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Related Research Units

Research Background

Ken Mandl directs the Computational Health Informatics Program at Boston Children’s Hospital and is the Donald A.B. Lindberg Professor of Pediatrics and Biomedical Informatics at Harvard Medical School. He is trained as a pediatrician and pediatric emergency physician.

His work at the intersection of population and individual health exerts a sustained influence on the developing field of biomedical informatics. He was a real time biosurveillance pioneer. Having long advocated for patient participation in producing and accessing data, Mandl was a designer of the first personal health and participatory surveillance systems.

Cognizant of electronic health record system limitations, Mandl was a developer of SMART on FHIR (substitutable apps running universally on health IT) for innovators to reach large markets and patients and doctors to access an “app store for health.” Through his influence on the 21st Century Cures Act, federal regulations require support for SMART interfaces, ensuring standardized access to individual and population data at system scale, “without special effort.”

He leads the federated Genomic Information Commons across nine top children’s hospitals and directs the Boston Children’s Hospital PrecisionLink Biobank for Health Discovery.

Dr. Mandl has been elected to the National Academy of Medicine, American Society for Clinical Investigation, Society for Pediatric Research, American College of Medical Informatics and American Pediatric Society. He is a recipient of the he Presidential Early Career Award for Scientists and Engineers, the Donald A.B. Lindberg Award for Innovation in Informatics and the Clifford A. Barger Award for top mentors at Harvard Medical School. His trainees lead informatics in academia and in the world’s largest technology companies.

He was advisor to two Directors of the CDC and chaired the Board of Scientific Counselors of the NIH’s National Library of Medicine

Dr. Mandl teaches and mentors extensively at the postgraduate level and leads an NIH-funded training program in biomedical informatics and genomics.

Publications

  1. Toward an artificial intelligence code of conduct for health and healthcare: implications for the biomedical informatics community. J Am Med Inform Assoc. 2025 Feb 01; 32(2):408-412. View Abstract
  2. The potential of Generative Pre-trained Transformer 4 (GPT-4) to analyse medical notes in three different languages: a retrospective model-evaluation study. Lancet Digit Health. 2025 Jan; 7(1):e35-e43. View Abstract
  3. Accuracy of ICD-10 Codes for Suicidal Ideation and Action in Pediatric Emergency Department Encounters. Pediatr Emerg Care. 2024 Dec 30. View Abstract
  4. Publisher Correction: Conflict of interest disclosure in biomedical research: a review of current practices, biases, and the role of public registries in improving transparency. Res Integr Peer Rev. 2024 Dec 20; 9(1):13. View Abstract
  5. Multisource representation learning for pediatric knowledge extraction from electronic health records. NPJ Digit Med. 2024 Nov 13; 7(1):319. View Abstract
  6. Generative artificial intelligence in primary care: an online survey of UK general practitioners. BMJ Health Care Inform. 2024 Sep 17; 31(1). View Abstract
  7. Cumulus: a federated electronic health record-based learning system powered by Fast Healthcare Interoperability Resources and artificial intelligence. J Am Med Inform Assoc. 2024 Aug 01; 31(8):1638-1647. View Abstract
  8. Accuracy of ICD-10 codes for suicidal ideation and action in pediatric emergency department encounters. medRxiv. 2024 Jul 24. View Abstract
  9. Discordance between a deep learning model and clinical-grade variant pathogenicity classification in a rare disease cohort. medRxiv. 2024 May 23. View Abstract
  10. Explainable machine learning for predicting conversion to neurological disease: Results from 52,939 medical records. Digit Health. 2024 Jan-Dec; 10:20552076241249286. View Abstract
  11. Real world performance of the 21st Century Cures Act population-level application programming interface. J Am Med Inform Assoc. 2024 Apr 19; 31(5):1144-1150. View Abstract
  12. Moving Biosurveillance Beyond Coded Data Using AI for Symptom Detection From Physician Notes: Retrospective Cohort Study. J Med Internet Res. 2024 Apr 04; 26:e53367. View Abstract
  13. Beyond compliance with the 21st Century Cures Act Rule: a patient controlled electronic health information export application programming interface. J Am Med Inform Assoc. 2024 04 03; 31(4):901-909. View Abstract
  14. GSDMB/ORMDL3 Rare/Common Variants Are Associated with Inhaled Corticosteroid Response among Children with Asthma. Genes (Basel). 2024 03 28; 15(4). View Abstract
  15. Integration of AI in healthcare requires an interoperable digital data ecosystem. Nat Med. 2024 Mar; 30(3):631-634. View Abstract
  16. Cumulus: A federated EHR-based learning system powered by FHIR and AI. medRxiv. 2024 Feb 06. View Abstract
  17. The SMART Text2FHIR Pipeline. AMIA Annu Symp Proc. 2023; 2023:514-520. View Abstract
  18. Generative Language Models and Open Notes: Exploring the Promise and Limitations. JMIR Med Educ. 2024 Jan 04; 10:e51183. View Abstract
  19. Emergency department visits and boarding for pediatric patients with suicidality before and during the COVID-19 pandemic. PLoS One. 2023; 18(11):e0286035. View Abstract
  20. Real World Performance of the 21st Century Cures Act Population Level Application Programming Interface. medRxiv. 2023 Oct 06. View Abstract
  21. Knowledge-Driven Online Multimodal Automated Phenotyping System. medRxiv. 2023 Oct 02. View Abstract
  22. Engaging a national-scale cohort of smart thermometer users in participatory surveillance. NPJ Digit Med. 2023 Sep 20; 6(1):175. View Abstract
  23. Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium. EClinicalMedicine. 2023 Oct; 64:102212. View Abstract
  24. Association between Neuroligin-1 polymorphism and plasma glutamine levels in individuals with autism spectrum disorder. EBioMedicine. 2023 Sep; 95:104746. View Abstract
  25. A computable case definition for patients with SARS-CoV2 testing that occurred outside the hospital. JAMIA Open. 2023 Oct; 6(3):ooad047. View Abstract
  26. Smart Thermometer-Based Participatory Surveillance to Discern the Role of Children in Household Viral Transmission During the COVID-19 Pandemic. JAMA Netw Open. 2023 06 01; 6(6):e2316190. View Abstract
  27. The SMART Text2FHIR Pipeline. medRxiv. 2023 Mar 27. View Abstract
  28. A computable phenotype for patients with SARS-CoV2 testing that occurred outside the hospital. medRxiv. 2023 Jan 19. View Abstract
  29. Comprehensive characterization of putative genetic influences on plasma metabolome in a pediatric cohort. Hum Genomics. 2022 12 08; 16(1):67. View Abstract
  30. The Patient Role in a Federal National-Scale Health Information Exchange. J Med Internet Res. 2022 11 04; 24(11):e41750. View Abstract
  31. Meeting the Moment: Addressing Barriers and Facilitating Clinical Adoption of Artificial Intelligence in Medical Diagnosis. NAM Perspect. 2022; 2022. View Abstract
  32. Pulmonary Hypertension in Children with Down Syndrome: Results from the Pediatric Pulmonary Hypertension Network Registry. J Pediatr. 2023 01; 252:131-140.e3. View Abstract
  33. Evaluation of Suicides Among US Adolescents During the COVID-19 Pandemic. JAMA Pediatr. 2022 07 01; 176(7):724-726. View Abstract
  34. International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality. NPJ Digit Med. 2022 Jun 13; 5(1):74. View Abstract
  35. Cardiac Catheterization and Hemodynamics in a Multicenter Cohort of Children with Pulmonary Hypertension. Ann Am Thorac Soc. 2022 06; 19(6):1000-1012. View Abstract
  36. Measuring Real-Time Medication Effects From Electroencephalography. J Clin Neurophysiol. 2024 Jan 01; 41(1):72-82. View Abstract
  37. How NFTs could transform health information exchange. Science. 2022 02 04; 375(6580):500-502. View Abstract
  38. Machine learning in medical education: a survey of the experiences and opinions of medical students in Ireland. BMJ Health Care Inform. 2022 Feb; 29(1). View Abstract
  39. Characterisation of paediatric pulmonary hypertensive vascular disease from the PPHNet Registry. Eur Respir J. 2022 01; 59(1). View Abstract
  40. Patient-led data sharing for clinical bioinformatics research: USCDI and beyond. J Am Med Inform Assoc. 2021 09 18; 28(10):2298-2300. View Abstract
  41. HIPAA and the Leak of "Deidentified" EHR Data. Reply. N Engl J Med. 2021 09 16; 385(12):e38. View Abstract
  42. Increased Prevalence of Familial Autoimmune Disease in Children With Opsoclonus-Myoclonus Syndrome. Neurol Neuroimmunol Neuroinflamm. 2021 11; 8(6). View Abstract
  43. Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents. EClinicalMedicine. 2021 Oct; 40:101112. View Abstract
  44. Machine-learning-based predictions of direct-acting antiviral therapy duration for patients with hepatitis C. Int J Med Inform. 2021 10; 154:104562. View Abstract
  45. Validation of an internationally derived patient severity phenotype to support COVID-19 analytics from electronic health record data. J Am Med Inform Assoc. 2021 07 14; 28(7):1411-1420. View Abstract
  46. Creative Approaches for Assessing Long-term Outcomes in Children. Pediatrics. 2021 07; 148(Suppl 1):s25-s32. View Abstract
  47. A high-throughput phenotyping algorithm is portable from adult to pediatric populations. J Am Med Inform Assoc. 2021 06 12; 28(6):1265-1269. View Abstract
  48. A landscape survey of planned SMART/HL7 bulk FHIR data access API implementations and tools. J Am Med Inform Assoc. 2021 06 12; 28(6):1284-1287. View Abstract
  49. Measuring the effects of sleep on epileptogenicity with multifrequency entropy. Clin Neurophysiol. 2021 09; 132(9):2012-2018. View Abstract
  50. HIPAA and the Leak of "Deidentified" EHR Data. N Engl J Med. 2021 Jun 10; 384(23):2171-2173. View Abstract
  51. International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries. JAMA Netw Open. 2021 06 01; 4(6):e2112596. View Abstract
  52. WEScover: selection between clinical whole exome sequencing and gene panel testing. BMC Bioinformatics. 2021 May 20; 22(1):259. View Abstract
  53. What Every Reader Should Know About Studies Using Electronic Health Record Data but May Be Afraid to Ask. J Med Internet Res. 2021 03 02; 23(3):e22219. View Abstract
  54. A proposal for shoring up Federal Trade Commission protections for electronic health record-connected consumer apps under 21st Century Cures. J Am Med Inform Assoc. 2021 03 01; 28(3):640-645. View Abstract
  55. Medication utilization in children born preterm in the first two years of life. J Perinatol. 2021 07; 41(7):1732-1738. View Abstract
  56. International Comparisons of Harmonized Laboratory Value Trajectories to Predict Severe COVID-19: Leveraging the 4CE Collaborative Across 342 Hospitals and 6 Countries: A Retrospective Cohort Study. medRxiv. 2021 Feb 05. View Abstract
  57. GenoPheno: cataloging large-scale phenotypic and next-generation sequencing data within human datasets. Brief Bioinform. 2021 01 18; 22(1):55-65. View Abstract
  58. Patients dispensed medications with actionable pharmacogenomic biomarkers: rates and characteristics. Genet Med. 2021 04; 23(4):782-786. View Abstract
  59. Privacy protections to encourage use of health-relevant digital data in a learning health system. NPJ Digit Med. 2021 Jan 04; 4(1):2. View Abstract
  60. The 21st Century Cures Act: A Competitive Apps Market and the Risk of Innovation Blocking. J Med Internet Res. 2020 12 11; 22(12):e24824. View Abstract
  61. Push Button Population Health: The SMART/HL7 FHIR Bulk Data Access Application Programming Interface. NPJ Digit Med. 2020 Nov 19; 3(1):151. View Abstract
  62. The role of environmental factors on transmission rates of the COVID-19 outbreak: an initial assessment in two spatial scales. Sci Rep. 2020 10 12; 10(1):17002. View Abstract
  63. US primary care in 2029: A Delphi survey on the impact of machine learning. PLoS One. 2020; 15(10):e0239947. View Abstract
  64. Limited Role of Bots in Spreading Vaccine-Critical Information Among Active Twitter Users in the United States: 2017-2019. Am J Public Health. 2020 10; 110(S3):S319-S325. View Abstract
  65. Claims-Based Algorithms for Identifying Patients With Pulmonary Hypertension: A Comparison of Decision Rules and Machine-Learning Approaches. J Am Heart Assoc. 2020 10 20; 9(19):e016648. View Abstract
  66. Adverse drug event presentation and tracking (ADEPT): semiautomated, high throughput pharmacovigilance using real-world data. JAMIA Open. 2020 Oct; 3(3):413-421. View Abstract
  67. International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium. NPJ Digit Med. 2020; 3:109. View Abstract
  68. Digitizing clinical trials. NPJ Digit Med. 2020; 3:101. View Abstract
  69. Experiences implementing scalable, containerized, cloud-based NLP for extracting biobank participant phenotypes at scale. JAMIA Open. 2020 Jul; 3(2):185-189. View Abstract
  70. Nonlinear Analysis of Visually Normal EEGs to Differentiate Benign Childhood Epilepsy with Centrotemporal Spikes (BECTS). Sci Rep. 2020 05 21; 10(1):8419. View Abstract
  71. Machine intelligence in healthcare-perspectives on trustworthiness, explainability, usability, and transparency. NPJ Digit Med. 2020; 3:47. View Abstract
  72. Early in the epidemic: impact of preprints on global discourse about COVID-19 transmissibility. Lancet Glob Health. 2020 05; 8(5):e627-e630. View Abstract
  73. FHIR Genomics: enabling standardization for precision medicine use cases. NPJ Genom Med. 2020; 5:13. View Abstract
  74. FHIR Genomics: enabling standardization for precision medicine use cases. NPJ Genom Med. 2020 Mar 18; 5(1):13. View Abstract
  75. The Role of Environmental Factors on Transmission Rates of the COVID-19 Outbreak: An Initial Assessment in Two Spatial Scales. SSRN. 2020 Mar 12; 3552677. View Abstract
  76. Data Citizenship under the 21st Century Cures Act. N Engl J Med. 2020 May 07; 382(19):1781-1783. View Abstract
  77. High Performance Computing on Flat FHIR Files Created with the New SMART/HL7 Bulk Data Access Standard. AMIA Annu Symp Proc. 2019; 2019:592-596. View Abstract
  78. Validation of an Electronic Health Record-Based Suicide Risk Prediction Modeling Approach Across Multiple Health Care Systems. JAMA Netw Open. 2020 03 02; 3(3):e201262. View Abstract
  79. Identifying Patients at Lowest Risk for Streptococcal Pharyngitis: A National Validation Study. J Pediatr. 2020 05; 220:132-138.e2. View Abstract
  80. Early in the Epidemic: Impact of preprints on global discourse of 2019-nCoV transmissibility. SSRN. 2020 Feb 12; 3536663. View Abstract
  81. External Validation of an Algorithm to Identify Patients with High Data-Completeness in Electronic Health Records for Comparative Effectiveness Research. Clin Epidemiol. 2020; 12:133-141. View Abstract
  82. Adverse drug event rates in pediatric pulmonary hypertension: a comparison of real-world data sources. J Am Med Inform Assoc. 2020 02 01; 27(2):294-300. View Abstract
  83. Correction: The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system. Genet Med. 2020 Feb; 22(2):449. View Abstract
  84. Early transmissibility assessment of a novel coronavirus in Wuhan, China. SSRN. 2020 Jan 24; 3524675. View Abstract
  85. SMART Markers: collecting patient-generated health data as a standardized property of health information technology. NPJ Digit Med. 2020; 3:9. View Abstract
  86. SMART Markers: collecting patient-generated health data as a standardized property of health information technology. NPJ Digit Med. 2020 Jan 23; 3(1):9. View Abstract
  87. The phenotypical implications of immune dysregulation in fragile X syndrome. Eur J Neurol. 2020 03; 27(3):590-593. View Abstract
  88. The Clinical Genome and Ancestry Report: An interactive web application for prioritizing clinically implicated variants from genome sequencing data with ancestry composition. Hum Mutat. 2020 02; 41(2):387-396. View Abstract
  89. Automatically Appraising the Credibility of Vaccine-Related Web Pages Shared on Social Media: A Twitter Surveillance Study. J Med Internet Res. 2019 11 04; 21(11):e14007. View Abstract
  90. The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system. Genet Med. 2020 02; 22(2):371-380. View Abstract
  91. A federated EHR network data completeness tracking system. J Am Med Inform Assoc. 2019 07 01; 26(7):637-645. View Abstract
  92. Racial and Ethnic Differences in Pediatric Pulmonary Hypertension: An Analysis of the Pediatric Pulmonary Hypertension Network Registry. J Pediatr. 2019 08; 211:63-71.e6. View Abstract
  93. Erratum: Author Correction: Developing and adopting safe and effective digital biomarkers to improve patient outcomes. NPJ Digit Med. 2019; 2:40. View Abstract
  94. The Association of Black Cardiologists (ABC) Cardiovascular Implementation Study (CVIS): A Research Registry Integrating Social Determinants to Support Care for Underserved Patients. Int J Environ Res Public Health. 2019 05 10; 16(9). View Abstract
  95. Modeling Spatiotemporal Factors Associated With Sentiment on Twitter: Synthesis and Suggestions for Improving the Identification of Localized Deviations. J Med Internet Res. 2019 05 08; 21(5):e12881. View Abstract
  96. The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Dev Cell. 2019 04 08; 49(1):10-29. View Abstract
  97. Artificial Intelligence and the Future of Primary Care: Exploratory Qualitative Study of UK General Practitioners' Views. J Med Internet Res. 2019 03 20; 21(3):e12802. View Abstract
  98. Developing and adopting safe and effective digital biomarkers to improve patient outcomes. NPJ Digit Med. 2019; 2(1). View Abstract
  99. Potential Excessive Testing at Scale: Biomarkers, Genomics, and Machine Learning. JAMA. 2019 Feb 26; 321(8):739-740. View Abstract
  100. Feature extraction for phenotyping from semantic and knowledge resources. J Biomed Inform. 2019 03; 91:103122. View Abstract
  101. Beyond One-Off Integrations: A Commercial, Substitutable, Reusable, Standards-Based, Electronic Health Record-Connected App. J Med Internet Res. 2019 02 01; 21(2):e12902. View Abstract
  102. The timing and frequency of trial inclusion in systematic reviews of type 2 diabetes drugs was associated with trial characteristics. J Clin Epidemiol. 2019 05; 109:62-69. View Abstract
  103. Computerization and the future of primary care: A survey of general practitioners in the UK. PLoS One. 2018; 13(12):e0207418. View Abstract
  104. Social media interventions for precision public health: promises and risks. NPJ Digit Med. 2018; 1. View Abstract
  105. Reimagining Health Data Exchange: An Application Programming Interface-Enabled Roadmap for India. J Med Internet Res. 2018 07 13; 20(7):e10725. View Abstract
  106. The Ad-Hoc Uncertainty Principle of Patient Privacy. AMIA Jt Summits Transl Sci Proc. 2018; 2017:132-138. View Abstract
  107. SMART Cancer Navigator: A Framework for Implementing ASCO Workshop Recommendations to Enable Precision Cancer Medicine. JCO Precis Oncol. 2018; 2018. View Abstract
  108. Measuring coverage and accuracy of whole-exome sequencing in clinical context. Genet Med. 2018 12; 20(12):1617-1626. View Abstract
  109. Adding patient-reported outcomes to a multisite registry to quantify quality of life and experiences of disease and treatment for youth with juvenile idiopathic arthritis. J Patient Rep Outcomes. 2018; 2. View Abstract
  110. Development of the Precision Link Biobank at Boston Children's Hospital: Challenges and Opportunities. J Pers Med. 2017 Dec 15; 7(4). View Abstract
  111. The Evolution of Patient Diagnosis: From Art to Digital Data-Driven Science. JAMA. 2017 Nov 21; 318(19):1859-1860. View Abstract
  112. Association of Sex With Recurrence of Autism Spectrum Disorder Among Siblings. JAMA Pediatr. 2017 11 01; 171(11):1107-1112. View Abstract
  113. Biases introduced by filtering electronic health records for patients with "complete data". J Am Med Inform Assoc. 2017 Nov 01; 24(6):1134-1141. View Abstract
  114. Patients Visiting Multiple Emergency Departments: Patterns, Costs, and Risk Factors. Acad Emerg Med. 2017 11; 24(11):1349-1357. View Abstract
  115. Antihyperglycemic Medications: A Claims-Based Estimate of First-line Therapy Use Prior to Initialization of Second-line Medications. Diabetes Care. 2017 11; 40(11):1500-1505. View Abstract
  116. Grappling with the Future Use of Big Data for Translational Medicine and Clinical Care. Yearb Med Inform. 2017 Aug; 26(1):96-102. View Abstract
  117. Pagers and Beyond in an Era of Microcommunications-What Is Old Is New Again. JAMA Intern Med. 2017 08 01; 177(8):1220-1221. View Abstract
  118. Evolving Research Data Sharing Networks to Clinical App Sharing Networks. AMIA Jt Summits Transl Sci Proc. 2017; 2017:302-307. View Abstract
  119. Provider Connectedness to Other Providers Reduces Risk of Readmission After Hospitalization for Heart Failure. Med Care Res Rev. 2019 02; 76(1):115-128. View Abstract
  120. A Computable Phenotype Improves Cohort Ascertainment in a Pediatric Pulmonary Hypertension Registry. J Pediatr. 2017 09; 188:224-231.e5. View Abstract
  121. Learning a Comorbidity-Driven Taxonomy of Pediatric Pulmonary Hypertension. Circ Res. 2017 Aug 04; 121(4):341-353. View Abstract
  122. Conclusions in systematic reviews of mammography for breast cancer screening and associations with review design and author characteristics. Syst Rev. 2017 05 22; 6(1):105. View Abstract
  123. A 21st-Century Health IT System - Creating a Real-World Information Economy. N Engl J Med. 2017 May 18; 376(20):1905-1907. View Abstract
  124. The effect of an electronic health record-based tool on abnormal pediatric blood pressure recognition. Congenit Heart Dis. 2017 Jul; 12(4):484-490. View Abstract
  125. Mapping information exposure on social media to explain differences in HPV vaccine coverage in the United States. Vaccine. 2017 05 25; 35(23):3033-3040. View Abstract
  126. Trends in Prostate-Specific Antigen Screening and Prostate Cancer Interventions 3 Years After the U.S. Preventive Services Task Force Recommendation. Ann Intern Med. 2017 03 21; 166(6):451-452. View Abstract
  127. Exclusion of Elderly People from Randomized Clinical Trials of Drugs for Ischemic Heart Disease. J Am Geriatr Soc. 2017 Nov; 65(11):2354-2361. View Abstract
  128. SMART-on-FHIR implemented over i2b2. J Am Med Inform Assoc. 2017 03 01; 24(2):398-402. View Abstract
  129. The Impact of Provider Networks on the Co-Prescriptions of Interacting Drugs: A Claims-Based Analysis. Drug Saf. 2017 03; 40(3):263-272. View Abstract
  130. Difference Between Estimated Purchase Price and Insurance Payments for Knee and Hip Implants in Privately Insured Patients Younger Than 65 Years. JAMA. 2017 02 28; 317(8):854-855. View Abstract
  131. Predicting Falls in People Aged 65 Years and Older from Insurance Claims. Am J Med. 2017 06; 130(6):744.e17-744.e23. View Abstract
  132. Opening the Duke electronic health record to apps: Implementing SMART on FHIR. Int J Med Inform. 2017 03; 99:1-10. View Abstract
  133. Accelerating Scientific Advancement for Pediatric Rare Lung Disease Research. Report from a National Institutes of Health-NHLBI Workshop, September 3 and 4, 2015. Ann Am Thorac Soc. 2016 12; 13(12):385-393. View Abstract
  134. Claims-Based Diagnostic Patterns of Patients Evaluated for Lyme Disease and Given Extended Antibiotic Therapy. Vector Borne Zoonotic Dis. 2017 02; 17(2):116-122. View Abstract
  135. Trends in Pharmacologic Interventions for Preventing Recurrence of Crohn's Disease After Ileocolonic Surgery. Inflamm Bowel Dis. 2016 10; 22(10):2432-41. View Abstract
  136. Financial competing interests were associated with favorable conclusions and greater author productivity in nonsystematic reviews of neuraminidase inhibitors. J Clin Epidemiol. 2016 12; 80:43-49. View Abstract
  137. The Drug Data to Knowledge Pipeline: Large-Scale Claims Data Classification for Pharmacologic Insight. AMIA Jt Summits Transl Sci Proc. 2016; 2016:105-11. View Abstract
  138. Creating a scalable clinical pharmacogenomics service with automated interpretation and medical record result integration - experience from a pediatric tertiary care facility. J Am Med Inform Assoc. 2017 01; 24(1):74-80. View Abstract
  139. Patient and Parent-Reported Signs and Symptoms for Group A Streptococcal Pharyngitis. Pediatrics. 2016 07; 138(1). View Abstract
  140. Prevalence and Characteristics of Interventional Trials Conducted Exclusively in Elderly Persons: A Cross-Sectional Analysis of Registered Clinical Trials. PLoS One. 2016; 11(5):e0155948. View Abstract
  141. Conflict of interest disclosure in biomedical research: A review of current practices, biases, and the role of public registries in improving transparency. Res Integr Peer Rev. 2016; 1. View Abstract
  142. Erratum to: Provider patient-sharing networks and multiple-provider prescribing of benzodiazepines. J Gen Intern Med. 2016 May; 31(5):588. View Abstract
  143. C3-PRO: Connecting ResearchKit to the Health System Using i2b2 and FHIR. PLoS One. 2016; 11(3):e0152722. View Abstract
  144. SMART precision cancer medicine: a FHIR-based app to provide genomic information at the point of care. J Am Med Inform Assoc. 2016 07; 23(4):701-10. View Abstract
  145. Mammography Risks: The Authors Reply. Health Aff (Millwood). 2016 Mar; 35(3):552. View Abstract
  146. SMART on FHIR: a standards-based, interoperable apps platform for electronic health records. J Am Med Inform Assoc. 2016 09; 23(5):899-908. View Abstract
  147. Data interchange using i2b2. J Am Med Inform Assoc. 2016 09; 23(5):909-15. View Abstract
  148. Time for a Patient-Driven Health Information Economy? N Engl J Med. 2016 Jan 21; 374(3):205-8. View Abstract
  149. Hospital Utilization Among Children With the Highest Annual Inpatient Cost. Pediatrics. 2016 Feb; 137(2):e20151829. View Abstract
  150. New Guidelines For Breast Cancer Screening. Health Aff (Millwood). 2016 Jan; 35(1):180. View Abstract
  151. A numerical similarity approach for using retired Current Procedural Terminology (CPT) codes for electronic phenotyping in the Scalable Collaborative Infrastructure for a Learning Health System (SCILHS). BMC Med Inform Decis Mak. 2015 Dec 11; 15:104. View Abstract
  152. Supporting Multi-sourced Medication Information in i2b2. AMIA Annu Symp Proc. 2015; 2015:747-55. View Abstract
  153. Comparison of Drug Utilization Patterns in Observational Data: Antiepileptic Drugs in Pediatric Patients. Paediatr Drugs. 2015 Oct; 17(5):401-10. View Abstract
  154. Using Nation-Wide Health Insurance Claims Data to Augment Lyme Disease Surveillance. Vector Borne Zoonotic Dis. 2015 Oct; 15(10):591-6. View Abstract
  155. Incidence and Patterns of Extended-Course Antibiotic Therapy in Patients Evaluated for Lyme Disease. Clin Infect Dis. 2015 Nov 15; 61(10):1536-42. View Abstract
  156. Provider Patient-Sharing Networks and Multiple-Provider Prescribing of Benzodiazepines. J Gen Intern Med. 2016 Feb; 31(2):164-171. View Abstract
  157. Breast Cancer Diagnoses: The Authors Reply. Health Aff (Millwood). 2015 Jul; 34(7):1253. View Abstract
  158. Driving Innovation in Health Systems through an Apps-Based Information Economy. Cell Syst. 2015 Jul; 1(1):8-13. View Abstract
  159. Associations Between Exposure to and Expression of Negative Opinions About Human Papillomavirus Vaccines on Social Media: An Observational Study. J Med Internet Res. 2015 Jun 10; 17(6):e144. View Abstract
  160. Industry-sponsored clinical research outside high-income countries: an empirical analysis of registered clinical trials from 2006 to 2013. Health Res Policy Syst. 2015 Jun 05; 13:28. View Abstract
  161. National expenditure for false-positive mammograms and breast cancer overdiagnoses estimated at $4 billion a year. Health Aff (Millwood). 2015 Apr; 34(4):576-83. View Abstract
  162. Federalist principles for healthcare data networks. Nat Biotechnol. 2015 Apr; 33(4):360-3. View Abstract
  163. Building a self-measuring healthcare system with computable metrics, data fusion, and substitutable apps. BMJ Outcomes. 2015 Apr; 2015(1):6-13. View Abstract
  164. Leaping the Data Chasm: Structuring Donation of Clinical Data for Healthcare Innovation and Modeling. Harvard Health Policy Rev. 2015; 14(2):18-21. View Abstract
  165. Ebola in the United States: EHRs as a public health tool at the point of care. JAMA. 2014 Dec 17; 312(23):2499-500. View Abstract
  166. ClinicalTrials.gov as a data source for semi-automated point-of-care trial eligibility screening. PLoS One. 2014; 9(10):e111055. View Abstract
  167. Availability and quality of mobile health app privacy policies. J Am Med Inform Assoc. 2015 Apr; 22(e1):e28-33. View Abstract
  168. Provider collaboration: cohesion, constellations, and shared patients. J Gen Intern Med. 2014 Nov; 29(11):1499-505. View Abstract
  169. Premarket safety and efficacy studies for ADHD medications in children. PLoS One. 2014; 9(7):e102249. View Abstract
  170. Are Meaningful Use Stage 2 certified EHRs ready for interoperability? Findings from the SMART C-CDA Collaborative. J Am Med Inform Assoc. 2014 Nov-Dec; 21(6):1060-8. View Abstract
  171. Finding the missing link for big biomedical data. JAMA. 2014 Jun 25; 311(24):2479-80. View Abstract
  172. Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): architecture. J Am Med Inform Assoc. 2014 Jul-Aug; 21(4):615-20. View Abstract
  173. Population-level evidence for an autoimmune etiology of epilepsy. JAMA Neurol. 2014 May; 71(5):569-74. View Abstract
  174. Is Biblioleaks inevitable? J Med Internet Res. 2014 Apr 22; 16(4):e112. View Abstract
  175. Consequences of antibiotics and infections in infancy: bugs, drugs, and wheezing. Ann Allergy Asthma Immunol. 2014 May; 112(5):441-445.e1. View Abstract
  176. A167: variations in patterns of care across pediatric rheumatic diseases in the childhood arthritis & rheumatology alliance network registry. Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S215-6. View Abstract
  177. Participatory medicine: a home score for streptococcal pharyngitis. Ann Intern Med. 2014 Feb 18; 160(4):289. View Abstract
  178. The effects of industry sponsorship on comparator selection in trial registrations for neuropsychiatric conditions in children. PLoS One. 2013; 8(12):e84951. View Abstract
  179. Participatory surveillance of diabetes device safety: a social media-based complement to traditional FDA reporting. J Am Med Inform Assoc. 2014 Jul-Aug; 21(4):687-91. View Abstract
  180. Association between pediatric clinical trials and global burden of disease. Pediatrics. 2014 Jan; 133(1):78-87. View Abstract
  181. Participatory medicine: A home score for streptococcal pharyngitis enabled by real-time biosurveillance: a cohort study. Ann Intern Med. 2013 Nov 05; 159(9):577-83. View Abstract
  182. Early detection of poor adherers to statins: applying individualized surveillance to pay for performance. PLoS One. 2013; 8(11):e79611. View Abstract
  183. Scalable decision support at the point of care: a substitutable electronic health record app for monitoring medication adherence. Interact J Med Res. 2013 Jul 22; 2(2):e13. View Abstract
  184. Twitter as a sentinel in emergency situations: lessons from the Boston marathon explosions. PLoS Curr. 2013 Jul 02; 5. View Abstract
  185. Analysis of pediatric clinical drug trials for neuropsychiatric conditions. Pediatrics. 2013 Jun; 131(6):1125-31. View Abstract
  186. App Store for EHRs and Patients Both. AMIA Jt Summits Transl Sci Proc. 2013; 2013:73. View Abstract
  187. Next-generation registries: fusion of data for care, and research. AMIA Jt Summits Transl Sci Proc. 2013; 2013:164-7. View Abstract
  188. An iOS Framework for the Indivo X Personally Controlled Health Record. AMIA Jt Summits Transl Sci Proc. 2013; 2013:196-200. View Abstract
  189. Development of a scalable pharmacogenomic clinical decision support service. AMIA Jt Summits Transl Sci Proc. 2013; 2013:60. View Abstract
  190. Participatory surveillance of hypoglycemia and harms in an online social network. JAMA Intern Med. 2013 Mar 11; 173(5):345-51. View Abstract
  191. Inpatient growth and resource use in 28 children's hospitals: a longitudinal, multi-institutional study. JAMA Pediatr. 2013 Feb; 167(2):170-7. View Abstract
  192. Apps to display patient data, making SMART available in the i2b2 platform. AMIA Annu Symp Proc. 2012; 2012:960-9. View Abstract
  193. A novel, privacy-preserving cryptographic approach for sharing sequencing data. J Am Med Inform Assoc. 2013 Jan 01; 20(1):69-76. View Abstract
  194. Pediatric versus adult drug trials for conditions with high pediatric disease burden. Pediatrics. 2012 Aug; 130(2):285-92. View Abstract
  195. Temporal patterns of medications dispensed to children and adolescents in a national insured population. PLoS One. 2012; 7(7):e40991. View Abstract
  196. An i2b2-based, generalizable, open source, self-scaling chronic disease registry. J Am Med Inform Assoc. 2013 Jan 01; 20(1):172-9. View Abstract
  197. Escaping the EHR trap--the future of health IT. N Engl J Med. 2012 Jun 14; 366(24):2240-2. View Abstract
  198. Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis. Arch Intern Med. 2012 Jun 11; 172(11):847-52. View Abstract
  199. Meaningful use of electronic health records. Health Aff (Millwood). 2012 Jun; 31(6):1365; author reply 1366. View Abstract
  200. Willingness to share personal health record data for care improvement and public health: a survey of experienced personal health record users. BMC Med Inform Decis Mak. 2012 May 22; 12:39. View Abstract
  201. Learning from hackers: open-source clinical trials. Sci Transl Med. 2012 May 02; 4(132):132cm5. View Abstract
  202. A pharmacoepidemiological network model for drug safety surveillance: statins and rhabdomyolysis. Drug Saf. 2012 May 01; 35(5):395-406. View Abstract
  203. The SMART Platform: early experience enabling substitutable applications for electronic health records. J Am Med Inform Assoc. 2012 Jul-Aug; 19(4):597-603. View Abstract
  204. The role and impact of research agendas on the comparative-effectiveness research among antihyperlipidemics. Clin Pharmacol Ther. 2012 Apr; 91(4):685-91. View Abstract
  205. Comparative effectiveness research: an empirical study of trials registered in ClinicalTrials.gov. PLoS One. 2012; 7(1):e28820. View Abstract
  206. Disclosing pathogenic genetic variants to research participants: quantifying an emerging ethical responsibility. Genome Res. 2012 Mar; 22(3):421-8. View Abstract
  207. Surveillance of an Online Social Network to Assess Population-level Diabetes Health Status and Healthcare Quality. Online J Public Health Inform. 2011; 3(3). View Abstract
  208. Surveillance of medication use: early identification of poor adherence. J Am Med Inform Assoc. 2012 Jul-Aug; 19(4):649-54. View Abstract
  209. Effect of expanded US recommendations for seasonal influenza vaccination: comparison of two pediatric emergency departments in the United States and Canada. CMAJ. 2011 Sep 20; 183(13):E1025-32. View Abstract
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  211. Health information management and perceptions of the quality of care for children with tracheotomy: a qualitative study. BMC Health Serv Res. 2011 May 23; 11:117. View Abstract
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  216. Patients treated at multiple acute health care facilities: quantifying information fragmentation. Arch Intern Med. 2010 Dec 13; 170(22):1989-95. View Abstract
  217. Indivo x: developing a fully substitutable personally controlled health record platform. AMIA Annu Symp Proc. 2010 Nov 13; 2010:6-10. View Abstract
  218. Adverse drug events in the outpatient setting: an 11-year national analysis. Pharmacoepidemiol Drug Saf. 2010 Sep; 19(9):901-10. View Abstract
  219. Patient-centered design of an information management module for a personally controlled health record. J Med Internet Res. 2010 Aug 30; 12(3):e36. View Abstract
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  225. Mychildren's: integration of a personally controlled health record with a tethered patient portal for a pediatric and adolescent population. AMIA Annu Symp Proc. 2009 Nov 14; 2009:65-9. View Abstract
  226. Longitudinal histories as predictors of future diagnoses of domestic abuse: modelling study. BMJ. 2009 Sep 29; 339:b3677. View Abstract
  227. Pediatric adverse drug events in the outpatient setting: an 11-year national analysis. Pediatrics. 2009 Oct; 124(4):e744-50. View Abstract
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  232. No small change for the health information economy. N Engl J Med. 2009 Mar 26; 360(13):1278-81. View Abstract
  233. Effect of environmental factors on the spatio-temporal patterns of influenza spread. Epidemiol Infect. 2009 Oct; 137(10):1377-87. View Abstract
  234. Revealing the spatial distribution of a disease while preserving privacy. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17608-13. View Abstract
  235. The Massachusetts Health and Homeland Alert Network: a scalable and secure public health knowledge management and notification system. AMIA Annu Symp Proc. 2008 Nov 06; 893. View Abstract
  236. Whose personal control? Creating private, personally controlled health records for pediatric and adolescent patients. J Am Med Inform Assoc. 2008 Nov-Dec; 15(6):737-43. View Abstract
  237. Re-identification of home addresses from spatial locations anonymized by Gaussian skew. Int J Health Geogr. 2008 Aug 12; 7:45. View Abstract
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  243. HealthMap: global infectious disease monitoring through automated classification and visualization of Internet media reports. J Am Med Inform Assoc. 2008 Mar-Apr; 15(2):150-7. View Abstract
  244. What are the benefits and risks of fitting patients with radiofrequency identification devices. PLoS Med. 2007 Nov 27; 4(11):e322. View Abstract
  245. Early experiences with personal health records. J Am Med Inform Assoc. 2008 Jan-Feb; 15(1):1-7. View Abstract
  246. Patients treated across multiple sites of care: a case for personally controlled health records. AMIA Annu Symp Proc. 2007 Oct 11; 881. View Abstract
  247. Multi-factor authentication using contents from disparate EHRs. AMIA Annu Symp Proc. 2007 Oct 11; 891. View Abstract
  248. Service-oriented architecture for pediatric immunization decision support. AMIA Annu Symp Proc. 2007 Oct 11; 1056. View Abstract
  249. Access controls for a pediatric personally controlled health record. AMIA Annu Symp Proc. 2007 Oct 11; 1131. View Abstract
  250. Indivo: a personally controlled health record for health information exchange and communication. BMC Med Inform Decis Mak. 2007 Sep 12; 7:25. View Abstract
  251. The tell-tale heart: population-based surveillance reveals an association of rofecoxib and celecoxib with myocardial infarction. PLoS One. 2007 Sep 05; 2(9):e840. View Abstract
  252. The value of patient self-report for disease surveillance. J Am Med Inform Assoc. 2007 Nov-Dec; 14(6):765-71. View Abstract
  253. AEGIS: a robust and scalable real-time public health surveillance system. J Am Med Inform Assoc. 2007 Sep-Oct; 14(5):581-8. View Abstract
  254. Automated real time constant-specificity surveillance for disease outbreaks. BMC Med Inform Decis Mak. 2007 Jun 13; 7:15. View Abstract
  255. An epidemiological network model for disease outbreak detection. PLoS Med. 2007 Jun; 4(6):e210. View Abstract
  256. Density-equalizing Euclidean minimum spanning trees for the detection of all disease cluster shapes. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9404-9. View Abstract
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  259. Linking surveillance to action: incorporation of real-time regional data into a medical decision rule. J Am Med Inform Assoc. 2007 Mar-Apr; 14(2):206-11. View Abstract
  260. An unsupervised classification method for inferring original case locations from low-resolution disease maps. Int J Health Geogr. 2006 Dec 08; 5:56. View Abstract
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  268. A susceptible-infected model of early detection of respiratory infection outbreaks on a background of influenza. J Theor Biol. 2006 Aug 21; 241(4):954-63. View Abstract
  269. Validation of syndromic surveillance for respiratory infections. Ann Emerg Med. 2006 Mar; 47(3):265.e1. View Abstract
  270. A proposed legal framework for addressing privacy for patient controlled health records in pediatrics. AMIA Annu Symp Proc. 2006; 861. View Abstract
  271. Reengineering real time outbreak detection systems for influenza epidemic monitoring. AMIA Annu Symp Proc. 2006; 866. View Abstract
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  273. A context-sensitive approach to anonymizing spatial surveillance data: impact on outbreak detection. J Am Med Inform Assoc. 2006 Mar-Apr; 13(2):160-5. View Abstract
  274. Running outside the baseline: impact of the 2004 Major League Baseball postseason on emergency department use. Ann Emerg Med. 2005 Oct; 46(4):386-7. View Abstract
  275. Implementation of laboratory order data in BioSense Early Event Detection and Situation Awareness System. MMWR Suppl. 2005 Aug 26; 54:27-30. View Abstract
  276. Simulation for assessing statistical methods of biologic terrorism surveillance. MMWR Suppl. 2005 Aug 26; 54:101-8. View Abstract
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  280. Factors affecting automated syndromic surveillance. Artif Intell Med. 2005 Jul; 34(3):269-78. View Abstract
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  283. Reverse geocoding: concerns about patient confidentiality in the display of geospatial health data. AMIA Annu Symp Proc. 2005; 905. View Abstract
  284. Feasibility of leveraging electronic data from pediatric hospitals for national surveillance: a survey of chief information officers. AMIA Annu Symp Proc. 2005; 954. View Abstract
  285. The PING personally controlled electronic medical record system: technical architecture. J Am Med Inform Assoc. 2005 Jan-Feb; 12(1):47-54. View Abstract
  286. Measuring outbreak-detection performance by using controlled feature set simulations. MMWR Suppl. 2004 Sep 24; 53:130-6. View Abstract
  287. Syndromic surveillance: the effects of syndrome grouping on model accuracy and outbreak detection. Ann Emerg Med. 2004 Sep; 44(3):235-41. View Abstract
  288. Use of emergency department chief complaint and diagnostic codes for identifying respiratory illness in a pediatric population. Pediatr Emerg Care. 2004 Jun; 20(6):355-60. View Abstract
  289. Is it influenza or anthrax? A decision analytic approach to the treatment of patients with influenza-like illnesses. Ann Emerg Med. 2004 Mar; 43(3):318-28. View Abstract
  290. Efficacy of an educational Web site for educating physicians about bioterrorism. Acad Emerg Med. 2004 Feb; 11(2):143-8. View Abstract
  291. Selective imaging strategies for the diagnosis of appendicitis in children. Pediatrics. 2004 Jan; 113(1 Pt 1):24-8. View Abstract
  292. Length-of-stay policies and ascertainment of postdischarge problems in newborns. Pediatrics. 2004 Jan; 113(1 Pt 1):42-9. View Abstract
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  294. Notifying emergency department patients of negative test results: pitfalls of passive communication. Pediatr Emerg Care. 2003 Aug; 19(4):226-30. View Abstract
  295. Prolonged partial thromboplastin times in children with fever and petechiae without bacteremia or sepsis. Pediatr Emerg Care. 2003 Aug; 19(4):244-7. View Abstract
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  297. Using temporal context to improve biosurveillance. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1961-5. View Abstract
  298. The value of parental report for diagnosis and management of dehydration in the emergency department. Ann Emerg Med. 2003 Feb; 41(2):196-205. View Abstract
  299. Time series modeling for syndromic surveillance. BMC Med Inform Decis Mak. 2003 Jan 23; 3:2. View Abstract
  300. Integrating syndromic surveillance data across multiple locations: effects on outbreak detection performance. AMIA Annu Symp Proc. 2003; 549-53. View Abstract
  301. Effects of a law against early postpartum discharge on newborn follow-up, adverse events, and HMO expenditures. N Engl J Med. 2002 Dec 19; 347(25):2031-8. View Abstract
  302. Effect of an imaging protocol on clinical outcomes among pediatric patients with appendicitis. Pediatrics. 2002 Dec; 110(6):1088-93. View Abstract
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  305. Integrating medical informatics and health services research: the need for dual training at the clinical health systems and policy levels. J Am Med Inform Assoc. 2002 Mar-Apr; 9(2):127-32. View Abstract
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  312. Effect of a reduced postpartum length of stay program on primary care services use by mothers and infants. Pediatrics. 2000 Oct; 106(4 Suppl):937-41. View Abstract
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  314. Parents as direct contributors to the medical record: validation of their electronic input. Ann Emerg Med. 2000 Apr; 35(4):346-52. View Abstract
  315. Four strategies for the management of esophageal coins in children. Pediatrics. 2000 Jan; 105(1):e5. View Abstract
  316. The spontaneous passage of esophageal coins in children. Arch Pediatr Adolesc Med. 1999 Oct; 153(10):1073-6. View Abstract
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  319. Infant health care use and maternal depression. Arch Pediatr Adolesc Med. 1999 Aug; 153(8):808-13. View Abstract
  320. The challenges of automating a real-time clinical practice guideline. Clin Perform Qual Health Care. 1999 Jan-Mar; 7(1):28-35. View Abstract
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  322. Healthconnect: clinical grade patient-physician communication. Proc AMIA Symp. 1999; 849-53. View Abstract
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  324. Social equity and access to the World Wide Web and E-mail: implications for design and implementation of medical applications. Proc AMIA Symp. 1998; 215-9. View Abstract
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