Research Overview

Dr. Madden conducts clinical research with a focus on finding risk factors for critical illness and its complications. This has included vitamin D deficiency and its relationship to illness severity and organ failure, quality improvement in severe sepsis and septic shock management, sedation management, early mobilization from critical illness, and delirium assessment. Current clinical research focuses on causes of delirium in critically ill children, as well as its assessment and management.

 

Research Background

Dr. Madden graduated from Brown University and Washington University Medical School at Saint Louis. She completed pediatrics residency, chief residency and pediatric critical care fellowship at Boston Children’s Hospital. She is currently an associate in the division of Pediatric Critical Care, and an Instructor in Anaesthesia at Harvard Medical School. Dr. Madden has studied various areas of clinical research, including vitamin D deficiency in critically ill children, sepsis management, delirium, and sedation in pediatric critical illness. After completing a clinical research fellowship at Harvard Medical School in 2012 with a Master’s of Medical Science, she has been involved in quality improvement initiatives in the division, as well as conducting clinical research projects. Dr. Madden serves as the physician lead for critical care on her hospital’s steering committee of a national “Improving Pediatric Sepsis Outcomes” collaborative (Children’s Hospital Association.)

 

Education

Graduate School

MMSc Harvard Medical School
Boston MA

Medical School

Washington University School of Medicine
St. Louis MO

Residency

Chief Resident, Pediatrics Boston Combined Residency Program (BCRP)
Boston MA

Fellowship

Pediatrics Critical Care Boston Children's Hospital
Boston MA

Publications

  1. Delirium Screening in Critically Ill Children: Secondary Analysis of the Multicenter PICU Up! Pilot Trial Dataset, 2019-2020. Pediatr Crit Care Med. 2024 Oct 01; 25(10):880-888. View Abstract
  2. The More Things Changed-Preservation of Cardiopulmonary Resuscitation Quality Despite Pandemic Impacts on the PICU Population. Pediatr Crit Care Med. 2022 11 01; 23(11):949-951. View Abstract
  3. Peripheral Vasopressors-Are We Avoiding the Central Issue Altogether? Pediatr Crit Care Med. 2022 08 01; 23(8):665-667. View Abstract
  4. Implementation Science in Pediatric Critical Care - Sedation and Analgesia Practices as a Case Study. Front Pediatr. 2022; 10:864029. View Abstract
  5. Risk and Resistance: Examining Our Antibiotic Use. Pediatr Crit Care Med. 2022 03 01; 23(3):227-228. View Abstract
  6. Association Between Anticholinergic Drug Burden and Adequacy of Enteral Nutrition in Critically Ill, Mechanically Ventilated Pediatric Patients. Pediatr Crit Care Med. 2021 12 01; 22(12):1083-1087. View Abstract
  7. Antipsychotic Drug Prescription in Pediatric Intensive Care Units: A 10-Year U.S. Retrospective Database Study. J Pediatr Intensive Care. 2024 Mar; 13(1):46-54. View Abstract
  8. Implementation of an Analgesia-Sedation Protocol Is Associated With Reduction in Midazolam Usage in the PICU. Pediatr Crit Care Med. 2021 10 01; 22(10):e513-e523. View Abstract
  9. Outcomes of Patients with Sepsis in a Pediatric Emergency Department after Automated Sepsis Screening. J Pediatr. 2021 08; 235:239-245.e4. View Abstract
  10. Comparison of Manual and Automated Sepsis Screening Tools in a Pediatric Emergency Department. Pediatrics. 2021 02; 147(2). View Abstract
  11. Effect of a Sepsis Screening Algorithm on Care of Children with False-Positive Sepsis Alerts. J Pediatr. 2021 04; 231:193-199.e1. View Abstract
  12. Toward a Better Understanding of Burnout Syndrome: Lump less, Split More. Crit Care Med. 2020 06; 48(6):930-931. View Abstract
  13. Measuring Central Cholinergic Inhibition As a Risk Factor for Delirium Remains a Challenge. Pediatr Crit Care Med. 2020 06; 21(6):590-591. View Abstract
  14. Exposure to Anticholinergic Medications in Pediatric Severe Sepsis and Feasibility of Delirium Screening. J Pediatr Intensive Care. 2020 Dec; 9(4):271-276. View Abstract
  15. Performance of an Automated Screening Algorithm for Early Detection of Pediatric Severe Sepsis. Pediatr Crit Care Med. 2019 12; 20(12):e516-e523. View Abstract
  16. Anticholinergic Medication Burden in Pediatric Prolonged Critical Illness: A Potentially Modifiable Risk Factor for Delirium. Pediatr Crit Care Med. 2018 10; 19(10):917-924. View Abstract
  17. Reading the Smoke Signals: What Is the Meaning of Burnout Among Pediatric Critical Care Physicians? Crit Care Med. 2018 01; 46(1):168-170. View Abstract
  18. The authors reply. Pediatr Crit Care Med. 2018 01; 19(1):87-88. View Abstract
  19. Caring for Long Length of Stay Patients in the Neonatal ICU and PICU: How Do We Ensure Coherent Decisions When the Physicians Are Continuously Rotating? Pediatr Crit Care Med. 2017 09; 18(9):907-908. View Abstract
  20. Differentiating Delirium From Sedative/Hypnotic-Related Iatrogenic Withdrawal Syndrome: Lack of Specificity in Pediatric Critical Care Assessment Tools. Pediatr Crit Care Med. 2017 Jun; 18(6):580-588. View Abstract
  21. Delirium in Critically Ill Children: An International Point Prevalence Study. Crit Care Med. 2017 Apr; 45(4):584-590. View Abstract
  22. Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections. Pediatr Crit Care Med. 2017 02; 18(2):103-111. View Abstract
  23. 1444: MANNOSE-BINDING LECTIN AND PEDIATRIC SEPSIS SUSCEPTIBILITY: A SYSTEMATIC REVIEW AND META-ANALYSIS. Crit Care Med. 2016 Dec; 44(12 Suppl 1):436. View Abstract
  24. Case Report of a Child after Hematopoietic Cell Transplantation with Acute Aspergillus Tracheobronchitis as a Cause for Respiratory Failure. Case Rep Pediatr. 2016; 2016:9676234. View Abstract
  25. Critically Ill Children Have Low Vitamin D-Binding Protein, Influencing Bioavailability of Vitamin D. Ann Am Thorac Soc. 2015 Nov; 12(11):1654-61. View Abstract
  26. Vitamin D deficiency in critically ill children. Pediatrics. 2012 Sep; 130(3):421-8. View Abstract
  27. Survival of neonates with enteroviral myocarditis requiring extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2011 May; 12(3):314-8. View Abstract

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