Adults With Simple Congenital Heart Defects Repaired in Childhood. J Am Heart Assoc. 2021 04 06; 10(7):e018580. View Abstract
Intergenerational Transmission of Cortical Sulcal Patterns from Mothers to their Children. Cereb Cortex. 2021 03 05; 31(4):1888-1897. View Abstract
Regional Alterations in Cortical Sulcal Depth in Living Fetuses with Down Syndrome. Cereb Cortex. 2021 01 05; 31(2):757-767. View Abstract
Fetal Cortical Plate Segmentation Using Fully Convolutional Networks With Multiple Plane Aggregation. Front Neurosci. 2020; 14:591683. View Abstract
Cortical sulci in the human fetal brain and development / The Neuroscience of Development. 2020. View Abstract
Advanced fetal MRI / Handbook of Pediatric brain imaging: Methods, Modalities and Applications. 2020. View Abstract
An Atypical Sulcal Pattern in Children with Disorders of the Corpus Callosum and Its Relation to Behavioral Outcomes. Cereb Cortex. 2020 07 30; 30(9):4790-4799. View Abstract
Temporal Patterns of Emergence and Spatial Distribution of Sulcal Pits During Fetal Life. Cereb Cortex. 2020 06 01; 30(7):4257-4268. View Abstract
Abnormal Left-Hemispheric Sulcal Patterns Correlate with Neurodevelopmental Outcomes in Subjects with Single Ventricular Congenital Heart Disease. Cereb Cortex. 2020 03 21; 30(2):476-487. View Abstract
Quantitative MRI Analyses of Regional Brain Growth in Living Fetuses with Down Syndrome. Cereb Cortex. 2020 01 10; 30(1):382-390. View Abstract
Longitudinal structural connectomic and rich-club analysis in adolescent mTBI reveals persistent, distributed brain alterations acutely through to one year post-injury. Sci Rep. 2019 12 11; 9(1):18833. View Abstract
Early-Emerging Sulcal Patterns Are Atypical in Fetuses with Congenital Heart Disease. Cereb Cortex. 2019 07 22; 29(8):3605-3616. View Abstract
Altered White Matter Organization in the TUBB3 E410K Syndrome. Cereb Cortex. 2019 07 22; 29(8):3561-3576. View Abstract
Altered structural brain connectivity involving the dorsal and ventral language pathways in 16p11.2 deletion syndrome. Brain Imaging Behav. 2019 Apr; 13(2):430-445. View Abstract
Altered White Matter Connectivity Associated with Intergyral Brain Disorganization in Hemiplegic Cerebral Palsy. Neuroscience. 2019 02 10; 399:146-160. View Abstract
Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification. Neuroimage. 2019 03; 188:473-482. View Abstract
Disorganized Patterns of Sulcal Position in Fetal Brains with Agenesis of Corpus Callosum. Cereb Cortex. 2018 09 01; 28(9):3192-3203. View Abstract
Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development. Neuron. 2018 09 05; 99(5):905-913.e7. View Abstract
Sulcal pits and patterns in developing human brains. Neuroimage. 2019 01 15; 185:881-890. View Abstract
Total MRI Small Vessel Disease Burden Correlates with Cognitive Performance, Cortical Atrophy, and Network Measures in a Memory Clinic Population. J Alzheimers Dis. 2018; 63(4):1485-1497. View Abstract
Vascular Effects on Depressive Symptoms in Cognitive Impairment. J Alzheimers Dis. 2018; 65(2):597-605. View Abstract
Can cerebellar and brainstem apparent diffusion coefficient (ADC) values predict neuromotor outcome in term neonates with hypoxic-ischemic encephalopathy (HIE) treated with hypothermia? PLoS One. 2017; 12(7):e0178510. View Abstract
Quantitative Folding Pattern Analysis of Early Primary Sulci in Human Fetuses with Brain Abnormalities. AJNR Am J Neuroradiol. 2017 Jul; 38(7):1449-1455. View Abstract
Higher Physical Activity Is Associated with Increased Attentional Network Connectivity in the Healthy Elderly. Front Aging Neurosci. 2016; 8:198. View Abstract
Early- vs late-onset subcortical vascular cognitive impairment. Neurology. 2016 Feb 09; 86(6):527-34. View Abstract
Clinical effect of white matter network disruption related to amyloid and small vessel disease. Neurology. 2015 Jul 07; 85(1):63-70. View Abstract
Development of PET/MRI with insertable PET for simultaneous PET and MR imaging of human brain. Med Phys. 2015 May; 42(5):2354-63. View Abstract
Structural brain changes after traditional and robot-assisted multi-domain cognitive training in community-dwelling healthy elderly. PLoS One. 2015; 10(4):e0123251. View Abstract
Atypical Sulcal Pattern in Children with Developmental Dyslexia and At-Risk Kindergarteners. Cereb Cortex. 2016 Mar; 26(3):1138-1148. View Abstract
Effects of amyloid and small vessel disease on white matter network disruption. J Alzheimers Dis. 2015; 44(3):963-75. View Abstract
Higher C-peptide levels are associated with regional cortical thinning in 1093 cognitively normal subjects. Eur J Neurol. 2014 Oct; 21(10):1318-23, e80-1. View Abstract
Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science. 2014 Feb 14; 343(6172):764-8. View Abstract
Altered white matter connectivity and network organization in polymicrogyria revealed by individual gyral topology-based analysis. Neuroimage. 2014 Feb 01; 86:182-93. View Abstract
Prediction for human intelligence using morphometric characteristics of cortical surface: partial least square analysis. Neuroscience. 2013 Aug 29; 246:351-61. View Abstract
Automated sulcal depth measurement on cortical surface reflecting geometrical properties of sulci. PLoS One. 2013; 8(2):e55977. View Abstract
Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer's disease. Neurobiol Aging. 2013 Jul; 34(7):1921.e9-1921.e15. View Abstract
Reliable identification of deep sulcal pits: the effects of scan session, scanner, and surface extraction tool. PLoS One. 2013; 8(1):e53678. View Abstract
Effect of kidney dysfunction on cortical thinning in patients with probable Alzheimer's disease dementia. J Alzheimers Dis. 2013; 33(4):961-8. View Abstract
Quantification and discrimination of abnormal sulcal patterns in polymicrogyria. Cereb Cortex. 2013 Dec; 23(12):3007-15. View Abstract
Cardiovascular risk factors cause cortical thinning in cognitively impaired patients: relationships among cardiovascular risk factors, white matter hyperintensities, and cortical atrophy. Alzheimer Dis Assoc Disord. 2012 Apr-Jun; 26(2):106-12. View Abstract
Topography of cortical thinning areas associated with hippocampal atrophy (HA) in patients with Alzheimer's disease (AD). Arch Gerontol Geriatr. 2012 Mar-Apr; 54(2):e122-9. View Abstract
The cortical neuroanatomy of neuropsychological deficits in mild cognitive impairment and Alzheimer's disease: a surface-based morphometric analysis. Neuropsychologia. 2011 Dec; 49(14):3931-45. View Abstract
Cortical thinning in verbal, visual, and both memory-predominant mild cognitive impairment. Alzheimer Dis Assoc Disord. 2011 Jul-Sep; 25(3):242-9. View Abstract
A multi-resolution scheme for distortion-minimizing mapping between human subcortical structures based on geodesic construction on Riemannian manifolds. Neuroimage. 2011 Aug 15; 57(4):1376-92. View Abstract
Quantitative comparison and analysis of sulcal patterns using sulcal graph matching: a twin study. Neuroimage. 2011 Aug 01; 57(3):1077-86. View Abstract
Cortical thinning related to periventricular and deep white matter hyperintensities. Neurobiol Aging. 2012 Jul; 33(7):1156-67. View Abstract
The relationship between the presence of sulcal pits and intelligence in human brains. Neuroimage. 2011 Apr 15; 55(4):1490-6. View Abstract
Spectral-based automatic labeling and refining of human cortical sulcal curves using expert-provided examples. Neuroimage. 2010 Aug 01; 52(1):142-57. View Abstract
Automatic extraction of sulcal lines on cortical surfaces based on anisotropic geodesic distance. Neuroimage. 2010 Jan 01; 49(1):293-302. View Abstract
Spatial distribution of deep sulcal landmarks and hemispherical asymmetry on the cortical surface. Cereb Cortex. 2010 Mar; 20(3):602-11. View Abstract
Effects of demographic factors on cortical thickness in Alzheimer's disease. Neurobiol Aging. 2011 Feb; 32(2):200-9. View Abstract
Cortical thinning in vascular mild cognitive impairment and vascular dementia of subcortical type. J Neuroimaging. 2010 Jan; 20(1):37-45. View Abstract
Sulcal morphology changes and their relationship with cortical thickness and gyral white matter volume in mild cognitive impairment and Alzheimer's disease. Neuroimage. 2008 Oct 15; 43(1):103-13. View Abstract
Human cortical anatomical networks assessed by structural MRI. Brain Imaging and Behavior. 2008; 2:289-299. View Abstract
Variations in cortical thickness with dementia severity in Alzheimer's disease. Neurosci Lett. 2008 May 09; 436(2):227-31. View Abstract
Brain size and cortical structure in the adult human brain. Cereb Cortex. 2008 Sep; 18(9):2181-91. View Abstract
Cortical thickness in single- versus multiple-domain amnestic mild cognitive impairment. Neuroimage. 2007 Jun; 36(2):289-97. View Abstract
Pattern classification using principal components of cortical thickness and its discriminative pattern in schizophrenia. Neuroimage. 2007 Feb 15; 34(4):1405-15. View Abstract
Fractal dimension in human cortical surface: multiple regression analysis with cortical thickness, sulcal depth, and folding area. Hum Brain Mapp. 2006 Dec; 27(12):994-1003. View Abstract
Gender difference analysis of cortical thickness in healthy young adults with surface-based methods. Neuroimage. 2006 May 15; 31(1):31-8. View Abstract