Information

Related Research Units

Neurology Research

Research Overview

Dr. LaRovere’s pursuit of a career in the field of pediatric neurocritical care led to residencies and fellowships in the fields of pediatrics, pediatric neurology, adult vascular/critical care neurology and pediatric critical care medicine. She also has specific training and expertise in a cranial ultrasound technique known as transcranial doppler ultrasonography. Her clinical and research interests are in severe traumatic brain injury and the various applications of transcranial doppler ultrasonography in children with neurological disorders in the ICU setting.

Dr. LaRovere’s contributions to the field of neurocritical care include a description of the first pediatric neurocritical care consult service at Boston Children’s Hospital and the use of portable head CT imaging in the intensive care units at Boston Children’s Hospital. She served as site PI for the “PANGEA” study (Prevalence of Acute critical Neurological disease in children: a Global Epidemiological Assessment), which is an international multi-center point prevalence study to describe the epidemiology and gross outcomes of acute critical neurological disease in critically-ill children. She is currently the site PI for a study that examines cerebral blood flow in children using transcranial Doppler ultrasound who are receiving extracorporeal membrane oxygenation (ECMO). She is also a site PI for the “ADAPT” trial (Approaches and Decisions for Acute Pediatric TBI), which is a multi-center, international study to determine optimal management strategies for children with severe traumatic brain injury.

Research Background

Dr. LaRovere is the Director of the Neuroscience Intermediate Care Program, which is an intermediate care service for children with acute neurological and neurosurgical disorders.

 

Education

Undergraduate School

Brown University
1997 Providence RI

Medical School

Tufts University School of Medicine
2001 Boston MA

Residency

Pediatrics Tufts University School of Medicine/The Floating Hospital for Children
2001 Boston MA

Residency

Neurology Tufts Medical Center/The Floating Hospital for Children & Boston Children's Hospital (Affiliated Neurology Resident)
2004 Boston MA

Fellowship

Adult Vascular and Critical Care Neurology Massachusetts General Hospital/Brigham & Women's Hospital
2007 Boston MA

Fellowship

Pediatric Critical Care Boston Children's Hospital
2008 Boston MA

Publications

  1. Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Outcomes and  Endpoints. Neurocrit Care. 2024 Sep 20. View Abstract
  2. Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group in the Pediatric Population. Neurocrit Care. 2024 Aug 27. View Abstract
  3. Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data. Neurocrit Care. 2024 Aug 26. View Abstract
  4. Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Outcomes and  Endpoints. Neurocrit Care. 2024 Oct; 41(2):357-368. View Abstract
  5. Update in Pediatric Neurocritical Care: What a Neurologist Caring for Critically Ill Children Needs to Know. Semin Neurol. 2024 Jun; 44(3):362-388. View Abstract
  6. Recommendations for the Management of Initial and Refractory Pediatric Status Dystonicus. Mov Disord. 2024 Sep; 39(9):1435-1445. View Abstract
  7. Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data. Neurocrit Care. 2024 Feb; 40(1):382-383. View Abstract
  8. Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group in the Pediatric Population. Neurocrit Care. 2024 Feb; 40(1):65-73. View Abstract
  9. Practice Standards for the Use of Multimodality Neuromonitoring: A Delphi Consensus Process. Crit Care Med. 2023 12 01; 51(12):1740-1753. View Abstract
  10. Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data. Neurocrit Care. 2023 Dec; 39(3):593-599. View Abstract
  11. Noninvasive Neuromonitoring Modalities in Children Part I: Pupillometry, Near-Infrared Spectroscopy, and Transcranial Doppler Ultrasonography. Neurocrit Care. 2024 Feb; 40(1):130-146. View Abstract
  12. Heart Rate Change as a Potential Digital Biomarker of Brain Death in Critically Ill Children With Acute Catastrophic Brain Injury. Crit Care Explor. 2023 May; 5(5):e0908. View Abstract
  13. Clinical Course Associated with Aseptic Meningitis Induced by Intravenous Immunoglobulin for the Treatment of Multisystem Inflammatory Syndrome in Children. J Pediatr. 2023 06; 257:113372. View Abstract
  14. Neuromonitoring During ECMO Support in Children. Neurocrit Care. 2023 Dec; 39(3):701-713. View Abstract
  15. The Spectrum of Quantitative EEG Utilization Across North America: A Cross-Sectional Survey. Pediatr Neurol. 2023 04; 141:1-8. View Abstract
  16. Changes in Distribution of Severe Neurologic Involvement in US Pediatric Inpatients With COVID-19 or Multisystem Inflammatory Syndrome in Children in 2021 vs 2020. JAMA Neurol. 2023 01 01; 80(1):91-98. View Abstract
  17. Pharmacokinetic Modeling of Optimized Midazolam and Pentobarbital Dosing Used in Treatment Protocols of Refractory Status Epilepticus. Pediatr Crit Care Med. 2023 01 01; 24(1):51-55. View Abstract
  18. Effectiveness of Training Programs for Reducing Adverse Psychological Outcomes in Parents of Children with Acquired Brain Injury: A Systematic Review and Meta-Analysis. Neurol Ther. 2022 Dec; 11(4):1691-1704. View Abstract
  19. Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury. JAMA Netw Open. 2022 03 01; 5(3):e220891. View Abstract
  20. Multisystem Inflammatory-like Syndrome in a Child Following COVID-19 mRNA Vaccination. Vaccines (Basel). 2021 Dec 30; 10(1). View Abstract
  21. Clinical Characteristics and Outcomes of Children with Acute Catastrophic Brain Injury: A 13-Year Retrospective Cohort Study. Neurocrit Care. 2022 06; 36(3):715-726. View Abstract
  22. A Survey of Neuromonitoring Practices in North American Pediatric Intensive Care Units. Pediatr Neurol. 2022 01; 126:125-130. View Abstract
  23. Cerebral Emboli Monitoring Using Transcranial Doppler Ultrasonography in Adults and Children: A Review of the Current Technology and Clinical Applications in the Perioperative and Intensive Care Setting. Anesth Analg. 2021 08 01; 133(2):379-392. View Abstract
  24. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurol. 2021 05 01; 78(5):536-547. View Abstract
  25. Improving "Neuro Checks" in Neonatal ICU and PICU Is a Serial Neurologic Assessment in Pediatrics. Pediatr Crit Care Med. 2021 05 01; 22(5):512-514. View Abstract
  26. Defining catastrophic brain injury in children leading to coma and disorders of consciousness and the scope of the problem. Curr Opin Pediatr. 2020 12; 32(6):750-758. View Abstract
  27. Practice Recommendations for Transcranial Doppler Ultrasonography in Critically Ill Children in the Pediatric Intensive Care Unit: A Multidisciplinary Expert Consensus Statement. J Pediatr Intensive Care. 2021 Jun; 10(2):133-142. View Abstract
  28. Neurobehavioral Complications After Abdominal Organ Transplantation: Considering a Broader Phenotype and Care Plan. Pediatr Crit Care Med. 2020 09; 21(9):837-838. View Abstract
  29. EEG features of brain injury during extracorporeal membrane oxygenation in children. Neurology. 2020 09 08; 95(10):e1372-e1380. View Abstract
  30. Variation in Treatment and Outcomes of Children With Acute Disseminated Encephalomyelitis. Hosp Pediatr. 2020 02; 10(2):159-165. View Abstract
  31. Transcranial Doppler Ultrasound During Critical Illness in Children: Survey of Practices in Pediatric Neurocritical Care Centers. Pediatr Crit Care Med. 2020 01; 21(1):67-74. View Abstract
  32. Outcomes measures in children after acute central nervous system infections and malaria. Curr Opin Pediatr. 2019 12; 31(6):756-762. View Abstract
  33. Muscle Weakness After Sepsis in the Critically Ill: Identifiable and Functionally Remediable? Pediatr Crit Care Med. 2019 09; 20(9):888-889. View Abstract
  34. Fully automated, real-time, calibration-free, continuous noninvasive estimation of intracranial pressure in children. J Neurosurg Pediatr. 2019 11 01; 24(5):509-519. View Abstract
  35. Outcomes measures in children after acute central nervous system infections and malaria. Curr Opin Pediatr. 2019 Aug 12. View Abstract
  36. A Time-Frequency Approach for Cerebral Embolic Load Monitoring. IEEE Trans Biomed Eng. 2020 04; 67(4):1007-1018. View Abstract
  37. Diagnosis of Concussion in the Hospital. Semin Pediatr Neurol. 2019 07; 30:54-59. View Abstract
  38. Cerebrovascular Physiology During Pediatric Extracorporeal Membrane Oxygenation: A Multicenter Study Using Transcranial Doppler Ultrasonography. Pediatr Crit Care Med. 2019 02; 20(2):178-186. View Abstract
  39. The authors reply. Pediatr Crit Care Med. 2019 01; 20(1):98. View Abstract
  40. Pediatric Neurocritical Care: Evolution of a New Clinical Service in PICUs Across the United States. Pediatr Crit Care Med. 2018 11; 19(11):1039-1045. View Abstract
  41. Is There More to Zika? Complex Cardiac Disease in a Case of Congenital Zika Syndrome. Neonatology. 2018; 113(2):177-182. View Abstract
  42. Patterns of Head Computed Tomography Abnormalities During Pediatric Extracorporeal Membrane Oxygenation and Association With Outcomes. Pediatr Neurol. 2017 Aug; 73:64-70. View Abstract
  43. Cerebral High-Intensity Transient Signals during Pediatric Cardiac Catheterization: A Pilot Study Using Transcranial Doppler Ultrasonography. J Neuroimaging. 2017 07; 27(4):381-387. View Abstract
  44. Current Opinion and Use of Transcranial Doppler Ultrasonography in Traumatic Brain Injury in the Pediatric Intensive Care Unit. J Neurotrauma. 2016 12 01; 33(23):2105-2114. View Abstract
  45. Reply. J Ultrasound Med. 2016 Mar; 35(3):672-3. View Abstract
  46. Transcranial Doppler ultrasound in children with stroke and cerebrovascular disorders. Curr Opin Pediatr. 2015 Dec; 27(6):712-8. View Abstract
  47. Transcranial Doppler Sonography in Pediatric Neurocritical Care: A Review of Clinical Applications and Case Illustrations in the Pediatric Intensive Care Unit. J Ultrasound Med. 2015 Dec; 34(12):2121-32. View Abstract
  48. Differences in medical therapy goals for children with severe traumatic brain injury-an international study. Pediatr Crit Care Med. 2013 Oct; 14(8):811-8. View Abstract
  49. Pediatric neurocritical care: a neurology consultation model and implication for education and training. Pediatr Neurol. 2013 Mar; 48(3):206-11. View Abstract
  50. Head computed tomography scanning during pediatric neurocritical care: diagnostic yield and the utility of portable studies. Neurocrit Care. 2012 Apr; 16(2):251-7. View Abstract
  51. Emerging subspecialties in neurology: building a career and a field: pediatric neurocritical care. Neurology. 2008 May 27; 70(22):e89-91. View Abstract
  52. Postvaricella acute transverse myelitis in a previously vaccinated child. Pediatr Neurol. 2008 May; 38(5):370-2. View Abstract

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